Challenges in Management of a Post-Traumatic Stiff Elbow – When to Perform Open Arthrolysis: A Case Report by S Adithyaa, K R Tarun Prashanth, M R Thirunthaiyan, R Dorai Kumar, B Sundararaja

“…The elbow joint is particularly susceptible to stiffness due to its highly congruent bony anatomy, relatively confined joint space tightly stabilizing collateral ligament complex, and the close relationship of the surrounding muscles acting as secondary stabilizers. …”
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PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control. by Romy Walser, John E Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L Williams, Muriel Laffargue, Matthias P Wymann

“…All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. …”
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Loss of ARID1A leads to a cold tumor phenotype via suppression of IFNγ signaling by Pamela M. Watson, Chelsea A. DeVaux, Kevin W. Freeman

“…Our work clarifies that the loss of ARID1A, which tightly associates with MYCN amplification, causes reduced inflammatory signaling. …”
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Glucose deprivation and identification of TXNIP as an immunometabolic modulator of T cell activation in cancer by Agathe Dubuisson, Adèle Mangelinck, Samantha Knockaert, Adrien Zichi, Etienne Becht, Wendy Philippon, Sandra Dromaint-Catesson, Manon Fasquel, Fabien Melchiore, Nicolas Provost, Dawid Walas, Dawid Walas, Hélène Darville, Jean-Pierre Galizzi, Céline Lefebvre, Véronique Blanc, Vincent Lombardi

“…BackgroundThe ability of immune cells to rapidly respond to pathogens or malignant cells is tightly linked to metabolic pathways. In cancer, the tumor microenvironment (TME) represents a complex system with a strong metabolism stress, in part due to glucose shortage, which limits proper T cell activation, differentiation and functions preventing anti-tumor immunity.MethodsIn this study, we evaluated T cell immune reactivity in glucose-restricted mixed lymphocyte reaction (MLR), using a comprehensive profiling of soluble factors, multiparametric flow cytometry and single cell RNA sequencing (scRNA-seq).ResultsWe determined that glucose restriction potentiates anti-PD-1 immune responses and identified thioredoxin-interacting protein (TXNIP), a negative regulator of glucose uptake, as a potential immunometabolic modulator of T cell activation. …”
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A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

“…Proteomics and biochemical reconstitution reveal that Ypl225w functions as a co-translational chaperone by forming dual interactions with the eEF1A G domain nascent chain and the UBA domain of ribosome-bound nascent polypeptide-associated complex (NAC). …”
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A fungal chromatin remodeler drives transcription by establishing an open chromatin architecture and activated histone environment by Mengting Xu, Qi Zhang, Yuan Li, Wei Zhou, Lingyun Lei, Fucheng Lin, Yanjun Kou, Zeng Tao

“…In the filamentous fungus Magnaporthe oryzae, we demonstrate that remodeling the structure of chromatin 1 (RSC1) functions as a critical regulator in this process. …”
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Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis by Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang, Zhe Chen, Xuan Lv, Zhouming Deng, Zan Huang, Lin Cai, Renxiong Wei

“…Mechanistically, NIBAN2 interacts with the HNRNPU‐cored spliceosome complex and alters its components to regulate the alternative splicing of RUNX2, which ultimately cause an increase in functional RUNX2 (nuclear localization sequence complete) but a decrease in dysfunctional RUNX2 (exon 6 exclusive) to reinforce osteoblast differentiation. …”
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Classification patterns identification of immunogenic cell death-related genes in heart failure based on deep learning by Zhihui Ma, Shixin Ma, Bin Chen, Yongjun Zhang, Jinmei Zeng, Jianping Tao, Yu Hu

“…Abstract Heart failure (HF) is a complex and prevalent condition, particularly in the elderly, presenting symptoms like chest tightness, shortness of breath, and dyspnea. …”
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The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride. by Rossana Segreto, Hoda Bazafkan, Julia Millinger, Martina Schenk, Lea Atanasova, Maria Doppler, Christoph Büschl, Mélanie Boeckstaens, Silvia Soto Diaz, Ulrike Schreiner, Fabiano Sillo, Raffaella Balestrini, Rainer Schuhmacher, Susanne Zeilinger

“…Here we describe how alteration of the activity of TOR1, the single and essential TOR kinase of T. atroviride, by treatment with chemical TOR inhibitors or by genetic manipulation of selected TOR pathway components affected various cellular functions. Loss of TSC1 and TSC2, that are negative regulators of TOR complex 1 (TORC1) in mammalian cells, resulted in altered nitrogen source-dependent growth of T. atroviride, reduced mycoparasitic overgrowth and, in the case of Δtsc1, a diminished production of numerous secondary metabolites. …”
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Effectuation control: Modified management control system for sustainability in facing the uncertainty by Setyarini Santosa, Tubagus Ismail, Imam Abu Hanifah, Munawar Muchlish

“…This study aims to investigate the functioning of joint control by introducing a novel construct known as effectuation control, which forms effectuation MCS. …”
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The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling by Elise S Bruguera, Jacob P Mahoney, William I Weis

“…Wnt/β-catenin signaling directs animal development and tissue renewal in a tightly controlled, cell- and tissue-specific manner. …”
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Exploiting <i>Brassica rapa</i> L. subsp. <i>pekinensis</i> Genome Research by Faujiah Nurhasanah Ritonga, Zeyu Gong, Yihui Zhang, Fengde Wang, Jianwei Gao, Cheng Li, Jingjuan Li

“…However, challenges exist in integrating multi-omics for the functional analysis of genes and for developing potential traits for Chinese cabbage improvement. …”
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The molecular mechanism of NF-κB dysregulation across different subtypes of renal cell carcinoma by Nour Abu Jayab, Alaa Abed, Iman M. Talaat, Rifat Hamoudi

“…Background: The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various cellular functions, including immune response, proliferation, growth, and apoptosis. …”
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Expression pattern of Calbindin-D28k, NeuN proteins, ATOH1 and EN2 genes in the human fetal cerebellum by Phanindra Prasad Poudel, Arnab Ghosh, Chacchu Bhattarai, Saman Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, R. Vani Lakshmi, Sneha Guruprasad Kalthur

“…Background: Human cerebellum plays a crucial role in motor coordination and cognitive functions. Series of events such as cell proliferation, migration, and differentiation occur during the development, which are tightly regulated by specific genes. …”
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Novel pathogenic mtDNA variants in Chinese children with neurological mitochondrial disorders by Zhimei Liu, Kexin Pan, Mingzhao Wang, Yijun Jin, Wenxin Yang, Keer Chen, Chaolong Xu, Xin Duan, Ying Zou, Changhong Ren, Lifang Dai, Suzhou Zhao, Ya Wang, Lijun Shen, Fang Fang, Hezhi Fang

“…Abstract Objective Pathogenic variations in the mitochondrial genome are tightly linked to neurological mitochondrial disorders in children. …”
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Integrative and comparative analysis of whole-transcriptome sequencing in circCOL1A1-knockdown and circCOL1A1-overexpressing goat hair follicle stem cells by Jian Wang, Xi Wu, Liuming Zhang, Xiaomei Sun, Wei Sun, Kunzhe Dong, Yongjun Li

“…Objective Hair morphogenesis is tightly related to hair follicle stem cells (HFSCs) proliferation and hair follicle (HF) development. …”
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The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 by Bitong Zhang, Bitong Zhang, Yahui Wang, Yahui Wang, Yahui Wang, Haoxiang Chang, Haoxiang Chang, Chong Wang, Chong Wang, Hong Fan, Hong Fan, Xiuyun Ren, Xiuyun Ren

“…BackgroundPeriodontal disease is a chronic inflammatory condition affecting the supporting structures of the teeth, involving complex interactions between systemic and local immune responses. …”
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THE DYNAMICS STUDY OF PATIENTS STATE WITH MUSCLE AND JOINT DYSFUNCTION OF TMJ, WHICH DECIDED TO COMPLETE THE TREATMENT AFTER ELIMINATION OF THEIR DISEASE SYMPTOMS ACHIEVED BY USING... by A.M. Boyan, V.I. Bessonov

“…Because of the treatment carried out during 3.5 ± 0.7 months, all 25 patients haven’t had any clinical aspects of muscle and joint dysfunction of the TMJ and all of them have had normal physiological functioning of the masticatory muscles and TMJ, which was confirmed by objective examination methods, including special ones. …”
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Plants Drive Microbial Biomass and Composition but Not Diversity to Promote Ecosystem Multifunctionality in Karst Vegetation Restoration by Yunlong Sun, Shu Zhang, Yueming Liang, Xuan Yu, Fujing Pan

“…The structure of plant, bacterial, and fungal communities varied across different stages of vegetation restoration, exhibiting the highest microbial diversity indices in the SH stage. Additionally, the tightness and complexity of co-occurrence networks of bacteria and fungi increased with advancing vegetation restoration, and higher positive links were observed in fungi than bacteria. …”
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Influence mechanisms of dynamic metamorphism on the evolution of micro/nano pore structures in tectonically deformed coals by Hewu LIU, Xiaoxue LYU, Chenliang HOU, Zuopeng XIONG

“…In detail, the aromatic structures in the TDCs experienced chemical changes like rotation, folding, and recombination, forming a more tightly arranged molecular structural configuration. …”
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