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52641
The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer
Published 2019-09-01“…The Q165P mutation causes structural changes in the MATH domain and impairs SPOP dimerization and substrate degradation. …”
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52642
Giant Outer Transiting Exoplanet Mass (GOT ‘EM) Survey. VI. Confirmation of a Long-period Giant Planet Discovered with a Single TESS Transit
Published 2025-01-01“…Based on giant planet structure models, TOI-4465 b appears to be enriched in heavy elements at a level consistent with late-stage accretion of icy planetesimals. …”
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52643
New possibilities of using perampanel in children. Efficacy and tolerability of perampanel in the treatment of epilepsy (literature review and experience of Svt. Luka’s Association...
Published 2024-11-01“…This study included 270 patients aged 4 to 43 years (125 males and 145 females; 255 children and adolescents aged 4–18 years; 15 adult patients; mean age at the time of perampanel therapy initiation was 11.8 years) who received perampanel and for whom we managed to collect clinical data for at least 6 months.The study sample included 114 patients with structural and presumably structural focal epilepsy, 120 patients with genetic and presumably genetic epilepsy (including Dravet and Angelman syndromes, Lafora disease, mutations in genes PCDH19, PHACTR1, CDKL5, ARX, PING, SCN2A, KIAA2022, chromosomal microdeletions, etc.), and 36 patients with focal epilepsy of unknown etiology. …”
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52644
Role of the Perceived Social Responsibility of the Company and the Psychological Mechanisms to Achieve the Employees' Creative Behavior (Case Study: Electro Kavir Company of Yazd)
Published 2025-03-01“…The data collection tool in this research was standard questionnaires, the validity of which was confirmed using the opinions of a number of experts in this field, and Cronbach's alpha coefficient and composite reliability were used to determine the reliability of the measurement tool, and the analysis method used in this research was structural equation modeling technique. …”
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52645
Pain, Function, and Elastosonographic Assessment After Shockwave Therapy in Non-Calcific Supraspinatus Tendinopathy: A Retrospective Observational Study
Published 2025-01-01“…SWE proved to be a reliable method for monitoring structural and clinical changes in SNCCT. Further research, including randomized controlled trials, is recommended to confirm these findings and explore longer-term outcomes.…”
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52646
Enhancing regeneration and functionality of excitable tissues via integrating bioelectronics and bioengineered constructs
Published 2024-01-01“…The inherent complexities of excitable cardiac, nervous, and skeletal muscle tissues pose great challenges in constructing artificial counterparts that closely resemble their natural bioelectrical, structural, and mechanical properties. Recent advances have increasingly revealed the beneficial impact of bioelectrical microenvironments on cellular behaviors, tissue regeneration, and therapeutic efficacy for excitable tissues. …”
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52647
STANDARDIZATION OF CLINICAL PHARMACIST FUNCTIONAL RESPONSIBILITIES IN HOSPITAL SETTING IN UKRAINE AND ABROAD
Published 2023-12-01“…The applied methods include a systematic approach, bibliographic, standardization, group method of expert evaluations, structural-logical, analytical-comparative, computer data processing, and modeling. …”
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52648
Modelling water table depth at rewetted peatlands with Sentinel-1 and Sentinel-2
Published 2025-06-01Get full text
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52649
Knowledge mapping and trend identification in UAV-enabled hybrid FSO/RF communication systems
Published 2025-09-01“…The study employed several types of analysis. These included structural, visual, and temporal analysis based on citation frequency to trace the origins of UHCN research, its evolution, and its current state. …”
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52650
Healthy ageing and psychological resilience among the empty-nest older adults: a cross-sectional survey in China
Published 2025-06-01“…A face-to-face questionnaire survey was conducted using the sociodemographic questionnaire, the Healthy Ageing Instrument, and the Connor-Davidson Resilience Scale. Data analysis was performed using SPSS (version 26.0) and AMOS (version 24.0), employing t-tests, ANOVA, Pearson correlation analysis, hierarchical linear regression, and structural equation modeling. …”
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52651
Intersectional associations between citizenship, English fluency and racialisation on access to health and sex work community services: findings from a prospective cohort of sex wo...
Published 2025-03-01“…Culturally responsive and language-tailored services that attend to and address these intersecting forms of structural marginalisation, along with the full decriminalisation of all aspects of sex work, and the removal of punitive sex work-related immigration policies, are recommended.…”
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52652
The corneoscleral shell of the eye: potentials of assessing biomechanical parameters in normal and pathological conditions
Published 2016-07-01“…Reduced CH in primary open-angle glaucoma occurs in parallel with the development of pathological structural changes of the optic disc, and deterioration of visual fields, which is an evidence of a specific character and sensitivity of this parameter. …”
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52653
Advanced generalized machine learning models for predicting hydrogen–brine interfacial tension in underground hydrogen storage systems
Published 2025-05-01“…IFT is key in fluid behavior, influencing structural and residual trapping capacities. However, measuring IFT for H2–brine systems is challenging due to H2’s volatility and the complexity of reservoir conditions. …”
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52654
Assessment of Risk Factors of Chronic Kidney Disease among Patients Attending Medical City Complex
Published 2023-06-01“… Chronic kidney disease is a worldwide health problem that is defined as structural abnormalities or progressive or permanent loss of renal function for 3 months or more, which is usually associated with a decrease in glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2 or persistent proteinuria, which can lead to end-stage renal disease (ESRD) or kidney failure. …”
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52655
Predicting changes in land use and land cover using remote sensing and land change modeler
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52656
Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
Published 2014-03-01“…In addition, in vitro probing with Pb2+ and RNase T1 revealed structural differences between the TCF21 variants in proximity of the rs12190287 variant, which are predicted to provide greater access to the C allele for miR-224 binding. miR-224 and TCF21 expression levels were anti-correlated in HCASMC, and miR-224 modulates the transcriptional response of TCF21 to transforming growth factor-β (TGF-β) and platelet derived growth factor (PDGF) signaling in an allele-specific manner. …”
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52657
Adoption of environmentally friendly urban freight logistics practices: the role of communication and governance
Published 2025-01-01“…AMOS SPSS version 26 was used to obtain the results for the structural model and measurement model, respectively. …”
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52658
How do strategic attributes of electronic commerce impel the perceived value and electronic loyalty of online food delivery applications (OFDAs)
Published 2024-08-01“…Confirmatory factor analysis was applied to evaluate the validity of the constructs, and structural equation modeling was employed to test the model through Smart-PLS. …”
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52659
Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 3; peer review: 1 approved, 2 approved with...
Published 2024-11-01“…Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. …”
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52660
Altered functional connectivity density in the brains of hemodialysis end-stage renal disease patients: An in vivo resting-state functional MRI study.
Published 2019-01-01“…<h4>Methods</h4>re-fMRI data were collected from 30 ESRD patients undergoing hemodialysis (14 men, 38.33±7.44 years old) and 30 matched healthy controls (13 men, 39.17±5.7 years old). …”
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