Rainfall as an important process for net N gain during the initial phase of natural recovery in karst desertification by Xia Li, Yu Pang, Hengsheng Lao, Linfang Luo, Tongxin He, Guangting Pei, Shuangshuang Xiao, Baoqing Hu, Jianfei Sun

“…We speculate that the three-layer vertical structure of soil–epikarst–bedrock in karst areas induce a complex hydrologic process, prolonging the time of water–soil interaction, and leading to a maximum threshold for hydrologic N losses under high rainfall, which effectively protect soil inorganic N. …”
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Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary... by Shigeharu Muto, Ayako Furuhama, Mika Yamamoto, Yasuteru Otagiri, Naoki Koyama, Seiji Hitaoka, Yusuke Nagato, Hirofumi Ouchi, Masahiro Ogawa, Kisako Shikano, Katsuya Yamada, Satoshi Ono, Minami Hoki, Fumiya Ishizuka, Soichiro Hagio, Chiaki Takeshita, Hisayoshi Omori, Kiyohiro Hashimoto, Satsuki Chikura, Masamitsu Honma, Kei-ichi Sugiyama, Masayuki Mishima

“…Abstract Background Primary aromatic amines (PAAs) present significant challenges in the prediction of mutagenicity using current standard quantitative structure activity relationship (QSAR) systems, which are knowledge-based and statistics-based, because of their low positive prediction values (PPVs). …”
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Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
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Recurrent Jetlets Associated with the Disappearance of a Satellite Spot by Liheng Yang, Xiaoli Yan, Jun Zhang, Zhike Xue, Zhe Xu, Jincheng Wang, Yijun Hou, Yian Zhou, Defang Kong, Roslan Umar, Xinsheng Zhang, Qiaoling Li, Liping Yang

“…The horizontal magnetic field of the satellite spot consistently exhibited a vortex structure throughout its evolution until it vanished. …”
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Molecular characteristic, evolution, and pathogenicity analysis of avian infectious bronchitis virus isolates associated with QX type in China by Yuanlu Lu, Yiran Zeng, Haowei Luo, Bingchen Qiao, Qi Meng, Zijian Dai, Na Chen, Lingcai Zhao, Xianchen Meng, Haitao Zhang, Jun Xia, Jihui Ping

“…Analysis of the S1 subunit structure revealed that mutations of amino acid residues in the hypervariable region (HVR) and the neutralizing epitope region resulted in antigenic variation in isolates by changing the antigen conformation. …”
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Exploring the impact of APOE ɛ4 on functional connectivity in Alzheimer’s disease across cognitive impairment levels by Kangli Dong, Wei Liang, Ting Hou, Zhijie Lu, Yixuan Hao, Chenrui Li, Yue Qiu, Nan Kong, Yan Cheng, Yaqi Wen, Wanyin Ma, Wenbin Zheng, Jitian Guan, Yan Lin, Kai Huang, Lu Zhang, Siya Chen, Xiangyuan Ma, Renhua Wu, Naili Wei

“…Studies have shown that APOE ɛ4 mediates the modulation of intrinsic functional brain networks in cognitively normal individuals and significantly disrupts the whole-brain topological structure in AD patients. However, how APOE ɛ4 regulates brain functional connectivity (FC) and consequently affects the levels of cognitive impairment in AD patients remains unknown. …”
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Understanding the Broad-line Region of Active Galactic Nuclei with Photoionization. I. The Moderate-accretion Regime by Qiaoya Wu, Yue Shen, Hengxiao Guo, Scott F. Anderson, W. N. Brandt, Catherine J. Grier, Patrick B. Hall, Luis C. Ho, Yasaman Homayouni, Keith Horne, Jennifer I-Hsiu Li, Donald P. Schneider

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Possible Carbon Dioxide above the Thick Aerosols of GJ 1214 b by Everett Schlawin, Kazumasa Ohno, Taylor J. Bell, Matthew M. Murphy, Luis Welbanks, Thomas G. Beatty, Thomas P. Greene, Jonathan J. Fortney, Vivien Parmentier, Isaac R. Edelman, Samuel Gill, David R. Anderson, Peter J. Wheatley, Gregory W. Henry, Nishil Mehta, Laura Kreidberg, Marcia J. Rieke

“…Further modeling of the planet’s atmosphere, interior structure and origins will provide valuable insights about how sub-Neptunes like GJ 1214 b form and evolve.…”
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Nematodes exposed to furfural acetone exhibit a species-specific vacuolar H+-ATPase response by Wanli Cheng, Wei Dai, Wen Chen, Hua Xue, Zhengzheng Zhao, Zhengbing Jiang, Huanan Li, Jiashu Liu, Feng Huang, Minmin Cai, Longyu Zheng, Ziniu Yu, Donghai Peng, Jibin Zhang

“…And the Spearman analysis results illustrated that the differential nematicidal activity of FAc against various nematodes is attributed to variations in the sequence and structure of the receptor proteins VHA-12 and VHA-13 among different nematode species. …”
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Analysis of ROH Characteristics Across Generations in Grassland-Thoroughbred Horses and Identification of Loci Associated with Athletic Traits by Wenqi Ding, Wendian Gong, Tugeqin Bou, Lin Shi, Yanan Lin, Xiaoyuan Shi, Zheng Li, Huize Wu, Manglai Dugarjaviin, Dongyi Bai

“…Principal component analysis (PCA) and STRUCTURE revealed clear distinctions among the generations, with a notable overlap between CY and F3. …”
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WRF-ELM v1.0: a regional climate model to study land–atmosphere interactions over heterogeneous land use regions by H. Huang, Y. Qian, G. Bisht, J. Wang, T. Chakraborty, D. Hao, J. Li, T. Thurber, B. Singh, Z. Yang, Y. Liu, P. Xue, P. Xue, W. J. Sacks, E. Coon, R. Hetland

“…It maintains the integrity of ELM's source code structure and facilitates the transfer of future developments in ELM to WRF-ELM.…”
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Sleep disturbances in SCN8A‐related disorders by Francesca Furia, Katrine M. Johannesen, Claudia M. Bonardi, Roberto Previtali, Angel Aledo‐Serrano, Massimo Mastrangelo, Jacopo Favaro, Silvia Masnada, Valentina diMicco, Jacopo Proietti, Pierangelo Veggiotti, Guido Rubboli, Gaetano Cantalupo, Kern Olofsson, Rikke S. Møller, Elena Gardella

“…Polysomnographic recordings (9 patients/20 nights) showed an altered sleep structure in 95%, with frequent arousals, mainly not seizure related. …”
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Impact of Thermal-Induced Turbulent Distribution Along FSO Link on Transmission of Photonically Generated mmW Signals in the Frequency Range 26–40 GHz by Luis Vallejo, Matej Komanec, Beatriz Ortega, Jan Bohata, Dong-Nhat Nguyen, Stanislav Zvanovec, Vicenc Almenar

“…The results show high electrical power decrease and fluctuation of the generated mmW signal according to the particular level of the turbulence in terms of refractive index structure parameter and thermal distribution along the FSO link. …”
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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference by Yinlei Lei, Min Li, Han Zhang, Yu Deng, Xinyu Dong, Pengyu Chen, Ye Li, Suhua Zhang, Chengtao Li, Shouyu Wang, Ruiyang Tao

“…The composition and structure of the bacteria at these three body sites were well characterized and found to differ regionally. …”
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Functional Connectivity Changes in Primary Motor Cortex Subregions of Patients With Obstructive Sleep Apnea by Lifeng Li, Qimeng Shi, Bowen Fang, Yuting Liu, Xiang Liu, Yongqiang Shu, Yingke Deng, Yumeng Liu, Haijun Li, Junjie Zhou, Dechang Peng

“…This study examined functional connectivity (FC) changes in subregions of the primary motor cortex (M1) in patients with OSA and their association with sleep structure, cognition, and clinical features. Methods Sixty‐five patients with OSA and 65 healthy controls (HC) participants matched in age and educational background were included. …”
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Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice by Victor J. Johnson, Cynthia V. Rider, Michael I. Luster, Cynthia J. Willson, Shawn Harris, Billie Stiffler, James Blake, Esra Mutlu, Veronica Godfrey, Brian Burback, Reshan Fernando, Suramya Waidyanatha, Gary R. Burleson, Dori R. Germolec

“…Careful characterization of strong positive and clear negative PACs is needed in order to lay the foundation for generating robust immunotoxicity data for structurally diverse PACs that have not yet been evaluated.MethodsIn the current study, adult B6C3F1/N female mice were treated daily for 28 consecutive days by oral administration of B(a)P to provide dose levels ranging between 2 and 150 mg/kg bodyweight/day. …”
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Locally-tailored vs. centrally-administered strategies for implementation of primary human papillomavirus (HPV) screening in an integrated healthcare system: a qualitative research... by Erin E. Hahn, Erin E. Hahn, Corrine Munoz-Plaza, Chunyi Hsu, Nancy T. Cannizzaro, Quyen Ngo-Metzger, Michael K. Gould, Brian S. Mittman, Melissa Hodeib, Devansu Tewari, Chun R. Chao, Chun R. Chao

“…Using a team coding approach, we developed an initial coding structure refined during iterative analysis; data were subsequently organized thematically into domains, key themes, and sub-themes using thematic analysis, followed by framework analysis informed by CFIR.ResultsThirty-two interviews were conducted. …”
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OUTPATIENT REGISTER OF CARDIOVASCULAR DISEASES IN THE RYAZAN REGION (RECVASA): PRINCIPAL TASKS, EXPERIENCE OF DEVELOPMENT AND FIRST RESULTS by S. A. Boytsov, S. S. Yakushin, S. Yu. Martsevich, M. M. Lukyanov, N. N. Nikulina, A. V. Zagrebelny, A. N. Vorobyov, K. G. Pereverseva, E. A. Pravkina, A. D. Deev, E. Yu. Andreenko, A. I. Ershova, A. N. Meshkov, R. P. Myasnikov, S. E. Serdyuk, М. S. Kharlap

“…To estimate risk factors and comorbidity structure, cardiovascular diseases outcomes, evaluate their diagnostics and treatment quality in real outpatient practice using a register of patients with arterial hypertension (HT), ischemic heart disease (IHD), chronic heart failure (CHF) and atrial fibrillation (AF) in the Ryazan Region – the territorial subject ofRussian Federation with high cardiovascular mortality rate.Material and methods. …”
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Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model. by Ernesto Luna, Pankaj Agrawal, Riyaz Mehta, Maria E Boone, Charlotte Vernhes, Colombe Denys, Robert Small, Bhaswati Mukherjee, Norbert Tennagels, Stefan Maerten, Donald R Drake

“…<h4>Background</h4>The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. …”
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Validation of Quantitative Ultrasound and Texture Derivative Analyses-Based Model for Upfront Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer by Adrian Wai Chan, Lakshmanan Sannachi, Daniel Moore-Palhares, Archya Dasgupta, Sonal Gandhi, Rossanna Pezo, Andrea Eisen, Ellen Warner, Frances C. Wright, Nicole Look Hong, Ali Sadeghi-Naini, Mia Skarpathiotakis, Belinda Curpen, Carrie Betel, Michael C. Kolios, Maureen Trudeau, Gregory J. Czarnota

“…Explanations for the misclassified cases included unplanned modifications made to the type of chemotherapy during treatment, inherent limitations of the predictive model, presence of DCIS in tumour structure, and an ill-defined tumour border in a minority of cases. …”
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