Characteristics of the gut virome in patients with premalignant colorectal adenoma by Pan Zhang, Xiaofeng Tuo, Jiong Jiang, Yue Zhang, Juhui Zhao, Chengzhao Deng, Gang Zhao, Yan Cheng, Lingqin Song, Yan Yang, Ruochun Guo, Huan Zhang, Hongli Zhao, Shiyang Ma, Lu Li, Haitao Shi

“…Results Our results revealed a notable shift in the gut virome structure of patients compared to healthy controls, characterized by a significant increase in viral families such as Microviridae, Podoviridae_crAss-like, and Quimbyviridae. …”
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Insights from a codesigned dynamic modelling study of child and adolescent obesity in Australia by Alison Hayes, Rebecca Wyse, Anna Lene Seidler, Kylie E Hunter, Rebecca K Golley, Louise A Baur, Anthony D Okely, Kenny Lawson, Jo-An Occhipinti, Louise Freebairn, Simon Keith Chiu, Joseph Carrello, L Kurt Kreuger

“…This research presents insights from a system dynamics model of childhood and adolescent obesity aimed at supporting evidence-based decision-making.Methods A system dynamics model was developed using the best available evidence and data, with input from research and industry experts to map the hypothetical causal structure of the factors contributing to childhood and adolescent obesity in Australia. …”
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Anti-HIV-1 Effect of the Fluoroquinolone Enoxacin and Modulation of Pro-Viral hsa-miR-132 Processing in CEM-SS Cells by Verena Schlösser, Helen Louise Lightfoot, Christine Leemann, Seyedeh Elnaz Banijamali, Aathma Merin Bejoy, Shashank Tiwari, Jeffrey L. Schloßhauer, Valentina Vongrad, Andreas Brunschweiger, Jonathan Hall, Karin J. Metzner, Jochen Imig

“…Results: We established that Enoxacin, but not the structurally similar compound nalidixic acid, exhibits strong anti-HIV-1 effects in the T-cell line CEM-SS, but not MT-4. …”
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Anatomical and histological characterization of the filum terminale in dogs by Christoforos Posporis, Javier Espinosa, Martí Pumarola, Ester Blasco Ortega, Jaume Alomar, Koen Santifort, Koen Santifort, Steven De Decker, Karol Lam, Juan José Mínguez, Patricia Álvarez, Vicente Aige-Gil

“…This study presents the first comprehensive anatomical and histological characterization of the normal canine FT, establishing baseline reference data to facilitate the identification of pathomorphological alterations associated with disorders involving this structure, such as tethered cord syndrome.…”
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Virtual Health Research Capacity Strengthening in Low- and Middle-Income Countries: A Systematic Integrative Review by Chelsea M. McGuire, Nikolina Boskovic, Bolatito Betty Fatusin, Pius Ameh, Taylor Reed, Priyanka Jethwani, David Flynn, Jo Cooke, Robert Saper

“…These include selecting well‑fitted program participants, intentionally designing program structure and content, conducting needs assessments or pilots, incorporating equity as a programmatic target, ensuring longitudinal program evaluation and monitoring, and utilizing a comprehensive conceptualization of program sustainability.…”
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Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study by Kerry Woolfall, Mark J Peters, Padmanabhan Ramnarayan, Elizabeth Deja, Jennifer Preston, Paul R Mouncey, Julie C Menzies, Doug William Gould, Tracy Karen Mitchell, Shelley Marsh, Jennifer Ainsworth, Hannah Sedgwick, Carly Tibbins

“…Findings provide insight into how the PICU platform trial should be designed and operationalised, including having a broad and inclusive population eligible for inclusion onto the platform trial, with different inclusion and exclusion criteria for each domain; starting the trial with no more than three domains and prioritising the outcomes of Child quality of life and Survival (all participants). Optimal governance structure and suggestions about how any challenges to the success of the full trial can be overcome are also presented.Conclusions Young people, parents/carers and PICU staff viewed the proposed PICU platform trial to be acceptable. …”
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Intensification of Natural Disasters in the State of Pará and the Triggering Mechanisms Across the Eastern Amazon by Everaldo B. de Souza, Douglas B. S. Ferreira, Luciano J. S. Anjos, Alan C. Cunha, João Athaydes Silva, Eliane C. Coutinho, Adriano M. L. Sousa, Paulo J. O. P. Souza, Waleria P. Monteiro Correa, Thaiane S. Silva Dias, Alexandre M. C. do Carmo, Carlos B. B. Gutierrez, Giordani R. C. Sodré, Aline M. M. Lima, Edson J. P. Rocha, Bergson C. Moraes, Luciano P. Pezzi, Tercio Ambrizzi

“…Furthermore, we conducted a comprehensive composite analysis on the tropical ocean–atmosphere dynamic structure that elucidated the various triggering mechanisms of disasters arising from Inundations, Droughts, and Forest fires (on seasonal scale), and Flash floods and Heavy rainfall (on sub-monthly scale) in Pará. …”
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A Multiwavelength Portrait of the 3C 220.3 Lensed System by Sóley Ó. Hyman, Belinda J. Wilkes, S. P. Willner, Joanna Kuraszkiewicz, Mojegan Azadi, D. M. Worrall, Adi Foord, Simona Vegetti, Matthew L. N. Ashby, Mark Birkinshaw, Christopher Fassnacht, Martin Haas, Daniel Stern

“…The new HST images also reveal extended emission around galaxy A, and the spectra show extended [O ii ] emission with irregular morphology and complex velocity structure. All indications are that the two lensing galaxies are a gravitationally interacting pair. …”
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Piloting the options assessment toolkit with national malaria programme leaders from the Asia–Pacific countries: a meeting report by Manash Shrestha, Sanjaya Acharya, Josselyn Neukom, Karma Lhazeen, Ngo Duc Thang, Muhammad Naeem Habib, Lyndes Wini, Tobgyel Tobgyel, Kesang Wangchuk, Huy Rekol, Lek Dysoley, Siv Sovannaroth, Minerva Simatuopang, Helen Dewi Prameswari, Asik Surya, Zau Ring, Mohammad Qasim Khan, Boualam Khamlome, Mohd Hafizi Abdul Hamid, Ram Kumar Mahato, Top Thapa, Sheen Angelou Juangco, Hee Il Lee, Hyun Il Shin, Kumudu Gunasekera, Champa Aluthwera, Prayuth Sudathip, Rungrawee Timpontree, Hoang Dinh Canh, Sonia Cheung, Muhammad Zeeshan Haroon, Shreehari Acharya, Robert J. Commons, Bipin Adhikari, Varunika Ruwanpura, Phone Si Hein, Abhijit Sharma, Poe Poe Aung, Neena Valecha, Kamala Thriemer, Caroline A. Lynch

“…Thematic analysis of qualitative data revealed that NMPs found the OAT useful and timely for structuring malaria policy discussions. …”
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The changing face of the Arctic: four decades of greening and implications for tundra ecosystems by Gerald V. Frost, Uma S. Bhatt, Matthew J. Macander, Logan T. Berner, Donald A. Walker, Martha K. Raynolds, Rúna Í. Magnússon, Annett Bartsch, Jarle W. Bjerke, Jarle W. Bjerke, Howard E. Epstein, Bruce C. Forbes, Scott J. Goetz, Elizabeth E. Hoy, Elizabeth E. Hoy, Stein R. Karlsen, Timo Kumpula, Trevor C. Lantz, Mark J. Lara, Efrén López-Blanco, Paul M. Montesano, Paul M. Montesano, Christopher S. R. Neigh, Ingmar Nitze, Kathleen M. Orndahl, Taejin Park, Taejin Park, Gareth K. Phoenix, Adrian V. Rocha, Brendan M. Rogers, Gabriela Schaepman-Strub, Hans Tømmervik, Mariana Verdonen, Mariana Verdonen, Alexandra Veremeeva, Anna-Maria Virkkala, Christine F. Waigl

“…Nonetheless, long-term increases in NDVI—commonly known as “the greening of the Arctic”—remain prominent across large areas in all available long-term spaceborne datasets and align with long-term shifts in vegetation structure documented in disparate Arctic regions. Common shifts reported from the Low Arctic, such as shrubification, generally portend declines in floristic diversity, and shifts in fauna that favor boreal forest species. …”
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Features of the Circulation of ARVI Pathogens During of Emergence and Widespread of SARS-CoV-2 in the 2018–2021 by E. I. Burtseva, L. V. Kolobukhina, O. L. Voronina, A. V. Ignatjeva, E. A. Mukasheva, A. D. Panova, E. L. Feodoritova, K. G. Krasnoslodotsev, S. V. Trushakova, L. N. Merkulova, I. N. Khlopova, N. V. Breslav, N. N. Ryzhova, M. S. Kunda, E. I. Aksenova, R. V. Vartanyan, L. B. Kisteneva, O. A. Burgasova, A. G. Rosatkevich, I. S. Kruzhkova, M. V. Bazarova, S. V. Smetanina, N. A. Tsvetkova, Yu. S. Levochkina, M. V. Kozlova, D. O. Korostin, E. I. Botsmanov

“…To identify the features of the structure of ARVI during the emergence and widespread spread of SARS-CoV-2. …”
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Improving regional care in the last year of life by setting up a pragmatic evidence-based Plan–Do–Study–Act cycle: results from a cross-sectional survey by Lena Ansmann, Holger Pfaff, Ingrid Schubert, Ludwig Kuntz, Stephanie Stock, Sheila Payne, Nadine Scholten, Ute Karbach, Stefanie Hamacher, Raymond Voltz, Christian Albus, Frank Jessen, Christian Rietz, Frank Schulz-Nieswandt, Julia Strupp, Gloria Dust, Nicolas Schippel

“…Objectives To set up a pragmatic Plan–Do–Study–Act cycle by analysing patient experiences and determinants of satisfaction with care in the last year of life.Design Cross-sectional postbereavement survey.Setting Regional health services research and development structure representing all health and social care providers involved in the last year of life in Cologne, a city with 1 million inhabitants in Germany.Participants 351 bereaved relatives of adult decedents, representative for age and gender, accidental and suspicious deaths excluded.Results For the majority (89%) of patients, home was the main place of care during their last year of life. …”
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Trauma systems: a global comparison by Theodore Miclau, MD, Zsolt J. Balogh, MD, PhD, Katherine R. Miclau, BA, Brian Bernstein, MD, Kodi Edson Kojima, MD, PhD, Taketo Kurozumi, MD, PhD, Ross K. Leighton, MD, PhD, Douglas W. Lundy, MD, MBA, Guy Putzeys, MD, Inger B. Schipper, MD, PhD, Wim Vandesande, MD, Marcos de Camargo Leonhardt, MD, MSc, Maria Adelaide Miranda Goncalves, MD, Guilherme Pelosini Gaiarsa, MD, MSc, Hans-Christoph Pape, MD

“…Trauma systems across countries vary significantly in the structure and regulation of trauma care, injury patterns, national data collection, and accessibility, reflecting diverse demographics and healthcare infrastructures. …”
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The OsZHD1 and OsZHD2, Two Zinc Finger Homeobox Transcription Factor, Redundantly Control Grain Size by Influencing Cell Proliferation in Rice by Mingliang Guo, Chun Zheng, Chao Shi, Xiaozhuan Lu, Zeyuan She, Shuyu Jiang, Dagang Tian, Yuan Qin

“…Abstract Grain size is vital determinant for grain yield and quality, which specified by its three-dimensional structure of seeds (length, width and thickness). The ZINC FINGER-HOMEODOMAIN (ZHD) proteins play critical roles in plant growth and development. …”
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Shifts in the rhizosphere microbiome and exudation profile of avocado (Persea americana Mill.) during infection by Phytophthora cinnamomi and in presence of a biocontrol bacterial... by Frédérique Reverchon, Mariel García-Meléndez, Edgar Guevara-Avendaño, Oscar Mora-Chávez, Itzel A. Solís-García, Wesley Dáttilo, José A. Guererro-Analco, Alfonso Méndez-Bravo, Juan L. Monribot-Villanueva, Violeta Patiño-Conde, Fernando Pineda-García, Eria A. Rebollar

“…The dysbiosis (disturbance of the microbiome structure of healthy plants) caused by these pathogens, combined with the recruitment of beneficial microorganisms by the diseased plant, may cause shifts in the rhizosphere microbiome during the infection process. …”
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Effector Pt31812 from Puccinia triticina acts as avirulence factor for Lr42-mediated resistance in wheat by Jianyuan Li, Jianyuan Li, Jiali Li, Jie Wei, Jie Wei, Lin Li, Yue Qi, Yue Qi, Yue Zhang, Yue Zhang, Wenxiang Yang, Qian-Hua Shen

“…In the study, Pt31812 was cloned by PCR, and the expression pattern and structure were analyzed by qRT-PCR and online softwares. …”
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Risk Factors and Prognostic Implications of Tumor‐Related Epilepsy in Diffuse Glioma Patients: A Real‐World Multicenter Study by Yao Xiao, Zhuang Nie, Jinsha Huang, Jie Zhao, Chengjun Dong, Yan Zou, Zikai Li, Bingqing Yan, Yue Hu, Fan Yang, Jong Woo Lee, Alexander P. Lin, Steven Tobochnik, Min Zhou, Ziqiao Lei

“…Multivariate analysis identified age as the only significant independent correlate of TRE in the OD/AC group (OR = 0.961; p = 0.004), while the absence of deep structure involvement was independently associated with TRE in the NOS/NEC and HGG groups. …”
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Do neonatal intensive care unit (NICU) health workers know about retinopathy of prematurity (ROP)? A qualitative study at a Regional Referral Hospital in Uganda by Henry Muwonge, Innocent Ayesiga, Primrose Magala, Tom Didimus Ediamu, Hana El Diwany, Ian LY Yeung, Alex Wasomoka, Phillip Musoke, Elias Musiime, Abraham Tumwesigye, Pius Atwau, Noreen Atwijukire, Iddi Ndyabawe, Anne Mpaire Musika, Himanshu I Patel, Aeesha NJ Malik, Ibrahim Bwaga, Sheba Gitta Nakacubo

“…We recommend developing a formal training structure and syllabus for ROP screening. The training can enhance task shifting among health workers in areas without specialised health workers. …”
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A 1.8 m Class Pathfinder Raman LIDAR for the Northern Site of the Cherenkov Telescope Array Observatory—Performance by Pedro José Bauzá-Ruiz, Oscar Blanch, Paolo G. Calisse, Anna Campoy-Ordaz, Sidika Merve Çolak, Michele Doro, Lluis Font, Markus Gaug, Roger Grau, Darko Kolar, Camilla Maggio, Manel Martinez, Samo Stanič, Santiago Ubach, Marko Zavrtanik, Miha Živec

“…The results show that the pBRL can provide valuable scientific results on aerosol characteristics and structure, although not all performance requirements could be validated under the conditions found at the two test sites. …”
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Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling by Jialu Shi, Wenjun Mao, Yuqing Song, Yuxin Wang, Lili Zhang, Yan Xu, Huiwen Gu, Siyu Yao, Yuanhang Yao, Zhifeng Liu, Vijaya Raghavan, Jin Wang

“…However, butyrate counteracted this loop by restoring microbiota structure and suppressing reactive oxygen species (ROS)/Notch cascades. …”
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