Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer. by Sheelagh Frame, Chiara Saladino, Craig MacKay, Butrus Atrash, Peter Sheldrake, Edward McDonald, Paul A Clarke, Paul Workman, David Blake, Daniella Zheleva

“…Here, we provide the first disclosure of the chemical structure of fadraciclib (CYC065), a CDK inhibitor and clinical candidate designed by further optimization from the aminopurine scaffold of seliciclib. …”
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THE PECULIARITIES OF THE U. S. HIGHER EDUCATION DEVELOPMENT STRATEGY IN THE CONTEXT OF CURRENT CONDITIONS by Olga I. Fomina

“…The research findings demonstrate that the diversification of funding sources, the concentration of talents in professorial, scientific, student communities, the guarantee of the academic mobility, and the favorable management structure of the US universities allow to lower dependence on economic instability, to provide development dynamism and adequately react to present calls. …”
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Effect of peritoneal dialysis and hemodialysis dialysis on myocardial injury by NING Ya-xian, WANG Jian-qin

“…Objective To compare the effects of two dialysis methods,peritoneal dialysis(PD)and hemodialysis(HD)on myocardial injury.Methods From May 2011 to May 2014,200 patients with end-stage renal disease in Second Hospital Affiliated to Lanzhou University were studied retrospectively.The patients were divided into HD group and PD group according to the dialysis methods.In PD group(100cases),there were 52 males and 48 females,and dialysis time was 4-19 months(mean 14.2±0.9months).In HD group(100cases),there were 48 males and 52 females,and dialysis time was 4-17months(mean 13.2±1.2months).All of the patients were tested for myocardial injury markers such as myoglobin,creatine kinase,troponin,B type natriuretic peptide,lactate dehydrogenase and hypersensitivity C reactive protein,and the difference in these indexes was compared between the two groups.Results No dialysis termination,kidney transplantation,loss of access and death were observed in the two groups during the follow-up period.There was no significant difference between the two groups in baseline data and characteristics(P>0.05),but the blood potassium was higher(P<0.05),and the serum CO2 binding capacity and serum ferritin levels were lower(P<0.05)in the HD group than in the PD group.Baseline adequacy,adequacy of dialysis,and baseline,cardiac structure,and cardiac function were not statistically different between the two groups(P>0.05).In HD group after dialysis,myoglobin,creatine kinase,cardiac troponin B,atrial natriuretic peptide and lactate dehydrogenase were 187ng/ml,14.5ng/ml,201ng/L,245ng/L,135U/L and10.8mg/L respectively,and those in PD group were 190ng/ml,14.7ng/ml,209ng/L,278ng/L,143U/L and 10.1mg/L respectively.During the follow-up period,there was no significant difference in cardiovascular diseases between two groups(P>0.05).Risk factors analysis indicated that troponin,myoglobin,creatine kinase,and B type natriuretic peptide could reflect the renal injury in uremic patients.Conclusions HD and PD have no significant difference in myocardial injury in uremic patients.…”
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Axiology of Transbaikal Territory Media Image by Irina V. Erofeeva, Natalya V. Prostakishina

“…The article presents the role of values in the media image structure, analyzes axiological components of the Transbaikal Territory media image, and shows its cultural and content characteristics. …”
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Neural network prediction of MHD thermo-solutal natural convection in ternary hybrid nanofluids within a curved enclosure by Saleh Mousa Alzahrani, Talal Ali Alzahrani, Imtiaz Ali Shah

“…Although variation in heat source parameters affects flow structure and thermal gradient differently, the overall convective behavior depends on their interplay. …”
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Local land‐use decisions drive losses in river biological integrity to 2099: Using machine learning to disentangle interacting drivers of ecological change in policy forecasts by Kimberly Bourne, Ryan S. D. Calder, Shan Zuidema, Celia Y. Chen, Mark E. Borsuk

“…Prospective climate and LULC scenarios are used to generate predictions of these variables and of EPT taxa richness trends through the year 2099. The model structure is mechanistically interpretable and performs well on test data (R2 ~ 0.4). …”
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Effectiveness of interventions to improve hand motor function in individuals with moderate to severe stroke: a systematic review protocol by Li Ding, Shugeng Chen, Hewei Wang, Jie Jia, Ray Arceo, Jun Yao

“…However, the rehabilitation of hand function after stroke can be rather difficult due to the complexity of hand structure and function, as well as neural basis that supports hand function. …”
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Graph-based reinforcement learning for software-defined networking traffic engineering by Jingwen Lu, Chaowei Tang, Wenyu Ma, Wenjuan Xing

“…Abstract With the continuous expansion of global Internet infrastructure, wide area networks play a crucial role in transmitting traffic between multiple data centers and users worldwide. However, efficient traffic management has become a core challenge due to the high costs of building and maintaining these networks. …”
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Production of aluminum alloys in electrolysis cells based on Hall-Héroult process: a review by ZHANG Cheng, XUE Ji-lai, LIU Xuan, LI Xiang, ZHU Jun, LIU Qiao-chu, QIAN Yi

“…Studies on the electrolyte structure, melting point, and conductivity of the cryolite-based electrolytes with varying compositions were described in details. …”
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Bioinformatics Analysis and Functional Verification of Phytoene Synthase Gene <i>Pj</i>PSY1 of <i>Panax japonicus</i> C. A. Meyer by Tingting Tang, Rui Jin, Xilun Huang, E Liang, Lai Zhang

“…The results showed that the open reading frame of the gene was 1269 bp, encoding 423 amino acids, with a protein molecular mass of 47,654.67 KDa and an isoelectric point (pI) of 8.63; the protein encoded by these amino acids was hydrophilic and localized in chloroplasts, and its three-dimensional structure was predicted by combining the pymol software to annotate the N site of action and active centre of the protein. …”
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The Emigration of Medical Doctors from Albania: Brain Drain vs Return and Cooperation by Ilir Gëdeshi, Russell King, Amarildo Ceka

“…On the other hand, the loss of medical professionals severely harms the structure and quality of the health service in the sending country. …”
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Supply–Demand Dynamics Quantification and Distributionally Robust Scheduling for Renewable-Integrated Power Systems with Flexibility Constraints by Jiaji Liang, Jinniu Miao, Lei Sun, Liqian Zhao, Jingyang Wu, Peng Du, Ge Cao, Wei Zhao

“…Third, the bilevel optimization structure is transformed into a solvable mixed-integer programming problem using a zero-sum game equivalence. …”
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Dual effects of digital technology on high quality development of road transportation in Heilongjiang Province China by Peng Li, Ke Chen, Lusheng Liu, Zhijia Hou, Dahong Yang, Huiji Zhang

“…Further analysis reveals pronounced regional disparities in their collaborative development, exhibiting a typical core-periphery structure. Core cities demonstrate substantial regional spillover effects through technological accumulation and institutional innovation, whereas peripheral cities confront challenges associated with delayed synergistic evolution. …”
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Detection of damage caused by Nezara viridula on soybean using novel imaging approaches based on computed tomography and image color analysis by Szilvia Gibicsár, Tamás Donkó, Dániel Fajtai, Sándor Keszthelyi

“…Image color analysis showed that the damaged samples were well distinguishable, and the differences were statistically verifiable. The achieved data derived from our external and internal imaging approaches contribute to a better understanding of the internal chemical processes, and CT analysis helps to understand the alteration trends of the hidden structure of seeds caused by a pest. …”
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Changes of regional mortality rates from cardiovascular diseases and cognitive disorders in Russia over 2019-2021 by I. V. Samorodskaya, M. A. Starinskaya, S. A. Boytsov

“…We analyzed Rosstat mortality data in 82 Russian regions in mid-year population in one-year age groups for 2019-2021. …”
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Gene Flow and Abundance of a Tropical Fruit Fly in a Horticultural Landscape Mosaic in Eastern Australia Is Limited by Cleared Grazing Land and Area‐Wide Management by James L. Ryan, Anthony R. Clarke, Alexander M. Piper, Susan Fuller, Peter J. Prentis

“…Genome‐wide SNP analysis estimated infinite effective population sizes at all sites and detected limited genetic structure across the landscape. However, fly abundance varied significantly among habitats, with cleared pasture negatively associated with population abundance and acting as a barrier to gene flow. …”
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THE JUSTIFICATION OF THE EFFICIENCY OF FINANCIAL SUPPORT OF EDUCATION IN THE CONTEXT OF THE NATIONAL ECONOMY DEVELOPMENT by A. Vorontsova, T. A. Vasylieva, T. Mayboroda

“…As a result of the study, the authors of the work revealed the current and long-term relationship between macroeconomic parameters that characterize sectoral and technological changes in the structure of the national economy and state financing of education. …”
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Interferon gamma induced-ACSL5 shapes the lipidome of kidney tubular cells by Virginie Poindessous, Julio L. Sampaio, Lydia Bouidghaghen, Ivan Nemazanyy, Alexandre Pallet, Maarten Naesens, Thibaut Vaulet, Dany Anglicheau, Nicolas Pallet

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Perception of Parental Attitudes and General Academic Achievement of High School Students: a Russian-Kyrgyz Study by T.N. Tikhomirova, S.B. Malykh

“…A cross-cultural analysis of the structure of associations between the characteristics of the perception of parental attitudes and academic performance is carried out. …”
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Clinical fnd epidemiological features of measles by adults in modern period by V. V. Basina, E. V. Esaulenko, K. E. Novak, M. A. Bichurina, L. V. Lyalina

“…Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology, biological material was used (nasopharyngeal washings, urine).Results: there was an increase in morbidity in some regions of the Northwestern Federal District in conditions of high coverage of the population with measles vaccinations. In the age structure in 2018–2019 the proportion of adults was 65%. 74% of patients were not vaccinated against measles. …”
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