Prescription of guideline‐directed medical therapy in heart failure: impact on mortality and readmission by Martin Möckel, Samipa Pudasaini, Kristina Feldmann, Henning Thomas Baberg, Benny Levenson, Jürgen Malzahn, Thomas Mansky, Guido Michels, Christian Günster, Elke Jeschke

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<i>PRKAG2</i> Syndrome: Clinical Features, Imaging Findings and Cardiac Events by Maria Sudomir, Przemysław Chmielewski, Grażyna Truszkowska, Mariusz Kłopotowski, Mateusz Śpiewak, Marta Legatowicz-Koprowska, Monika Gawor-Prokopczyk, Justyna Szczygieł, Joanna Zakrzewska-Koperska, Mariusz Kruk, Jolanta Krzysztoń-Russjan, Jacek Grzybowski, Rafał Płoski, Zofia T. Bilińska

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We know less about phosphorus retention in constructed wetlands than we think we do: A quantitative literature synthesis by Kenneth J. Anderson, Bishwodeep Adhikari, Olivia F. Schloegel, Raissa Marques Mendonca, Michael P. Back, Nicholas Brocato, Jacob A. Cianci-Gaskill, Steven E. McMurray, Christie Bahlai, David M. Costello, Lauren Kinsman-Costello

“…We found that, while differences among broad wetland structural groupings exist, measured rates of phosphorus retention are highly variable. …”
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Efficacy and safety of cannabidiol in a single-center pediatric drug-resistant epilepsy cohort: a retrospective study by Ambra Butera, Ambra Butera, Giulia Spoto, Graziana Ceraolo, Maria Grella, Ivana Giunta, Maria Ludovica Albertini, Carla Consoli, Caterina Sferro, Maria Spanò, Gabriella Di Rosa, Antonio Gennaro Nicotera

“…Clinical, demographic, and instrumental data were retrospectively extracted from the medical records and caregivers’ reports. …”
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Phenotypically distinguishable eosinophilic cells do not impact epithelial functions in a triple-culture in vitro intestinal model by Christoph Benkstein, Laurin Mosig, Daniel Vondran, Heidi Schlichting, Lea Kissing, Bente Wohlert, Ida Gensmer, Larissa Nogueira de Almeida, Peter König, Peter König, Kerstin Fibelkorn, Anna Kordowski, Stefanie Derer-Petersen, Christian Sina, Christian Sina, Yves Laumonnier, Yves Laumonnier

“…In-depth characterization by real-time PCR, flow cytometry, functional assay and electron microscopy showed that only butyrate and dibutyryl-cAMP generated phenotypically distinct eosinophilic cells with different activation statuses, marked by differential expression of surface markers CD11c and CD62L, increased expression of eosinophil specific genes, and development of eosinophilic structural features. Then, a triple-culture system encompassing the enterocytic cell line Caco-2 and the secretory cell line HT29-MTX complemented with eosinophilic differentiated cells was established. …”
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Feasibility study of single-image super-resolution scanning system based on deep learning for pathological diagnosis of oral epithelial dysplasia by Zhaochen Liu, Zhaochen Liu, Peiyan Wang, Peiyan Wang, Nian Deng, Hui Zhang, Hui Zhang, Fangjie Xin, Xiaofei Yu, Xiaofei Yu, Mujie Yuan, Mujie Yuan, Qiyue Yu, Yuhao Tang, Keke Dou, Jie Zhao, Bing He, Jing Deng, Jing Deng

“…Both the DS30R and Nikon scanners demonstrate high sensitivity and specificity for detecting structural features in OED pathological images; however, DS30R excels at identifying certain cellular features. …”
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Quality of Surface and Groundwater in the Sierra de Amula Region, Jalisco, Mexico by Oscar Raúl Mancilla-Villa, Fabiola Villafaña-Castillo, Álvaro Can-Chulim, Rubén Darío Guevara-Gutiérrez, José Luis Olguín-López, Elia Cruz-Crespo, Jonas Alan Luna-Fletes, Juan Uriel Avelar-Roblero

“…Each sample was evaluated for its pH, electrical conductivity, and ionic concentration (Ca²⁺, Mg²⁺, Na⁺, K⁺, CO₃²⁻, HCO₃⁻, CI⁻, SO₄²⁻). For data analysis, we determined the ionic concentrations and the salinity and sodicity indexes, including the electrical conductivity, pH, sodium adsorption ratio (SAR), and cationic ratio of soil structural stability (CROSS). …”
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Comparative genetic mapping and a consensus interspecific genetic map reveal strong synteny and collinearity within the Citrus genus by Patrick Ollitrault, Patrick Ollitrault, Barbara Hufnagel, Barbara Hufnagel, Franck Curk, Aude Perdereau, Pierre Mournet, Pierre Mournet, Maëva Miranda, Maëva Miranda, Gilles Costantino, Yann Froelicher, Yann Froelicher, Mônica Alves, Maria Angeles Forner Giner, Malcolm W. Smith, Pablo Aleza, François Luro, Nelson A. Wulff, Leandro Peña, Raphaël Morillon, Raphaël Morillon, Arnaud Lemainque

“…The consensus genetic map is a useful tool to check the accuracy of genome assemblies, identify large structural variation and focus on analyzing potential relationships with phenotypic variations. …”
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Social networks, environmental, and individual factors associated with COVID-19 vaccination and booster uptake– The prospective PRIME cohort study by Céline J.A. van Bilsen, Lisanne C.J. Steijvers, Stephanie Wagner, Demi M.E. Pagen, Senne M.C.E. Wijnen, Kevin Konings, Christian J.P.A. Hoebe, Annemarie Koster, Nicole H.T.M. Dukers-Muijrers

“…Methods: In the PRIME longitudinal cohort study, we used online questionnaires to collect baseline data at the end of 2021, including participants' COVID-19 vaccination status and various factors, i.e., structural and functional social network characteristics (interpersonal factors), societal (social and physical living environment) community (work and social participation), and individual (sociodemographics, health) factors. …”
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Correlates of duration between initial drug use and first drug injection among people who inject drugs in Iran, 2020 by Zahra Abdolahinia, Zahra Jaafari, Ali Karamoozian, Soheil Mehmandoost, Nima Ghalekhani, Mehrdad Khezri, Ghazal Mousavian, Mostafa Shokoohi, Ali Mirzazadeh, Ali Akbar Haghdoost, Mohammad Karamouzian, Mohammad Mehdi Gooya, Samaneh Akbarpour, Hamid Sharifi, Fatemeh Tavakoli

“…Policymakers should prioritize evidence-based, multi-faceted approaches that target both individual and structural factors to delay or prevent the transition to injection drug use and reduce associated health risks.…”
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Multi-element Accurate Analysis of Sulfide Minerals by Low-temperature Ablation LA-ICP-MS by Huilai LI, Fan LI, Dingwen ZHANG, Wei GUO, Lanlan JIN, Shenghong HU

“…The ablation craters on the chalcopyrite showed a two-layer cyclic structure, in which the inner layer was a light-colored melting zone, and the outer layer was a white aerosol vapor sediment. …”
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Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a b... by Surajit Dey, Wenying Lu, Prabuddha S. Pathinayake, Maddison Waters, Greg Haug, Josie Larby, Heinrich C. Weber, Peter A. B. Wark, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal

“…Additionally, the degree of RBM fragmentation was evaluated, a key tissue structural marker of EMT.ResultsCompared to healthy controls and asthmatics, ACO had the greatest fragmentation of RBM (P &lt; 0.01). …”
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Co-circulation and genetic characterization of genotype I and II feline bocavirus strains in domestic cats from Northern Vietnam by Hieu Van Dong, Giang Thi Huong Tran, Yen Hoang Thi Nguyen, Thiet Chi Ngo, Amonpun Rattanasrisomporn, Chaiwat Boonkaewwan, Dao Anh Tran Bui, Jatuporn Rattanasrisomporn

“…DNA was extracted and screened for FBoV using conventional polymerase chain reaction targeting the non-structural (NS)-1 gene. Positive samples were subjected to Sanger sequencing, and partial NS1 sequences were analyzed using MEGA X for phylogenetic inference. …”
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Cultural and behavioral drivers of zoonotic disease transmission and persistence among diverse pastoralist communities in East Africa by Dismas C.O. Oketch, Ruth Njoroge, Tonny O. Ngage, Asha Abdikadir Omar, Abdulai Magarre, Raphael Pasha, John Gachohi, Samuel Waiguru Muriuki, Samoel Ashimosi Khamadi, Ali Duba Boru, Boku Bodha, Lydia Kilowua, Nazaria Wanja Nyaga, Humphrey Kariuki Njaanake, Eunice Kamaara, Walter Jaoko, M. Kariuki Njenga, Eric Osoro, Dalmas Omia

“…Methods This study adopts a One Health approach, employing a range of participatory methods including informal observations, “go-along interviews,” narrative-, and key informant- interviews, to explore the cultural, behavioral, and structural drivers of zoonotic disease transmission among pastoralist communities in East Africa. …”
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Efficacy and mechanisms underlying MRI-guided high-definition transcranial direct current stimulation for depression among university students: study protocol for a stepped wedge c... by Yuanle Chen, Rongxun Liu, Jinnan Yan, Peng Luo, Luhan Yang, Yongbin Wang, Guangjun Ji, Chuansheng Wang, Wei Zheng, Fei Wang, Yong Meng, Yange Wei

“…All groups will be receiving active intervention in week 5. Structural MRI data for each participant will be acquired to select the optimal electrode placement and correct for individual anatomical differences. …”
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The association between the gut microbiome and antituberculosis drug-induced liver injury by Shengfei Pei, Li Yang, Huixia Gao, Yuzhen Liu, Jianhua Lu, Er hei Dai, Chunyan Meng, Fumin Feng, Yuling Wang

“…At the same time, we constructed mouse models to explore the effects of different anti-tuberculosis drugs on gut microbiota.ResultsFollowing anti-TB treatment, we observed a decrease in microbial diversity and significant structural changes in the gut microbiota of TB patients (P &lt; 0.05). …”
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Hsa_Circ_0105596/FTO inhibits progression of Parkinson's disease by sponging miR-187-3p and regulating eEF2 by Jiahao Feng, Jin Zhao, Yong Kuang, Yuheng Zhou, Ziheng Ye, Yutong He, Dandan Chen, Li Zhang, Tingying Zhang, Qingqing Zhu, Shumin Cheng, Taoli Liu

“…The binding regulation relationship between circFTO-miR-187-3p-EEF2 was determined through structural analysis, RIP, and dual luciferase reporter assay. …”
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Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice by Victor J. Johnson, Cynthia V. Rider, Michael I. Luster, Cynthia J. Willson, Shawn Harris, Billie Stiffler, James Blake, Esra Mutlu, Veronica Godfrey, Brian Burback, Reshan Fernando, Suramya Waidyanatha, Gary R. Burleson, Dori R. Germolec

“…Careful characterization of strong positive and clear negative PACs is needed in order to lay the foundation for generating robust immunotoxicity data for structurally diverse PACs that have not yet been evaluated.MethodsIn the current study, adult B6C3F1/N female mice were treated daily for 28 consecutive days by oral administration of B(a)P to provide dose levels ranging between 2 and 150 mg/kg bodyweight/day. …”
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Genetic Interplay Between Attention-Deficit/Hyperactivity Disorder and Pain Suggests Neurodevelopmental Pathways and Comorbidity Risk by Nicolas P. Ciochetti, Victor F. de Oliveira, Iago Junger-Santos, Cibele E. Bandeira, Maria E. Tavares, Eduardo S. Vitola, Luis A. Rohde, Gustavo Melo de Andrade, Bruna S. da Silva, Eugenio H. Grevet, Claiton H. Dotto Bau, Diego L. Rovaris

“…In the independent sample, higher MCP PRSs were linked to structural brain features, increased comorbidity with substance use and bipolar disorder, and heightened severity of ADHD symptoms. …”
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Adherence to Life’s Essential 8 enhances gut microbiota diversity and cognitive performance by Yannick N. Wadop, Jazmyn Muhammad, Rebecca Bernal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Alexa Beiser, Alexa Beiser, Alexa Beiser, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramnik Xavier, Ramnik Xavier, Ramnik Xavier, Tiffany Kautz, Tiffany Kautz, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Bernard Fongang, Bernard Fongang, Bernard Fongang

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