Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
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Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome by Cristina Alonso, Alicia García-Culebras, Valentina Satta, Inés Hernández-Fisac, Álvaro Sierra, José A. Guimaré, Ignacio Lizasoain, Javier Fernández-Ruiz, Onintza Sagredo

“…However, the levels of endogenous IgG in this brain structure were significantly elevated in DS mice compared to controls, directly indicating the occurrence of extravasation into the brain parenchyma and indirectly that the BBB in DS mice may be relatively affected, a fact confirmed by the reduction in the levels of BBB-related proteins such as ZO-1 in these mice. …”
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A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response by Xiao‐Ming Lyu, Xiao‐Wei Zhu, Manli Zhao, Xian‐Bo Zuo, Zhong‐Xi Huang, Xiao Liu, Tao Jiang, Xue‐Xi Yang, Xin Li, Xiao‐Bing Long, Jian‐Guo Wang, Jin‐Bang Li, Ming‐Yu Han, Shuang Wang, Teng‐Fei Liu, Bo Zhang, Tao Sun, Zhi Cheng, Mo‐Chang Qiu, Lei Dong, Lu Zheng, Long‐Cheng Zhang, Jia‐Hong Wang, Gan‐Guan Wei, Kaitai Yao, Qian Wang, Hou‐Feng Zheng, Xin Li

“…Abstract The major histocompatibility complex (MHC) is most closely associated with nasopharyngeal carcinoma (NPC), but the complexity of its genome structure has proven challenging for the discovery of causal MHC loci or genes. …”
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Mapping the Filamentary Nebula of NGC 1275 with Multiwavelength SITELLE Observations by Carter Lee Rhea, Julie Hlavacek-Larrondo, Marie-Lou Gendron-Marsolais, Benjamin Vigneron, Megan Donahue, Auriane Thilloy, Laurie Rousseau-Nepton, Mar Mezcua, Norbert Werner, Jorge Barrera-Ballesteros, Hyunseop Choi, Alastair Edge, Andrew Fabian, G. Mark Voit

“…The filamentary nebula encompassing the central galaxy of the Perseus Cluster, NGC 1275, is a complex structure extending dozens of kiloparsecs from NGC 1275. …”
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The Magnetic Field in Quiescent Star-forming Filament G16.96+0.27 by Qi-Lao Gu, Tie Liu, Zhi-Qiang Shen, Sihan Jiao, Julien Montillaud, Mika Juvela, Xing Lu, Chang Won Lee, Junhao Liu, Pak Shing Li, Xunchuan Liu, Doug Johnstone, Woojin Kwon, Kee-Tae Kim, Ken’ichi Tatematsu, Patricio Sanhueza, Isabelle Ristorcelli, Patrick Koch, Qizhou Zhang, Kate Pattle, Naomi Hirano, Dana Alina, James Di Francesco

“…The average magnetic field orientation, which roughly agrees with the larger-scale magnetic field orientation traced by the Planck 353 GHz data, is approximately perpendicular to the filament structure. …”
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Evaluation of the innate immunostimulatory potential of originator and non-originator copies of insulin glargine in an in vitro human immune model. by Ernesto Luna, Pankaj Agrawal, Riyaz Mehta, Maria E Boone, Charlotte Vernhes, Colombe Denys, Robert Small, Bhaswati Mukherjee, Norbert Tennagels, Stefan Maerten, Donald R Drake

“…<h4>Background</h4>The manufacture of insulin analogs requires sophisticated production procedures which can lead to differences in the structure, purity, and/or other physiochemical properties of resultant products that can affect their biologic activity. …”
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Validation of Quantitative Ultrasound and Texture Derivative Analyses-Based Model for Upfront Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer by Adrian Wai Chan, Lakshmanan Sannachi, Daniel Moore-Palhares, Archya Dasgupta, Sonal Gandhi, Rossanna Pezo, Andrea Eisen, Ellen Warner, Frances C. Wright, Nicole Look Hong, Ali Sadeghi-Naini, Mia Skarpathiotakis, Belinda Curpen, Carrie Betel, Michael C. Kolios, Maureen Trudeau, Gregory J. Czarnota

“…Explanations for the misclassified cases included unplanned modifications made to the type of chemotherapy during treatment, inherent limitations of the predictive model, presence of DCIS in tumour structure, and an ill-defined tumour border in a minority of cases. …”
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Genome-Wide Identification of <i>G3BP</i> Family in U’s Triangle <i>Brassica</i> Species and Analysis of Its Expression in <i>B. napus</i> by Alain Tseke Inkabanga, Qiheng Zhang, Shanshan Wang, Yanni Li, Jingyi Chen, Li Huang, Xiang Li, Zihan Deng, Xiao Yang, Mengxin Luo, Lingxia Peng, Keran Ren, Yourong Chai, Yufei Xue

“…We then analyzed their gene structure, protein motifs, gene duplication type, phylogeny, subcellular localization, SSR loci, and upstream miRNAs. …”
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Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease by Da-Ya Zhang, Da Li, Shi-Ju Chen, Li-Jun Zhang, Xu-Li Zhu, Fa-Di Chen, Chen Chen, Qi Wang, Yiping Du, Jian-Xin Xiong, Shi-Mei Huang, Xiao-Dong Zhang, Yan-Ting Lv, Fan Zeng, Run-Xiang Chen, Xianfeng Huang, Fengjiao Mao, Shuo Zhou, Qicen Yao, Yuliang Huang, Runyu Chen, Ying Mo, Yunqian Xie, Yue-Hong Jiang, Zhai Chen, Cui-Yi Mo, Jia-Jia Chen, Fei-Hu Bai

“…Distinct differences were identified in both the microbial community structure and metabolomic profiles between MAFLD patients and healthy controls. …”
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Cluster Candidates with Massive Quiescent Galaxies at z ∼ 2 by Tomokazu Kiyota, Makoto Ando, Masayuki Tanaka, Alexis Finoguenov, Sadman Shariar Ali, Jean Coupon, Guillaume Desprez, Stephen Gwyn, Marcin Sawicki, Rhythm Shimakawa

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Explaining the Earnings Management Prediction Model Using the Hybrid of Machine Learning Methods by Hassan Hassani, Esfandiar Malekian Kallehbasti, Yahya Kamyabi

“…In addition, the results indicated that the most important features for prediction are related to the auditor's features in the first place and then to the features of the company's ownership structure. In other words, investors should pay a lot of attention to the features of the auditor and the ownership structure of companies in predicting earnings management. …”
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Ordovician conodonts of the Katkoyeh formation in the Kuh-e-Bonorg section, Kalmard Horst (west of Tabas) by Mohammad Nezhadabbas, Abbas Ghaderi, Hadi Jahangir, Ali Reza Ashouri

“…The Katkoyeh formation with 214.8 meter thickness is divided into three lithostratigraphic members including the Lower Sandstone (mostly quartzarenite to litharenite), Middle Shale (red to green shales interbedded with some dolomitic and calcareous sandstones, in laminated wavy stromatolite structure at the base) and Upper Carbonate (limestones, dolostones and marls). …”
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Analysis of ROH Characteristics Across Generations in Grassland-Thoroughbred Horses and Identification of Loci Associated with Athletic Traits by Wenqi Ding, Wendian Gong, Tugeqin Bou, Lin Shi, Yanan Lin, Xiaoyuan Shi, Zheng Li, Huize Wu, Manglai Dugarjaviin, Dongyi Bai

“…Principal component analysis (PCA) and STRUCTURE revealed clear distinctions among the generations, with a notable overlap between CY and F3. …”
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WRF-ELM v1.0: a regional climate model to study land–atmosphere interactions over heterogeneous land use regions by H. Huang, Y. Qian, G. Bisht, J. Wang, T. Chakraborty, D. Hao, J. Li, T. Thurber, B. Singh, Z. Yang, Y. Liu, P. Xue, P. Xue, W. J. Sacks, E. Coon, R. Hetland

“…It maintains the integrity of ELM's source code structure and facilitates the transfer of future developments in ELM to WRF-ELM.…”
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Sleep disturbances in SCN8A‐related disorders by Francesca Furia, Katrine M. Johannesen, Claudia M. Bonardi, Roberto Previtali, Angel Aledo‐Serrano, Massimo Mastrangelo, Jacopo Favaro, Silvia Masnada, Valentina diMicco, Jacopo Proietti, Pierangelo Veggiotti, Guido Rubboli, Gaetano Cantalupo, Kern Olofsson, Rikke S. Møller, Elena Gardella

“…Polysomnographic recordings (9 patients/20 nights) showed an altered sleep structure in 95%, with frequent arousals, mainly not seizure related. …”
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Impact of Thermal-Induced Turbulent Distribution Along FSO Link on Transmission of Photonically Generated mmW Signals in the Frequency Range 26&#x2013;40 GHz by Luis Vallejo, Matej Komanec, Beatriz Ortega, Jan Bohata, Dong-Nhat Nguyen, Stanislav Zvanovec, Vicenc Almenar

“…The results show high electrical power decrease and fluctuation of the generated mmW signal according to the particular level of the turbulence in terms of refractive index structure parameter and thermal distribution along the FSO link. …”
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Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference by Yinlei Lei, Min Li, Han Zhang, Yu Deng, Xinyu Dong, Pengyu Chen, Ye Li, Suhua Zhang, Chengtao Li, Shouyu Wang, Ruiyang Tao

“…The composition and structure of the bacteria at these three body sites were well characterized and found to differ regionally. …”
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Functional Connectivity Changes in Primary Motor Cortex Subregions of Patients With Obstructive Sleep Apnea by Lifeng Li, Qimeng Shi, Bowen Fang, Yuting Liu, Xiang Liu, Yongqiang Shu, Yingke Deng, Yumeng Liu, Haijun Li, Junjie Zhou, Dechang Peng

“…This study examined functional connectivity (FC) changes in subregions of the primary motor cortex (M1) in patients with OSA and their association with sleep structure, cognition, and clinical features. Methods Sixty‐five patients with OSA and 65 healthy controls (HC) participants matched in age and educational background were included. …”
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Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice by Victor J. Johnson, Cynthia V. Rider, Michael I. Luster, Cynthia J. Willson, Shawn Harris, Billie Stiffler, James Blake, Esra Mutlu, Veronica Godfrey, Brian Burback, Reshan Fernando, Suramya Waidyanatha, Gary R. Burleson, Dori R. Germolec

“…Careful characterization of strong positive and clear negative PACs is needed in order to lay the foundation for generating robust immunotoxicity data for structurally diverse PACs that have not yet been evaluated.MethodsIn the current study, adult B6C3F1/N female mice were treated daily for 28 consecutive days by oral administration of B(a)P to provide dose levels ranging between 2 and 150 mg/kg bodyweight/day. …”
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Locally-tailored vs. centrally-administered strategies for implementation of primary human papillomavirus (HPV) screening in an integrated healthcare system: a qualitative research... by Erin E. Hahn, Erin E. Hahn, Corrine Munoz-Plaza, Chunyi Hsu, Nancy T. Cannizzaro, Quyen Ngo-Metzger, Michael K. Gould, Brian S. Mittman, Melissa Hodeib, Devansu Tewari, Chun R. Chao, Chun R. Chao

“…Using a team coding approach, we developed an initial coding structure refined during iterative analysis; data were subsequently organized thematically into domains, key themes, and sub-themes using thematic analysis, followed by framework analysis informed by CFIR.ResultsThirty-two interviews were conducted. …”
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