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    A novel decoding strategy for ProteinMPNN to design with less visibility to cytotoxic T-lymphocytes by Hans-Christof Gasser, Ajitha Rajan, Javier A. Alfaro

    Published 2025-01-01
    “…In this study, we introduce CAPE-Beam, a novel decoding strategy for the established ProteinMPNN protein design model. Our approach minimizes CTL immunogenicity risk by limiting designs to only consist of kmers that are either predicted not to be presented to CTLs or are subject to central tolerance that prevents CTLs from attacking self-peptides. …”
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