A variant form of receptor activator of nuclear factor-κB functions as an osteoprotegerin mimic in bone and cardiac development by Riko Kitazawa, Ryuma Haraguchi, Sohei Kitazawa

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Osteoclastic activity was associated with the development of steroid-induced osteonecrosis of femoral head by Min-Cong He, Jin Zhang, Xiao-Jun Chen, Ying-Shan Shen, Bin Fang, Yi-Xian Qin, Wei He, Qiu-Shi Wei

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Protective effects of liraglutide on hypercholesterolemia-associated atherosclerosis involve attenuation of endothelial-monocyte adhesion through down-regulating the LOX-1/NF-κB si... by Aiping Wu, Ying Wu, Meiyan Song, Wen Chen, Kaizu Xu, Meifang Wu, Liming Lin

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Stellate ganglion irradiation alleviates airway inflammation in asthmatic mice via activating SIRT1 signaling pathway by Kaixuan Zhao, Haoyue Zhang, Yanbo Liu, Ying Zhou, Juan Zhi, Qianyu Wang, Dong Yang

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The Mechanism of Calcium Handling Proteins and NF-κB in Calcium Dyshomeostasis of Cardiomyocytes Caused by Acute MDMA Exposure by WANG Rong-shuai, HUANG Si-zhe, WANG Yun-yun, DENG Yan-fei, DING Zi-jiao, ZHANG Jie, LIU Yong, REN Liang, LIU Liang

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Association of and gene polymorphisms with susceptibility of gastric cancer by Dan Li, Chuancheng Wu, Yuanhua Cai, Baoying Liu

“…Chronic inflammation plays an important role in the occurrence of gastric cancer, in which the nuclear factor-κB signaling pathway of the inflammatory reaction begins and plays an important role in the amplification process. …”
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Immunological mechanism and research progress of peri-implant bone resorption by HE Yehong, FAN Zhen

“…Osteoclasts are currently the only known cells in the human body that can cause bone resorption, so their generation has been used as a clue to sort out several key pathways and factors that regulate this process, such as macrophage polarization, receptor activator of nuclear factor-κB ligand (RANKL) / receptor activator of nuclear factor-κB (RANK) / osteoprotegerin (OPG) pathway and nuclear factor-κB (NF-κB) pathway. …”
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Bispecific antibody suppresses osteosarcoma aggressiveness through regulation of NF-κB signaling pathway by Gui-Hua Yu, Ai-Min Li, Xiang Li, Zhong Yang, Hao Peng

“…BsAbBmi/TRIM administration significantly inhibited nuclear factor-κB expression derived by matrix metalloproteinase–9 promoter. …”
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Kruppel-like factor 4 inhibits non–small cell lung cancer cell growth and aggressiveness by stimulating transforming growth factor-β1-meidated ERK/JNK/NF-κB signaling pathways by Renzhi Yu, Lei Han, Xin Ni, Minghuan Wang, Ping Xue, Li Zhang, Mei Yuan

“…Kruppel-like factor 4 overexpression inhibited transforming growth factor-β1, extracellular signal–regulated protein kinase, C-jun N-terminal kinase, and nuclear factor-κB expression levels in non–small cell lung cancer cells. …”
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Research progress on the regulation of signal pathways related to lung injury in sepsis by the active components of traditional Chinese medicine by RONG Jilintai*，SU He，ZHANG Ruifen，ZHANG Hairong，JIA Tingting，GUO Sihan，ZHAO Jian，LI Xiao，ZHONG Xin

“…Recent studies have shown that active components of traditional Chinese medicine（TCM）can exert anti⁃inflammatory，anti⁃oxidative stress，anti⁃pyroptosis，and anti⁃ferroptosis effects by regulating signaling pathways such as Toll⁃like receptor 4（TLR4）/nuclear factor κB（NF⁃κB），mitogen⁃activated protein kinase（MAPK），NOD⁃like receptor family pyrin domain containing 3（NLRP3）/caspase⁃1，phosphatidylinositol 3⁃kinase/protein kinase B，and nuclear factor E2⁃related factor 2/heme oxygenase⁃1，thereby alleviating sepsis⁃induced lung injury. …”
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Experimental study of the effect of Zfp260 on the differentiation of osteoclasts in periodontitis by GONG Ruonan, WANG Zuolin

“…The transfected cells were induced into osteoclasts by receptor activator of nuclear factor κB ligand (RANKL） for 7 days. Differentiated cells were harvested for tartrate resistant acid phosphatase (TRAP) staining. …”
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Regulation mechanism of curcumin mediated inflammatory pathway and its clinical application: a review by Meihua Liu, Jingyi Wang, Zhen Song, Yong Pei

“…By searching the databases of Web of Science, PubMed, Google Scholar and CNKI, and integrating the latest research progress, it was found that curcumin exerted its core anti-inflammatory effects mainly by inhibiting the activation of nuclear factor-κB (NF-κB) signaling pathway, regulating the mitogen-activated protein kinase extracellular signal-regulated kinase (ERK) phosphorylation cascade, and regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. …”
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Effects of Huoshanhuangya tea extract on lipid accumulation and inflamma-tory response in palmitic acid-induced cells by ZUO Xinxin, CHEN Wei, DING Lejia, SHI Yuxuan, ZHOU Jihong, LIU Zhonghua, WANG Yuefei

“…To further explore its mechanism of action, it was found that HTE down-regulated the expression of Toll-like receptor 4 (TLR4) and nuclear factor-κB RelA<italic/>(NF-κB p65) in the inflammatory signaling pathway of BV-2 cells, suggesting that HTE may relieve the palmitic acid-induced inflammatory damage of BV-2 cells by inhibiting the activation of the TLR4/NF-κB signaling pathway.…”
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Novel mitophagy inducer TJ0113 alleviates pulmonary inflammation during acute lung injury by Zhengyuan Liu, Danruo Fang, Kaijun Chen, Lingling Dong, Huaqiong Huang, Zhihua Chen

“…Finally, we found that TJ0113 inhibited LPS-induced inflammation by inducing mitophagy and inhibiting nuclear factor κB (NF-κB) and inflammasome activation.ConclusionTJ0113 alleviates LPS-induced inflammation by inducing mitophagy and inhibiting NF-κB and inflammasome activation. …”
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Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis by Liangzi Yin, Liangzi Yin, Chenglin Sun, Junjie Zhang, Yan Li, Yansheng Wang, Yansheng Wang, Lunhao Bai, Zeming Lei, Zeming Lei

“…Emerging evidence highlights the pivotal roles of the RANKL/RANK/OPG axis, nuclear factor-κB (NF-κB) signaling, and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) cascades in osteoclast differentiation and pathological bone resorption. …”
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The effect of 4-octyl itaconate on lipopolysaccharide-induced murine calvarial osteolysis by WEN Congpeng, TONG Wuyou, CHEN Xuzhuo, LAI Linfeng

“…TRAP staining showed that 4-OI effectively inhibited the osteoclast differentiation induced by receptor activator of nuclear factor κB ligand (RANKL). Micro-CT and histological staining demonstrated that 4-OI effectively alleviated the inflammatory response and bone resorption around the osteolysis site. …”
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Tricyclic Isatin Derivatives as Anti-Inflammatory Compounds with High Kinase Binding Affinity by Alexander V. Uvarov, Igor A. Schepetkin, Mark T. Quinn, Andrei I. Khlebnikov

“…NS-102), which have an unsubstituted oxime group, inhibited lipopolysaccharide (LPS)-induced nuclear factor-κB/activating protein 1 (NF-κB/AP-1) transcriptional activity in human THP-1Blue monocytic cells and interleukin-6 (IL-6) production in human MonoMac-6 monocytic cells, with IC₅₀ values in the micromolar range. …”
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Deferoxamine Treatment Effectively Prevents Periodontitis Progression by Reducing Inflammation and Osteoclastogenesis in Experimental Periodontitis Rats by Zhu Y, Qiao S, Pang Y, Wang H, Zhou Y

“…Immunofluorescence and molecular biology methods were employed to assess osteoclast differentiation in RAW264.7 cells after nuclear factor-κB ligand (RANKL) induction. A rat model of periodontitis was es\lished using ligature wires, and alveolar bone loss was assessed via micro-computed tomography. …”
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Effect of lincRNA-EPS on osteoclastogenesis of RAW264.7 cells induced by RANKL and LPS: An experimental study by ZHANG Xu, WANG Yabing, SU Jiansheng

“…[Objective:] To study the effect of long non-coding RNA-EPS (lincRNA-EPS) on osteoclastogenesis of RAW264.7 cells induced by receptor activator for nuclear factor-κB ligand (RANKL) and lipopolysaccharide (LPS). …”
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Protective effects of paederoside in rotenone-induced cellular models of Parkinson’s disease by Juan Lang, Juan Lang, Zhongkui Xiong, Zhongkui Xiong

“…Paederoside induced a dose-dependent reduction in inducible nitric oxide synthase (iNOS) activity in the rotenone-treated BV-2 cells. When the nuclear factor-κB (NF-κB) inhibitor BAY11-7082 was added 2 h before rotenone exposure, no statistically significant difference in NO levels was observed between the paederoside-treated and untreated groups. …”
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