Assessment of the quality of life in metastatic colorectal cancer patients with KRAS gene mutant: a case-control study by Fahmideh Bagrezaei, Bahram Pourghassem Gargari, Reza Eghdam Zamiri, Abdolrasoul Safaiyan, Mohammad Alizadeh

“…Abstract Background The mutation of the KRAS (Kirsten rat sarcoma virus) gene is a prevalent genetic alteration in metastatic colorectal cancer (mCRC). …”
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A scoping review on the obstacles faced by beta thalassemia major patients in Pakistan- Matter of policy investment by Ali Hussain Ansari, Saqib Hussain Ansari, Mubarak Jabeen Salman, Muhammad Usman Hussain Ansari, Rawshan Jabeen

“…These largely include hepatitis C, hepatitis B, and the Human immunodeficiency virus (HIV). TTIs impact the quality of life of these patients and their overall survival. …”
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Aetiology of vaginal discharge, urethral discharge, and genital ulcer in sub-Saharan Africa: A systematic review and meta-regression. by Julia Michalow, Magdalene K Walters, Olanrewaju Edun, Max Wybrant, Bethan Davies, Tendesayi Kufa, Thabitha Mathega, Sungai T Chabata, Frances M Cowan, Anne Cori, Marie-Claude Boily, Jeffrey W Imai-Eaton

“…In 2015, estimated primary aetiologies for vaginal discharge were candidiasis (69.4% [95% confidence interval (CI): 44.3% to 86.6%], n = 50), bacterial vaginosis (50.0% [95% CI: 32.3% to 67.8%], n = 39), chlamydia (16.2% [95% CI: 8.6% to 28.5%], n = 50), and trichomoniasis (12.9% [95% CI: 7.7% to 20.7%], n = 80); for urethral discharge were gonorrhoea (77.1% [95% CI: 68.1% to 84.1%], n = 68) and chlamydia (21.9% [95% CI: 15.4% to 30.3%], n = 48); and for genital ulcer were herpes simplex virus type 2 (HSV-2) (48.3% [95% CI: 32.9% to 64.1%], n = 47) and syphilis (9.3% [95% CI: 6.4% to 13.4%], n = 117). …”
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Drug-Drug Interactions Between HIV Antivirals and Concomitant Drugs in HIV Patients: What We Know and What We Need to Know by Emanuela De Bellis, Danilo Donnarumma, Adele Zarrella, Salvatore Maria Mazzeo, Annarita Pagano, Valentina Manzo, Ines Mazza, Francesco Sabbatino, Graziamaria Corbi, Pasquale Pagliano, Amelia Filippelli, Valeria Conti

“…Protease inhibitors, followed by nonnucleoside reverse transcriptase inhibitors and integrase inhibitors have been recognized as the main players in DDIs with antivirals used to control co-infection, such as Hepatitis C virus, or with drugs commonly used to treat HIV comorbidities, such as lipid-lowering agents, proton pump inhibitors and anticancer drugs. …”
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Gingival Anaplastic Large-Cell Lymphoma Mimicking Hyperplastic Benignancy as the First Clinical Manifestation of AIDS: A Case Report and Review of the Literature by Rafaela Elvira Rozza-de-Menezes, Stefânia Jeronimo Ferreira, Diogo Lenzi Capella, Stephan Schwartz, Ana Helena Willrich, Lúcia de Noronha, Aline Cristina Batista Rodrigues Johann, Paulo Henrique Couto Souza

“…Further laboratory tests revealed positivity for human immunodeficiency virus (HIV). The patient was submitted to chemotherapy, but four months after diagnosis, the patient died due to pneumonia and respiratory failure. …”
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A Performance Evaluation and Inter-laboratory Comparison of Community Face Coverings Media in the Context of COVID-19 Pandemic by Soleiman Bourrous, Mathieu Barrault, Victor Mocho, Stéphane Poirier, Nathalie Bardin-Monnier, Augustin Charvet, Dominique Thomas, Alexandre Bescond, Axel Fouqueau, Tatiana Mace, François Gaie-Levrel, François-Xavier Ouf

“…To ensure the quality of such devices and their relevance to slow down the virus spreading, a quick reaction of the certification organisms was necessary to fix the minimal acceptable performances requirements. …”
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Impact of pulmonary yoga module on lung capacity of COVID-19 adult survivors by Adarsh Tomar, Sudhanshu Verma

“…Nowadays, yogic practices are being used as a preventive measure against this deadly virus. There is a hypothesis that yoga improves lung capacity significantly, which is a front-line fighter against any pathogens or viruses that intrude inside the body. …”
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AI-Driven Plant Health Assessment: A Comparative Analysis of Inception V3, ResNet-50 and ViT with SHAP for Accurate Disease Identification in Taro by Valeria Maeda-Gutiérrez, Juan José Oropeza-Valdez, Luis C. Reveles-Gómez, Cristian Padron-Manrique, Osbaldo Resendis-Antonio, Luis Octavio Solís-Sánchez, Hector A. Guerrero-Osuna, Carlos Alberto Olvera Olvera

“…This study addresses the challenges of Taro disease identification by employing two key strategies: integrating explainable artificial intelligence techniques to interpret deep learning models and conducting a comparative analysis of advanced architectures Inception V3, ResNet-50, and Vision Transformers for classifying common Taro diseases, including leaf blight and mosaic virus, as well as identifying healthy leaves. The novelty of this work lies in the first-ever integration of SHapley Additive exPlanations (SHAP) with deep learning architectures to enhance model interpretability while providing a comprehensive comparison of state-of-the-art methods for this underexplored crop. …”
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Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution. by Nicolas Tessandier, Baptiste Elie, Vanina Boué, Christian Selinger, Massilva Rahmoun, Claire Bernat, Sophie Grasset, Soraya Groc, Anne-Sophie Bedin, Thomas Beneteau, Marine Bonneau, Christelle Graf, Nathalie Jacobs, Tsukushi Kamiya, Marion Kerioui, Julie Lajoie, Imène Melki, Jean-Luc Prétet, Bastien Reyné, Géraldine Schlecht-Louf, Mircea T Sofonea, Olivier Supplisson, Chris Wymant, Vincent Foulongne, Jérémie Guedj, Christophe Hirtz, Marie-Christine Picot, Jacques Reynes, Vincent Tribout, Édouard Tuaillon, Tim Waterboer, Michel Segondy, Ignacio G Bravo, Nathalie Boulle, Carmen Lía Murall, Samuel Alizon

“…We performed 974 on-site visits for a total of 1,619 months of follow-up. We collected data on virus load, local immune cell populations, local concentrations of cytokines, and circulating antibody titres. …”
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COVID-19 EM PEDIATRIA: PERFIL EPIDEMIOLÓGICO DOS CASOS SUSPEITOS by Khétene Joyce Freitas Zacarias, Victoria Liery Ribeiro Alves, Yure Batista de Sousa, Mirela Lopes Figueiredo, Ana Augusta Maciel de Souza, Patrícia Fernandes do Prado

“…Dentre as 268 crianças inclusas, 14 (5.22%) foram diagnosticadas com presença de antígenos do vírus SARS-CoV-2. Os resultados permitem concluir que houve maior prevalência da faixa etária 0 a 2 anos (53.36%), do sexo masculino (57.47%) e da raça/cor parda (68.65%). …”
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A Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin Mimics by Dimitrios-Petrou Bogdanos, Heather Smith, Yun Ma, Harold Baum, Giorgina Mieli-Vergani, Diego Vergani

“…On the basis of the reported association between hepatitis B vaccination (HBvacc) and autoimmune demyelinating complications such as multiple sclerosis (MS), we have looked for aminoacid similarities between the small hepatitis B virus surface antigen (SHBsAg), and the MS-autoantigens myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) that could serve as targets of immunological cross-reactivity. …”
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Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis by EBENEZER OLUWAKEMI, BODEDE OLUSOLA, AWOLADE PAUL, JORDAAN MARYAM A., OGUNSAKIN ROPO E., SHAPI MICHAEL

“…The chemotypes identified herein can be adopted as a starting point for developing new drugs to contain the novel virus.…”
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Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit by Arthur Kwizera, Mary Nabukenya, Agaba Peter, Lameck Semogerere, Emmanuel Ayebale, Catherine Katabira, Samuel Kizito, Cecilia Nantume, Ian Clarke, Jane Nakibuuka

“…In high-income countries, improved survival has been documented among intensive care unit (ICU) patients infected with human immune deficiency virus (HIV). There are no data from low-income country ICUs. …”
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Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections by Yan T, Wang Q, Ma C, Teng X, Gong Z, Chu W, Zhou Q, Liu Z

“…Genome analysis revealed that vB_Kpn_HF0522 is a double-stranded linear DNA virus. Biological characterization demonstrated that this phage specifically targets serotype K1 K. pneumoniae with an optimal multiplicity of infection (MOI) of 0.01, effectively disrupting biofilms and inhibiting bacterial growth. …”
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Prevalence, aetiology, and service mapping of dementia in rural Uganda. Part of DEPEND Uganda (Dementia Epidemiology, unmet Need and co-Developing Solutions in Uganda). [version 2;... by Joseph Mugisha, Nicholas J Ashton, Claire J Steves, Racheal Alinaitwe, Josephine Prynn, Tunde Peto, Beatrice Kimono, Martin Prince

“…Methods The study is nested within the General Population Cohort run by the Medical Research Council/Uganda Virus Research Institute & London School of Hygiene and Tropical Medicine Research Unit. …”
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Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C by Manuela G. Neuman, Hemda Schmilovitz-Weiss, Nir Hilzenrat, Marc Bourliere, Patrick Marcellin, Cristhian Trepo, Tony Mazulli, George Moussa, Ankit Patel, Asad A. Baig, Lawrence Cohen

“…High levels of profibrinogenic cytokine transforming factor beta (TGF-β), metalloprotease (MMP2), and tissue inhibitor of matrix metalloprotease 1 (TIMP1) contribute to fibrogenesis in hepatitis C virus (HCV) infection and in alcohol-induced liver disease (ALD). …”
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A20 as a Potential Therapeutic Target for COVID‐19 by Yongyao Wu, Lilan He, Rong Li, Jiuxuan Li, Qing Zhao, Bin Shao

“…This inopportune immune rhythm not only makes patients more susceptible to the virus but also leads to numerous complications resulting from the excessive production of inflammatory factors. …”
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Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis by Masahito Ebina, Hiroyuki Taniguchi, Taku Miyasho, Shingo Yamada, Naoko Shibata, Hiromitsu Ohta, Shu Hisata, Shinya Ohkouchi, Tsutomu Tamada, Hidekazu Nishimura, Akitoshi Ishizaka, Ikuro Maruyama, Yoshinori Okada, Kondo Takashi, Toshihiro Nukiwa

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A Truncated Multi-Thiol Aptamer-Based SARS-CoV-2 Electrochemical Biosensor: Towards Variant-Specific Point-of-Care Detection with Optimized Fabrication by Sergio Roberto Molina Ramirez, Nafiseh Samiseresht, Mateo Alejandro Martínez-Roque, Ferdinando Catania, Kevin Graef, Martin Rabe, Andreas Offenhäusser, Dirk Mayer, Gabriela Figueroa-Miranda

“…Even more, it showed a three times higher sensitivity for the Omicron in comparison to the Wuhan strain (wild type), alpha, and beta variants of the SARS-CoV-2 virus. Those results demonstrate the creation of an affordable and variant-selective refined C9t aptasensor that outperformed current rapid diagnosis tests.…”
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The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections by Mohamed, Moubarak, Keneth Iceland, Kasozi, Helal F., Hetta, Hazem M., Shaheen, Abdur, Rauf, Hayder M., Al-kuraishy, Safaa, Qusti, Eida M., Alshammari, Emmanuel Tiyo, Ayikobua, Fred, Ssempijja, Adam Moyosore, Afodun, Ritah, Kenganzi, Ibe Michael, Usman, Juma John, Ochieng, Lawrence Obado, Osuwat, Kevin, Matama, Ali I., Al-Gareeb, Emmanuel, Kairania, Monica, Musenero, Susan, Christina Welburn, Gaber, El-Saber Batiha

“…PCR remains the standard benchmark for initial diagnosis of COVID-19 infection, while advances in immunological profiling are guiding clinical treatment. The SARS- Cov-2 virus has undergone multiple mutations since its emergence in 2019, resulting in changes in virulence that have impacted on disease severity globally. …”
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