Pegilated interferon alpha 2b «Pegaltevir» chronic hepatitis C treatment (randomized clinical trial) by Marina V. Mayevskaya, Ye. N. Bessonova, P. O. Bogomolov, N. I. Geyvandova, K. V. Zhdanov, V. G. Morozov, V. D. Pasechnikov, I. Yu. Khomenko, A. V. Yagoda, V. T. Ivashkin

“…Assessment of Pegaltevir® efficacy was carried out in 4 weeks (rapid virologic response, RVR) and 12 weeks of treatment (early virologic response, EVR) in groups 1 and 3 in comparison to corresponding scores in groups 2 and 4 (primary criteria of efficacy were estimated in all 140 patients enrolled in original study. …”
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Disease burden of influenza in Spain: A five-season study (2015–2020) by Iván Sanz-Muñoz, Irene Arroyo-Hernantes, Alejandro Martín-Toribio, Marina Toquero-Asensio, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Silvia Rojo-Rello, Marta Domínguez-Gil, Marta Hernández-Pérez, Eduardo Tamayo, Ruth Gil-Prieto, Ángel Gil-de-Miguel, José M Eiros

“…In this period, approximately 7.8% of those hospitalized required ICU admission, and 5.7% died in the hospital due to influenza, with wide differences in these parameters depending on the season due to the virological characteristics of the major circulating viruses. …”
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Type B non-Hodgkin lymphoma in a patient with acquired immunodeficiency virus with no detected viral load. Case report by Edwin Marcelo Miranda Solìs, Juan Fernando Orozco Herrera

“…For these reasons, we present the case of a 58-year-old patient, diagnosed with acquired immunodeficiency virus in the year 2000, who in the last ten years presented adequate clinical, virological, and pharmacological control. Suddenly and a few months ago, he began with symptoms related to a spinal cord compression syndrome at the lumbar level characterized by pain, functional impotence of the extremities and paresthesias. …”
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Sarcoid-like reaction at the patient with chronic hepatitis C on a background of antiviral therapy by A. V. Lapshin, N. I. Kokina, M. V. Mayevskaya, I. A. Sokolina, V. T. Ivashkin

“…Immune-suppressive therapy by methylprednisolon and phosphogliv was prescribed, that resulted in complete regression of clinical symptoms and radiological changes in the lungs. Sustained virologic response was preserved in the patient.Conclusion. …”
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Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons by Charitha Gowda, Noah McKittrick, Deborah Kim, Rosemarie A. Kappes, Vincent Lo Re, Pablo Tebas

“…HIV-infected individuals demonstrate lower immunogenicity to the influenza vaccine, despite immunologic and virologic control of HIV infection. Obesity has been previously shown to be associated with diminished antibody responses to other vaccines in HIV-uninfected persons. …”
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Iatrogenic Cushing Syndrome Secondary to Ritonavir-Epidural Triamcinolone Interaction: An Illustrative Case and Review by Sapna Sadarangani, Melody L. Berg, William Mauck, Stacey Rizza

“…We describe a 48-year-old woman with immunologically and virologically well-controlled HIV on ritonavir-based ART, who developed headache, dizziness, and candida and herpes simplex virus (HSV) ulcerative esophagitis 7 days after receiving an epidural triamcinolone injection for cervical radicular pain. …”
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HIV-1 resistance mutations and genetic diversity among children failing antiretroviral treatment in five healthcare facilities in Benin, West Africa. by Edwige Hermione Dagba Gbessin, Edmond Tchiakpe, René Kpemahouton Keke, Nicole Vidal, Michel Kiréopori Gomgnimbou, Haziz Sina, Euloge Senan Adjou, Aldric Afangnihoun, Moussa Bachabi, Akadiri Yessoufou, Abdoul-Salam Ouedraogo, Lamine Baba-Moussa

“…This study aimed to present the frequency of HIV-1 antiretroviral resistance mutations and the genetic diversity among children with virological failure in five pediatric care facilities in Benin.…”
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Direct-Acting Antivirals for the Treatment of Chronic Hepatitis C: Open Issues and Future Perspectives by Hee Bok Chae, Seon Mee Park, Sei Jin Youn

“…Combination of drugs with different mechanisms shows a good sustained virological response (SVR). But several mutations are associated with viral resistance to DAAs. …”
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Pegilated interferon α2а in treatment of chronic hepatitis C by P. O. Bogomolov, S. V. Koblov, A. O. Buyeverov, M. V. Matsiyevich, O. S. Kuzmina, N. A. Barsukova, N. V. Dubinina

“…In 227 of patients the 1-st HCV genotype was revealed, 2nd genotype – in 24, 3rd genotype – in 41cases.Results. Sustained virologic response (SVR) after the termination of antiviral therapy was achieved in 70,1% of patients. …”
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A single-site randomized controlled trial of partner navigation to HCV treatment for people who inject drugs: a study protocol for the You’re Empowered for Treatment Initiation (YE... by Meghan D. Morris, Judy Y. Tan, Claire C. McDonell, Maia Scarpetta, Tiffany N. Nguyen, Jennifer C. Price, Torsten B. Neilands

“…The primary outcome is the initiation of HCV treatment, with secondary outcomes including treatment completion and sustained virologic response 12 weeks post-treatment. Data will be collected through questionnaires and electronic health records and analyzed using intention-to-treat and mixed-effects models. …”
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Safety of Sofosbuvir and Ribavirin Combination Therapy in a Patient Who Developed Anemia due to Ribavirin by Hirokazu Suii, Itaru Ozeki, Ryoji Tatsumi, Masakatsu Yamaguchi, Mutsuumi Kimura, Tomohiro Arakawa, Tomoaki Nakajima, Yasuaki Kuwata, Takumi Ohmura, Shuhei Hige, Yoshiyasu Karino, Joji Toyota

“…However, SOF/RBV therapy was effective and she achieved sustained virologic response (SVR) with a maximum change in Hb from baseline of only −1.2 g/dL. …”
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Treatment-Resistant Hepatitis C Viral Infection: A Case Report and Literature Review by Victoria Green, Marina Roytman

“…The goal of therapy is to achieve a sustained virologic response (SVR-12), defined as undetectable HCV-RNA within 12 weeks after treatment completion. …”
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Establishment of Gill-Derived Primary Cell Cultures from Largemouth Bass (<i>Micropterus salmoides</i>) as an Alternative Platform for Studying Host–Virus Interactions by Ziwen Wang, Li Nie, Chenjie Fei, Jiong Chen

“…A primary cell culture derived from the gill tissues of largemouth bass (<i>Micropterus salmoides</i>) was successfully established and characterized, providing a physiologically relevant model for virological research. Gill tissues were enzymatically dissociated, and their cells were cultured in M199 supplemented with 20% fetal bovine serum at 25 °C, yielding optimal growth. …”
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Characterization of HIV-1 Infection and Innate Sensing in Different Types of Primary Human Monocyte-Derived Macrophages by Elisabeth A. Diget, Kaja Zuwala, Randi K. Berg, Rune R. Laursen, Stine Søby, Lars Østergaard, Jesper Melchjorsen, Trine H. Mogensen

“…In this study, we investigated the differences between various monocyte-derived macrophages (MDMs) generated through different differentiation protocols and evaluated different cellular, immunological, and virological properties. We found that elevated and persistent HIV-1 pWT/BaL replication could be obtained only in MDMs grown in RPMI containing macrophage colony-stimulating factor (M-CSF). …”
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Establishment of an animal model for monkeypox virus infection in dormice by Gaojie Song, Lingling Cheng, Jun Liu, Yu Zhou, Cuiling Zhang, Yuping Zong

“…Dormice infected with MPXV exhibited typical symptoms such as appetite loss, continuous body weight reduction, aggravated respiratory difficulties, accompanied by lethargy, chills, and other clinical manifestations similar to human monkeypox infection. Virological tests further confirmed the distribution of MPXV in multiple vital organs of dormice, including the lungs, liver, spleen, and trachea, with particularly significant pathological damage observed in lung tissue. …”
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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection by Romain Vial, Christine Zandotti, Sophie Alain, Alexandre Decourt, Noémie Jourde-Chiche, Raj Purgus, Charleric Bornet, Laurent Daniel, Valérie Moal, Tristan Legris

“…Despite a large decrease in immunosuppression, CMV disease was not controlled and a salvage therapy with Brincidofovir (BCV), which is an oral lipid conjugate of cidofovir with limited nephrotoxicity, was attempted. Clinical and virological remission was observed after a 21-day course of BCV, despite mild and reversible liver toxicity. …”
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The Relationship between Inflammatory Marker Levels and Hepatitis C Virus Severity by Qitian He, Quan He, Xue Qin, Shan Li, Taijie Li, Li Xie, Yan Deng, Yu He, Yongbin Chen, Zhifu Wei

“…We included fifty-two chronic HCV and 42 HCV-related cirrhosis patients and 84 healthy controls. Hematological and virological parameters and liver function biomarkers of HCV-related patients at admission were recorded. …”
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A simple tool to evaluate the effectiveness of HIV care for settings with gaps in data availability (ESTIHIV). by Dorthe Raben, Marie L Jakobsen, Jamina Trajanovska, Justyna Kowalska, Anna Vassilenko, Snezana Dragas, Arjan Harxhi, Gordana Dragovic, Nadine J Jaschinski, Bastian Neesgaard, Klaus Hjorth-Larsen, Harmony Garges, Joel Gallant, Jens D Lundgren, Andrew Philips, Valentina Cambiano, Yazdan Yazdanpanah, Amanda Mocroft

“…Many HIV clinics with poor IT-infrastructure are unable to report data on individuals in care with HIV, on antiretroviral treatment (ART) and virologically suppressed (VS), with the aim of monitoring the HIV Continuum of Care to estimate efficacy of HIV treatment programmes. …”
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Common protocol for validation of the QCOVID algorithm across the four UK nations by Ronan A Lyons, Aziz Sheikh, Vahe Nafilyan, Frank Kee, Carol Coupland, Julia Hippisley-Cox, Chris Robertson, Ben Humberstone, Jane Lyons, Christopher R Cardwell, Steven Kerr

“…Linked datasets comprising of primary and secondary care records, virological testing data and death registrations will be assembled in trusted research environments in England, Scotland, Northern Ireland and Wales. …”
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Long-Term Consequences of Hepatitis C Viral Clearance on the CD4 (+) T Cell Lymphocyte Course in HIV/HCV Coinfected Patients by J. Dazley, R. Sison, J. Slim

“…Of the 116 patients enrolled, 54 (46.6%) reached a sustained virological response. During a follow-up of 24 months, the SVR group showed a mean annual increase in CD4 + T cell from baseline of 84 cells/ll at 1 year and of a further 38 cells/ll within the second year (P=0.01, 0.001, resp.). …”
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