Treatment of chronic hepatitis C by cepeginterferon alpha-2b in combination to ribavirin by M. V. Mayevskaya, O. O. Znoyko, Ye. A. Klimova, S. L. Maximov, S. N. Kizhlo, N. A. Petrochenkova, F. I. Nagimova, Yu. N. Linkova

“…Therefore the response at the end of treatment (direct virologic response, DVR) and sustained virologic response (SVR) were estimated for patients of the 1-st and 2-nd groups in common (n=100). …”
Get full text

The prognostic value of ferritinemia level in patients with chronic hepatitis C by N. C. Sargsyants, E. H. Grigoryan

“…Application of logistical regression analysis demonstrated, that the baseline ferritin level is independent predictor of sustained virologic response at treatment by pegilated interferon α-2a with ribavirin.…”
Get full text

Triple Active Antiretroviral Regimen Including Enfuvirtide Via the Biojector is Effective and Safe by Mona Loutfy, Colin Kovacs

“…For full HIV virological suppression, three fully active antiretroviral agents are required. …”
Get full text

Relapse of Visceral Leishmaniasis in an HIV-Infected Patient Successfully Treated with a Combination of Miltefosine and Amphotericin B by Shauna McQuarrie, Ken Kasper, Dana C Moffatt, Daniel Marko, Yoav Keynan

“…The present report documents a 49-year-old HIV-infected man receiving antiretroviral therapy with a suboptimal immune response and a CD4 count of 95 cells/mm3, despite virological suppression. Investigation of bone marrow was conducted and yielded a diagnosis of visceral leishmaniasis. …”
Get full text

Graves' Disease as a Manifestation of Immune Reconstitution in HIV-Infected Individuals after Initiation of Highly Active Antiretroviral Therapy by Samad Rasul, Robert Delapenha, Faria Farhat, Jhansi Gajjala, Syeda Mehreen Zahra

“…This phenomenon should be suspected in individuals who present with clinical deterioration and a presentation suggestive of hyperthyroidism despite good virological and immunological response to HAART. Signs and symptoms of hyperthyroidism may be discrete or overt and typically develop 8–33 months after initiating therapy. …”
Get full text

Efficacy and Safety of Sofosbuvir-Based Direct-Acting Antiviral Agents Treatment for Patients with Genotype 3/6 Hepatitis C Virus Infection by Yong-yu Mei, You-ming Chen, Yuan-kai Wu, Xiao-hong Zhang, Wen-xiong Xu

“…In patients with chronic hepatitis C and liver cirrhosis, sustained virological response 12 weeks after the end of treatment (SVR12) was 97.4% and 96.7%, respectively, and rapid virological response (RVR) was 75.0% and 57.1%, respectively. …”
Get full text

Efficacy of pegylated interferon alfa-2b «Algeron» in the treatment of chronic hepatitis C by M. V. Mayevskaya, O. O. Znoyko, E. A. Klimova, S. L. Maximov, S. N. Kizhlo, N. A. Petrochenkova, F. I. Nagimova, R. A. Ivanov, Yu. N. Linkova, T. V. Chernovskaya

“…Primary efficacy endpoints were rapid and early virologic response (RVR and EVR).Results. Comparative analysis of virologic response rate after 4th and 12th weeks of the therapy and biochemical response did not show any statistically significant differences between the groups. …”
Get full text

Combined Treatment with Antiviral Therapy and Rituximab in Patients with Mixed Cryoglobulinemia: Review of the Literature and Report of a Case Using Direct Antiviral Agents-Based A... by Teresa Urraro, Laura Gragnani, Alessia Piluso, Alessio Fabbrizzi, Monica Monti, Elisa Fognani, Barbara Boldrini, Jessica Ranieri, Anna Linda Zignego

“…Here, we report a complete remission of MC after a sustained virological response following a combined RTX/Peg-IFN+RBV+DAA (boceprevir) treatment and review the literature about the combined RTX/AT.…”
Get full text

Avian influenza annual report 2023 by European Food Safety Authority (EFSA), José Cortiñas Abrahantes, Inma Aznar, Iancu Catalin, Lisa Kohnle, Kenneth Fergus Mulligan, Lina Mur, Anca Stoicescu, Aniek vanHoutum, Gabriele Zancanaro

“…Of the 2626 PEs sampled for virological testing, 180 PEs (6.85%) were positive for influenza A(H5/H7) viruses. …”
Get full text

Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa by Carole L. Wallis, John W. Mellors, Willem D. F. Venter, Ian Sanne, Wendy Stevens

“…This study examined drug resistance patterns emerging in 75 HIV-1 infected adults experiencing virologic failure on a second-line regimen containing 2 NRTI and lopinavir/ritonavir. …”
Get full text

Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings by Kevin Peterson, Sabelle Jallow, Sarah L. Rowland-Jones, Thushan I. de Silva

“…Nucleoside analogues alone are not sufficiently potent enough to achieve durable virologic control. Some protease inhibitors, in particular those without ritonavir boosting, are not sufficiently effective against HIV-2. …”
Get full text

Long-Term Real-World Outcomes of Tenofovir Alafenamide in Chronic Hepatitis B: Detailed Analysis of Treatment-Naive and Experienced Patients by Yu-Xuan Song, Guang-Jun Song, Hui Ma, Bo Feng, Yan-Di Xie

“…In treatment- naive patients, the rates of a virological response, HBeAg conversion, and HBsAg loss at 192 weeks were 100%, 33.3%, and 2%, respectively. …”
Get full text

Multiple fusiform and saccular aneurysms in a person living with Human Immunodeficiency Virus by Talia Unice, Poobalan Naidoo, Pranav Hiralal, Yeshkhir Naidoo, Somasundram Pillay

“…We report on a 21-year-old male with human immunodeficiency virus infection and suboptimal virological control, despite highly active antiretroviral therapy. …”
Get full text

An Update on the Management of Chronic Hepatitis C: 2015 Consensus Guidelines from the Canadian Association for the Study of the Liver by Robert P Myers, Hemant Shah, Kelly W Burak, Curtis Cooper, Jordan J Feld

“…Specifically, direct-acting antiviral agents with dramatically improved rates of virological clearance compared with standard therapy have been developed and interferon-free, all-oral antiviral regimens have been approved. …”
Get full text

Management of the Kidney Transplant Patient with Chronic Hepatitis C Infection by Ignatius Y. S. Tang, Natasha Walzer, Nidhi Aggarwal, Ivo Tzvetanov, Scott Cotler, Enrico Benedetti

“…Achievement of sustained virological response (SVR) may reduce the risks for both posttransplantation hepatic and extrahepatic complications such as de novo or recurrent glomerulonephritis associated with HCV. …”
Get full text

Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis by Pinelopi Arvaniti, Kalliopi Zachou, George K. Koukoulis, George N. Dalekos

“…After careful exclusion of other hepatitis causes by imaging, virological, immunological, and microbiological investigations, a diagnosis of acute severe AIH (AS-AIH) was established. …”
Get full text

HIV-1 Trans Infection of CD4+ T Cells by Professional Antigen Presenting Cells by Charles R. Rinaldo

“…The end result is that HIV-1 can sequester within the APC for several days and be transmitted via membrane extensions intracellularly and extracellularly to T cells across the virologic synapse. Virus replication requires activated T cells that can develop concurrently with the events of virus transmission. …”
Get full text

Imaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization by Agata Kublicka, Daria Lorek, Agata Mikołajczyk-Martinez, Grzegorz Chodaczek, Aleksandra Chwirot, Barbara Bażanów, Anna Karolina Matczuk

“…Imaging flow cytometry, which integrates the advantages of both methodologies, offers significant potential in virological studies. In this investigation, we employed imaging flow cytometry coupled with immunostaining to monitor the entry of equine arteritis virus EAV into Vero cells via the endosomal trafficking route. …”
Get full text

Simeprevir and Sofosbuvir Combination Treatment in a Patient with HCV Cirrhosis and HbS Beta 0-Thalassemia: Efficacy and Safety despite Baseline Hyperbilirubinemia by Nikolaos Papadopoulos, Melanie Deutsch, Athanasios Georgalas, Helias Poulakidas, Lazaros Karnesis

“…Hyperbilirubinemia was benign and fully reversible and our patient finally achieved sustained virological response 24 weeks after the end of treatment.…”
Get full text

The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance by Mark A. Wainberg

“…The use of highly active antiretroviral therapy (HAART) involves combinations of drugs to achieve maximal virological response and reduce the potential for the emergence of antiviral resistance. …”
Get full text