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141
Combined Effects of 2-Methoxyestradiol (Hypoxia-Inducible Factor 1α Inhibitor) and Dasatinib (A Second-Generation Tyrosine Kinase Inhibitor) on Chronic Myelocytic Leukemia Cells
Published 2022-01-01“…The levels of HIF-1α, vascular endothelial growth factor (VEGF), and glutamate synthase 1 (GLU1) genes in K-562 cells were affected dose-dependently after 2-ME2 administration. 2-ME2 induced cell apoptosis by downregulating antiapoptotic protein expressions of Bcl-xl and Bcl-2. …”
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142
Evaluation of Retinal Pigment Epithelial Cell Cytotoxicity of Recombinant Tissue Plasminogen Activator Using Human-Induced Pluripotent Stem Cells
Published 2019-01-01“…RPE function was evaluated by measuring the secretion of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) and RPE-specific gene expression. …”
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143
Application of deep learning algorithm for judicious use of anti-VEGF in diabetic macular edema
Published 2025-02-01“…The standard treatment involves anti-VEGF (Vascular Endothelial Growth Factor) therapy, but approximately 36% of patients do not respond adequately, highlighting the need for more precise predictive models to guide treatment. …”
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144
The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
Published 2015-01-01“…On the other hand, modulating the expression of proangiogenic factors such as vascular endothelial growth factor, angiopoietin-1, or interleukin-8, influencing inflammatory reaction, and affecting tumor suppressors, such as SuFu and Fus-1, miR-378a is considered as a part of an angiogenic network in tumors. …”
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145
Pigment Epithelium-Derived Factor-Loaded PEGylated Nanoparticles as a New Antiangiogenic Therapy for Neovascularization
Published 2022-01-01“…The antiangiogenic effects of vascular endothelial growth factor (VEGF), pure PEDF, and NP-PEG-PEDF on proliferation, migration, and tube formation were evaluated. …”
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146
Caveolin-1 Scaffolding Domain Peptide Regulates Colon Endothelial Cell Survival through JNK Pathway
Published 2020-01-01“…In this study, we examined how the antennapedia- (AP-) conjugated caveolin-1 scaffolding domain (AP-Cav) modulates vascular endothelial growth factor- (VEGF-) dependent colon endothelial cell angiogenic responses, as seen during colitis. …”
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147
Modulation of gut microbiota in targeted cancer therapy: insights on the EGFR/VEGF/KRAS pathways
Published 2024-12-01“…Key oncogenic targets, including epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and kirsten rat sarcoma viral oncogene homologue (KRAS), have emerged as focal points in the development of targeted agents. …”
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148
Microenvironment Influence of a Novel Bioengineered Wound Product, APIS®: A Preliminary In Vitro Analysis of Inflammatory Marker and Growth Factor Secretion
Published 2021-01-01“…Additionally, the secretion of prohealing growth factors such as basic fibroblast growth factor (FGFb) and vascular endothelial growth factor (VEGF) was observed. Conclusion. …”
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149
Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy
Published 2024-12-01“…Key tumor angiogenesis markers, such as vascular endothelial growth factor (VEGF) and its receptor (VEGFR), are critical in driving tumor progression in advanced cervical cancer. …”
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150
Regulator of Calcineurin 1 in Periodontal Disease
Published 2016-01-01“…HUVEC were incubated for 2 h with Vascular Endothelial Growth Factor (VEGF) or with wild type and laboratory strains of Porphyromonas gingivalis (P. gingivalis). …”
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151
A potential VEGF-driven hypothesis of calvarial centripetal proliferation in cerebral proliferative angiopathy
Published 2025-01-01“…We hypothesized that this may be related to elevated vascular endothelial growth factor levels due to the proangiogenic nature of CPA.…”
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152
Kolaviron Improved Resistance to Oxidative Stress and Inflammation in the Blood (Erythrocyte, Serum, and Plasma) of Streptozotocin-Induced Diabetic Rats
Published 2014-01-01“…Serum levels of proinflammatory cytokines and growth factor: interleukin- (IL-) 1, monocyte chemotactic protein-1 (MCP-1), and vascular endothelial growth factor (VEGF), respectively, were also analyzed. …”
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153
Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma
Published 2024-09-01“…Glioblastoma (GBM) remains a formidable challenge in neuro-oncology due to its aggressive nature and propensity for therapeutic resistance. Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resistance that limits their clinical efficacy. …”
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154
Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use
Published 2017-01-01“…Additionally, this patient was taking ranibizumab, a vascular endothelial growth factor (VEGF) inhibitor for macular degeneration. …”
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155
Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress
Published 2009-01-01“…Moreover, activation of Akt and ERK1/2 in response to vascular endothelial growth factor was significantly lower in cells with low levels of caveolin-1. …”
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156
Update on the Treatment of Diabetic Retinopathy
Published 2008-01-01“…This review examines evidence from preclinical and clinical studies that shows that targeting inhibition of the renin-angiotensin system, vascular endothelial growth factor, corticosteroids, protein kinase C, growth hormone, and advanced glycation end-products are potential treatments for DR.…”
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157
Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease
Published 2021-01-01“…We observed that serum vascular endothelial growth factor (VEGF) levels were increased in KD patients and sera from KD patients upregulated the expression of VEGF receptor 2 (VEGFR2) and neuropilin-1 (NRP1) in human coronary artery endothelial cells (HCAECs). …”
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158
Perbedaan Rerata Kadar Soluble Fms-Like Tyrosine Kinase-1 (Sflt-1) Serum pada Penderita Early Onset, Late Onset Preeklampsia Berat / Eklampsia dan Kehamilan Normal
Published 2016-01-01“…Kegagalan pengaturan dan ketidakseimbangan agen vasoaktif proangiogenik dan antiangiogenik plasenta, <em>soluble fms</em><em>-like tyrosine kinase</em>-1 (sFlt-1), <em>vascular endothelial growth factor</em> (VEGF) dan <em>placental growth factor</em> (PlGF) memainkan peran penting dalam patogenesis preeklampsia. …”
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159
Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia
Published 2020-01-01“…H&E staining was used to examine the pathological changes in the retina, and immunohistochemistry was performed to determine the retinal expression of VEGF (vascular endothelial growth factor). The modeling resulted in 77% tree shrews with diabetes. …”
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160
Dietary Supplemental Glutamine Enhances the Percentage of Circulating Endothelial Progenitor Cells in Mice with High-Fat Diet-Induced Obesity Subjected to Hind Limb Ischemia
Published 2020-01-01“…The HG group had higher circulating EPCs on day 1 while muscle vascular endothelial growth factor, matrix metalloproteinase-9, and hypoxia-inducible factor-1 gene expressions were higher on day 7 postischemia than those of the HI group. …”
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