AIGC Using Behavior Analysis from the Perspective of Artificial Intelligence Literacy by Yuhong CUI, Jintao ZHAO

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The mechanism of parvalbumin interneurons regulating glutamatergic neurons involvement in stress induced anxiety in the basolateral amygdala of male mice by Xiaorui Su, Xuetong Dong, Chao-Long Lu, Minglong Zhang, Yaping Li, Han Xiao, Jian Wang, Yufei Sun, Bin Cong, Songjun Wang

“…This study aims to explore the neural mechanisms by which stress-induced imbalances in the basolateral amygdala (BLA) parvalbumin interneurons (PV-INs) and glutamatergic neurons lead to anxiety. This study used behavioral analysis, morphology, patch clamp electrophysiology, and viral interference techniques to detect the number of BLA PV-INs and glutamatergic neurons, as well as the excitability of glutamatergic neurons. …”
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PTEN in somatostatin neurons regulates fear and anxiety and is required for inhibitory synaptic connectivity within central amygdala by Timothy W. Holford, Kaitlyn N. Letourneau, Carolyn Von-Walter, Daniela Moncaleano, Cody L. Loomis, M. McLean Bolton

“…PTEN provides a target for investigation because it regulates the development of inhibitory neurons arising from the medial ganglionic eminence, promoting the survival and maturation of parvalbumin (PV+) neurons at the expense of somatostatin (SOM+) neurons.MethodsHere, we investigate how PTEN regulates SOM+ neurons at the cellular and circuit level in the central lateral amygdala (CeL), an area that governs the key ASD behavioral symptoms of social anxiety and altered emotional motivation for social engagement using behavioral analysis, electrophysiology, and two-photon local circuit mapping.ResultsWe found that knocking out PTEN in SOM+ neurons results in elevated levels of fear and anxiety and decreases CeL local circuit connectivity. …”
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