Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro by Ting Li, Ting Fang, Linxin Xu, Xiangyang Liu, Xiaoyu Li, Mei Xue, Xiaochen Yu, Bei Sun, Liming Chen

“…Background: Metabolic associated fatty liver disease (MAFLD), characterized by hepatic lipid accumulation and fatty degeneration, is intertwined with obesity and type 2 diabetes mellitus (T2DM). Empagliflozin is a sodium-glucose cotransporter-2 inhibitor that effectively lowers blood glucose, but its effect on MAFLD and associated mechanisms are not fully understood.Methods: Eight-week-old db/db mice, an in vivo model, were administered empagliflozin or saline intragastrically. …”
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Sodium-Glucose Co-transporter-2 Inhibitors in Heart Failure with Preserved Ejection Fraction: A Breakthrough in Improvement of Clinical Outcomes? by Alexander E. Berezin, Alexander A. Berezin

“…The authors included eight studies and two meta-analyses that have been reported as completed and found that there were high heterogeneous data regarding the fact that SGLT2 inhibitors had strict resemblance in their efficacy among patients with HFpEF with and without Type 2 diabetes. Due to the use of unpublished data and findings from the trials ended early, there is a lack of upper left ventricular ejection fraction threshold levels to identify inclusion criteria and no agreement in heart failure with reduced ejection fraction determination. …”
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The Food Resources and Kitchen Skills intervention: Protocol of a randomized controlled trial. by Armando Peña, Emily Dawkins, Mariah Adams, Lyndsi R Moser, Amy Carter, Rebecca L Rivera, Deanna Reinoso, Wanzhu Tu, Richard J Holden, Daniel O Clark

“…<h4>Introduction</h4>Individuals with food insecurity are disproportionately burdened by hypertension (HTN) and type 2 diabetes and face greater barriers to self-managing these conditions.…”
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The urinary microbiome in association with diabetes and diabetic kidney disease: A systematic review. by Tiscar Graells, Yi-Ting Lin, Shafqat Ahmad, Tove Fall, Johan Ärnlöv

“…In total, the urobiome of 1,571 people was sequenced, of which 662 people had diabetes, and of these 36 had confirmed diabetic kidney disease; 609 were healthy individuals, 179 had prediabetes or were at risk of type 2 diabetes mellitus and 121 did not have diabetes but had other comorbidities. …”
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Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential by Jingyi Yuan, Zhenmin Li, Yongjiang Yu, Xiuge Wang, Yunyun Zhao

“…This disorder affects approximately 6–20% of individuals, primarily emerging during early adolescence, and considerably increases the risk of conditions such as impaired glucose tolerance, type 2 diabetes, endometrial cancer, cardiovascular diseases, dyslipidemia, and postpartum complications. …”
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Alpinia oxyphylla Miq. Extract Prevents Diabetes in Mice by Modulating Gut Microbiota by Yiqiang Xie, Man Xiao, Yali Ni, Shangfei Jiang, Guizhu Feng, Shenggang Sang, Guankui Du

“…Recently, the role of gut microbiota in the development of obesity and type 2 diabetes mellitus (T2DM) has been highlighted. …”
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Integrating mandatory occupational health practice and workplace health promotion programs to reduce the high burden of work-related diseases by Francesco CHIRICO, Angelo SACCO, Nicola MAGNAVITA

“…Sedentary occupations and metabolic syndrome (MetS) are associated with an increased risk of type 2 diabetes mellitus (T2DM) and coronary heart disease, contributing to elevated mortality rates from CVDs. …”
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The Role of the Liver in the Pathophysiology of PCOS: A Literature Review by Abrar Alhermi, Heather Perks, Varsha Nigi, Noor Altahoo, Stephen L. Atkin, Alexandra E. Butler

“…Women with PCOS commonly have insulin resistance, increased susceptibility to type 2 diabetes mellitus, dyslipidemia, hyperinsulinemia, increased cardiovascular risk, hepatic steatosis, infertility, and an overall reduction in physical and psychological well-being. …”
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The Role of Helicobacter pylori Seropositivity in Insulin Sensitivity, Beta Cell Function, and Abnormal Glucose Tolerance by Lou Rose Malamug, Rudruidee Karnchanasorn, Raynald Samoa, Ken C. Chiu

“…Infection, for example, Helicobacter pylori (H. pylori), has been thought to play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our aim was to determine the role of H. pylori infection in glucose metabolism in an American cohort. …”
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Targeting Transcriptional Regulators Affecting Acarbose Biosynthesis in <i>Actinoplanes</i> sp. SE50/110 Using CRISPRi Silencing by Saskia Dymek, Lucas Jacob, Alfred Pühler, Jörn Kalinowski

“…SE50/110, is an α-glucosidase inhibitor and is used as a medication to treat type 2 diabetes. While the biosynthesis of acarbose has been elucidated, little is known about its regulation. …”
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The Effectiveness of Self-Care in Diabetics on Self-Insulin Administration and Behavioral Markers Among Adolescents with Type 1 Diabetes by Ochappan Selvarajan, Kannan Rajendran, A. Helen Mary Perdita

“…Background: Diabetes mellitus is a long-term, progressive metabolic disease that is primarily caused by an absolute type 1 diabetes or relative type 2 diabetes, which lacks the hormone insulin. Diabetes education is essential, but patients must fully realize its benefits through action or self-care activities. …”
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The Relationship between Estimated Glomerular Filtration Rate and Diabetic Retinopathy by Jingyang Wu, Jin Geng, Limin Liu, Weiping Teng, Lei Liu, Lei Chen

“…This is a hospital-based study and the aim of it was to examine the relationship between the GFR and DR in patients with type 2 diabetes mellitus (T2DM). We used CKD-EPI equation to estimate GFR and SPSS 19.0 and EmpowerStats software to assess their relationship. …”
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The Change in HbA1c Associated with Initial Adherence and Subsequent Change in Adherence among Diabetes Patients Newly Initiating Metformin Therapy by Gregory A. Nichols, A. Gabriela Rosales, Teresa M. Kimes, Kaan Tunceli, Karen Kurtyka, Panagiotis Mavros

“…We conducted a observational study of 2,844 type 2 diabetes patients who initiated metformin as their first antihyperglycemic drug. …”
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Nonsevere Hypoglycemia Episode Clinical and Economic Outcomes: A Comparison between Sulfonylurea and Sodium-Glucose Cotransporter 2 Inhibitor as Add-On to Metformin from a Canadian... by Pendar Farahani

“…To estimate prevalence of NSHEs and associated economic outcomes attributable to sulfonylurea (SU) versus sodium-glucose cotransporter 2 inhibitor (SGLT2i) initiation after metformin over one year for Canadian patients with type 2 diabetes (T2DM). Methods. Risk difference for NSHEs was calculated for SU and SGLT2i from RCT data. …”
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Activation of PPAR𝛾 by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats by Mahmoud Mansour, Elaine Coleman, John Dennis, Benson Akingbemi, Dean Schwartz, Tim Braden, Robert Judd, Eric Plaisance, Laura Ken Stewart, Edward Morrison

“…Because PPAR𝛾 activation by thiazolidinedione increased insulin sensitivity in type 2 diabetes, understanding the long term impact of PPAR𝛾 activation on steroid sex hormones in males is critical. …”
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High Fasting Plasma Glucose during Early Pregnancy: A Review about Early Gestational Diabetes Mellitus by E. Cosson, L. Carbillon, P. Valensi

“…Although eGDM is characterized by insulin resistance and associated with classical risk factors for type 2 diabetes and incident diabetes after delivery, it is not necessarily associated with preexisting prediabetes. …”
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Genetic risk factors associated with gestational diabetes in a multi-ethnic population. by Paula Benny, Hyeong Jun Ahn, Janet Burlingame, Men-Jean Lee, Corrie Miller, John Chen, Johann Urschitz

“…<h4>Aims</h4>Genome-wide association studies have shown an increased risk of type-2-diabetes (T2DM) in patients who carry single nucleotide polymorphisms in several genes. …”
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An Update on Less Invasive and Endoscopic Techniques Mimicking the Effect of Bariatric Surgery by Froukje J. Verdam, Ruben Schouten, Jan Willem Greve, Ger H. Koek, Nicole D. Bouvy

“…Obesity (BMI 30–35 kg/m2) and its associated disorders such as type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease have reached pandemic proportions worldwide. …”
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Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study by Maryam Mosavat, Mitra Mirsanjari, Bashir A. Lwaleed, Maherah Kamarudin, Siti Zawiah Omar

“…Adipocytokines participate in regulating the inflammatory response in glucose homeostasis and type 2 diabetes. However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestational diabetes (GDM) has not been fully investigated. …”
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Nomogram-Based Prediction of the Risk of Diabetic Retinopathy: A Retrospective Study by Ruohui Mo, Rong Shi, Yuhong Hu, Fan Hu

“…This study is aimed at developing a risk nomogram of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes mellitus (T2DM). Methods. A questionnaire survey, biochemical indicator examination, and physical examination were performed on 4170 T2DM patients, and the collected data were used to evaluate the DR risk in T2DM patients. …”
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