Metformin Suppressed CXCL8 Expression and Cell Migration in HEK293/TLR4 Cell Line by Zhihui Xiao, Wenjun Wu, Vladimir Poltoratsky

“…It also enhances tumor cell proliferation and migration. Metformin, type II diabetes medication, demonstrates anticancer properties via suppressing inflammation, tumor cell proliferation, angiogenesis, and metastasis. …”
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Updating Experimental Models of Diabetic Cardiomyopathy by J. Fuentes-Antrás, B. Picatoste, A. Gómez-Hernández, J. Egido, J. Tuñón, Ó. Lorenzo

“…Inflammation, hypertrophy, fibrosis, steatosis, and apoptosis in the myocardium have been studied in numerous diabetic experimental models in animals, mostly rodents. Type I and type II diabetes were induced by genetic manipulation, pancreatic toxins, and fat and sweet diets, and animals recapitulate the main features of human diabetes and related cardiomyopathy. …”
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Mathematical modelling and simulation analysis of a modified Butterworth van Dyke circuit model for non‐invasive diabetes detection by Srinivasan Lekha, Suchetha Manikandan

“…This study studies these characteristics and evaluates the behaviour of the sensor in the presence of various acetone concentrations in breath sample for healthy, type 1 and type 2 diabetic subjects.…”
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Exercise and the Cardiovascular System by Saeid Golbidi, Ismail Laher

“…There are alarming increases in the incidence of obesity, insulin resistance, type II diabetes, and cardiovascular disease. The risk of these diseases is significantly reduced by appropriate lifestyle modifications such as increased physical activity. …”
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Primary Carcinoma in Squamous Cells of the Gallbladder by Javier Martínez Navarro, Virgen Yazmín Martínez Navarro, Lisanka Fumero Roldán

“…A case of an 81 year old patient is presented, with antecedents of type II diabetes mellitus and high blood pressure on permanent drug treatment. …”
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An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome by Angela J. Westover, Kimberly A. Johnston, Deborah A. Buffington, H. David Humes

“…These results allow for the planning of first-in-man studies in obese type 2 diabetic patients.…”
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Catecholamines Mediate Multiple Fetal Adaptations during Placental Insufficiency That Contribute to Intrauterine Growth Restriction: Lessons from Hyperthermic Sheep by D. T. Yates, A. S. Green, S. W. Limesand

“…These adrenergically influenced adaptive responses promote in utero survival but also cause asymmetric intrauterine growth restriction and small-for-gestational-age infants that are at greater risk for serious metabolic disorders throughout postnatal life, including obesity and type II diabetes.…”
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Height Constitutes an Important Predictor of Mortality in End-Stage Renal Disease by Tsuneo Takenaka, Takahiko Sato, Hitoshi Hoshi, Nobutaka Kato, Keita Sueyoshi, Masahiro Tsuda, Yusuke Watanabe, Hiroshi Takane, Yoichi Ohno, Hiromichi Suzuki

“…Fifty two hypertensive patients with type 2 diabetic nephropathy receiving hemodialysis and 52 patients with nondiabetic nephropathy were enrolled. …”
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Implementation of medication management services at the primary healthcare level – a pilot study by Brajković Andrea, Mucalo Iva, Vidović Toni, Gonzaga Mariana Martins, Nascimento Do, Balenović Antonija, Protrka Ino, De Oliveira Djenane Ramalho

“…Multiple regression analysis showed that type 2 diabetic patients (p = 0.025) and patients using five or more medications (p = 0.011) should be prioritized to receive CMM services as potentially they have a higher number of DTPs, and could, therefore, obtain a greater benefit from the service.…”
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PREVALENCE OF RAMADAN AND FASTING RELATED DIABETICCOMPLICATIONS AMONG DIABETIC PATIENTS by Aisha Noreen et al

“…Adjusting of drug regimen along with control over the diet and daily activities composed a Ramadan 3D Triangle through which a proper supervision and education came in to being concluding that few of the type I and most of the type II diabetes mellitus patients who wanted to fast could carefully manage it. …”
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Rare Case of Aspergillus ochraceus Osteomyelitis of Calcaneus Bone in a Patient with Diabetic Foot Ulcers by Farhang Babamahmoodi, Tahereh Shokohi, Fatemeh Ahangarkani, Mojtaba Nabili, Elham Afzalian Ashkezari, Sosan Alinezhad

“…The case was a 68-year-old male with a history of type II diabetes for 2 years. The patient had two ulcers on the right heel bones for the past 6 months with no significant improvement. …”
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The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinica... by Yuqi Liu, Juan Li, Jinfang Ma, Nanwei Tong

“…However, these are realized only if the HbA1c in type 1 or type 2 diabetic patients is reduced at least by 0.8% versus the control group or it is reduced to <7% and >3 years of intensive glucose control is required. …”
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Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism by Alice J. Kroker, John B. Bruning

“…While endogenous ligands of PPARγ include fatty acids and eicosanoids, synthetic full agonists of the receptor, including members of the thiazolidinedione (TZD) class, have been widely prescribed for the treatment of type II diabetes mellitus (T2DM). Unfortunately, the use of full agonists has been hampered by harsh side effects with some removed from the market in many countries. …”
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Along for the Ride: Intrahepatic Cholangiocarcinoma with Concomitant LECT2 Amyloidosis by Phoenix D. Bell, Aaron R. Huber, Tom C. DeRoche

“…We present a case of a 69-year-old Hispanic male with a past medical history of type II diabetes mellitus who presented with a two-month history of abdominal pain. …”
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Gender Differences in Metabolic Disorders and Related Diseases in Spontaneously Diabetic Torii-Leprfa Rats by Takeshi Ohta, Yoshiaki Katsuda, Katsuhiro Miyajima, Tomohiko Sasase, Shuichi Kimura, Bin Tong, Takahisa Yamada

“…The Spontaneously Diabetic Torii Leprfa (SDT fatty) rat is a novel type 2 diabetic model wherein both male and female rats develop glucose and lipid abnormalities from a young age. …”
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Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK1/2-MAPK Signaling Pathway in Diabetic Nephropathy by Luwei Zhang, Jinhang Zhang, Xinnong Liu, Shengli Liu, Jun Tian

“…To reveal the expression and possible role of tribbles homolog 3 (TRB3) in the incidence of type 2 diabetic nephropathy, we used immunohistochemistry, real-time quantitative PCR, western blot analysis, and enzyme-linked immunosorbent assay (ELISA) to study the expression of TRB3, extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase (ERK1/2 MAPK), transforming growth factor β1 (TGF-β1), and collagen type IV in kidneys of db/db diabetic mice and in murine renal mesangial cells stimulated with high glucose. …”
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The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists by Tamotsu Tsukahara

“…In recent years, peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be a target for the treatment of type II diabetes. Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers. …”
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Risk Factors for Microvascular Complications of Diabetes in a High-Risk Middle East Population by Sohaila Cheema, Patrick Maisonneuve, Mahmoud Zirie, Amin Jayyousi, Hekmat Alrouh, Amit Abraham, Sura Al-Samraye, Ziyad Mahfoud, Ibrahim Mohammed Al-Janahi, Buthaina Ibrahim, Albert B. Lowenfels, Ravinder Mamtani

“…We collected information via a structured questionnaire and directly from the patient’s record on 1034 adult type 2 diabetic patients who were attending outpatient clinics in Qatar. …”
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A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle by R. W. A. Mackenzie, P. Watt

“…In addition, hypoxic exposure has been shown to improve glucose control in type 2 diabetics. The literature surrounding hypoxia-induced changes to glycemic control appears to be confusing and conflicting. …”
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Signaling Pathway Puts the Break on Fat Cell Formation by Ormond A. MacDougald

“…Unfortunately, excess fat or adipose tissue is associated with a wide array of health problems, including increased incidence of type II diabetes, cardiovascular disease, hypertension, sleep apnea, and skeletomuscular problems [4,5,6]. …”
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