Reduced TCA Flux in Diabetic Myotubes: Determined by Single Defects? by Michael Gaster

“…ATP production was measured by luminescence with or without concomitant ATP utilisation by hexokinase in mitochondria isolated from myotubes established from eight lean and eight type 2 diabetic subjects. The ATP production of investigated substrate combinations was significantly reduced in mitochondria isolated from type 2 diabetic subjects compared to lean. …”
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The Need for Improved Management of Painful Diabetic Neuropathy in Primary Care by Teresa Sobhy

“…The provision of care for patients with type II diabetes in primary care must involve assessing patients for peripheral neuropathy of the feet. …”
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Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin by Neeraj Khatri, Amin Sagar, Nagesh Peddada, Vikas Choudhary, Bhupinder Singh Chopra, Veena Garg, Renu Garg, Ashish

“…The study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice. …”
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Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GCâMS and molecular docking by Deepu Mathew, Lidiya John P., Manila T.M., Divyasree P., Sandhya Rajan V.T.K.

“…Keywords: Breast cancer, Drug discovery, Herbal medicine, In silico, Malaria, Measles, Phyto-compounds, Rheumatoid arthritis, Sickle cell disease, Type II diabetes…”
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Antidiabetic Effect of Fenugreek Seed Powder Solution (Trigonella foenum-graecum L.) on Hyperlipidemia in Diabetic Patients by Genet Alem Geberemeskel, Yared Godefa Debebe, Nigisty Abraha Nguse

“…This study investigated the effect of Trigonella foenum-graecum seed powder solution on the lipid profile of newly diagnosed type II diabetic patients. Methods. A total of N=114 newly diagnosed type II diabetic patients without any significant diabetes complication were selected. …”
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A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling by Qi-qi Liu, Wei-wei Wu, Jian Yang, Rui-bin Wang, Ling-ling Yuan, Pei-zhao Peng, Mao-yun Zeng, Ke Yu

“…Then, LMT-28 was administered by gavage at 0.23 mg/kg once every 5 days for 2 weeks to type 2 diabetic rats with peri-implantitis induced by LPS injection and silk ligature. …”
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Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives by Amit Pithadia, Jeffrey R. Brender, Carol A. Fierke, Ayyalusamy Ramamoorthy

“…Because of the probable link between hIAPP and the development of type II diabetes, there has been strong interest in developing reagents to study the aggregation of hIAPP and possible therapeutics to block its toxic effects. …”
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Correlation of serum C - reactive protein with clinical parameters in diabetic patients having chronic periodontitis before and after treatment by Arkhawan Ali Abdulhaq, Ziwar Ahmed Salih, Solaf Abdulqadir Mustafa

“…The present study was performed to determine whether presence of periodontitis and non-surgical periodontal therapy could influence the serum levels of CRP in type II diabetes mellitus disease patients. Materials and methods: A total of 60 subjects were selected for study. …”
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C-Peptide: A New Mediator of Atherosclerosis in Diabetes by Dusica Vasic, Daniel Walcher

“…In this paper we discuss the role of C-peptide and its effects in the development of atherosclerosis in type 2 diabetic patients.…”
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Exenatide with Metformin Ameliorated Visceral Adiposity and Insulin Resistance by Xuan Du, Wen Lu, Zijun Lu, Xinyu Shao, Chunhong Hu, Bimin Shi

“…Exenatide is an ideal treatment for obese type 2 diabetic patients in the aspect of adipose tissue distribution. …”
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Insulin Detemir Causes Lesser Weight Gain in Comparison to Insulin Glargine: Role on Hypothalamic NPY and Galanin by Mohammad Ishraq Zafar, Cuining Hu, Danfeng Liu, Raja Adeel Shafqat, Feng Gao

“…Insulin detemir decreased food intake in type 2 diabetic rats, which led to reduced weight gain when compared to insulin glargine treatment. …”
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Nonalcoholic Fatty Hepatitis: An Important Clinical Condition by Samuel W. French, Leslie B. Eidus, J. Freeman

“…The roles of alcohol, obesity and type II diabetes are stressed where inhibition of fatty acid oxidation by the liver is the basic defect in metabolism leading to fatty change, balloon degeneration and Mallory body formation. …”
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Preparation, Identification, and Enzyme Inhibition Kinetic Analysis of Phosvitin α-Amylase Inhibitory Peptides by Tianrui XUE, Binfei LÜ, Mingran ZHANG, Can LI, Xiaowei ZHANG

“…This study highlights the potential use of PPP as a new hypoglycemic substance in developing functional foods for alleviating type Ⅱ diabetes mellitus.…”
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Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy by Ruixia Ma, Ying Wang, Yan Xu, Rui Wang, Xianghua Wang, Ning Yu, Minghui Li, Yan Zhou

“…The purpose of this study was to investigate the potential mechanism of podocyte protection by tacrolimus in a type 2 diabetic mellitus (T2DM) rat model and in immortalized mouse podocytes (MPC5). …”
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Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol by S. Serge Barold, Scott Upton

“…This report describes the occurrence of asymptomatic hyperkalemia induced by the sequential administration of metoprolol and carvedilol in an 81-year-old man with type II diabetes and stable stage III renal insufficiency. …”
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Bariatric surgery and HIV: Joint venture between family, primary care, and HIV physicians by Ceren Aydemir, Raniah Al Saidi, Ji Soo Choi, Mohamed H. Ahmed, Dushyant Mital

“…Her medication included diltiazem 60 mg once a day, glyceryl trinitrate (GTN) spray, metformin 1 g twice daily, and linagliptin 500 mg once daily for her type II diabetes with glycated hemoglobin (HbA1c) of 8.4%. …”
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Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes by Steven Daniel Funk, Arif Yurdagul, A. Wayne Orr

“…Some of this confusion derives from studies in type 2 diabetics where multiple components of metabolic syndrome show proatherosclerotic effects independent of underlying diabetes. …”
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An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment by Shijin Xia, Xinyan Zhang, Songbai Zheng, Ramin Khanabdali, Bill Kalionis, Junzhen Wu, Wenbin Wan, Xiantao Tai

“…Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer’s disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. …”
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Lactobacillus gasseri Causing Bilateral Empyema by Angela Esquibel, Ala S. Dababneh, Bharath Raj Palraj

“…This is a case of a 49-year-old male with previously undiagnosed type two diabetes mellitus who presented with a 3-month history of cough and was found to have right sided Lactobacillus gasseri empyema for which he underwent video-assisted thoracoscopic surgery (VATS) with chest tube placement. …”
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Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity by Anna Leonardini, Luigi Laviola, Sebastio Perrini, Annalisa Natalicchio, Francesco Giorgino

“…PPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity. …”
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