Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm by Andrew A. Davis, Virginia G. Kaklamani

“…The insulin-leptin-adiponectin axis has been implicated mechanistically in breast cancer tumorigenesis. Specifically, increased leptin and decreased adiponectin levels disrupt homeostatic signaling pathways involved in cell proliferation, survival, cell-cycle regulation, and angiogenesis. …”
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Aging, cancer, and autophagy: connections and therapeutic perspectives by Begoña Zapatería, Esperanza Arias, Esperanza Arias

“…The interplay between aging, cancer, and autophagy reveals key insights into tumorigenesis, cellular senescence, and proteostasis dysfunction. …”
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Induced Pluripotent Stem Cells in Cardiovascular Medicine by Toru Egashira, Shinsuke Yuasa, Keiichi Fukuda

“…Human iPS cells are currently generated by transgene introduction principally through viral vectors, which integrate into host genomes, although the associated risk of tumorigenesis is driving research into nonintegration methods. …”
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Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis by Mones Abu-Asab, Ming Zhang, Dennis Amini, Nihad Abu-Asab, Hakima Amri

“…In addition, it has identified disruptions within the major regulatory pathways including those involved in cell proliferation, steroidogenesis, angiogenesis, cytoskeletal organization and integrity, and tumorigenesis, as well as cell adhesion and migration. …”
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Tumor cells escape immunosurveillance by hampering LFA-1 by Shishir Upadhyay, Lewis Murugu, Lena Svensson, Lena Svensson

“…In this review, we first detail how leukocytes utilize LFA-1 during immunosurveillance and then explore how tumors counteract this process in the tumor microenvironment (TME) by either altering LFA-1 functions or exploiting it to drive tumorigenesis. Moreover, we discuss therapeutic strategies targeting LFA-1, including inhibitors tested in laboratory studies and animal models, highlighting their potential as anticancer interventions and the need for further research to evaluate their clinical utility.…”
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TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression by Menghan Cao, Zhiying Shao, Xingyou Qian, Miaolei Chen, Chuyin Deng, Xintian Chen, Tingting Tang, Kaixu Zhang, Sufang Chu, Junnian Zheng, Jin Bai, Zhongwei Li

“…Furthermore, we demonstrate that TRIM21 suppresses the proliferation, tumorigenesis, migration, and metastasis of CRC cells by promoting the ubiquitination-mediated degradation of PRMT1. …”
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Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis by Kakali Ghoshal, Maitree Bhattacharyya

“…Platelets activation and dysfunction have been implicated in diabetes, renal diseases, tumorigenesis, Alzheimer’s, and CVD. In conclusion, this paper elucidates that platelets are not that innocent as they keep showing and thus numerous novel platelet biomarkers are upcoming very soon in the field of clinical research which can be important for predicting and diagnosing disease state.…”
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Simultaneous Detection of Different MicroRNA Types Using the ZIP-Code Array System by Sonja U. Weishaupt, Steffen Rupp, Karin Lemuth

“…Their implication in tumorigenesis is based on their dysregulation in many human cancer diseases. …”
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The Impact of the Metabolic Syndrome Severity on the Appearance of Primary and Permanent DNA Damage by Mirta Milić, Luka Kazensky, Martina Matovinović

“…Such changes contribute to an increased risk of tumorigenesis, cancer progression, and mortality. The alkaline comet and micronucleus <i>cytome</i> assay are commonly used assays for DNA damage evaluation. …”
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Glioma Stem Cells: Signaling, Microenvironment, and Therapy by Brandon D. Liebelt, Takashi Shingu, Xin Zhou, Jiangong Ren, Seul A. Shin, Jian Hu

“…Further, GSCs possess unique surface markers, modulate characteristic signaling pathways to promote tumorigenesis, and play key roles in glioma vascular formation. …”
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ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway by Liang Jiang, Shuai Zhang, Ning An, Guoqing Chai, Changhong Ye

“…Upregulation of ASPM promotes the malignant properties of ATC cells and contributes to tumorigenesis through the Wnt/β-catenin signaling pathway.…”
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FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A by Xing Wang, Ying Li, Yongning Li, Peng Liu, Songbai Liu, Yaozhen Pan

“…Cancer stem cells (CSCs) comprise a subset of tumor cells that can initiate tumorigenesis and promote tumor advance. A previous study showed that the expression of FBXW7 in hepatocellular carcinoma (HCC) clinical samples was lower than that in the adjacent nontumor tissues and was negatively correlated with the invasion and migration of HCC cells. …”
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Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

“…Our methodology brings critical insights into chromosomal aberrations and highlights the ubiquitous aneuploidy process during tumorigenesis. The copy number and scRT profiles obtained by analysing >119,000 high-quality human single cells from different cell lines, patient tumours and patient-derived xenograft samples leads to a multi-sample heterogeneity-resolved scRT atlas. …”
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PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation... by Xiang You, Dan Dan Xu, Di Zhang, Jie Chen, Feng Guang Gao

“…PYR-41 and thalidomide have therapeutic effects on inflammation-associated diseases with side effects such as tumorigenesis. Cross-presentation allows dendritic cells (DC) to present endogenous antigen and induce protective immunity against microbe infection and tumors. …”
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VEGF Promotes Proliferation of Human Glioblastoma Multiforme Stem-Like Cells through VEGF Receptor 2 by Chengshi Xu, Xing Wu, Jianhong Zhu

“…GBM is a lethal cancer, characterized by florid vascularization and aberrantly elevated vascular endothelial growth factor (VEGF). VEGF promotes tumorigenesis and angiogenesis of human GBM stem-like cells (GBSCs). …”
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Aging and tumors: a dynamic interaction by Yudi Zhang, Siqiang Zhu, Zhaodong Liu, Yonghao Hu, Yongjian Zhang, Liang Shang, Leping Li

“…This article initially examines the role of cellular senescence in tumorigenesis, emphasizing the correlation between telomere length—a marker of cellular senescence—and tumor risk. …”
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Targeting lipid metabolism of macrophages: A new strategy for tumor therapy by Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu

“…Tumor-associated macrophage (TAM) has emerged as a crucial regulator in tumorigenesis and promising target for tumor treatment.Aim of review: A thorough understanding of TAM lipid metabolism and its value in tumorigenesis may provide new ideas for TAM-based anti-tumor therapy.Key scientific concepts of review: TAMs can be divided into two main types, M1-like TAMs and M2-like TAMs, which play anti-tumor and pro-tumor functions in tumor occurrence and development, respectively. …”
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PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis by Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim

“…Methods: The effects of HBV replicative capacity, ER stress signaling, inflammation, cell death, and tumorigenesis resulting from PreS1 deletions were investigated through in vitro and in vivo experiments. …”
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Anticancer Role of PPARγ Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes by P. J. Simpson-Haidaris, S. J. Pollock, S. Ramon, N. Guo, C. F. Woeller, S. E. Feldon, R. P. Phipps

“…It is well accepted that inflammation and tumorigenesis are linked. Because peroxisome proliferator-activated receptor (PPAR)-γ agonists are potent mediators of anti-inflammatory responses, it was a logical extension to examine the role of PPARγ agonists in the treatment and prevention of cancer. …”
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Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils by Ming Yuan, Ha Zhu, Junfang Xu, Yuanyuan Zheng, Xuetao Cao, Qiuyan Liu

“…Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a key role in multiple aspects of cancer biology. …”
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