A comprehensive pan-cancer analysis of RNF187 in human tumors by Xuezhong Zhang, Xuebin Zhang, Tonggang Liu, Kaihui Sha

“…Abstract Purpose RING Finger 187 (RNF187) has recently emerged as a potential contributor to tumorigenesis. However, a comprehensive pan-cancer analysis of RNF187 in human tumors has not been undertaken until now. …”
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Orphan nuclear receptor NR2E3 is a new molecular vulnerability in solid tumors by activating p53 by Yidan Wang, Todd G. Kroll, Linhui Hao, Zhi Wen

“…Abstract The orphan nuclear receptor NR2E3 has emerged as a potential tumor suppressor, yet its precise mechanisms in tumorigenesis require further investigation. Here, we demonstrate that the full-length protein isoform of NR2E3 instead of its short isoform activates wild-type p53 and is capable of rescuing certain p53 mutations in various cancer cell lines. …”
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Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment by Yue Wang, Yiwen Wang, Yuhang Zhou, Yun Feng, Tao Sun, Junnan Xu

“…This review examined the impact of intestinal fungi and peri-tumor fungi on tumorigenesis, cancer progression, and response to anticancer therapies. …”
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Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis by F. A. Tucci, R. Pennisi, D. C. Rigiracciolo, M. G. Filippone, R. Bonfanti, F. Romeo, S. Freddi, E. Guerrera, C. Soriani, S. Rodighiero, R. H. Gunby, G. Jodice, F. Sanguedolce, G. Renne, N. Fusco, P. P. Di Fiore, G. Pruneri, G. Bertalot, G. Musi, G. Vago, D. Tosoni, S. Pece

“…In mouse models, targeted Numb ablation induces spontaneous tumorigenesis and sensitizes the urothelium to carcinogenic insults, accelerating tumor onset and progression. …”
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Differences in gene expression profile between vocal cord Leukoplakia and normal larynx mucosa by gene chip by Jianhua Peng, He Li, Jun Chen, Xianming Wu, Tao Jiang, Xiaoyun Chen

“…Abstract Background Long non-coding RNAs (lncRNAs) play an important role in tumorigenesis. Vocal cord leukoplakia is a precancerous lesion in otolaryngological practice. …”
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MTHFD1 Regulates Autophagy to Promote Growth and Metastasis in Colorectal Cancer via the PI3K‐AKT–mTOR Signaling Pathway by Zhihao Li, Haoxian Ke, Jiawei Cai, Shubiao Ye, Junfeng Huang, Chi Zhang, Ming Yuan, Ping Lan, Xianrui Wu

“…Conclusions MTHFD1 can modulate the PI3K‐AKT‐mTOR signaling pathway to suppress autophagy and stimulate tumorigenesis and metastasis.…”
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Equivocating and Deliberating on the Probability of COVID-19 Infection Serving as a Risk Factor for Lung Cancer and Common Molecular Pathways Serving as a Link by Abdelbasset Amara, Saoussen Trabelsi, Abdul Hai, Syeda Huma H. Zaidi, Farah Siddiqui, Sami Alsaeed

“…First, this article reports that SARS-CoV-2 induces severe inflammatory response and cellular stress, potentially leading to tumorigenesis through common pathways between SARS-CoV-2 infection and cancer. …”
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The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis by Paulina Marona, Rafał Myrczek, Iga Piasecka, Judyta Gorka, Oliwia Kwapisz, Ewelina Pospiech, Janusz Rys, Jolanta Jura, Katarzyna Miekus

“…These findings highlight the critical role of MCPIP1 RNase activity in modulating the c-Met/CD44 axis, thereby influencing stemness and tumorigenesis.…”
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Axl deficiency promotes preeclampsia and vascular malformations in mice by Chan Zhou, Yunqing Zhu, Liang Zhang, Miaomiao Zhao, Cong Zhang

“…However, the underlying mechanisms of this condition remain unclear. Placentation and tumorigenesis both share many characteristics, but PE is the result of insufficient placentation, in contrast to the overaggression of tumorigenesis. …”
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Novel Genomic Aberrations in Testicular Germ Cell Tumors by Array-CGH, and Associated Gene Expression Changes by Rolf I. Skotheim, Reija Autio, Guro E. Lind, Sigrid M. Kraggerud, Peter W. Andrews, Outi Monni, Olli Kallioniemi, Ragnhild A. Lothe

“…Conclusion: This first genome-wide integrated array-CGH and gene expression profiling of TGCT provides novel insights into the genome biology underlying testicular tumorigenesis.…”
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Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant by Qipan Deng, Hui Hu, Xinfang Yu, Shuanglin Liu, Lei Wang, Weiqun Chen, Chi Zhang, Zhaoyang Zeng, Ya Cao, Zijun Y. Xu-Monette, Ling Li, Mingzhi Zhang, Steven Rosenfeld, Shideng Bao, Eric Hsi, Ken H. Young, Zhongxin Lu, Yong Li

“…We generated a mouse line carrying this variant and found that it accelerates spontaneous tumorigenesis and glioma development, but strikingly, delays mammary tumorigenesis. …”
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Development of the Mammary Gland in Mouse: A Whole-Mount Microscopic Analysis by Bo Wang, Yuchen Xie, Zejian Yang, Jingyue Zhang, Huiwen Zhang, Peijun Liu

“…This method can provide invaluable insights, particularly in the study of mammary gland morphogenesis and tumorigenesis, underscoring its significance in both basic research and clinical applications.…”
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Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1 by Baocheng Xie, Peishan Wu, Hongyu Liu, XiangDi Yang, Linxuan Huang

“…The aim of this study was to investigate the role of MIR4435-2HG in regulating CSC characteristics, tumorigenesis, and chemoresistance in pancreatic cancer. …”
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Loss of phosphatase and tensin homolog (PTEN) increases Lysyl oxidase-like 2 (LOXL2) expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroi... by Angela Russo, Junlone Moy, Manead Khin, Timothy R. Dorsey, Alfredo Lopez Carrero, Joanna E. Burdette

“…Although LOXL2 is known to drive transformation and invasion in solid tumors and is associated with a poor prognosis in ovarian cancer, its specific role in the tumorigenesis of ovarian cancer originating from FTE remains unclear. …”
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The transmembrane protein LRIG2 increases tumor progression in skin carcinogenesis by Christine Hoesl, Thomas Fröhlich, Jennifer E. Hundt, Hermann Kneitz, Matthias Goebeler, Ronald Wolf, Marlon R. Schneider, Maik Dahlhoff

“…We employed the 7,12‐dimethylbenz(a)anthracene/12‐O‐tetra‐decanoylphorbol‐13‐acetate (DMBA/TPA) two‐stage chemical carcinogenesis model and analyzed the skin during homeostasis and tumorigenesis. LRIG2‐TG mice did not exhibit alterations in skin development or homeostasis but showed an interaction between LRIG2 and thrombospondin‐1, which is often involved in angiogenesis and tumorigenesis. …”
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CTCF, Cohesin, and Chromatin in Human Cancer by Sang-Hyun Song, Tae-You Kim

“…Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression.…”
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The promising role of nanopore sequencing in cancer diagnostics and treatment by Xinming Su, Qingyuan Lin, Bin Liu, Chuntao Zhou, Liuyi Lu, Zihao Lin, Jiahua Si, Yuemin Ding, Shiwei Duan

“…In essence, this technology stands poised to unearth novel mechanisms underlying tumorigenesis while providing dependable support for the diagnosis and treatment of cancer.…”
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Long non-coding RNAs-sphingolipid metabolism nexus: Potential targets for cancer treatment by Yan Chen, Jing Dai, Peng Chen, Quan Dai, Ya Chen, Yuying Li, Man Lu, Shugang Qin, Qiuju Wang

“…Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis. Sphingolipid metabolism has garnered interest as a potential target for cancer therapy owing to its considerable diagnostic and prognostic value. …”
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<i>O</i>-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway by Zhiwei Zhang, Tomoya Isaji, Yoshiyuki Oyama, Jianwei Liu, Zhiwei Xu, Yuhan Sun, Tomohiko Fukuda, Haojie Lu, Jianguo Gu

“…However, the regulatory mechanisms of FAK during tumorigenesis and progression still need to be fully understood. …”
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Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling by Xi Xiao Huang, Ley Moy Ng, Po-Hsien Lee, Peiyong Guan, Mun Juinn Chow, Aisyah Binte Mohamed Bashir, Meina Lau, Kenric Yi Shu Tan, Zhimei Li, Jason Yongsheng Chan, Jing Han Hong, Sheng Rong Ng, Tun Kiat Ko, Hong Lee Heng, Hsiang Ling Teo, Daniela Rhodes, Patrick Tan, Puay Hoon Tan, Donald P. McDonnell, Bin Tean Teh

“…These findings provide insights into how RARα mutations may contribute to tumorigenesis.…”
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