PPARG Epigenetic Deregulation and Its Role in Colorectal Tumorigenesis by Lina Sabatino, Alessandra Fucci, Massimo Pancione, Vittorio Colantuoni

“…Its function in colon carcinogenesis has largely been debated; accumulating evidence, however, supports a role as tumor suppressor through modulation of crucial pathways in cell differentiation, apoptosis, and metastatic dissemination. …”
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Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer by Negar Soltani Irdmusa, Haniyeh Bashi Zadeh Fakhar, Masoumeh Heshmati, Mohammad Esmaiel Akbari, Sara Rahimi

“…In this study, we examined the expression of the tumor suppressor gene BRCA1 and the tumor marker CA15-3 in women diagnosed with BC, focusing on different cancer grades. …”
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Lung Cancer Prediction Using Neural Network Ensemble with Histogram of Oriented Gradient Genomic Features by Emmanuel Adetiba, Oludayo O. Olugbara

“…These machine learning classifiers were trained to predict lung cancer using samples of patient nucleotides with mutations in the epidermal growth factor receptor, Kirsten rat sarcoma viral oncogene, and tumor suppressor p53 genomes collected as biomarkers from the IGDB.NSCLC corpus. …”
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MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer by Zhiguang Liu, Xinlian Wang, Liqiang Cao, Xiaowei Yin, Qian Zhang, Lan Wang

“…Many researches revealed that microRNAs (miRNAs) function as potential oncogene or tumor suppressor gene. As an antioncogene, miR-877-5p was reduced in many tumors. …”
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Somatic Mutations from Whole Exome Sequencing Analysis of the Patients with Biliary Tract Cancer by Kyong-Ah Yoon, Sang Myung Woo, Yun-Hee Kim, Sun-Young Kong, Sung-Sik Han, Sang-Jae Park, Woo Jin Lee

“…We discovered inactivating mutations of tumor suppressor genes, including APC, TP53, and ARID1A, in three patients. …”
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The Role of the PAX8/PPARγ Fusion Oncogene in Thyroid Cancer by Kimberly A. Placzkowski, Honey V. Reddi, Stefan K. G. Grebe, Norman L. Eberhardt, Bryan McIver

“…The recent discovery of the PAX8/PPARγ translocation in follicular thyroid carcinoma has promoted progress in the role of PPARγ as a tumor suppressor and potential therapeutic target. The PAX8/PPARγ fusion gene appears to be an oncogene. …”
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The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells by Yun Zhao, Shanel Dhani, Vladimir Gogvadze, Boris Zhivotovsky

“…Additionally, the expression of PDCD4 (a tumor suppressor highly associated with lung cancer) in NSCLC cells with low endogenous levels was attenuated by SND1 silencing, implying that SND1 might function as a molecular regulator upstream of PDCD4. …”
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EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction by Rui Liu, Zongwei Li, Rui Chen, Zhihong Fang, Zhiqiang Liu, Huan Liu

“…This complex promotes trimethylation at lysine 27 of histone H3 (H3K27me3) in the promoter region of the tumor suppressor gene EMP1, resulting in transcriptional silencing. …”
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Alu-Sc-mediated exonization generated a mitochondrial LKB1 gene variant found only in higher order primates by Ivan Tan, Sonia Chothani, Hong-Hwa Lim, Kong-Peng Lam

“…Abstract The tumor suppressor LKB1/STK11 plays important roles in regulating cellular metabolism and stress responses and its mutations are associated with various cancers. …”
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Role of Thyroid Hormone in Neurodegenerative Disorders of Older People by Arshag D. Mooradian, Michael J. Haas

“…This protein is 83% homologous to mouse c-Abl-interacting protein-2 (Abi2), a c-Abl-modulating protein with tumor suppressor activity. In cell cultures, increasing THRP expression either with TH treatment or exogenously through transfecting neuronal or PC 12 cells causes cell necrosis. …”
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Dual EMCV-IRES-integrated dengue virus can express an exogenous gene and cellular Mdm2 integration suppresses the dengue viral replication by Tadahisa Teramoto

“…It was also revealed that a cellular gene, Mdm2, which antagonizes tumor suppressor protein p53 (TP53), could terminate the viral replication in BHK21 cells. …”
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Molecular landscape of lung cancer: insights into therapeutic targets and clinical outcomes by Saloni Mangal, Abhijit Debnath, Rupa Mazumder, Avijit Mazumder, Rajesh Kumar Singh, Jahanvi Sanchitra, S.K. Asif Jan, Pratibha Pandey, Bimlesh Kumar, Anil Kumar Singh

“…Genetic mutations, chromosomal abnormalities, transcription factors, mutations in tumor suppressor genes, and mutations in oncogenes have all been associated with an increased risk of LC development. …”
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Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature by Siobhan S. Pattwell, Eric Q. Konnick, Yajuan J. Liu, Rebecca A. Yoda, Laligam N. Sekhar, Patrick J. Cimino

“…Hereditary pilocytic astrocytoma is often associated with germline genetic alterations in the tumor suppressor NF1, the gene responsible for the syndrome neurofibromatosis type 1. …”
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Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer by Anita Thyagarajan, Zaid Sirhan, Ravi P. Sahu

“…While the activation of oncogenes fuels cancer progression and escape mechanisms, tumor suppressors regulate and counterbalance the negative effects of oncogenic signaling. …”
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Interplay between Epigenetics and Genetics in Cancer by Jae Duk Choi, Jong-Soo Lee

“…Growing evidence points to an epigenome-wide disruption that involves large-scale DNA hypomethylation but specific hypermethylation of tumor suppressor genes, large blocks of aberrant histone modifications, and abnormal miRNA expression profile. …”
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The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer by J. L. Schwartz, A. N. Shajahan, R. Clarke

“…While the mechanisms that regulate endocrine responsiveness and cell fate are not fully understood, interferon regulatory factor-1 (IRF1) is strongly implicated as a key regulatory node in the underlying signaling network. IRF1 is a tumor suppressor that mediates cell fate by facilitating apoptosis and can do so with or without functional p53. …”
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miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1 by Fakai Wang, Huanjun Zhang, Bing Liu, Wei Liu, Zengchao Zhang

“…This study has suggested that miR-6869-5p is a useful tumor suppressor and prognostic marker in glioma.…”
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Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction by Gogsen Onalan, Yunus Kasim Terzi, Yusuf Aytac Tohma, Erkan Yurtcu, Esra Kuscu, Feride Iffet Sahin, Hulusi Bulent Zeyneloglu

“… Objective: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein. Here we report maspin expression in placental tissues of preeclampsia or intrauterine growth retardation pregnancies. …”
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LncRNA MBNL1-AS1 Suppresses Cell Proliferation and Metastasis of Pancreatic Adenocarcinoma through Targeting Carcinogenic miR-301b-3p by Chouman Sulidankazha, null Alidake, Hai Lin, Tieying He, Wei Han, Qilong Chen

“…Here, we identified a novel tumor-suppressor long noncoding RNA (lncRNA) MBNL1-AS1, in PAAD and revealed its downstream mechanism. …”
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CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells by Kiel T. Tietz, Braedan M. McCluskey, Conor R. Miller, Yingming Li, Sarah A. Munro, Scott M. Dehm

“…Altered alternative polyadenylation occurs in numerous cancers and can downregulate tumor-suppressor genes and upregulate oncogenes. We found that the cleavage and polyadenylation specificity factor (CPSF) complex factor CPSF1 is upregulated in patients with advanced prostate cancer, with high CPSF1 expression correlating with worse progression-free survival. …”
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