Insights Into the Role of Bmi‐1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review by Fatima Shaalan, Nissrine Ballout, Wafaa Takash Chamoun

“…We find that Bmi‐1 participates in regulating the gene expression and chromatin structure of several tumor suppressor genes or cell cycle inhibitors. Bmi‐1 has a critical role in modulating the tumor microenvironment to support the plasticity of GBM stem cells.We explore Bmi‐1's involvement in maintaining glioma stem cell (GSC) proliferation and senescence evasion upon regulating the chromatin structure of several tumor suppressor genes, cell cycle inhibitors, or stem cell genes in tumor cells. …”
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The miRNA‐mRNA Regulatory Network in Human Hepatocellular Carcinoma by Transcriptomic Analysis From GEO by Razieh Heidari, Vahideh Assadollahi, Seyedeh Negar Marashi, Fatemeh Elahian, Seyed Abbas Mirzaei

“…The reduced levels of tumor suppressor miRNAs or down regulated DEmiRs may be increased levels of oncogenes, the oncomirs or up regulated DEmiRs may be decreased levels of tumor suppressor genes in cancerous cells. …”
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Epilepsy and preventive antiepileptic treatment in tuberous sclerosis complex. Literature review by I. Kasiulevičiūtė

“…The pathogenic mutation is found in either the TSC1 or TSC2 tumor suppressor genes. The presence of cortical or subcortical tubers is associated with focal epileptiform discharges on the electroencephalogram and subclinical seizures prior to the onset of clinical seizures. …”
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Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer by Jie Ma, Huaxi Xu, Shengjun Wang

“…Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs is gradually emerging. …”
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Familial Aggregation of Urinary Tract and Bone Tumors: Searching for a Syndrome by Andreas Frings, Jochen B. Geigl, Bernadette Liegl-Atzwanger, Andreas Leithner

“…To confirm Li-Fraumeni syndrome, we set out to investigate this case by analyzing the tumor suppressor gene p53. However, taking into account all the diagnostic results obtained, Li-Fraumeni syndrome could not be confirmed, but there is still uncertainty regarding a definitive diagnosis.…”
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PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women by H. Gbelcová, P. Bakeš, P. Priščáková, V. Šišovský, I. Hojsíková, Ľ. Straka, M. Konečný, J. Markus, C. W. D’Acunto, T. Ruml, D. Böhmer, Ľ. Danihel, V. Repiská

“…Phosphatase and tensin homolog (PTEN) is a protein that acts as a tumor suppressor by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. …”
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MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A by Abdullah Alatawi, SoonJye Kho, Michael P. Markey

“…The p53 tumor suppressor integrates upstream signals such as DNA damage and active oncogenes to initiate cell cycle arrest or apoptosis. …”
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Nongenomic Mechanisms of PTEN Regulation by Jimmie E. Fata, Shawon Debnath, Edmund C. Jenkins, Marcia V. Fournier

“…A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. …”
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Preclinical Studies of Chemotherapy Using Histone Deacetylase Inhibitors in Endometrial Cancer by Noriyuki Takai, Hisashi Narahara

“…Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in endometrial cancers, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. …”
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Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection by Rajnish Kumar Singh, Ramakrishna Vangala, Atharva S. Torne, Dipayan Bose, Erle S. Robertson

“…The resultant reprogramming can lead to activation of oncogenes, silencing of tumor suppressor genes, and evasion of the immune response, which ultimately contributes to the oncogenic potential of these viruses. …”
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Cell-Specific Dual Role of Caveolin-1 in Pulmonary Hypertension by Rajamma Mathew

“…Caveolin-1, also known as a tumor-suppressor factor, interacts with a number of transducing molecules that reside in or are recruited to caveolae, and it inhibits cell proliferative pathways. …”
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Long-Term Remission of a Spinal Atypical Teratoid Rhabdoid Tumor in Response to Intensive Multimodal Therapy by Fahd Refai, Haneen Al-Maghrabi, Hassan Al Trabolsi, Jaudah Al-Maghrabi

“…Provided clinical and diagnostic suspicion is high, the histopathological diagnosis is relatively straightforward to secure by testing for the characteristic loss of the tumor suppressor protein SMARCB1/INI1. Here, we describe a case of thoracic spinal ATRT in a three-year-old boy that showed characteristic aggressive progression until managed with intensive multimodal therapy to achieve durable long-term remission. …”
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Molecular profiling and detection methods of microRNA in cancer research by Nurul-Syakima Ab Mutalib, Imilia Ismail, Hooi-Leng Ser

“…Acting like a “double-edge” sword, miRNAs can control and/or act as tumor suppressor genes and oncogenes, thus any unwanted alterations in their expression would bring upon disastrous effects on the host. …”
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A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System by Amy Adamson, Dennis LaJeunesse

“…Via our GMR-R model system, we have found that BRLF1 expression results in overproliferation of fly tissue, unlike BZLF1, and does so through the interaction with known tumor suppressor genes. Through an additional genetic screen, we have identified several Drosophila genes, with human homologs, that may offer further insights into the pathways that BRLF1 interacts with in order to promote EBV replication.…”
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Expression of LGI1 Impairs Proliferation and Survival of HeLa Cells by Nadia Gabellini, Valentina Masola

“…The LGI1 gene was suggested to function as tumor suppressor for its ability to reduce malignant features of glioblastoma cells. …”
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胃癌中 MTS1 基因异常甲基化的研究 by 全欣鑫, 周晓东

“…【目的】探讨多肿瘤抑制基因(multiple tumor suppressor gene 1, MTS1)5′端 CpG 岛异常甲基化与原发性胃癌发 病机制之间的关系。…”
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Biomarkers for Risk Stratification of Neoplastic Progression in Barrett Esophagus by Marjon Kerkhof, Johannes G. Kusters, Herman van Dekken, Ernst J. Kuipers, Peter D. Siersema

“…In this review, we will summarize the most promising tissue biomarkers, i.e. proliferation/cell cycle proteins, tumor suppressor genes, adhesion molecules, DNA ploidy status and inflammation associated markers, that can be used for risk stratification in BE, and discuss their respective clinical application.…”
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KLF4: a multifunctional nexus connecting tumor progression and immune regulation by Yunjie Ju, Wen Xiao, Bryan James Mathis, Ying Shi

“…KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor. …”
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MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment by Di Cao, Shi-Juan Mai, Hui-yun Wang, Ge Ren, Yue-Ning Wang, Chao-Yue Sun, Haojiang Li, Yu-Feng Zhou, Mei-Yin Zhang, Shuo-Cheng Wang

“…Background The biological significance of MAF1, a tumor suppressor, in carcinogenesis and immune response of hepatocellular carcinoma (HCC) remains unreported. …”
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PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate by Robert I. Glazer, Hongyan Yuan, Zhihui Xie, Yuzhi Yin

“…There is now emerging evidence that PPARs regulate tumor suppressor genes and developmental pathways associated with transformation and cell fate determination. …”
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