Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…Comprehensive translational research is required to validate CLO’s efficacy and safety of use in humans. …”
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Establishing an Electrophysiological Recording Platform for Epidural Spinal Cord Stimulation in Neuropathic Pain Rats by Yang CT, Shyu BC, Lin WT, Lu KH, Lin CR, Wen YR, Chen CC

“…., New Taipei City, Taiwan; 5Department of Anesthesiology, National Cheng Kung University Hospital, Tainan, Taiwan; 6Pain Management and Research Center, Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan; 7Chun Chuan Orthopedic and Pain Specialty Hospital, Taichung, Taiwan; 8Pain Management Center, Department of Anesthesiology, Jen-Ai General Hospital, Taichung, Taiwan; 9Neuroscience Program of Academia Sinica, Academia Sinica, Taipei, Taiwan; 10Taiwan Mouse Clinic, Biomedical Translational Research Center, Academia Sinica, Taipei, Taiwan*These authors contributed equally to this workCorrespondence: Chih-Cheng Chen; Yeong-Ray Wen, Email chih@ibms.sinica.edu.tw; yray.wen@gmail.comPurpose: Spinal cord stimulation (SCS) is pivotal in treating chronic intractable pain. …”
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Electrodermal activity and skin temperature characteristics related to stress and depression: A 4-week observational study of office workers by Yuki Ishikawa, Tatsuki Sugio, Kiko Shiga, Keisuke Izumi, Kazumichi Minato, Momoko Kitazawa, Sayaka Hanashiro, Ryo Takemura, Hiroyuki Uchida, Taishiro Kishimoto

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Race as a prognostic factor of breast mucinous carcinoma by Dingyuan Wang, Yang Wang, Songlin Gao, Rongshou Zheng, Guijian Wu, Jianping Wang, Can Lu, Kena Bu, Chun Zhang, Wanqing Chen, Bailin Zhang

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Non-Luminal Disease Score for Everolimus in Patients with Hormone Receptor‑positive and Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: A Mult... by Tan Y, Jiang H, Tian X, Ma F, Wang J, Zhang P, Xu B, Fan Y, Zhao W

“…Yujing Tan,1,* Hanfang Jiang,2,* Xinzhu Tian,1,* Fei Ma,1 Jiayu Wang,1 Pin Zhang,1 Binghe Xu,1 Ying Fan,1 Weihong Zhao3 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, People’s Republic of China; 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, People’s Republic of China; 3Department of Medical Oncology, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Fan; Weihong Zhao, Email fanying@cicams.ac.cn; zhaowh0818@163.comPurpose: This study aims to explore the role of the non-luminal disease score (NOLUS) for everolimus in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC).Methods: NOLUS has previously been established as an algorithm: NOLUS (0– 100) = − 0.45 × ER(%) − 0.28 × PR(%) + 0.27 × Ki67(%) + 73. …”
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Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions by Chen-Yu Zou, Chen Han, Fei Xing, Yan-Lin Jiang, Ming Xiong, Jesse Li-Ling, Hui-Qi Xie

“…Finally, the challenges facing the development of biopolymer-based hemostatic sponges are emphasized, and future directions for in vivo biosafety, emerging materials, multiple application scenarios and translational research are proposed.…”
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Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer’s Disease by Romero-ElKhayat L, Dakterzada F, Huerto R, Carnes-Vendrell A, Mínguez O, Pujol Sabaté M, Targa A, Barbé F, Milanesi E, Dobre M, Manda G, Cuadrado A, Piñol-Ripoll G

“…Leila Romero-ElKhayat,1 Farida Dakterzada,1 Raquel Huerto,1 Anna Carnes-Vendrell,1 Olga Mínguez,2 Montserrat Pujol Sabaté,2 Adriano Targa,3,4 Ferran Barbé,3,4 Elena Milanesi,5,6 Maria Dobre,5 Gina Manda,5 Antonio Cuadrado,5,7– 10 Gerard Piñol-Ripoll1,11 1Unitat de Trastorns Cognitius, Cognition and Behavior Study Group, Universitat de Lleida, IRBLleida, Lleida, 25198, Spain; 2Unitat de Son, Hospital Universitari Santa Maria de Lleida, Lleida, Spain; 3Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; 4Center for Biomedical Research in Respiratory Diseases Network (CIBERES), Madrid, Spain; 5“Victor Babes” National Institute of Pathology, Bucharest, 050096, Romania; 6Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania; 7Department of Endocrine Physiology and Nervous System, Instituto de Investigaciones Biomédicas “Alberto Sols” UAM-CSIC, Madrid, 28029, Spain; 8Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, 28049, Spain; 9Neuroscience Section, Instituto de Investigación Sanitaria La Paz (Idipaz), Madrid, 28046, Spain; 10Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid, 28031, Spain; 11Alzheimer’s Disease and Other Cognitive Disorders Unit, Hospital Clínic de Barcelona, Fundació de Recerca Clínic Barcelona – Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, SpainCorrespondence: Gerard Piñol-Ripoll, Cognitive Disorders Unit, Hospital Universitari Santa Maria, Rovira Roure no. 44, Lleida, 25198, Spain, Tel +34-937-727222, Ext. 173, Fax +34-976-727366, Email gerard_437302@hotmail.comIntroduction: Obstructive sleep apnoea (OSA) is the sleep disorder most frequently found in patients with Alzheimer’s disease (AD). …”
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Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer by Wang L, Deng X, Tang J, Gong Y, Bu S, Li Z, Liao B, Ding Y, Dai T, Liao Y, Li Y

“…Ling Wang,1,2,* Xuemei Deng,1,* Jiaxi Tang,3 Yi Gong,2 Shaojin Bu,4 Zuli Li,1 Bin Liao,2 Yao Ding,2 Tingting Dai,1,5 Yong Liao,1 Yongsheng Li2,6 1Department of Infectious Diseases, Second Affiliated Hospital, Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Phase I Clinical Trial Ward, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China; 3Department of Anesthesiology, Chongqing University Cancer Hospital, Chongqing, China; 4Department of Anesthesiology, Fengdu People’s Hospital, Chongqing, People’s Republic of China; 5Department of Medical Oncology, Chongqing University Fuling Hospital, Chongqing, China; 6Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong Liao, Department of Infectious Diseases, Second Affiliated Hospital, Chongqing Medical University, NO. 288 Chayuan Astronomy Avenue, Nanan District, Chongqing, 401336, People’s Republic of China, Email yongliao@cqmu.edu.cn Yongsheng Li, Department of Medical Oncology, Chongqing University Cancer Hospital, No. 181 hanyu Road, Shapingba District, Chongqing, 400030, People’s Republic of China, Email yongshengli2005@163.comPurpose: Colorectal cancer (CRC) is a prevalent malignancy, and lactate metabolism significantly influences tumorigenesis and progression. …”
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Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination by Zachary S Morris, Paul M Sondel, Amy K Erbe, Alexander L Rakhmilevich, Amber M Bates, Peter M Carlson, Alexander A Pieper, Ravi B Patel, Jen Birstler, Joseph Grudzinski, Reinier Hernandez, Bryan P Bednarz, Jamey P Weichert, Arika S Feils, Matthew Rodriquez, Claire Sun, Ian Marsh

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A Standardized Classification Scheme for Gastroduodenal Disorder Evaluation Using the Gastric Alimetry System: Prospective Cohort Study by Chris Varghese, Gabriel Schamberg, Emma Uren, Stefan Calder, Mikaela Law, Daphne Foong, Vincent Ho, Billy Wu, I-Hsuan Huang, Peng Du, Thomas Abell, Charlotte Daker, Christopher N. Andrews, Armen A. Gharibans, Gregory O’Grady

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The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial by Elena Giudice, Tzu-Ting Huang, Jayakumar R. Nair, Grant Zurcher, Ann McCoy, Darryl Nousome, Marc R. Radke, Elizabeth M. Swisher, Stanley Lipkowitz, Kristen Ibanez, Duncan Donohue, Tyler Malys, Min-Jung Lee, Bernadette Redd, Elliot Levy, Shraddha Rastogi, Nahoko Sato, Jane B. Trepel, Jung-Min Lee

“…Toxicity was manageable. Translational research was an exploratory endpoint. Potential biomarkers were investigated using pre-treatment fresh biopsies and serial blood samples. …”
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Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation by Tingyi Luo, Yujing Tang, Wangcheng Xie, Zhilong Ma, Jian Gong, Yonggui Zhang, Tingsong Yang, Xuyang Jia, Jia Zhou, Zhengyu Hu, Lin Han, Qigang Wang, Zhenshun Song

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Rapid identification and phenotyping of nonalcoholic fatty liver disease patients using a machine‐based approach in diverse healthcare systems by Anna O. Basile, Anurag Verma, Leigh Anne Tang, Marina Serper, Andrew Scanga, Ava Farrell, Brittney Destin, Rotonya M. Carr, Anuli Anyanwu‐Ofili, Gunaretnam Rajagopal, Abraham Krikhely, Marc Bessler, Muredach P. Reilly, Marylyn D. Ritchie, Nicholas P. Tatonetti, Julia Wattacheril

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Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

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Spontaneous high clonal expansion of Wilms’ tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms’ tumor gene 1-expressing solid tumor by Soyoko Morimoto, Yukie Tanaka, Jun Nakata, Fumihiro Fujiki, Kana Hasegawa, Hiroko Nakajima, Sumiyuki Nishida, Akihiro Tsuboi, Naoki Hosen, Naoki Kagawa, Motohiko Maruno, Akira Myoui, Takayuki Enomoto, Shuichi Izumoto, Mitsugu Sekimoto, Naoya Hashimoto, Toshiki Yoshimine, Atsushi Kumanogoh, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama

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Anterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth by Giorgia Picci, Nathan M. Petro, Chloe C. Casagrande, Lauren R. Ott, Hannah J. Okelberry, Danielle L. Rice, Anna T. Coutant, Grace C. Ende, Erica L. Steiner, Yu-Ping Wang, Julia M. Stephen, Vince D. Calhoun, Tony W. Wilson

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Hyperbaric oxygen therapy improves the effects of systemic steroid therapy for sudden sensorineural hearing loss by Yu-Ching Chen, Yu-Hsi Liu, Bor‐Hwang Kang, Cai-Sin Yao, Yao-Shen Chen, Wen-Chung Liu

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Relationship between neutropenia caused by nanoliposomal irinotecan/fluorouracil/leucovorin and treatment outcomes in the NAPOLEON-2 study (NN-2301) by Tomonori Araki, Yuki Sonoda, Mototsugu Shimokawa, Taiga Otsuka, Kohei Hayashi, Takuya Honda, Kazuhiko Nakao, Taro Shibuki, Junichi Nakazawa, Shiho Arima, Keisuke Miwa, Yoshinobu Okabe, Futa Koga, Yujiro Ueda, Yoshihito Kubotsu, Hozumi Shimokawa, Shigeyuki Takeshita, Azusa Komori, Kazuo Nishikawa, Satoshi Otsu, Ayumu Hosokawa, Hisanobu Oda, Tatsunori Sakai, Shuji Arita, Machiko Kawahira, Hiroki Taguchi, Kengo Tsuneyoshi, Yasunori Kawaguchi, Toshihiro Fujita, Takahiro Sakae, Tsuyoshi Shirakawa, Toshihiko Mizuta, Kenji Mitsugi

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Cognition and objective sleep quality in post-COVID-19 patients by Anna Carnes-Vendrell, Gerard Piñol-Ripoll, Adriano Targa, Nuria Tahan, Mar Ariza, Neus Cano, Neus Cano, Barbara Segura, Barbara Segura, Barbara Segura, Barbara Segura, Carme Junque, Carme Junque, Carme Junque, Carme Junque, Javier Béjar, Cristian Barrue, Nautilus Project Collaborative Group, Maite Garolera, Maite Garolera, Linh Viet Nguyen, Vanesa Arauzo, Jose A. Bernia, Marta Balague-Marmaña, Berta Valles-Pauls, Jesús Caballero, Ester Gonzalez-Aguado, Carme Tayó-Juli, Eva Forcadell-Ferreres, Silvia Reverte-Vilarroya, Susanna Forné, Anna Bartes-Plans, Jordina Muñoz-Padros, Jose A, Anna Prats-Paris Muñoz-Moreno, Inmaculada Rico, Nuria Sabé, Marta Almeria, Laura Casas, Maria José Ciudad, Anna Ferré, Tamar Garzon, Manuela Lozano, Marta Cullell, Sonia Vega, Sílvia Alsina, Maria J. Maldonado-Belmonte, Susana Vazquez-Rivera, Eva Baillès, Sandra Navarro, Ayoze González Hernández, Yaiza Molina, Victoria Olive, Silvia Cañizares

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Risk and Prognosis of Hepatocellular Carcinoma in Mexican Americans with Type 2 Diabetes Mellitus by Hatia RI, Hwang LY, Li R, Troisi C, Jalal PK, Amos CI, Gomez HF, Chun YS, Rashid A, Kaseb AO, Scheet PA, Hassan MM

“…Rikita I Hatia,1 Lu-Yu Hwang,2 Ruosha Li,3 Catherine Troisi,4 Prasun K Jalal,5 Christopher I Amos,6 Henry F Gomez,1 Yun Shin Chun,7 Asif Rashid,8 Ahmed O Kaseb,9 Paul A Scheet,1 Manal M Hassan1 1Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA; 3Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA; 4Department of Management, Policy & Community Health, School of Public Health, The University of Health Science Center at Houston, Houston, TX, USA; 5Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX, USA; 6Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA; 7Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 8Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 9Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Manal M Hassan, Department of Epidemiology, Unit 735, The University of Texas MD Anderson Cancer Center, 6900 Fannin Street, Houston, TX, 77030, USA, Tel +1-713-794-5452, Email mhassan@mdanderson.org Lu-Yu Hwang, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Pressler Street, RAS E717, Houston, TX, 77030, USA, Tel +1-713-500-9384, Email lu-yu.hwang@uth.tmc.eduIntroduction: Hepatocellular carcinoma (HCC) disproportionately affects Hispanic persons with higher age-specific incidence and increased mortality rates compared to non-Hispanic Whites. …”
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