Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation by Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu

“…Similarly, BSHX treatment reduced the levels of hydroxyproline, transforming growth factor-β, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inactivated the Smad2/3 signaling pathway in Ang II-treated HK-2 cells. …”
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Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors by Constantin Jotzu, Eckhard Alt, Gabriel Welte, Jie Li, Bryan T. Hennessy, Eswaran Devarajan, Srinivasalu Krishnappa, Severin Pinilla, Lilly Droll, Yao-Hua Song

“…The conditioned medium from MDAMB231 and MCF7 contains significant amounts of transforming growth factor-beta 1 (TGFβ1) and the differentiation of hASCs towards CAFs is dependent on TGFβ1 signaling via Smad3 in hASCs. …”
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Contradictory Effect of Lymphocyte Therapy and Prednisolone Therapy on CD3+CD8+CD56+ Natural Killer T Population in Women with Recurrent Spontaneous Abortion by Fatemeh Rezayat, Nafiseh Esmaeil, Abbas Rezaei, Roya Sherkat

“…Furthermore, the concentration of interferon-gamma (IFN-γ), transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10) was measured quantitatively using the enzyme-linked immunosorbent assay technique. …”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Augmented CCL5 secretion promotes MP recruitment via CCL5/C-C chemokine receptor 5 (CCR5) crosstalk, which subsequently hinders FAP clearance through elevated Transforming growth factor-β1 (TGFβ1). Maraviroc-mediated pharmacological blockade of the CCL5/CCR5 axis effectively mitigates muscle dystrophy and improves muscle performance. …”
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Pretreatment with AM1241 Enhances the Analgesic Effect of Intrathecally Administrated Mesenchymal Stem Cells by Junran Xie, Jinxuan Ren, Na Liu, Chengwei Wu, Dongju Xiao, Huanyu Luo, Jingxian Du

“…The expression of transforming growth factor-β1 (TGF-β1) was also analyzed in the dorsal root ganglion (DRGs) and spinal cord of CCI mice. …”
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Synthesis and Evaluation of PCL/Chitosan/CQD‐Fe Magnetic Nanocomposite for Wound Healing: Emphasis on Gene Expression by Elham Maghareh Abed, Fatemeh Yazdian, Abbas Akhavan Sepahi, Behnam Rasekh

“…The relative expression of genes platelet‐derived growth factor (PDGF), transforming growth factor beta (TGF‐β), and matrix metalloproteinase‐1 (MMP1) was assessed through RT‐PCR. …”
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The role of ultrasound combined with water bath in the establishment of animal models of rat urethral stricture by Xiaojian Ye, Xianjing Lin, Yehui Chen, Rongquan Xu, Jiawei Zhou

“…The surgical groups underwent urethral injury induced by recombinant transforming growth factor-β1 (TGF-β1) solution, followed by the random selection of one surgical group (n = 6) to receive treatment with mesenchymal stem cell (MSC) exosomes. …”
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Mechanism of triptolide regulating proliferation and apoptosis of hepatoma cells by inhibiting JAK/STAT pathway by Wang Guanglian, Zhu Zhenxin, Sun Zhengang, Yang Zhiqi

“…The apoptosis rate of 10 ng/mL transforming growth factor-beta + high-dose group was reduced than that in the high-dose group, and the expression of p-JAK1 and p-STAT3 protein was higher than that in the high-dose group (P < 0.05). …”
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Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma by Małgorzata Banaszkiewicz, Jolanta Małyszko, Krzysztof Batko, Ewa Koc-Żórawska, Marcin Żórawski, Paulina Dumnicka, Artur Jurczyszyn, Karolina Woziwodzka, Joanna Tisończyk, Marcin Krzanowski, Jacek Małyszko, Anna Waszczuk-Gajda, Ryszard Drożdż, Marek Kuźniewski, Katarzyna Krzanowska

“…Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor-β superfamily, participates in processes associated with myeloma development and its end-organ complications. …”
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A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor... by Lejing Qu, Meizhi Jiao, Zilong Zhang, Yuanyuan Ou, Xue Zhao, Yajun Zhang, Xinfeng Zhao

“…They blocked the AT1R pathway to down-regulate the expression of transforming growth factor-β1 (TGF-β1) and stimulate matrix metalloproteinase-1 (MMP-1) expression. …”
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Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice by Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi

“…Pirfenidone significantly reduced pro-inflammatory cytokines including interleukin-6, interleukin-1β, transforming growth factor-β, tumor necrosis factor- α, high-mobility group box-1, and toll-like receptor-4, elevated gamma-aminobutyric acid, decreased glutamate levels, modulated aspartate aminotransferase and alanine aminotransferase levels. …”
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Suppressing GDF15 enhances the chemotherapeutic effect of 5 FU on MSI-H CRC by regulating the ferroptosis pathway SLC7A11/GSH/GPX4 by Zhi min Huang Fu, Ming Xiao, Hailun Xie, Shuxian Zhang, Tang Yi, Qingshu Li, Ming Li, Yalan Wang

“…Abstract Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor beta (TGF-β) superfamily and is related to metabolism, injury, and aging. …”
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3,5,6,7,8,3’,4’- Heptamethoxyflavonoid inhibits TGF-β1-induced epithelial–mesenchymal transition by regulating oxidative stress and autophagy through MEK/ERK/PI3K/AKT/mTOR signalin... by Yiting Wang, Zhiheng Ma, Weiwen Peng, Qinglian Yu, Wenjie Liang, Liu Cao, Zhuqiang Wang

“…However, it remains unclear whether and how HMF alleviates transforming growth factor-β1 (TGF-β1)-induced EMT. The objective of this study was to investigate the impact of HMF on TGF-β1-induced EMT in human alveolar Type II epithelial cells (A549) and its underlying mechanism. …”
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Evaluation of the Diversities in the Inflammatory Responses in Cats With Bacterial and Viral Infections by Songul Erhan, Bengu Bilgic, Ezgi Ergen, Mert Erek, Elif Ergul Ekiz, Mukaddes Ozcan, Mehmet Erman Or, Banu Dokuzeylul, Erdal Matur

“…Total and differential leukocyte counts, C‐reactive protein (CRP), transforming growth factor beta (TGF‐β), interleukin‐6 (IL‐6), tumour necrosis factor‐alpha (TNF‐α), interleukin‐1 beta (IL‐1β) and interleukin‐10 (IL‐10) concentrations were assessed in the blood samples collected from sick and healthy animals. …”
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Comparison of Immunomodulation Properties of Porcine Mesenchymal Stromal/Stem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue by Sun-A Ock, Raghavendra Baregundi Subbarao, Yeon-Mi Lee, Jeong-Hyeon Lee, Ryoung-Hoon Jeon, Sung-Lim Lee, Ji Kwon Park, Sun-Chul Hwang, Gyu-Jin Rho

“…Accordingly, we herein investigated the capacity of MSCs derived from several tissue sources to modulate both proinflammatory (interferon [IFN] γ and tumor necrosis factor [TNF] α) and immunosuppressive cytokines (transforming growth factor [TGF] β and interleukin [IL] 10) employing xenogeneic human MSC-mixed lymphocyte reaction (MLR) test. …”
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Regeneration of Rabbit Auricular Cartilage After the Intravenous Stem Cell Injection by Pavlo Virych, Nadiia Shuvalova, Anton Karas, Galina Karas, Svitlana Chaika, Tetiana Kucherenko, Ganna Minina, Marina Timchenko, Oleg Melnykov, Yurii Minin

“…In addition, the amount of interleukin-6 (IL-6) and the transforming growth factor β1 (TGF-β1) in the blood serum were determined. …”
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In vitro and in vivo studies on bioactive hydroxyapatite-coated magnesium for glaucoma drainage implant by Huanhuan Gao, Yi Chen, Xia Chen, Liandi Huang, Hao Yao, Xiaomin Zhu, Min Tang, Yong Wang, Xiangji Li, Lin Xie

“…In vitro experiments showed the surface modification of Mg affects the adhesion behavior and the reorganization of cytoskeleton of Human Western blot analysis and immunofluorescence found that Mg@HA regulates the adhesion and motility of human Tenon's capsule fibroblasts mainly by down-regulating the phosphorylation of Smad2 and Smad3 in the canonical transforming growth factor-beta (TGF - β) signaling pathway. …”
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Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy by Zebo Hu, Qianwen Zhu, Ying Wang, Xue Deng, Hui Yang, Mingjun Zhou, Jiyuan Zhang, Hao Wang, Haosen Wang, Lin Wang, Cui Zhang, Shu Li

“…Moreover, the protein expression levels of transforming growth factor β1 (TGF-β1) and connective tissue growth factor (CTGF) in diabetic kidneys were decreased by YC-1 treatment. …”
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Exposure to Air Pollution Exacerbates Inflammation in Rats with Preexisting COPD by Jing Wang, Ya Li, Peng Zhao, Yange Tian, Xuefang Liu, Huihui He, Rui Jia, Brian G. Oliver, Jiansheng Li

“…PM2.5 exposure resulted in greater lung function decline and histopathological changes, as reflected by increased Mucin (MUC) 5ac, MUC5b, Collagen I, Collagen III, and the profibrotic cytokine α-smooth muscle-actin (SMA), transforming growth factor- (TGF-) β1 in lung tissues. PM2.5 also aggravated inflammation, increasing neutrophils and eosinophils in bronchoalveolar lavage fluid (BALF) and cytokines including Interleukin- (IL-) 1β, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-4. …”
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Effects of kelp phlorotannins on the growth, immunity, intestinal health and disease resistance against Vibrio splendidus of sea cucumber Apostichopus japonicus by Zhikai Zhang, Yan Chi, Yongheng Du, Feng Li, Ning Ma, Song Qin

“…The intestinal health of sea cucumbers was also enhanced by phlorotannins, as expressed by the higher intestine fold height, up-regulation of tight junction genes (ZO-1 and occludin) and down-regulation of two proinflammatory genes (interleukin 17 and transforming growth factor - beta). In conclusion, the present work reported the promoting effects of phlorotannins on growth and disease resistance of sea cucumbers, which could be attributed to the abilities to improve the immunity, redox homeostasis and intestinal healthy condition. …”
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