Epigenetic Regulation of Stromal and Immune Cells and Therapeutic Targets in the Tumor Microenvironment by Kang Liu, Yue Li, Minmin Shen, Wei Xu, Shanshan Wu, Xinxin Yang, Bo Zhang, Nengming Lin

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Current and future therapeutic options for chronic hepatitis D virus infection by Mariantonietta Pisaturo, Antonio Russo, Pierantonio Grimaldi, Salvatore Martini, Nicola Coppola

“…In the last few years there have been innovations in HDV therapy which have brought new excitement in the scientific community also considering the few therapeutic opportunities. Recently, new molecular targets have been identified, both in monotherapy and in combination with peginterferon alpha (PegIFNα). …”
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Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis by Qianlei Wang, James Asenso, Ning Xiao, Jinzhang Gao, Feng Xiao, Jiajie Kuai, Wei Wei, Chun Wang

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Biomarkers of sepsis-induced coagulopathy: diagnostic insights and potential therapeutic implications by Anaïs Curtiaud, Toshiaki Iba, Eduardo Angles-Cano, Ferhat Meziani, Julie Helms

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Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches by Lucia Centanni, Clelia Cicerone, Fabrizio Fanizzi, Ferdinando D’Amico, Federica Furfaro, Alessandra Zilli, Tommaso Lorenzo Parigi, Laurent Peyrin-Biroulet, Silvio Danese, Mariangela Allocca

Subjects: “…new therapeutic targets…”
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Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential by Yijie Huang, Ying Tang, Ruiqi Zhang, Xiao Wu, Li Yan, Xiling Chen, Qianqi Wu, Yiyan Chen, Yingtao Lv, Yuan Su

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miRNAs Participate in MS Pathological Processes and Its Therapeutic Response by Ting Wu, Guangjie Chen

“…In this review, we discuss microRNAs participating in the pathological processes of MS, including periphery inflammation, blood-brain barrier disruption, and CNS lesions, and in its therapeutic response, in order to find biomarkers of disease severity and to predict the response to therapy of the diseases.…”
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Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review) by O.O. Nikitina, D.S. Tsyba

“…The aim of the work was to evaluate the pharmacological effects and therapeutic potential of individual compounds and extracts of B. monnieri based on the analysis of data from scientific periodicals regarding chemical composition and biological action. …”
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Endoscopic submucosal dissection for proximal colonic lesions: An effective therapeutic option by Ludovico Alfarone, Roberta Maselli, Cesare Hassan, Paola Spaggiari, Marco Spadaccini, Antonio Capogreco, Davide Massimi, Roberto De Sire, Elisabetta Mastrorocco, Alessandro Repici

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Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential by Tohada M. AL-Noshokaty, Rehab Abdelhamid, Nourhan M. Abdelmaksoud, Aya Khaled, Mariam Hossam, Razan Ahmed, Toka Saber, Shahd Khaled, Shereen Saeid Elshaer, Ahmed I. Abulsoud

“…Glucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and a promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, and satiety. …”
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Therapeutic Outcomes of Patients with Multifocal Papillary Thyroid Microcarcinomas and Larger Tumors by Soh-Ching Ng, Sheng-Fong Kuo, Szu-Tah Chen, Chuen Hsueh, Bie-Yu Huang, Jen-Der Lin

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Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer by Niki Tavakoli, Emma J. Fong, Abigail Coleman, Yu-Kai Huang, Mathias Bigger, Michael E. Doche, Seungil Kim, Heinz-Josef Lenz, Nicholas A. Graham, Paul Macklin, Stacey D. Finley, Shannon M. Mumenthaler

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Immunobiologics in juvenile dermatomyositis: a systematic review of promising therapeutic advances by Aline Maria de Oliveira Rocha, Gabriel Fidelis Ribeiro, Juliana Capecce Silva

“…Conclusions For severe or refractory disease, biologics tend to be the medication with the best therapeutic response.…”
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Management of Severe Hypertriglyceridemia in Pregnancy With Niacin: Reevaluating Safety and Therapeutic Benefits by Nisha Suda, Daisy Leon-Martinez, Patricia R. Peter, Clare A. Flannery, Roxanna A. Irani

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Intervention program through therapeutic physical exercise in patients with lung cancer by Onesio Esteban de León Gutierrez, Israel Triana Pérez, Iván Castillo Ledo

“…<br /><strong>Objective</strong>: to describe the results of a therapeutic intervention program in patients with lung cancer.…”
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Elucidating the role of pyrimidine metabolism in prostate cancer and its therapeutic implications by Liang Huang, Yu Xie, Shusuan Jiang, Kan Liu, Zhihao Ming, Hong Shan

“…Targeting this metabolic pathway offers a promising strategy for the development of new therapeutic approaches, particularly for overcoming drug resistance and improving outcomes in patients with advanced prostate cancer.…”
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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…Cancer remains one of the most formidable challenges in modern medicine, due to its complex and dynamic nature, which demands innovative therapeutic approaches. One major challenge to cancer treatment is the tumour microenvironment and in particular tumour hypoxia (low oxygen levels), which contributes to tumour progression and immune evasion. …”
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The Enteric Nervous System and Its Emerging Role as a Therapeutic Target by Mark A. Fleming, Lubaina Ehsan, Sean R. Moore, Daniel E. Levin

“…Exciting opportunities in which the ENS could be used as a therapeutic target for common GI diseases will also be highlighted, as the further unlocking of such mechanisms could open the door to more therapy-related advances and ultimately change our treatment approach.…”
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Emerging Lung Cancer Therapeutic Targets Based on the Pathogenesis of Bone Metastases by Moses O. Oyewumi, Adnan Alazizi, Daniel Wehrung, Rami Manochakian, Fayez F. Safadi

“…We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. Thus, this paper discusses some of the emerging molecular targets that have provided insights into the cascade of metastases in lung cancer with the focus on bone invasion. …”
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Identification of glutamine as a potential therapeutic target in dry eye disease by Xiaoniao Chen, Chuyue Zhang, Fei Peng, Lingling Wu, Deyi Zhuo, Liqiang Wang, Min Zhang, Zhaohui Li, Lei Tian, Ying Jie, Yifei Huang, Xinji Yang, Xiaoqi Li, Fengyang Lei, Yu Cheng

“…Our study demonstrated that co-treatment with mesenchymal stem cells (MSCs) and thymosin beta-4 (Tβ4) yielded the best therapeutic outcome against dry eye, surpassing monotherapy outcomes. …”
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