Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53 by Iulianna C. Taritsa, Eric T. Fossel

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Digital therapeutics in Korea: current status, challenges, and future directions – a narrative review by Hee Jun Shin, Ik Tae Cho, Wan Suk Choi, Hong Rae Kim, Min Bong Kang, Won Jong Yang

“…Digital therapeutics (DTx) are emerging as a transformative innovation in healthcare offering evidence-based digital interventions for the treatment, management, and prevention of various diseases and disorders. …”
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A Canadian Working Group Report on Fecal Microbial Therapy: Microbial Ecosystems Therapeutics by Emma Allen-Vercoe, Gregor Reid, Norman Viner, Gregory B Gloor, Susy Hota, Peter Kim, Christine Lee, Kieran C O’Doherty, Stephen J Vanner, J Scott Weese, Elaine O Petrof

“…The report highlights the promise of fecal microbial therapy and related synthetic stool therapy (together called ‘microbial ecosystems therapeutics’) for the treatment of Clostridium difficile colitis and, possibly, other disorders. …”
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Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria by Amrutha Surendran, Agnes Turnbull, Allen Flockhart, Fern Findlay-Greene, Martyna Nowosielska, Donald Morrison, David J. Mincher, Samantha Donnellan

“…We hypothesise that antimicrobial resistance (AMR) cannot be overcome by simply ‘drugging’ single biological targets, therefore, our focus is developing broad-spectrum therapeutics. Herein we present the synthesis of two novel spacer-linked, anthraquinone-triphenylphosphonium (AQ-TPP) conjugates (4) and (5) as early lead compounds in a new class of agent designed to penetrate the lipophilic barriers of the membranes of a diverse family of species; and establish bacterial growth inhibitory properties against methicillin-resistant Staphylococcus aureus (NCTC 13616) and Mycobacterium smegmatis [mc2155] (as a surrogate for Mycobacterium tuberculosis). …”
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Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies by Niloofar Javid, Ali Asadipour, Ehsan Salarkia, Mohammad Amin Langarizadeh, Fatemeh Sharifi, Mohammad Mahdavi, Bagher Amirheidari, Aida Iraji, Hojjat Rezaiezadeh, Gholamreza Hassanpour, Yaghoub Pourshojaei

“…In light of these limitations, developing new therapeutic agents that can effectively disrupt the parasite’s life cycle at multiple stages is of paramount importance. …”
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Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake... by Çağla Eliküçük, Fatma Esen Aydinli, Nazan Has Selmi, Cansu Uzunoğlu, Murathan Köksal, Volkan Öter, Belgin Akan, Erdal Birol Bostanci, Güldeniz Argun

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Comparison of the sociodemographic and clinical profiles of cancer patients admitted to a tertiary palliative care unit before and during the COVID-19 pandemic by Bruno Fernando da Silva Reis, Gisele O’Dwyer, Valeria Teresa Saraiva Lino, Lívia Costa de Oliveira, Karla Santos da Costa Rosa, Simone Garruth dos Santos Machado Sampaio

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The evolving spectrum of interstitial lung disease in myositis—Management pearls by Takahisa Gono

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Therapeutic Potential of Targeting Ferroptosis in Periprosthetic Osteolysis Induced by Ultra-High-Molecular-Weight Polyethylene Wear Debris by Takuya Ogawa, Shunichi Yokota, Liyile Chen, Yuki Ogawa, Yoshio Nishida, Taiki Tokuhiro, Hend Alhasan, Tomoyo Yutani, Tomohiro Shimizu, Daisuke Takahashi, Takuji Miyazaki, Tsutomu Endo, Ken Kadoya, Mohamad Alaa Terkawi, Norimasa Iwasaki

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Trifolirhizin: A Phytochemical with Multiple Pharmacological Properties by Varun Jaiswal, Hae-Jeung Lee

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Investigations of Long-Acting Formulations in Children, Adolescents, and Pregnant Women: A Systematic Review by Lynn Bertagnolli, Zhengyi Deng, Melissa Davy-Rothwell, Elaine J. Abrams, Charles Flexner, Ethel D. Weld

Subjects: “…long-acting therapeutics…”
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CLOVES Syndrome: A Review of Clinical, Genetic, and Therapeutic Aspects by Julianna Podolec, Silvia Ciraolo, Joanna Wojda, Adam Sobiński, Zuzanna Kościuszko, Katarzyna Kurza, Agnieszka Kulczycka-Rowicka, Matylda Czerwonka, Katarzyna Lesiczka-Fedoryj, Anna Walczak

“…The primary materials used in the research include: clinical case reports and studies, imaging studies, genetic analysis, therapeutic interventions, epidemiological data, literature review and data analysis. …”
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Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases by Yurong Zhang, Dianlun Qian, Xiangfeng Bai, Shibo Sun

“…Ferroptosis may be a potential therapeutic target for pulmonary infectious diseases. …”
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T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications by Claudio Fozza, Maurizio Longinotti

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PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…This review of the current literature highlights the potential of PPARγ agonists as novel therapeutic modalities in lung cancer, either as monotherapy or in combination with standard cytotoxic chemotherapy.…”
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Therapeutic Benefit of Dillenia indica in Diabetes and Its Associated Complications by Parul Kamboj, Narayan C. Talukdar, Sanjay K. Banerjee

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Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure by Qiujin Jia, Hao Li, Huan Zhou, Xiaonan Zhang, Ao Zhang, Yingyu Xie, Yanyang Li, Shichao Lv, Junping Zhang

“…Cardiovascular Therapeutics…”
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Novel Therapeutic Targets in Metabolic Disorders: From the Bench to the Bedside by Maddalena Illario, Carolina Di Somma, Guido Iaccarino, Pietro Campiglia, Uma Sankar, Nunzia Montuori

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Nanobody engineering: computational modelling and design for biomedical and therapeutic applications by Nehad S. El Salamouni, Jordan H. Cater, Lisanne M. Spenkelink, Haibo Yu

“…This review further underscores the advantages of nanobodies over conventional antibodies from a biosynthesis perspective, including their small size, stability, and solubility, which make them ideal candidates for economical antigen capture in diagnostics, therapeutics, and biosensing. We discuss the recent advancements in computational methods for nanobody modelling, epitope prediction, and affinity maturation, shedding light on their intricate antigen‐binding mechanisms and conformational dynamics. …”
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Giant Squamous Cell Papilloma of the Eyelid—Diagnostic and Therapeutic Challenges by Attila Vass, Gábor Vass, Erika Gabriella Kis, Levente Kuthi, Judit Oláh, Tibor Hortobágyi, Edit Tóth-Molnár

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