Telomerase and cells youth. by Alexander Benavides Couto, Osvaldo Morales Mondeja

“…Telomerase is an enzyme formed by a protein-ribonucleic acid complex that allows telomere enlargement, non codifying DNA structures. …”
Get full text

Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics by Songting Shou, Ayidana Maolan, Di Zhang, Xiaochen Jiang, Fudong Liu, Yi Li, Xiyuan Zhang, En Geer, Zhenqing Pu, Baojin Hua, Qiujun Guo, Xing Zhang, Bo Pang

“…Abstract Telomeres and telomerase play crucial roles in the initiation and progression of cancer. …”
Get full text

TnT: T Antigen and Telomerase, an Explosive Route to Cancer by F. Andrew Ray

Get full text

Usefulness of Immunological Detection of the Human Telomerase Reverse Transcriptase by Annalisa Volpi, Sara Bravaccini, Laura Medri, Serenella Cerasoli, Michele Gaudio, Dino Amadori

“…In situ analysis using well characterised antibodies directed against the human telomerase reverse transcriptase (hTERT) would therefore appear to be important to morphologically identify the nature of telomerase positive cells. …”
Get full text

Telomere Biology: Key to unlocking the fountain of youth…A Systematic Review. by Anirban Poddar, Anup Kumar Rana, Ranjita Santra, Phalguni Chakrabarti

Subjects: Get full text

Relationship between Dyskerin Expression and Telomerase Activity in Human Breast Cancer by Lorenzo Montanaro, Maria Calienni, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Stefano Pileri, Davide Treré, Massimo Derenzini

“…We found that when dyskerin mRNA values were very low the telomerase activity was markedly reduced, independently of the expression of other important components of the telomerase complex such as telomerase reverse transcriptase (TERT). …”
Get full text

Telomerase Allows Human Preosteoblasts to Maintain Their Phenotype during the Immortalization Process by Christian Darimont, Ornella Avanti, Yvonne Tromvoukis, Patricia Leone, Elizabeth Offord, Matthew A. Roberts, Andrea Pfeifer, Katherine Macé

Get full text

Processivity of C-Myc-Induced Telomerase Activation in Rat Cell Lines by Soleman Sasgary, Gerlinde Schmidt, Barbara Skrzypek, Christa Cerni

Get full text

Recent Advances in DNA Systems for In Situ Telomerase Activity Detection and Imaging by Shiyi Zhang, Wenjing Xiong, Shuyue Xu, Ruocan Qian

Subjects: “…telomerase activity…”
Get full text

Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq by Nicholas M. Forino, Jia Zheng Woo, Arthur J. Zaug, Arcelia Gonzalez Jimenez, Eva Edelson, Thomas R. Cech, Silvi Rouskin, Michael D. Stone

“…These hTR domains bind the telomerase reverse transcriptase (hTERT) protein and are essential for telomerase activity. …”
Get full text

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length by Fan Zhang, De Cheng, Kenneth I. Porter, Emily A. Heck, Shuwen Wang, Hui Zhang, Christopher J. Davis, Gavin P. Robertson, Jiyue Zhu

“…Abstract Telomeres shorten with each cell division, serving as biomarkers of aging, with human tissues exhibiting short telomeres and restricted telomerase expression. In contrast, mice have longer telomeres and widespread telomerase activity, limiting their relevance as models for human telomere biology. …”
Get full text

Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma by Qiangan Jing, Yunyi Wu, Yanchun Li, Chaoting Zhou, Junyu Zhang, Jun Xia, Keyi Li, Yuhuan Shen, Hongfeng Yao, Xiangmin Tong, Jing Du, Lushan Yu, Ying Wang

“…Abstract Thioredoxin1 (TRX1) and telomerase are both attractive oncology targets that are tightly implicated in tumor initiation and development. …”
Get full text

Telomerase inhibiting phytochemicals derived from Blumea eriantha for cancer treatment: A comprehensive computational analysis by Rahil Ummar Faruk Abbu, Shaik Mohammad Abdul Fayaz, Divyashree M S, Raghu Chandrashekhar H, Prasanna Kumar Reddy Gayam, Archana Mahadev Rao

Subjects: Get full text

Telomerase Activity Levels in the Surgical Margin and Tumour Distant Tissue of the Squamous Cell Carcinoma of the Head-And-Neck by Eva‐Maria Fabricius, Ulrike Gurr, Gustav‐Paul Wildner

“…Six of the 20 tumour distant tissues revealed increased telomerase levels. Telomerase positivity in carcinoma‐free tumour margins correlated with a good prognosis. …”
Get full text

Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts by Xuehong Zhang, Paiyun Li, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang, Dajun Deng, Jing Ni

“…P16 inactivation is frequently accompanied by telomerase reverse transcriptase (TERT) amplification in human cancer genomes. …”
Get full text

Cerebrovascular ageing: how zebrafish can contribute to solving the puzzle by Guy Malkinson, Guy Malkinson, Catarina M. Henriques, Catarina M. Henriques

Subjects: Get full text

Telomerase and mitochondria inhibition promote apoptosis and TET2 and ANMT3a expression in triple negative breast cancer cell lines by Zeinab Mazloumi, Ali Rafat, Khadijeh Dizaji Asl, Mohammad Karimipour, Dariush Shanehbandi, Mehdi Talebi, Majid Montazer, Ali Akbar Movassaghpour, Alireza Dehnad, Raheleh Farahzadi, Hojjatollah Nozad Charoudeh

Subjects: Get full text

TERT promoter mutations in thyroid cancer by Michiko Matsuse, Norisato Mitsutake

Subjects: Get full text

Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells by Seyung S. Chung, Yong Wu, Quincy Okobi, Debbie Adekoya, Mohammad Atefi, Orette Clarke, Pranabananda Dutta, Jaydutt V. Vadgama

“…The binding of STAT3 to the hTERT promoter region and telomerase activity showed reduction with withaferin A treatments. …”
Get full text

TERT de novo mutation-associated dyskeratosis congenita and porto-sinusoidal vascular disease: a case report by Ge Yu, Guijie Xin, Xu Liu, Wanyu Li, Chen Shao, Runping Gao

Subjects: Get full text