Quantification and correlation of amyloid-β plaque load, glial activation, GABAergic interneuron numbers, and cognitive decline in the young TgF344-AD rat model of Alzheimer’s dise... by Anett Futácsi, Anett Futácsi, Anett Futácsi, Kitti Rusznák, Kitti Rusznák, Gergely Szarka, Gergely Szarka, Gergely Szarka, Béla Völgyi, Béla Völgyi, Ove Wiborg, Boldizsár Czéh, Boldizsár Czéh, Boldizsár Czéh

“…In this study, we examined neuronal and glial alterations in the hippocampus and medial prefrontal cortex (mPFC) of young TgF344-AD rats and correlated these changes with cognitive decline and amyloid-β plaque load.MethodsWe compared TgF344-AD and non-transgenic littermate rats aged 7–8 months of age. We systematically quantified β-amyloid plaques, astrocytes, microglia, four different subtypes of GABAergic interneurons (calretinin-, cholecystokinin-, parvalbumin-, and somatostatin-positive neurons), and newly generated neurons in the hippocampus. …”
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Understanding Psychological Wellbeing Among Iranian Healthcare Workers: The Role of Resilience and Social Capital by Maryam Akbari, Mohammad Hossein Kaveh, Rosanna Cousins, Hamidreza Mokarami, Mehdi Jahangiri, Changiz Rahimi Taghanaki

“…This study aimed to clarify the contribution of resilience and social capital as predictors of psychological well-being as a first step toward developing evidence-based interventions to improve psychological wellbeing in healthcare workers.Methods: This cross-sectional study was conducted on Iranian healthcare workers. Systematic random sampling was used to recruit 140 employees working in healthcare centers in Shiraz, Iran, in 2021. …”
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Navigating the future of agri-food supply chain: A conceptual framework using bibliometric review by Abdul Kafi, Nizamuddin bin Zainuddin, Mohd Fitri Mansor, Mohamed Najib Bin Salleh, Adam bin Mohd Saifudin, Nurhaizal Azam Arif, Syairah Aimi Shahron, Ravi Ramasamy, Ibrahim Hassan mohamud

“…A rigorous inclusion and exclusion process was carried out by using articles whose titles contained only 'agri-food' and 'supply chain' terms. This systematic approach ensured a feasible dataset for analysis. …”
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A meta-analysis of the value of indocyanine green fluorescence imaging in guiding surgical resection of primary and metastatic liver cancer by Dali Xiong, Jiaran Li, Li Li, Fuhao Xu, Tao Hu, He Zhu, Xiaohui Xu, Yawen Sun, Shuanghu Yuan

“…Objective: This meta-analysis aimed to evaluate the value of indocyanine green fluorescence imaging in precision resection surgery for primary and metastatic liver cancer. Methods: A systematic search of PubMed, Embase, Scopus, Cochrane Library, Web of Science, ScienceDirect, and major scientific websites was conducted until June 2024. …”
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Methodological advances in seismic noise imaging of the Alpine area by Paul, Anne, Pedersen, Helle A., Bodin, Thomas, Kästle, Emanuel, Soergel, Dorian, Alder, Chloé, Lu, Yang, Nouibat, Ahmed

“…A beamforming approach has been developed to avoid systematic errors in the measurement of azimuthal anisotropy from seismic noise. …”
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Expert Consensus on the Management of Acute Otitis Media in India: A Delphi Study by Tanu Singhal, Shyam Kukreja, Jaydeep Choudhury, Vijay Yewale, Balasubramanian Sundaram, Jagdish Chinnappa, Suhas Prabhu, Balaji Veeraraghavan, Camilla Rodrigues, Vidya Krishna, Winsley Rose, Samir Bhargava

“…Conclusion: The consensus recommendations provide systematic guidance to clinicians on the appropriate management of AOM and OME. …”
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A new strategy for pharmacodynamic substance screening and research on gut microbiota pathway mechanisms based on UPLC-Q-orbitrap-MS and 16S rRNA by Zhiying Yu, Tong Li, Jie Yang, Jianghua He, Weijiang Zhang, Siyuan Li, Yunpeng Qi, Yihui Yin, Ling Dong, Wenjuan Xu

“…Conclusion: This study focused on the key issues in the gut microbiota pathway and developed a progressive research strategy to understand the transformation mechanisms of colonic components. This research systematically analyzed the active components and metabolic transformation of GQD in the colon during the pathological state of UC, as well as changes in the structure and function of the gut microbiota, clarified the mechanism of GQD and its active components in improving UC via the gut microbiota pathway.…”
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Optimization of a microarray for fission yeast by Dong-Uk Kim, Minho Lee, Sangjo Han, Miyoung Nam, Sol Lee, Jaewoong Lee, Jihye Woo, Dongsup Kim, Kwang-Lae Hoe

“…Bar-code (tag) microarrays of yeast gene-deletion collections facilitate the systematic identification of genes required for growth in any condition of interest. …”
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THE ROLE OF DIET DURING HEALTH EDUCATION PROGRAMS FOR THE IMPROVEMENT OF CLINICAL OUTCOMES IN COPD PATIENTS: LITERATURE REVIEW by Rita Citarella, Adriano Brenca, Myriam Palomba, Maria Guarnaccia, Giuseppina Gargiulo, Diodato Ferrante, Jessica Marano, Aniello Lanzuise, Serena Pannetta

“…Studies that responded to the hypotheses of bibliographic research were considered. Primary studies, systematic reviews and guidelines were included. Bibliographic research was conducted from 1 June 2024 to 24 October 2024. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Purpose: This article investigates the apoptotic mechanisms and anticancer potential of oridonin, including its modulatory effects on signaling pathways and its derivatives' enhanced efficacy against drug-resistant cancer cells. Methods: A systematic literature search was conducted using Scopus, PubMed, SpringerLink, ScienceDirect, Wiley Online, and Web of Science databases, covering the period from 2007 to 2024. …”
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A Survey on Reconfigurable Intelligent Surface for Physical Layer Security of Next-Generation Wireless Communications by Ravneet Kaur, Bajrang Bansal, Sudhan Majhi, Sandesh Jain, Chongwen Huang, Chau Yuen

“…Then, a detailed and systematic classification of the various RIS-assisted wireless system topologies exhibiting multiple scenarios, system models, channel fading models, performance metrics and objectives is done. …”
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Developing a core outcome set for interventions in people with mild cognitive impairment: study protocol by Angus G K McNair, Nicholas Turner, Alan Richardson, Elizabeth Coulthard, Jemima Dooley, Julie Clayton, Sam Harding, Sarah Rudd, Victoria Grace Gabb, Winsome Barrett-Muir, Natalie Woodward, Sophie Alderman, Joseph Webb

“…This study aims to develop a COS for adults living with MCI intended for use in interventional and clinical settings.Methods and analysis The COS will be developed using a five-stage study design: (1) systematic literature search, (2) qualitative interviews, (3) evidence synthesis from stages 1 and 2, (4) two-round Delphi survey and (5) consensus meeting(s). …”
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Long-term hypoxic atmosphere enhances the stemness, immunoregulatory functions, and therapeutic application of human umbilical cord mesenchymal stem cells by Qi-Ming Huang, You-Qiong Zhuo, Zhong-Xin Duan, Yin-lin Long, Jia-Nan Wang, Zhou-hang Zhang, Shao-Yong Fan, Yong-Ming Huang, Ke-Yu Deng, Hong-Bo Xin

“…The comparison between both atmospheres systematically analyzed the biological functions of MSCs, mainly including stemness maintenance, immune regulation, and resistance to chondrocyte apoptosis, and studied their joint function and anti-inflammatory effects in osteoarthritis (OA) rats constructed by collagenase II. …”
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Enhanced biomechanical and biological performance of titanium scaffolds with gradient in pore sizes by Ara Jung, Jinju Jang, Hun Yeong Ban, Hee Jin Kim, Bomi Gweon, Dohyung Lim

“…Among various methods, powder bed fusion (PBF) stands out for its precision in implant design and fabrication. This study systematically investigates the structural, mechanical, and biological aspects of titanium scaffolds using PBF technology with varying pore sizes (400 μm, 600 μm, 800 μm, and 1000 μm). …”
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Acute Stroke in northern Portugal: outcomes and characteristics of patients in a Medical-Surgical Emergency Department by Sandra Domingues, Tiago Barros, João Correia, Arlindo Cruz, Nuno Araújo, Liliana Silva

“…Conclusion: The Emergency Department demonstrated improvement in acute stroke care. Enhanced systematic data recording and new technologies are needed to optimize care. …”
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Pisco, an Appellation of Origin from Peru: A review by Juan Carlos Palma, Johana Fabián-Campos, Jacqueline Jannet Dioses-Morales, Amelia Devorah Arias-Durand, Gaby Espinoza-Córdova, Miki Gonzales-Uscamayta, Joel C. Rengifo-Maravi, Epifanio Teófilo Chire-Murillo, Víctor A. Caro Sánchez-Benites, Paola Jorge-Montalvo, Lizardo Visitación-Figueroa

“…This review aims to systematize the information related to the Appellation of Origen Pisco and its production process, facilitating the development of research on quality improvements and identifying opportunities for the valorization of the residues generated during production.…”
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Phylogenetic and pangenomic analyses of members of the family <i>Micrococcaceae</i> related to a plant-growth-promoting rhizobacterium isolated from the rhizosphere of potato (<i>S... by S. Yu. Shchyogolev, G. L. Burygin, L. A. Dykman, L. Yu. Matora

“…However, these strains were isolated from strongly contrasting ecological and geographical habitats, which could not but affect their genotypes and phenotypes and which should be taken into account in evaluation of their systematic position. This contradiction was resolved by a pangenomic analysis, which showed that the strains differed strongly in the number of accessory and strain-specific genes determining their individuality and possibly their potential for adaptation to different ecological niches. …”
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Arteritis de células gigantes: actualización diagnóstica y terapéutica by Paloma Muñoz-Reinoso, Ana Domínguez-Mayoral, Francisco J. Toyos-Sáenz de Miera, Laura Castillo-Moreno, Sara Banda-Ramírez, José J. Pérez-Venegas

“…Se ha realizado una revisión sistemática según la metodología PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis). Se han tomado como referencia los protocolos diagnósticos y terapéuticos elaborados por el American College of Rheumatology y la European Alliance of Associations for Rheumatology. …”
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Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review by Simone Schiavo, Julian DeBacker, Carine Djaiani, Anuj Bhatia, Marina Englesakis, Rita Katznelson

“…Human studies demonstrated beneficial effects of HBOT in improving clinical outcomes such as pain scores, pain-related symptoms, and quality of life. A systematic methodology of HBOT application is necessary to confirm its safety and efficacy.…”
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Management of tuberculosis risk, screening and preventive therapy in patients with chronic autoimmune arthritis undergoing biotechnological and targeted immunosuppressive agents by Andrea Picchianti-Diamanti, Alessandra Aiello, Chiara De Lorenzo, Giovanni Battista Migliori, Delia Goletti

“…As conceivable, the risk is associated with age ≥65 years and is higher in endemic regions, but immunosuppressive therapy plays a pivotal role. Several systematic reviews have analysed the impact of anti-TNF-α agents on the risk of TB in patients with chronic autoimmune arthritis, as well as for other biologic disease-modifying immunosuppressive anti-rheumatic drugs (bDMARDs) such as rituximab, abatacept, tocilizumab, ustekinumab, and secukinumab. …”
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