Asymptomatic primary tumour in incurable metastatic colorectal cancer: is there a role for surgical resection prior to systematic therapy or not? by Narimantas E. Samalavicius, Audrius Dulskas, Edita Baltruskeviciene, Giedre Smailyte, Marija Skuciene, Rasa Mikelenaite, Rasa Venslovaite, Eduardas Aleknavicius, Almantas Samalavicius, Raimundas Lunevicius

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Acquired ROS1 fusion and iruplinalkib response in advanced NSCLC after multiple lines of systematic therapy: a case report by Jiarui Liu, Jiarui Liu, Zhichao Jiao, Zhichao Jiao, Jun Zhou, Yuan Yuan, Qiguang Li, Wei Zhou, Shuai Zhang, Shuping Yang

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Investigation of the fabomotizol dihydrochloride effect on the morphological picture of the heart left ventricle in rats with the subacute myocardial infarction by I. A. Miroshkina, A. V. Sorokina, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskiy, A. D. Durnev

“…Investigation of the effect of the fabomotizol dihydrochloride systematic therapy on the morphological picture of the heart left ventricle (LV) in rats in the subacute period of myocardial infarction. …”
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An experiment of Kartalin liniment for palmar-plantar form psorias and other keratodermias by V. S. Dmitruk

“…Besides local treatment, the patients got systematic therapy corresponding to the standards of medical treatment for each nogological form.For estimation of clinical effectiveness of the suggested complex of general and local arrangements there was done a calculation of the number of days spent in hospital white curing keratodermias. …”
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Efficacy and safety of immunotherapy for head and neck squamous cell carcinoma: a meta-analysis of randomized clinical trials by Cailing Jiang, Shuqin Wang, Lijun Zhu

“…Furthermore, the occurrence of grade 3 or higher adverse events related to the drugs was lower than systematic therapy (OR 0.35, 95% CI 0.17-0.73).ConclusionsThe study has provided compelling evidence that immunotherapy is a significant benefit in OS for HNSCC patients, either R/M HNSCC or LA HNSCC, immunochemotherapy may benefit more for these patients, but double-agent immunotherapy showed no more benefit for R/M HNSCC patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/, identifier CRD42023471570.…”
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Treatment-related pure large-cell neuroendocrine carcinoma of the prostate with systemic metastases in a young adult: a rare case report by Baolin Zhang, Yifan Zhu, Renpeng Huang, Feng Zhou, Zhixin Ling

“…Here we reported a rare case of treatment-related LCNEPC, who had experienced systematic therapy with comprehensive care. These diagnostic and therapeutic approaches may improve the management capability and highlight the critical role of multimodal strategies in the subsequent cases.…”
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Development and validation of nomogram model predicting overall survival and cancer specific survival in glioblastoma patients by Yingming Mu, Junchi Luo, Tao Xiong, Junheng Zhang, Jinhai Lan, Jiqin Zhang, Ying Tan, Sha Yang

“…The multivariate Cox analysis revealed that age, tumor size, sex, primary tumor site, laterality, number of primary tumors, surgery, chemotherapy, radiotherapy, systematic therapy, marital status, median household income, first malignant primary indicator were independent prognostic factors of overall survival (OS) for GBMs. …”
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On the mechanism of the antiarrhythmic action of fabomotizole hydrochloride in alcoholic cardiomyopathy by I. A. Miroshkina, L. M. Kozhevnikova, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskii, A. D. Durnev

“…It is shown that against the background of systematic therapy fabomotizole dihydrochloride (15 mg/kg, i.p.) daily within 28 days after 24 weeks of alcoholization, in comparison with alcoholized control the fat dystrophy of a myocardium significantly decreases and the threshold of electric fibrillation of heart ventricles is restored. …”
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Long-term response to pimitespib in postoperative recurrent gastrointestinal stromal tumors with PDGFRA D842V mutation: a case report by Ryugo Teranishi, Tsuyoshi Takahashi, Yukinori Kurokawa, Takuro Saito, Kazuyoshi Yamamoto, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki

“…In the Japanese GIST guidelines, no standard systematic therapy is available for this type of GIST, which is refractory after recurrence. …”
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Consolidative stereotactic radiotherapy for oligo-residual non-small cell lung cancer after first-line chemoimmunotherapy: A single-arm, phase 2 trial from China. by Hongru Chen, Lu Yu, Fei Liang, Yue Zhou, Li Chu, Xiao Chu, Xi Yang, Junhua Zhang, Yechun Pang, Zezhou Wang, Zhiyong Yuan, Jianjiao Ni, Zhengfei Zhu

“…Moreover, a prespecified propensity score-matched comparison was conducted with a contemporary cohort of patients who developed ORD but received systematic therapy alone, which found that incorporating consolidative SRT was associated with prolonged PFS (adjusted HR 0.286, P < 0.001) and OS (adjusted HR 0.229, P = 0.023). …”
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Efficacy of immunotherapy remained in patients with recurrent/metastatic non‐small‐cell lung cancer after surgery with or without postoperative thoracic radiotherapy: a bi‐center r... by Yuqi Wu, Renda Li, Fengwei Tan, Jianzhong Cao, Nan Bi

“…Similar mPFS were reported in the stage III subgroup (RT vs. non‐RT, 8.10 vs. 8.45 months, p = 0.86) or the subgroup treated by ICIs as primary systematic therapy (RT vs. non‐RT, 13.6 vs. 16.1 months, p = 0.45). …”
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Efficacy of first-line chemotherapy combined with immunotherapy or anti-angiogenic therapy in advanced KRAS-mutant non-small cell lung cancer by Huiping Qiang, Yue Wang, Yao Zhang, Jingwen Li, Lincheng Zhang, Huawei Du, Xuxinyi Ling, Shuhui Cao, Yan Zhou, Runbo Zhong, Hua Zhong

“…Results: A total of 273 patients received first-line systematic therapy. The most common mutation was KRAS G12C (34.3 %). …”
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„Ku nowym czynom, ukochany mężu...” O Stukasach Karla Rittera by Krzysztof Kozłowski

“…Nevertheless, it is by no means medications and systematic therapies that play the part of Asclepius, but the power of Wagner’s music (rooted in mythology). …”
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