Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System by Jason Charng, Zheng He, Algis J. Vingrys, Rebecca L. Fish, Rachel Gurrell, Bang V. Bui, Christine T. Nguyen

“…In conscious animals, systemic administration of muscimol resulted in retinal and brain biopotential changes, whereas systemic delivery of isoguvacine did not. …”
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Online by Choice: Design Options for Flexible K-12 Learning. (2023). by Tim Dolighan

“…The authors stress the collaborative effort required between system administrators and teachers for successful online implementation. …”
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Toll-Like Receptor-Based Strategies for Cancer Immunotherapy by Saghar Pahlavanneshan, Ali Sayadmanesh, Hamidreza Ebrahimiyan, Mohsen Basiri

“…These strategies include systemic administration of TLR antagonist along with immune cell transfer and also genetic engineering of the immune cells using TLR signaling components to improve the function of genetically engineered immune cells such as chimeric antigen receptor-modified T cells. …”
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Cyclooxygenase Inhibition in Sepsis: Is There Life after Death? by David M. Aronoff

“…Animal models of sepsis, using the systemic administration of pathogen-associated molecular patterns (PAMPs) or live pathogens, have been used to examine the effectiveness of COX inhibition as a treatment for severe sepsis. …”
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Self‐Healing COCu‐Tac Hydrogel Enhances iNSCs Transplantation for Spinal Cord Injury by Promoting Mitophagy via the FKBP52/AKT Pathway by Zhenming Tian, Han‐Jian Hu, Chun Cheung Chan, Tian Hu, Chaoyang Cai, Hong Li, Limin Rong, Gang‐Biao Jiang, Bin Liu

“…Tacrolimus, known for its dual role as an immunosuppressant and promoter of neural regeneration, holds the potential for enhancing iNSC transplantation. However, systemic administration of tacrolimus often comes with severe side effects. …”
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Transglutaminase 2 Induces Deficits in Social Behavior in Mice by Amanda Crider, Talisha Davis, Anthony O. Ahmed, Lin Mei, Anilkumar Pillai

“…In addition, systemic administration of cysteamine, a TG2 inhibitor, attenuated social behavior deficits. …”
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Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-α Contents and by Stimulating Newly Formed Neurogenesis by Chong-Un Cheong, Ching-Ping Chang, Chien-Ming Chao, Bor-Chih Cheng, Chung-Zhing Yang, Chung-Ching Chio

“…Seven days after systemic administration of etanercept, levels of etanercept can be detected in the contused brain tissues. …”
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Protective Effects of Carvacrol against Oxidative Stress Induced by Chronic Stress in Rat’s Brain, Liver, and Kidney by Saeed Samarghandian, Tahereh Farkhondeh, Fariborz Samini, Abasalt Borji

“…The animals received systemic administrations of CAR daily for 21 days. To evaluate the changes of the oxidative stress parameters following restraint stress, the levels of malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and catalase (CAT) activities were measured in the brain, liver, and kidney. …”
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Bilateral chemogenetic activation of intratelencephalic neurons in motor cortex reduces spontaneous locomotor activity in mice by Mihai Atudorei, Christian del Agua Villa, Ulrik Gether, Maria Angela Cenci, Hartwig Roman Siebner, Mattias Rickhag

“…This anti-motor effect was achieved in separate experiments with either administration of two chemogenetic actuators, clozapine N-oxide and deschloroclozapine. A systemic administration of the dopamine D1 receptor agonist SKF82958 reversed the chemogenetic effect on locomotor activity. …”
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Biodistribution of intravenously delivered PEGylated carbon nanotubes to the rat brain cortex by Gisele Eva Bruch, Gisele Eva Bruch, Lidiane Dal Bosco, Lidiane Dal Bosco, Arthur P. Cordeiro, Marcos F. Cordeiro, Sangram K. Sahoo, Carolina Peixoto, Marta C. Klosterhoff, Luis Alberto Romano, Cristiano Fantini, Adelina P. Santos, Daniela M. Barros

“…Our preliminary experimental results clearly indicate that SWCNT-PEG were able to cross biological membranes and reach the rat brain cortex parenchyma (but not other brain structures) after systemic administration without the presence of acute toxic effects. …”
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DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel‐Induced Pain and Anxiety in Male Mice by Lixia Tian, Xu‐Hui Li, Yu‐Long Zhao, Hui‐Yuan Yi, Xue‐Ru Liu, Rongrong Yao, Xue‐Mei Hou, Xuan Zhu, Fu‐Quan Huo, Tao Chen, Lingli Liang

“…In this study, systemic administration of PTX leads to a decrease in the expression of the DNA methyltransferase DNMT3a, while concurrently upregulating the expression of Gabrb1 mRNA and its encoded GABAARβ1 protein in the medial PFC (mPFC) of male mice. …”
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Cryopreservation of Bone Marrow Mononuclear Cells Alters Their Viability and Subpopulation Composition but Not Their Treatment Effects in a Rodent Stroke Model by Bing Yang, Kaushik Parsha, Krystal Schaar, Nikunj Satani, Xiaopei Xi, Jaroslaw Aronowski, Sean I. Savitz

“…The systemic administration of autologous bone marrow (BM) derived mononuclear cells (MNCs) is under investigation as a novel therapeutic modality for the treatment of ischemic stroke. …”
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Radiosynthesis and Evaluation of 5-[I]Iodoindol-3-yl-β--Galactopyranoside as a β-Galactosidase Imaging Radioligand by Marcian E. Van Dort, Kuei C. Lee, Christin A. Hamilton, Alnawaz Rehemtulla, Brian D. Ross

“…Based on dynamic SPECT imaging and blood metabolite analysis, we conclude that although [ 125 I]IBDG is an efficient in vivo substrate for β-galactosidase, its rapid renal clearance hampers its intratumoral availability on systemic administration.…”
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An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Dis... by Eduardo Riquelme, Jorge Abarca, Jorge M. Campusano, Gonzalo Bustos

“…The decrease in TH-positive cells and trkB expression in SNc was significantly prevented by systemic administration of Ifenprodil, a specific antagonist of NR2B-containing NMDA receptors. …”
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Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors by Lu Wang, Li Ding, Gang Chen, Zhou Xu, Yanqing Zhang, Bin Deng, Xiya Wang, Yemin Xu, Mengyue Wu, Yinhe Xia, Zhennan Cao, Ruilong Song

“…This endows T cells with delayed senescence and declined apoptosis to maintain their tumor-killing potency. Systemic administration of surface-engineered T cells resulted in superior infiltration in solid tumors and improved antitumor efficacy by enhancing the secretion of cytotoxic molecules, thereby prolonging the survival of mice bearing colorectal carcinoma and melanoma xenografts.Conclusions Lipid-metabolically remodeled T cells with delayed senescence increase efficacy in tumor microenvironment, highlighting a novel strategy for solid tumor immunotherapy.…”
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The Nasal Route as a Potential Pathway for Delivery of Erythropoietin in the Treatment of Acute Ischemic Stroke in Humans by Julio Cesar García-Rodríguez, Iliana Sosa Teste

“…With this technology, it will be possible to eliminate systemic administration and its potential side effects. Using the intranasal delivery system, researchers have demonstrated neuroprotective effects in different animal models of stroke using erythropoietin (EPO) as a neuroprotector or other different types of EPO without erythropoiesis-stimulating activity. …”
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Open-label use of Anakinra (Kineret) in the treatment of patients with osteoarthritis by Craig Davis Scoville, John Partridge Dickson

“…Results: One of the two patients receiving systemic administration of Kineret showed mild efficacy. A total of 21 IA Kineret injections were performed on nine patients. …”
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A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration by Ryunosuke Oyama, Akira Nabeshima, Makoto Endo, Alexey Novikov, Toshifumi Fujiwara, Capucine Phelip, Nobuhiko Yokoyama, Yoshinao Oda, Martine Caroff, Yoshihiro Matsumoto, Jerome Kerzerho, Yasuharu Nakashima

“…Lipo-MP-LPS exhibited an optimal safety and solubility profile for systemic administration at an effective dose. We evaluated tumour growth, lung metastases, and immune cell infiltration in wild-type and TLR4-mutant mice and performed selective immunodepletion. …”
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Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief by Nicholas J. Wright, Yutaka Matsuoka, Hyeri Park, Wei He, Caroline G. Webster, Kenta Furutani, Justin G. Fedor, Aidan McGinnis, Yiquan Zhao, Ouyang Chen, Sangsu Bang, Ping Fan, Ivan Spasojevic, Jiyong Hong, Ru-Rong Ji, Seok-Yong Lee

“…Additionally, our inhibitor exhibits less cardiac side effect than dilazep via systemic administration and shows no side effects via local/intrathecal administration. …”
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Macrophages overexpressing interleukin‐10 target and prevent atherosclerosis: Regression of plaque formation and reduction in necrotic core by Mingyi Wang, Shanshan Zhou, Yingyun Hu, Wei Tong, Hao Zhou, Mingrui Ma, Xingxuan Cai, Zhengbin Zhang, Luo Zhang, Yundai Chen

“…Although interleukin (IL)‐10 is widely acknowledged for its anti‐inflammatory effects, systemic administration of IL‐10 has limitations due to its short half‐life and significant systemic side effects. …”
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