Preparation of curcumin submicron particles by supercritical antisolvent method with external adjustable annular gap nozzle by Yechen Wang, Zirui Li, Sun Fayu, Fei Li, Weiqiang Wang

“…Curcumin was used as a model drug, ethanol as the solvent, and supercritical carbon dioxide (SC-CO2) as the antisolvent. Building on single-factor experiments, a Box-Behnken Design-Response Surface Methodology (BBD-RSM) was employed to systematically investigate the effects of four process parameters—crystallizer pressure (12–16 MPa), crystallizer temperature (313–323 K), solution concentration (1–2 mg/mL), and CO2/solution flow rate ratio (133–173 g/g)—on the morphology and particle size of curcumin particles. …”
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Kinetics of Supercritical CO₂ Extraction from Burrito (<i>Aloysia polystachya</i>) Leaves and Sucupira-Preta (<i>Bowdichia virgilioides</i>) Seeds by Gabrielle Vaz Vieira, Michel Rubens dos Reis Souza, Carlos Toshiyuki Hiranobe, José Eduardo Goncalves, Cristiane Mengue Feniman Moritz, Otávio Akira Sakai, Leila Maria Sotocorno e Silva, Michael Jones da Silva, Erivaldo Antônio da Silva, Renivaldo José dos Santos, Edson Antônio da Silva, Lucio Cardozo-Filho, Leandro Ferreira-Pinto

“…This study investigated the application of supercritical carbon dioxide (CO₂) for the extraction of essential oils from plant materials with anxiolytic potential, focusing on the leaves of burrito (<i>Aloysia polystachya</i>) and the seeds of sucupira-preta (<i>Bowdichia virgilioides</i>). …”
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