Association of iron deficiency with kidney outcome and all-cause mortality in chronic kidney disease patients without anemia by Hongxue Yu, Xian Shao, Zhixin Guo, Mingzhen Pang, Shan Chen, Caoxiang She, Lisha Cao, Fan Luo, Ruixuan Chen, Shiyu Zhou, Xin Xu, Sheng Nie

“…The robustness of results was supported by subgroup analyses. However, there was no significant association found between ferritin levels and the risk of CKD progression or all-cause mortality (P > 0.05). …”
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Deep-Learning-Based Reconstruction of Single-Breath-Hold 3 mm HASTE Improves Abdominal Image Quality and Reduces Acquisition Time: A Quantitative Analysis by Felix Kubicka, Qinxuan Tan, Tom Meyer, Dominik Nickel, Elisabeth Weiland, Moritz Wagner, Stephan Rodrigo Marticorena Garcia

“…<b>Method:</b> MRI of the upper abdomen with DL-HASTE was performed in 35 participants (5 healthy volunteers and 30 patients) at 3 Tesla. In a subgroup of five healthy participants, signal-to-noise ratio (SNR) analysis was used after DL reconstruction to identify the smallest possible layer thickness (1, 2, 3, 4, 5 mm). …”
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Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia by Xiaoqian Ma, Nana Feng, Lena Palaniyappan, Luolong Cao, Zixin Gu, Jujiao Kang, Liu Yuan, Lijun Ouyang, Yujue Wang, Chunwang Li, Ke Jin, Xiaogang Chen, Jianfeng Feng, Ying He, Qiang Luo

“…The stratified UFR-SZ subgroup with smaller right putamen had a smaller volume in the left caudate when compared to HC; this caudate volume was associated with both a higher level of SLE and more psychotic symptoms. …”
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Improving glycemic control by transitioning from the MiniMedTM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study by Satoshi Kubota, Ai Sato, Manami Hosokawa, Yosuke Okubo, Shohei Takayama, Atsuko Kaneko, Yasuho Shimada, Yuki Asano, Yoshihiko Sato, Masanori Yamazaki, Mitsuhisa Komatsu

“…Time below the range remained unchanged (54–69 mg/dL: 1.8 [0.4–2.4] to 2.1 [0.4–3.9] %, p = 0.24; &lt;54 mg/dL: 0.2 [0.0–1.0] to 0.5 [0.1–1.3] %, p = 0.14). In a subgroup of 12 patients with a high HCL implementation rate, the basal insulin infusion decreased immediately after mealtime insulin administration and increased after approximately 120 minutes. …”
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Artificial intelligence conversational agents in mental health: Patients see potential, but prefer humans in the loop by Hyein S. Lee, Hyein S. Lee, Colton Wright, Julia Ferranto, Jessica Buttimer, Clare E. Palmer, Andrew Welchman, Kathleen M. Mazor, Kimberly A. Fisher, David Smelson, Laurel O’Connor, Laurel O’Connor, Nisha Fahey, Nisha Fahey, Apurv Soni, Apurv Soni, Apurv Soni

“…Most participants desired some human involvement in AI-driven therapy and expressed concern about the risk of AI conversational agents being seen as replacements for therapy. A subgroup preferred AI conversational agents for administrative tasks rather than care provision.ConclusionsAI conversational agents were perceived as useful and beneficial for increasing access to care, but concerns about AI’s empathy, capabilities, safety, and human involvement in mental healthcare were prevalent. …”
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Impact of Sex on Infection Risk in Patients with Systemic Lupus Erythematosus by R. Borrelli, S. Nicola, F. Corradi, I. Badiu, L. Lo Sardo, N. Rashidy, A. Quinternetto, M. Mazzola, F. Meli, E. Saracco, I. Vitali, S. Negrini, L. Brussino

“…Our findings emphasize the need for tailored clinical management, with increased vigilance for infections in male patients, to improve prevention strategies and targeted therapeutic interventions in this subgroup.…”
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Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression by Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Rubén Ciria, Marina E. Sánchez-Frias, Maite G. Fernández-Barrena, Iker Uriarte, Eduardo Chicano-Galvez, Ignacio Ortea, Ángela Peralbo-Molina, Javier Briceño, Matías A. Avila, Manuel Rodríguez-Perálvarez, Raúl M. Luque, Juan L. López-Cánovas, Manuel D. Gahete

“…Conclusions Quantitative proteomics defines two prognosis-related proteomic HCC subgroups. ARSs machinery is dysregulated in the aggressive subgroup, bearing potential as prognostic biomarkers. …”
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Ultrasound and histopathological assessment of benign, borderline, and malignant thyroid tumors in pediatric patients: an illustrative review and literature overview by Dominika Januś, Dominika Januś, Monika Kujdowicz, Monika Kujdowicz, Aleksandra Kiszka-Wiłkojć, Aleksandra Kiszka-Wiłkojć, Konrad Kaleta, Anna Taczanowska-Niemczuk, Anna Taczanowska-Niemczuk, Jan Radliński, Kamil Możdżeń, Zuzanna Nowak, Wojciech Górecki, Wojciech Górecki, Jerzy B. Starzyk, Jerzy B. Starzyk

“…This retrospective assessment included an examination of demographic data, hormonal profiles, ultrasound findings, and histopathology reports.ResultsUltrasound and histopathology of thyroid nodules provided insights into subgroup differentiation. Benign nodules like dyshormonogenetic goiter showed solid hypoechoic features on ultrasound and dense fibrosis on histopathology, while thyroid follicular nodular disease exhibited isoechoic nodules with halos, histologically revealing dilated follicles. …”
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Indocyanine Green Fluorescence Plus Blue Dye for Sentinel Lymph Node Biopsy in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer: A Multicenter, Prospective Cohort Stu... by Miao Liu, Yang Yang, Bin Hua, Rui Feng, Tianyu Xu, Mengyuan Wang, Xiaowei Qi, Yingming Cao, Bo Zhou, Fuzhong Tong, Peng Liu, Hongjun Liu, Lin Cheng, Houpu Yang, Fei Xie, Siyuan Wang, Chaobin Wang, Yuan Peng, Danhua Shen, Lei Chen, Jun Jiang, Shu Wang

“…Negative predictive value was 95.7% (88/92; 95% CI, 89.4%–98.3%). In the subgroup analysis stratified by ycN status, FNR was 4.0% (1/25; 95% CI, 0.7%–19.5%) and 8.6% (3/35; 95% CI, 3.0%–22.4%) in the ycN0 and ycN+ subgroups, respectively. …”
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Usefulness of a personalized algorithm‐based discharge checklist in patients hospitalized for acute heart failure by Florent Allain, Virginie Loizeau, Laure Chaufourier, Maya Hallouche, Laurence Herrou, Amir Hodzic, Katrien Blanchart, Annette Belin, Alain Manrique, Paul Milliez, Rémi Sabatier, Damien Legallois

“…During the 6 month follow‐up period, 59 patients (42.4%) reached the primary endpoint in the PCL cohort vs. 92 patients (50.5%) in the control cohort [hazard ratio (HR): 0.79, 95% confidence interval (CI) (0.57–1.09), P = 0.15]. Subgroup analysis including only patients with either altered (<40%) or mid‐range or preserved (≥40%) LVEF showed no significant difference among groups. …”
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Efficacy and safety of first-line PD-1/PD-L1 inhibitor in combination with CTLA-4 inhibitor in the treatment of patients with advanced non-small cell lung cancer: a systemic review... by Huimin Zhao, Shanshan Huang, Jianyu Wu, Yanlan Lu, Yue Zou, Haijian Zeng, Chunlan Li, Jin Wang, Xiaochen Zhang, Xiaochen Zhang, Siliang Duan, Siliang Duan, Weiming Liang

“…Compared to the P group, there was no significant difference in OS (MD: -0,25, 95% CI: -2.47-1.98, p = 0.83), PFS (MD: -0.91, 95% CI: -3.19-1.36, p = 0.43), and ORR (OR:1.05, 95% CI. 0.80-1.36, p = 0.73). Subgroup analysis revealed that CP provided superior OS compared with P in patients with PD-L1 expression &lt; 1%.ConclusionCP was a feasible and safe first-line therapy for patients with advanced NSCLC. …”
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Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study by Haiyu Wang, Guangying Cui, Ming Cheng, Tuerganaili Aji, Guotao Li, Xinjun Hu, Guangming Li, Shixi Zhang, Yanyang Zhang, Linqi Diao, Pan Li, Ling Wang, Yiqiang Yuan, Guowu Qian, Ruiqing Zhang, Xiaoli Jin, Juan Wang, Hong Luo, Donghua Zhang, Mingming Wang, Silin Li, Zhan Song, Mengzhao Yang, Guanyue Su, Ranran Sun, Junbiao Chang, Zujiang Yu, Zhigang Ren

“…Fewer adverse events were observed in the azvudine group. Subgroup analysis revealed that azvudine provided greater benefits for patients with malignant tumors, significantly reducing both all-cause death (hazard ratio [HR]: 0.33, 95% CI: 0.20−0.54) and composite disease progression (HR: 0.54, 95% CI: 0.33−0.88). …”
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Syncopes and clinical outcome in heart failure: results from prospective clinical study data in Germany by Djawid Hashemi, Moritz Blum, Meinhard Mende, Stefan Störk, Christiane E. Angermann, Sabine Pankuweit, Elvis Tahirovic, Rolf Wachter, Burkert Pieske, Frank Edelmann, Hans‐Dirk Düngen, the German Competence Network for Heart Failure

“…HoS was more frequent in the overall cohort of patients with HF compared with controls (P < 0.001)—mainly driven by the HFpEF subgroup (HFpEF vs. controls: 25.0% vs. 12.8%, P < 0.001). …”
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A meta-analysis of randomized controlled trials: evaluating the efficacy of isokinetic muscle strengthening training in improving knee osteoarthritis outcomes by Wanqin Guo, Jingyang Gao, Dawazhuoma, Xiuling Mi, Ciwang, Bianba

“…The therapeutic effect of IMST on KOA remained significant after rigorous testing of subgroup and sensitivity analyses. Conclusions In patients with KOA, IMST improves muscle strength and relieves joint pain and stiffness. …”
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Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis by Ye Liu, Ziwei Chen, Chang Li, Tianhan Sun, Xuanmei Luo, Boyue Jiang, Meilan Liu, Qing Wang, Tong Li, Jianfu Cao, Yayu Li, Yuan Chen, Lu Kuai, Fei Xiao, Hongtao Xu, Hongyuan Cui

“…We subsequently performed subgroup, sensitivity, and publication bias analyses. cirrhosis dysbiosis ratio. …”
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A semantic strength and neural correlates in developmental dyslexia by Sladjana Lukic, Sladjana Lukic, Sladjana Lukic, Fei Jiang, Maria Luisa Mandelli, Maria Luisa Mandelli, Ting Qi, Sarah M. Inkelis, Sarah M. Inkelis, Emily Rosenthal, Emily Rosenthal, Zachary Miller, Zachary Miller, Emma Wellman, Emma Wellman, Silvia A. Bunge, Silvia A. Bunge, Silvia A. Bunge, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Christa Watson Pereira, Christa Watson Pereira

“…Differential dynamic rs-fMRI connectivity (shorter average dwell time and greater brain state switches) was observed between the high and average groups in a large-scale bilateral frontal-temporal-occipital network.DiscussionThese data demonstrate that a subgroup of children with dyslexia perform above average on semantic fluency tasks and their performance is strongly linked to distinct psycholinguistic patterns and differences in a task-free resting-state brain network, which includes regions previously implicated in semantic processing. …”
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Association of blood cadmium and physical activity with mortality: A prospective cohort study by Yilin Chen, Cien Zhen, Lin Zeng, Hongliang Feng, Jinyu Wang, Qi Yong H. Ai, Sizhi Ai, Jihui Zhang, Yannis Yan Liang, Huachen Xue, Yujing Zhou

“…Blood cadmium and PA had multiplicative interactions on mortality risk (all P interaction < 0.05). Compared with the subgroup with the lowest quartile of blood cadmium and recommended PA, the combination of the highest quartile of blood cadmium and without recommended PA was associated with the highest risks of all-cause and cancer mortality, followed by those meeting recommended PA but in the highest quartile of blood cadmium (hazard ratios, 2.43; 95 % confidence interval, 1.95–3.02). …”
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Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics by Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert

“…Remarkably, most tumor-associated peptides and proteins are subgroup-specific, whereas shared presentation among all subgroups of medulloblastoma (WNT, SHH, Group 3 and Group 4) is rare. …”
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Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong by Yin Zhang, Francisco T T Lai, Shirley Chiu Wai Chan, Chak Sing Lau, Xue Li, Eric Yuk Fai Wan, Lung Yi Mak, Celine S L Chui, Ivan F N Hung, Esther Wai Yin Chan, Vincent Ka Chun Yan, Deliang Yang, Carlos Wong, Ian Chi-Kei Wong

“…Findings were consistent across subgroups of age, sex, health status and vaccination status. …”
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Impact of Immune Checkpoint Inhibitors and Local Radical Treatment on Survival Outcomes in Synchronous Oligometastatic NSCLC by Mandy Jongbloed, MD, Valentina Bartolomeo, MD, Martina Bortolot, MD, Shahan Darwesh, MD, Jarno W.J. Huijs, MD, Safiye Dursun, MD, Juliette Degens, MD, PhD, Ben E.E.M. van den Borne, MD, PhD, Maggy Youssef-El Soud, MD, PhD, Marcel Westenend, MD, PhD, Cordula Pitz, MD, PhD, Dirk K.M. De Ruysscher, MD, PhD, Lizza E.L. Hendriks, MD, PhD

“…Primary end points were progression-free survival and overall survival (OS) for an ICI-based versus chemotherapy-only strategy. Subgroup analyses were performed for patients who were deemed candidates for LRT in the multidisciplinary meeting and those proceeding to LRT. …”
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