Impact of Initial Heart Rate, Diastolic Pressure, and Pulse Pressure on Prognostic Outcomes in Heart Failure Patients with Mildly Reduced Ejection Fraction by Hu H, Liu Z, Zeng J, Jiang M

“…While heart failure with mildly reduced ejection fraction (HFmrEF) is a distinct subgroup of heart failure, the prognostic impact of these hemodynamic parameters in this population remains unclear, necessitating focused investigation. …”
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Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction by Stéphanie Verbeke, Aurélien Bourdon, Mathilde Lafon, Vanessa Chaire, Bertolo Frederic, Amina Naït Eldjoudi, Marie-Alix Derieppe, Francis Giles, Antoine Italiano

“…Moreover, we identified GPX4 as a gene involved in resistance and showed synergy between BET inhibition and ferroptosis induction.The present study demonstrated that dual BET/EP300 inhibitors have a relevant antitumor activity in a subgroup of UPS characterized by expression of MYC-targets pathway and identified a potent combination therapeutic strategy that deserves further investigation in the clinical setting.…”
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Effectiveness of eHealth literacy interventions: a systematic review and meta-analysis of experimental studies by Chiara Barbati, Elvira Maranesi, Cinzia Giammarchi, Matteo Lenge, Manila Bonciani, Elisa Barbi, Giacomo Pietro Vigezzi, Mauro Dragoni, Tania Bailoni, Anna Odone, Roberta Bevilacqua

“…In the analysis between the intervention and control groups, we found a statistically significant difference in eHL improvement in favour of the intervention group, with mean eHEALS scores 3.62 points (95% CI = 1.63–5.60, N = 1258) higher in the intervention group than in the control groups. Subgroup analyses by intervention type, stratified by Collaborative Learning (CL) or Individualistic Learning (IL) showed significant increases in eHealth Literacy in the pre-post intervention analysis (CL: UMD = 5.19, CI = 0.01–10.38, N = 402; IL: UMD = 6.05; CI = 3.14–8.97, N = 623) and in the intervention vs. control analysis in the IL group (DMD = 4.98; CI = 1.77–8.12, N = 540). …”
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Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis by Chao Li, Didi Zuo, Tao Liu, Libin Yin, Chenyao Li, Lei Wang

“…Among 33 included studies (n=6032 patients), there were no associations between combined MUC phenotype expression levels and overall survival (OS) or disease-free survival (DFS)/relapse-free survival (RFS) in patients with CRC. In subgroup analyses, the upregulated MUC1 expression (HR=1.50; 95% CI, 1.29–1.74; P<0.00001) was associated with poor OS. …”
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The serum hepcidin and the hepcidin/ferritin ratio in NAFLD: a systematic review and meta-analysis by Jingmin Song, Heqing Wang, Xiaolian Gao, Fen Yang, Xinhong Zhu, Guiyuan Qiao, Ting Gan, Junxiu Tao

“…Significant heterogeneity was observed across studies for both hepcidin (I² = 98.2%) and the hepcidin/ferritin ratio (I² = 93.3%), and the limited number of studies on hepcidin/ferritin were acknowledged as key limitations. Subgroup analysis revealed that patients with obesity exhibited higher levels of hepcidin (SMD = 1.12, 95% CI: 0.40 to 1.97) than overweight (SMD = 0.88, 95% CI: 0.05 to 1.72). …”
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Systemic Inflammatory Markers for Predicting Overall Survival in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis by Xiaotong Song, Hao Zhang, Fanxing Yin, Panpan Guo, Xiaocheng Yang, Jinzhu Liu, Yanshuo Han, Zhaozhou Ren

“…However, the correlation between LMR or PLR and the prognosis of osteosarcoma is not statistically significant (HR=0.60, 95% CI: 0.30-1.18, P=0.138; HR=1.13, 95% CI: 0.85-1.49, P=0.405, respectively). The outcomes of subgroup analysis to NLR and CRP suggested that histology, ethnicity, metastasis, and sample size all have an impact on its prognosis of patients with osteosarcoma. …”
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Efficacy and safety of sequential therapy for primary osteoporosis with bone formation promoters followed by bone resorption inhibitors: a meta-analysis by Yuxin Liu, Xin Liu, Yuefeng Wu, Tao Luo

“…Data from clinical studies that met the eligibility criteria were extracted, and quality assessment and meta-analysis were performed using RevMan v5.4 and Stata v15.0. Sensitivity and subgroup analyses were performed to find the source of heterogeneity and discover more findings. …”
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Impact of Low Inclusion Rate of Olive Cake in Dairy Cow Rations on Uterine Health and Fertility Indices During Early Lactation by Ioannis Nanas, Themistoklis Giannoulis, Eleni Dovolou, Ilias Giannenas, Georgios S. Amiridis

“…Blood samples, uterine epithelial cells, and endometrial tissue samples were collected from a subgroup of healthy animals in both groups at specific time points. …”
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Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study by Qingzheng Wu, Bing Li, Yuepeng Wang, Yuepeng Wang, Yue Zhang, Qian Wang, Binqi Li, Binqi Li, Wei Jing, Jing Yang, Yiming Mu

“…After adjusting for all factors with the exception of the stratified variable, this association held true in age, sex, BMI, hypertension, and hyperlipidemia subgroup and was especially pronounced in those aged &lt;60 years, BMI ≥24 kg/m2, and males, with interactions between WWI and age, sex, and BMI (P for interaction &lt;0.05).ConclusionWWI was positively associated with T2DM in Chinese urban adults, especially in young and middle-aged males with BMI ≥24 kg/m2.…”
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RECIST 1.1 versus mRECIST for assessment of tumour response to molecular targeted therapies and disease outcomes in patients with hepatocellular carcinoma: a systematic review and... by Yao Yang, Yuping Bai, Hongli Yu, Qiang Zhu, Xiaoyu Xie, Yuemin Feng

“…OS was significantly longer in response group than non-response group according to mRECIST (HR 0.56, 95% CI 0.41 to 0.78, p=0.0004) calculated from 7 studies including 566 patients, however, the RECIST1.1 could not distinguish the OS well (HR 0.68, 95% CI 0.44 to 1.05, p=0.08). Subgroup analusis by type of treatment was conducted.Conclusions mRECIST may be more accurate than RECIST 1.1 in assessing ORR after molecular targeted therapies in HCC patients and can better assess the prognosis. …”
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Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged and elderly population: a meta-analysis and systematic review... by Chenqi Xie, Jianbao Gong, Chenglong Zheng, Junwei Zhang, Jie Gao, Chunyan Tian, Xiaofei Guo, Shiyou Dai, Tianlin Gao

“…However, there was no significant effect of vitamin K supplementation on other bone metabolism markers, such as cross-linked telopeptide of type 1 collagen (NTx), bone alkaline phosphatase (BAP), and procollagen I N-terminal propeptide (PINP). Subgroup analysis revealed that vitamin K notably enhanced bone health in females by increasing lumbar spine BMD (p = 0.028) and decreasing ucOC (p < 0.001). …”
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Correlation between Preoperative Platelet Count/(Lymphocyte Count × Prealbumin Count) Ratio and the Prognosis of Patients with Gastric Cancer Undergoing Radical Operation by Yi Liu, Yanguang Yang, Guomei Tai, Feng Ni, Cenming Yu, Wenjing Zhao, Ding Wang

“…In stage I–III patients, the prognosis was better in the low-ratio set than in the high-ratio set (P<0.001), subgroup analysis indicated the prognosis was obviously better in the low-ratio set than in the high-ratio set in stage II and III patients (P<0.05 and P<0.001), but there was no difference in stage I patients (P>0.05). …”
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Improving Outcomes and Quality of Life for Patients With Hand and Foot Eczema: Randomized Study of a Patient-Centered Monitoring App by Aimee Bruch, Wanja Weigandt, Yannic Schardt, Raphael Herr, Johannes Benecke, Astrid Schmieder

“…A trend toward a greater improvement of the HECSI in the intervention group compared to the control group was noticed (week 60: Coef=0.597; P=.05). Subgroup analysis revealed that patients who used the app with a usage frequency of less than 20% demonstrated a significant reduction in the HECSI from week 0 to week 60 (week 60: Coef=–1.275; P=.04) and a significant reduction in the Dermatology Life Quality Index (week 60: Coef=–1.246; P=.04) compared to the control group. …”
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Balanced crystalloid versus saline for resuscitation in pediatric septic shock: a systematic review and meta-analysis by Barkhá Vijendra, Ana Beatriz Bertol, Mylena Maria Guedes de Almeida, Pedro Henrique Aquino Gil de Freitas, Áurea Maria Salomão Simão, Bianca Lisa de Faria

“…Hospital length of stay in days was significantly longer with BS compared to NS (MD 3.38; 95% CI 1.13 to 5.64; p = 0.003; I² = 0%) and the occurrence of hyperchloremia was lower in the BS compared to NS (RR 0.70; 95% CI 0.59 to 0.82; p = 0.0001; I² = 0%). In a subgroup analysis of RCTs only, AKI occurrence was not significantly different between BS and NS groups (RR 0.81; 95% CI 0.48 to 1.38; p = 0.44; I² = 18%). …”
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Efficacy & safety of brolucizumab 6.0 mg versus 3.6 mg in diabetic macular edema by Sanjay Kumar Mishra, Pradeep Kumar, Amrita Joshi, Aman Saraf, Abhijeet Awasthi, Supriya Dhar, Khaleel M, Atul Kumar, Vipin Rana, Ravi D

“…The re-injection interval was 14.21 weeks in 6.0 mg group and 15.56 weeks for 3.6 mg subgroup. The total number of adverse events in both groups were similar at 70 in 6.0 mg group and 47 in 3.6 mg group with only one grade 4 adverse event occurring in each group. …”
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Oura Ring as a Tool for Ovulation Detection: Validation Analysis by Nina Thigpen, Shyamal Patel, Xi Zhang

“…We compared performance across cycle length, cycle variability, and participant age. In each subgroup, we compared the algorithm’s performance with the traditional calendar method, which estimates the ovulation date based on an individual’s last period start date and average menstrual cycle length. …”
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Collecting Real-World Data via an In-Home Smart Medication Dispenser: Longitudinal Observational Study of Survey Panel Persistency, Response Rates, and Psychometric Properties by Benjamin Ogorek, Thomas Rhoads, Erica Smith

“…The large SD was apparent in the subgroup analysis, where a responder versus nonresponder dichotomy was observed. …”
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The association of triglyceride-glucose and triglyceride-glucose related indices with the risk of heart disease in a national by Xiaodi Tang, Kexin Zhang, Rong He

“…Multivariate Cox proportional hazards models, restricted cubic spline (RCS), Kaplan-Meier (KM) curves, subgroup analysis and sensitivity analysis were used to analyze the associations between TyG, TyG related indices and the risk of heart disease in national participants and in type 2 diabetes (T2D) or non-T2D patients respectively. …”
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Associations between hypovitaminosis D, adiposity indices and insulin resistance in adolescents: mediation analyses from NHANES 2011–2018 by Yaping Deng, Yingting Luo, Yilei Shen, Yong Zhao, Wei Cao, Jie Cao, Lijuan Xu, Lin Kong

“…Results Our study revealing significant correlations between adiposity indices, hypovitaminosis D, and IR after variable adjustment. Notably, subgroup analysis indicated a pronounced hypovitaminosis D -adiposity association in female adolescents, which was not observed in males. …”
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Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients by Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Piotr Ceranowicz, Jakub Kucharz, Anna Ząbek-Adamska, Barbara Maziarz, Ryszard Drożdż, Marek Kuźniewski

“…Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control. In a subgroup of 29 patients, retrospective data were available on changes in eGFR and uACR over one year. …”
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