Identifying compound heterozygous variants in the EEFSEC gene linked to progressive cerebellar atrophy by Zhen Liu, Mei He, Xuan Luo, Hu Pan, Juanli Hu, Zhengqing Wan, Yin Peng, Yixiao Luo, Hua Wang, Xiao Mao

“…Both functional prediction tools and structural analysis underscored the detrimental impact of the p.R443P variant. …”
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History, status and genetic characteristics of native cattle breeds from the Republic of Kazakhstan by A. K. Khamzina, A. A. Yurchenko, N. S. Yudin, P. Sh. Ibragimov, Y. S. Ussenbekov, D. M. Larkin

“…Unique genetic components characterizing Kazakhstan cattle breeds were described, and comparisons were made with genetic data from other breeds. Structural analysis showed that the Kazakh white-headed breed contains genetic components of the Hereford, Kalmyk, and Altai cattle. …”
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The crystal structure of GH57 family amylopullulanase reveals its dual binding pockets sharing the same catalytic dyad by Zhimin Zhu, Weiwei Wang, Minjun Li, Qin Xu, Huan Zhou, Liqing Huang, Qisheng Wang, Feng Yu

“…In this study, we report the first crystal structures of a GH57 amylopullulanase from Aquifex aeolicus (AaApu) in complex with oligosaccharides containing both α-1,4 and α-1,6 glycosidic bonds. Our structural analysis reveals that GH57 amylopullulanase features dual binding pockets arranged in a “Y”-shaped configuration, which accommodates branched-chain starches. …”
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Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis by Zhongzheng Li, Mengke Zhang, Yujie Zhang, Yulong Gan, Zhao Zhu, Jiawei Wang, Yanlin Zhou, Guoying Yu, Lan Wang

“…Methods Utilizing a bleomycin-induced pulmonary fibrosis model, we conducted a comprehensive analysis of the interplay between chromatin structure, chromatin accessibility, gene expression patterns, and cellular heterogeneity. Our chromatin structure analysis included 5 samples (2 control and 3 bleomycin-treated), while accessibility and expression analysis included 6 samples each (3 control and 3 bleomycin-treated). …”
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Nuisance Growth of <i>Cissus verticillata</i> (Vitaceae) Negatively Affects the Structure of Mangroves in Marismas Nacionales Nayarit, Mexico by Olivia Millán-Aguilar, María Luisa Ordóñez-Rosas, Isaac Castillo-Cruz, Lidia Rodríguez-Arredondo, Marcelino Ruiz-Domínguez, Miguel Ángel Hurtado-Oliva, Marlenne Manzano-Sarabia

“…This contribution reports the impact of <i>Cissus verticillata</i>—a climbing plant species—in the structure of mangroves distributed in this Natural Protected Area during 2019 and 2022. Forest structure analysis was compared in four plots of 20 m × 20 m each, all of them influenced by San Pedro Mezquital river. …”
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Genome-Wide Identification and Evolutionary Analysis of the <i>SnRK2</i> Gene Family in <i>Nicotiana</i> Species by Yu Tang, Yangxin Zhang, Zhengrong Hu, Xuebing Yan, Risheng Hu, Jibiao Fan

“…In silico promoter analysis uncovered regulatory networks involving light, hormones, stress, and developmental signals, with prevalent ABA-responsive elements (ABREs) supporting conserved stress-adaptive roles. Structural analysis highlighted functional diversification through variations in intron–exon architecture and conserved kinase motifs. …”
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Research on the GST gene family in Salix lindleyana reveals Trp162 and Pro202 as key amino acids controlling the release rate of GS-X by Nan Xu, Yu-Wen Wang, Chang Qu, Zhao-Qun Wu, Xiu-Xing Zhang, Shi-Yi Wang, Ye-Bo Yang, Jing Xue, Hai-Ling Yang

“…Three genes under positive selection from Clade a were chosen for 36 site-directed mutations, with Trp162 and Pro202 crucially affecting variations in GST enzyme activity. Crystal structure analysis of SliGSTU7 complexed with GSH revealed that the Trp162 residue was located at the bottom of the hydrophobic cavity. …”
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Personal experiences of living with sucrose intolerance and attitudes towards genetic research in Greenland - a user study by Silvia Isidor, Ninna Senftleber, Cecilie Schnoor, Kristine Skoett Pedersen, Lene Seibæk, Marit Eika Jørgensen, Jette Marcussen

“…The analysis was based on the phenomenological-hermeneutic approach of Paul Ricoeur, consisting naïve reading, structural analysis, interpretation and discussion. We identified two themes; “Sucrose intolerance impacts daily living”, dealt with physical and emotional reactions and coping with social adaption to activities. …”
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Quercetin-Fortified Animal Forage from Onion Waste: A Zero-Waste Approach to Bioactive Feed Development by Janusz Wojtczak, Krystyna Szymandera-Buszka, Joanna Kobus-Cisowska, Kinga Stuper-Szablewska, Jarosław Jakubowicz, Grzegorz Fiutak, Joanna Zeyland, Maciej Jarzębski

“…Furthermore, digital and optical microscopy were applied for structure analysis. Microscopic imaging results confirmed that the onion structures were visible in the whole length of feed material and analyzed cross-sections. …”
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Development and Validation of a Theoretical Model for Flexural Behavior in Timber-Concrete and Bamboo-Concrete Composite Beams by Thaís P. L. Siqueira, M’hamed Y. R. da Glória, Enzo Martinelli, Romildo D. Toledo Filho

“…This approach provides a reliable and versatile tool for the structural analysis and design of composite beams.…”
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Relationship Between Pore-Size Distribution and 1D Compressibility of Different Reconstituted Clays Based on Fractal Theory by Yanhao Zheng, Tanfang Zhu, Junqi Chen, Kun Shan, Junru Li

“…This is associated with distinct pore size evolution patterns under 1D loading while also emphasising the crucial role of mesopores in macroscopic clay deformation. (2) Fractal dimensions increase with loading, reflecting the progressive refinement of the pore structure, with natural Shenzhen clay demonstrating the most pronounced change. (3) A mathematical relationship between fractal dimension and 1D compressibility is established for each clay type, providing a quantitative tool for predicting 1D compressibility based on fractal dimensions. (4) The testing procedures and methods to ensure the representativeness of pore structure analysis are elaborated, ensuring reliable PSD data. …”
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Identification of Hybrid Sturgeon (<i>Acipenser baerii</i> × <i>Acipenser schrenckii</i>) from Their Parents Using Germplasm by Shiyong Yang, Zhongmeng Zhao, Zihan Xu, Ya Liu, Menghao Jiang, Lin Fu, Jin Zhang, Zhaoxin Jing, Xiaojian Pang, Wuyuntana Shao, Chaoyang Zhang, Yunkun Li, Xiaogang Du, Jiayun Wu

“…Additionally, genetic structure analysis and factor correlation analysis (FCA) were conducted using six microsatellite loci among 100 samples, including eight species and two hybrid sturgeon. …”
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Human adaptation and diversification in the Microsporum canis complex by Xin Zhou, Sarah A. Ahmed, Chao Tang, Maria Eduarda Grisolia, José Francisco Ghignatti Warth, Kristen Webster, Andrea Peano, Silke Uhrlass, Claudia Cafarchia, Marie Pierre Hayette, Rosalie Sacheli, Tadeja Matos, Yingqian Kang, G. Sybren de Hoog, Peiying Feng

“…To clarify the evolutionary relationship between the three species and explore the potential host shift process, this study used phylogenetic analysis, population structure analysis, multispecies coalescent analyses, determination of MAT idiomorph distribution, sexual crosses, and macromorphology and physicochemical features to address the above questions. …”
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Dimerization of ADAR1 modulates site-specificity of RNA editing by Allegra Mboukou, Vinod Rajendra, Serafina Messmer, Therese C. Mandl, Marjorie Catala, Carine Tisné, Michael F. Jantsch, Pierre Barraud

“…Here, we report on the structural analysis of the third double-stranded RNA-binding domain of ADAR1 (dsRBD3), which reveals stable dimer formation through a large inter-domain interface. …”
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Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex by Yingyuan Sun, Yaru Wang, Zheng Xing, Dongyu Li, Rong Wang, Baozhi Chen, Ning Zhou, Alyssa Ayala, Benjamin P. Tu, Xiaofeng Qi

“…Here, we present the cryogenic electron microscopy (cryo-EM) structures of the human MPC1-2 complex in the mitochondrial intermembrane space (IMS)-open state and the inhibitor-bound in the mitochondrial matrix-open state. Structural analysis shows that the transport channel of MPC is formed by the interaction of transmembrane helix (TM) 1 and TM2 of MPC1 with TM2 and TM1 of MPC2, respectively. …”
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Genomic Analysis of Indel and SV Reveals Functional and Adaptive Signatures in Hubei Indigenous Cattle Breeds by Liangyu Shi, Pu Zhang, Bo Yu, Lei Cheng, Sha Liu, Qing Liu, Yuan Zhou, Min Xiang, Pengju Zhao, Hongbo Chen

“…The variants were also found to overlap with economically important traits, such as meat quality, reproduction, and immune response. Population structure analysis revealed genetic differentiation among the breeds, with Wuling cattle showing the highest differentiation. …”
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A State-of-the-Art Review on the Influence of Porosity on the Compressive Strength of Porous Concrete for Infrastructure Applications by Rajab Abousnina, Fahad Aljuaydi, Benchaa Benabed, Magdi H. Almabrok, Vanissorn Vimonsatit

“…This work comprehensively evaluates and synthesises existing methods for pore structure analysis, thereby enhancing our understanding of how porosity influences concrete behaviour. …”
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Hepatotoxicity Evaluation of Levornidazole and Its Three Main Impurities: Based on Structure–Toxicity Classification Prediction Combined with Zebrafish Toxicity Assessment by Ting Liu, Song Yuan, Luyong Zhang, Dousheng Zhang

“…The hepatotoxicity of levornidazole and impurity II was confirmed using a zebrafish toxicity study, with impurity II demonstrating hepatotoxicity at lower doses. Molecular structure analysis revealed that the electronegativity of the side-chain groups and the molecular polarity structure were correlated with the degree of hepatotoxicity. …”
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Functionalization of Oligosiloxane for Polyester Comonomer by Satoru Saotome, Jiaorong Kuang, Reina Akashi, Momoko Takahashi, Yujia Liu, Takayuki Iijima, Masafumi Unno

“…Furthermore, the flexibility imparted by the silicone components effectively mitigated the brittleness of polyester at sub-zero temperatures, resulting in superior impact resistance. Structural analysis, contact angle measurements, and low-temperature impact tests were conducted on the copolymers. …”
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It is all about an appealing environment: Linking the learning environment dimensions with student engagement in Ethiopian higher education context by Bekalu Tadesse Moges, Yalalem Assefa, Shouket Ahmad Tilwani, Yibeltal Aemro Azmera

“…Moreover, two-group structural analysis revealed that the relationship between learning environment and cognitive engagement is significantly different for males and females, whereas other engagement dimensions did not exhibit such differences. …”
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