A novel loss-of-function variant in STAT1 causes Mendelian susceptibility to mycobacterial disease by Kunlun Lv, Zhuoqing Gong, Zhuoqing Gong, Yiting Fu, Sisi Zhao, Yinggai Song, Huijun Wang, Zhimiao Lin

“…A luciferase reporter assay evaluated its transcriptional activity. Additionally, structural analysis using AlphaFold3 predicted the variant’s functional impact.ResultsA novel STAT1 variant (c.2120T>C, p.Ile707Thr) was identified. …”
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Structural basis for cholesterol sensing of LYCHOS and its interaction with indoxyl sulfate by Zhenhua Wang, Jingjing He, Yufan Yang, Yonglin He, Hongwu Qian

“…Advanced 3D classification reveals two distinct states of LYCHOS. Comparative structural analysis between these two states demonstrated a cholesterol-related movement of GPCR domain relative to permease domain, providing structural insights into how LYCHOS senses lysosomal cholesterol levels. …”
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Genomic resequencing reveals genetic diversity, population structure, and core collection of durian germplasm by Yiwang Zhong, Liying Feng, Huidong Deng, Xiaohao Ji, Jing Zhang, Yangyang Sun, Peifan Lin, Yang Qiao, Shenghua Xie, Haibo Wang, Lijun Guo, Xuejie Feng

“…We performed whole-genome resequencing of 114 diverse durian accessions collected in China, identifying over 39 million high-quality SNPs across the genome, revealing genome-wide patterns of diversity. Population structure analysis revealed three major genetic clusters, supported by PCA, phylogenetic analysis, and STRUCTURE modeling. …”
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CO₂ Interaction Mechanism of SnO₂-Based Sensors with Respect to the Pt Interdigital Electrodes Gap by Adelina Stanoiu, Alexandra Corina Iacoban, Catalina Gabriela Mihalcea, Ion Viorel Dinu, Ovidiu Gabriel Florea, Ioana Dorina Vlaicu, Cristian Eugen Simion

“…X-ray diffraction, low-magnification and high-resolution transmission electron microscopy, and electrical and contact potential difference investigations were employed to understand the sensing mechanism involved in CO₂ detection. The morpho-structural analysis revealed that the SnO₂ nanoparticles exhibit well-defined facets along the (110) and (101) crystallographic planes. …”
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Insight into structural, Opto-electronic and elastic properties of lead-free double perovskites Cs2TlInX6 (X = Cl, Br and I) for optoelectronic applications: A first principles cal... by Nimra Ehsan, Tasawer Shahzad Ahmad, Mian HR Mahmood, Salhah Hamed Alrefaee, Naseem Akhter, Tatyana Orlova, Vineet Tirth, Ali Algahtani, Amnah Mohammed Alsuhaibani, Moamen S. Refat, Abid Zaman

“…Structural optimizations reveal increasing lattice constants (11.05 Å −12.28 Å) with larger anions, while band structure analysis indicates indirect band gaps of 3.52 eV, 2.49 eV and 1.45 eV for Cl, Br, and I variants suitable for visible to ultra-visible applications. …”
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Two-dimensional boron nitride allotrope Irida-B12N12 with 3-6-8 membered rings and wide-bandgap semiconducting properties by Marcelo L. Pereira, Djardiel da S. Gomes, Kleuton A. L. Lima, Georges D. A. Nze, Fábio L. L. Mendonça, Luiz A. Ribeiro

“…The electronic structure analysis reveals that Ir-BN is a wide-bandgap semiconductor, with band gaps ranging from 2.4 to 3.2 eV. …”
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Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection by Lei Yu, Yajie Wang, Yuanchen Liu, Xiaomin Xing, Chen Li, Xun Wang, Jialu Shi, Wentai Ma, Jiayan Li, Yanjia Chen, Rui Qiao, Xiaoyu Zhao, Shilei Tian, Ming Gao, Shuhua Wen, Yingxue Xue, Tianyi Qiu, Hongjie Yu, Yongjun Guan, Hin Chu, Lei Sun, Pengfei Wang

“…It also displayed broad neutralization activity against SARS-CoV and related sarbecoviruses. Structural analysis revealed that these antibodies target shared hotspot but mutation-resistant epitopes, with their Fabs locking receptor binding domains (RBDs) in the “down” conformation through interactions with adjacent Fabs and RBDs, and cross-linking Spike trimers into di-trimers. …”
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Structural stabilization of the intrinsically disordered SARS-CoV-2 N by binding to RNA sequences engineered from the viral genome fragment by Sara Landeras-Bueno, Chitra Hariharan, Ruben Diaz Avalos, Andrew S. Norris, Dalton T. Snyder, Kathryn M. Hastie, Stephanie Harkins, Michelle Zandonatti, Roshan R. Rajamanickam, Eduardo Olmedillas, Robyn Miller, Sujan Shresta, Vicki H. Wysocki, Erica Ollmann Saphire

“…However, the inherent disorder of full-length N hampers its structural analysis. Here, we describe a stepwise method using viral-derived RNAs to stabilize SARS-CoV-2 N for EM analysis. …”
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Geology of Bajalia Anticline of the low folded zone of Iraq by Wathiq Ghazi Abdulnaby, Maher Mandeel Mahdi, Rafed Abd Al-Muhamed, Nagham Adil Darweesh, Ahmed Muhsen Hashoosh

“…The geometrical structural analysis depicts that the Anticline is non-cylindrical, asymmetrical, close, sub-horizontal, steeply inclined, and linear fold. …”
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Genetic Diversity and Variability in Endangered Pantesco and Two Other Sicilian Donkey Breeds Assessed by Microsatellite Markers by Salvatore Bordonaro, Anna Maria Guastella, Andrea Criscione, Antonio Zuccaro, Donata Marletta

“…Reynolds’ (𝐷𝑅) genetic distances, correspondence, and population structure analysis reproduced the same picture, revealing that, (a) Pantesco breed is the most differentiated in the context of the Sicilian indigenous breeds, (b) within Ragusano breed, two well-defined subgroups were observed. …”
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Elaboration of fibrous structured activated carbon from olive pomace via chemical activation and low-temperature pyrolysis by Imad Alouiz, Mouhssine Benhadj, Elmontassir Dahmane, Mohamed Sennoune, Mohamed-Yassine Amarouch, Driss Mazouzi

“…According to the findings, the most effective conditions to achieve high-performance activated carbon were 22 vol% of H3PO4, a 2-h chemical activation impregnation residence time at 50 °C, and a 500 °C pyrolysis temperature for 1 h. Structural analysis revealed that activated carbons possess highly developed textural and structural properties, resulting in an iodine value of 923 mg/g and a specific surface of 1400 m2/g. …”
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Triple-chord trussed submerged floating tunnels: hybrid construction concept, feasibility and design by Fa-Cheng Wang, Tao Zhuge, Zheng-Qing Cheng, Lin-Hai Han, Jian-Min Zhang, Leroy Gardner

“…We further develop a multi-scale structural analysis methodology that integrates three-dimensional solid finite element (3-D FE) and simplified fibre modelling for the efficient evaluation of global deformations, fire performance and joint behaviour. …”
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Design and analysis of quasi-vertical multi-fin GaN power devices based on epitaxially grown GaN-on-sapphire by Jeong Woo Hong, Sang Ho Lee, Jin Park, Min Seok Kim, Seung Ji Bae, Won Suk Koh, Gang San Yun, In Man Kang

“…This study's systematic optimization and structural analysis provide valuable insights into enhancing device characteristics for high-power semiconductor applications and contribute to a deeper understanding of the electrical properties of quasi-vertical fin-type power devices.…”
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Machine Learning simulations reveal oxygen’s phase diagram and thermal properties at conditions relevant to white dwarfs by Yunlong Wang, Jiuyang Shi, Zhixin Liang, Tianheng Huang, Junjie Wang, Chi Ding, Chris J. Pickard, Hui-Tian Wang, Dingyu Xing, Dongdong Ni, Jian Sun

“…We determine the crystal structures of oxygen up to 1 PPa (1000 TPa), identifying a novel two-dimensionally bonded body-centered tetragonal (bct) phase and a fully polymerized hexagonal close-packed (hcp) phase. Electronic structure analysis reveals significant bond softening in the bct phase with increasing pressure, which may affect the dynamic behavior under finite temperatures. …”
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Microwave-Assisted Synthesis of 1-(5-Substituted-4-hydroxy-2-methyl-1<i>H</i>-pyrrol-3-yl)ethan-1-ones from 2-Amino Acid-Derived Enamine-Type Schiff Bases by Diego Quiroga, Sergio Torres-Cortés, Ericsson Coy-Barrera

“…Steric hindrance from bulkier groups reduced yields, while the electronic nature of R¹ influenced reactivity. Structural analysis (NMR, HR-ESI-MS) confirmed product identities, and a 5-<i>exo-trig</i> cyclization mechanism explained base-mediated deprotonation and steric effects. …”
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Optimization of preparation process and characteristics analysis of porcine hemoglobin modified by enzymatic hydrolysis-phosphorylation by SU Kenan, LIU Lili, CHENG Weiwei, DING Yue, XU Baocheng

“…Electrophoresis results indicated no significant change in molecular weight. Structural analysis revealed that the phosphate groups were mostly attached to the N atoms. …”
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Matrix metalloproteinase-2 as a novel regulator of glucose utilization by adipocytes by Melissa D. Lempicki, Ryan J. Garrigues, Alexander D. Hondros, Tonya N. Zeczycki, Brandon L. Garcia, John Cavanagh, Thurl E. Harris, Akshaya K. Meher

“…In vitro, metabolic studies in 3T3-L1 adipocytes revealed MMP2 attenuated glucose uptake and glycolysis, which were recovered by an MMP2 inhibitor. In silico structural Analysis using AlphaFold identified a putative MMP2 cleavage site on the extracellular domain of GLUT4. …”
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Scalable Fabrication of Highly Organized, Horizontally Aligned Sub‐5 nm Silicon Nanowires via Chemical Vapor Etching by Juyeon Seo, Peiyun Feng, Jianlin Li, Sanghyun Hong, Sen Gao, Ji Young Byun, Yung Joon Jung

“…In time‐resolved structural analysis, it is revealed that rapid, aggressive etching is crucial for creating an inhomogeneous spatial distribution of vapor etchants, inducing surface defects acting as preferential sites for localized anisotropic silicon etching along <111> direction. …”
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SHOOTING MISTAKES IN BIATHLON AS A RESULT OF INCORRECT PRONE SHOOTING POSITION by M. Klechorov

“…The following methods are used to resolve the tasks of the research: analysis of the specialized literature on the topic of the research; content analysis of the shooting protocols; system and structure analysis; pedagogical observation; discussion with biathlon coaches. …”
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Synthesis, Molecular Structure, and Computational Studies of Dinuclear d⁰ Titanium(IV) Complex with P-P-Bonded Diphosphine Ligand by Tomoyuki Toda, Yuya Toma, Miku Nishiguchi, Katsuhiko Takenaka

“…The final structure of titanium complex <b>2</b> was determined by single-crystal X-ray structural analysis. The molecular structure of the complex was found to be a dinuclear d⁰-titanium complex coordinated to diphosphine on the same side, and the central titanium atoms were bridged to each other by chlorides. …”
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