Hidden diversity in anthropophilic sand flies of the Monticola Series (Diptera, Psychodidae) by Bruno Leite Rodrigues, Alessandra Gutierrez de Oliveira, Leonardo Estevam Honorato da Silva, Thiago Vasconcelos dos Santos, Lidiane de Nazaré Carvalho de Oliveira, Felipe Dutra Rêgo, Andrey José de Andrade, Glédson Bandeira Maia, Israel de Souza Pinto, José Dilermando Andrade Filho, Eunice Aparecida Bianchi Galati

“…Moreover, population structure analysis showed a strong correlation between Atlantic Forest areas of endemism as sources of molecular variation in Pi. monticola. …”
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Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation by Cefan Zhou, Xueying Dong, Shi Li, Yue Xi, Yuan Liu, Xuehong Qian, Ziyan Song, Li Zhou, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Weiyong Liu, Yan Xiong, Zhentian Wang, Chaojun Yan, Zijian Zhang, Haichuan Zhu, Xing-Zhen Chen, Zhiyin Song, Jingfeng Tang

“…We further showed that STYK1-mediated GSK3β sequestration is impaired by autophagy inhibitors or in ATG7 knockout cells, linking this process to autophagic regulation. Structural analysis identified conserved tyrosine-based (Y191QRL194) and dileucine-based (GDLL203-204) sorting motifs in STYK1, which facilitate clathrin/AP2-dependent internalization essential for GSK3β sequestration. …”
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Genotyping-by-sequencing derived SNP markers reveal genetic diversity and population structure of Dactylis glomerata germplasm by Muhammad Tanveer Altaf, Pablo Federico Cavagnaro, Kağan Kökten, Amjad Ali, Andres Morales, Andres Morales, Muhammed Tatar, Mehmet Bedir, Muhammad Azhar Nadeem, Muhammad Aasim, Nafiz Çeliktaş, Sheikh Mansoor, Faheem Shehzad Baloch, Faheem Shehzad Baloch

“…Notably, accessions from Erzurum exhibited the highest GD (mean GD: 0.26; He: 0.5328), while provinces such as Bursa and Muğla demonstrated lower GD (mean GD: 0.15; He < 0.22), suggesting potential genetic bottlenecks. Population structure analysis using Bayesian clustering, PCoA and UPGMA dendrograms divided the accessions into three distinct clusters, with cluster membership largely reflecting geographical origins, and dry biomass content. …”
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A Two-Dimensional Thiotitanate Ion Exchanger with High Cs⁺ Removal Performance by Chang Wei, Shaoqing Jia, Yingying Zhao, Jiating Liu, Haiyan Sun, Meiling Feng, Xiaoying Huang

“…Through a single-crystal X-ray structural analysis, we elucidated the mechanism of Cs⁺ capture, revealing the ion exchange pathways between Cs⁺ and Rb⁺ in Rb-TiS₂. …”
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A Comprehensive Analysis In Silico of <i>KCS</i> Genes in Maize Revealed Their Potential Role in Response to Abiotic Stress by Xinyi Chen, Aixia Zhang, Chenyan Liu, Muhammad Saeed, Junyi Li, Ying Wu, Yunhao Wu, Haijing Gu, Jinchao Yuan, Baohua Wang, Ping Li, Hui Fang

“…Collinearity analysis revealed 102 gene pairs between maize and three other monocots, whereas only five gene pairs were identified between maize and three dicots, underscoring the evolutionary divergence of <i>KCS</i> genes between monocotyledonous and dicotyledonous plants. Structural analysis revealed that 20 out of 29 <i>ZmKCS</i> genes are intronless. …”
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Investigating the temperature-dependent selectivity of CO2 reduction on Ru-cluster catalysts supported by MXene by Yueying Liu, Xiang Li, Yi Li, Rong Wei, Hongwei Tan, Xichen Li, Guangju Chen

“…In this study, the detailed reaction mechanism of CO2 reduction on composite Run@Mo2TiC2O2 catalysts was investigated theoretically, employing the four-atom Ru4 cluster as the model system. Electronic structure analysis revealed that the orbital interactions between the Ru4 cluster and CO2 play a pivotal role in determining the adsorption configuration of the CO2 molecule. …”
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Deciphering Chemical Rules for Drug Penetration into Strongyloides by Miguel Marín, Javier Sánchez-Montejo, Sergio Ramos, Antonio Muro, Julio López-Abán, Rafael Peláez

“…Unfortunately, the most potent dye, Methylene Blue, was unable to prevent the infection in a preliminary in vivo mouse model assay, presumably due to fast dye clearance. Structural analysis showed that positive charges facilitated the access of the compounds to the L3 tissue, thus providing a structural tool for the introduction of activity. …”
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Enhancing mechanical strength and reducing drying shrinkage in high-volume fly ash mortar: Synergistic effects of steel fibers and nano-SiO2 by Junliang Zhao, Jingjing Huang, Zhongkun Wang, Dongyan Wu, Gengying Li

“…The mechanisms by which steel fibers and nano-SiO2 influence high-volume fly ash mortar were discussed based on macroscopic tests and microscopic structural analysis. The results show that while nano-SiO2 and steel fibers had negligible effects on the fluidity of fly ash mortar, they significantly enhanced its mechanical properties. …”
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The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens by Xia Chen, Ming Kong, Chunxi Ma, Manyu Zhang, Zenglei Hu, Min Gu, Xiaoquan Wang, Ruyi Gao, Shunlin Hu, Yu Chen, Xiaowen Liu, Daxin Peng, Xiufan Liu, Jiao Hu

“…By analysing the polymorphism of this residue in various subtype viruses, we found that PA-X 100 was highly variable in H7N9 viruses. Structural analysis revealed that 100 V was generally close to the PA-X endonuclease active site, which may account for its host shutoff activity. …”
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PIK3R1 mutations in individuals with insulin resistance or growth retardation: Case series and in silico functional analysis by Tomofumi Takayoshi, Yushi Hirota, Aki Sugano, Kenji Sugawara, Takehito Takeuchi, Mika Ohta, Kai Yoshimura, Seiji Nishikage, Akane Yamamoto, Yu Mimura, Shinji Higuchi, Jun Mori, Rie Kawakita, Tohru Yorifuji, Yutaka Takaoka, Wataru Ogawa

“…Materials and Methods Gene sequencing was performed to identify PIK3R1 mutations. 3D structural analysis of wild‐type and mutant p85α proteins was performed by homology modeling, and structural optimization and molecular dynamics simulations confirmed stable trajectories. …”
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Comprehensive Structural, Chemical, and Optical Characterization of Cu₂ZnSnS₄ Films on Kapton Using the Automated Successive Ionic Layer Adsorption and Reacti... by Perla J. Vázquez-González, Martha L. Paniagua-Chávez, Lizette A. Zebadua-Chavarria, Rafael Mota-Grajales, C. A. Meza-Avendaño, Enrique Campos-González, A. Escobosa-Echavarría, Yaoqiao Hu, Aldo E. Pérez-Ramos, Manuel-Matuz, Carlos A. Hernández-Gutiérrez

“…The films exhibited p-type conductivity, as inferred from a valence band structure analysis. Density Functional Theory (DFT) calculations provided insights into the observed band gap variations, further substantiating the findings.…”
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Preliminary Study on the Genetic Structure and Functional Candidate Genes of Grassland-Thoroughbreds Based on Whole-Genome Resequencing by Wenqi Ding, Wendian Gong, Tugeqin Bou, Lin Shi, Yanan Lin, Xiaoyuan Shi, Zheng Li, Huize Wu, Manglai Dugarjaviin, Dongyi Bai, Yiping Zhao

“…Principal component analysis, population structure analysis, and phylogenetic tree results indicated that the CYs had a distinct genetic background from MGs, TBs, and XLs, but based on PCA and phylogenetic clustering, they showed greater genetic similarity to Thoroughbreds. …”
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Synthesis of Nanocrystalline Mn-Doped Bi₂Te₃ Thin Films via Magnetron Sputtering by Joshua Bibby, Angadjit Singh, Emily Heppell, Jack Bollard, Barat Achinuq, Sarah J. Haigh, Gerrit van der Laan, Thorsten Hesjedal

“…At an Mn concentration of ∼6.0%, a magnetic moment of (3.48 ± 0.25) <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi mathvariant="sans-serif">μ</mi><mi mathvariant="normal">B</mi></msub></semantics></math></inline-formula>/Mn was determined. Structural analysis indicated the presence of a secondary <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>MnTe</mi><mi>x</mi></msub></mrow></semantics></math></inline-formula> phase, which complicates the interpretation of the magnetic properties. …”
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Lupus nephritis and U1-RNP-antibodies are associated with low bone mineral density and osteoporosis in patients with systemic lupus erythematosus: baseline findings in a sub-cohort... by Edgar Wiebe, Elisa Celine Schilling, Dörte Huscher, Andriko Palmowski, Zhivana Boyadzhieva, Sandra Hermann, Burkhard Muche, Mirella Lopez Picazo, Gerhard Krönke, Falk Hiepe, Tobias Alexander, Frank Buttgereit

“…Our findings suggest that 3D bone structure analysis may be helpful in discriminating past vertebral fractures. …”
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Rapidly emerging SARS-CoV-2 B.1.1.7 sub-lineage in the United States of America with spike protein D178H and membrane protein V70L mutations by Lishuang Shen, Jennifer Dien Bard, Timothy J. Triche, Alexander R. Judkins, Jaclyn A. Biegel, Xiaowu Gai

“…Phylogenetic analysis and transmission inference with Nextstrain suggest this sub-lineage likely originated in either California or Washington. Structural analysis revealed that the S:D178H mutation is in the NTD of the S protein and close to two other signature mutations of B.1.1.7, HV69-70del and Y144del. …”
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Genetic structure, selective characterization and specific molecular identity cards of high-yielding Houdan chickens based on genome-wide SNP by Cong Liu, Pingquan Liu, Shuangxing Liu, Haishan Guo, Tingqi Zhu, Wenting Li, Kejun Wang, Xiangtao Kang, Guirong Sun

“…These findings suggest a need for appropriate strategies to enhance genetic diversity conservation in this breed. Population structure analysis demonstrated that GGF was genetically distinct from both the red jungle fowl (RJF) and Chinese indigenous chicken (CIC) populations, highlighting GGF as a unique genetic resource warranting intensive protection and utilization. …”
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Genome-Wide Identification and Expression Analysis of Hexokinase Gene Family Under Abiotic Stress in Tomato by Jing Li, Xiong Yao, Jianling Zhang, Maoyu Li, Qiaoli Xie, Yingwu Yang, Guoping Chen, Xianwei Zhang, Zongli Hu

“…In this study, six HXK genes were identified from the tomato genome distributed across six different chromosomes, named <i>SlHXK1-6</i>. Gene structure analysis showed that the <i>SlHXK</i> genes contain the same number of introns and exons. …”
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Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus by Peiwen Liu, Feng Liu, Hao-Ran Lu, Jinbao Gu, Xiaohong Zhou, Yang Wu, Zhen Zou, Xiang Guo, Wenqiang Yang, Shan Li, Ziyao Li, Xiao-Guang Chen

“…Comparative genomic analysis was performed to identify gene families related to detoxification, diapause, innate immunity, and sex determination. Gene structure analysis focused on the male-determining factor and its evolutionary relationships with other mosquito vectors. …”
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miRNA-34a-5p inhibits chicken myoblasts proliferation and differentiation via NOTCH1 inhibition by Xuanze Ling, Qifan Wang, Jin Zhang, Honghong Zhang, Liqi Zhang, Chuwen Zhuo, Tao Zhang, Genxi Zhang

“…Motif identification and gene structure analysis revealed that the NOTCH genes of H. sapiens, M. musculus, and G. gallus had similar gene structures, indicating that they may have similar biological functions. …”
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Current methods for detecting and assessing HIV-1 antibody resistance by Stanley Odidika, Stanley Odidika, Stanley Odidika, Martin Pirkl, Martin Pirkl, Thomas Lengauer, Thomas Lengauer, Thomas Lengauer, Philipp Schommers, Philipp Schommers, Philipp Schommers

“…In recent years, a variety of methods have been developed to detect, characterize and predict HIVAR. Structural analysis of antibody-HIV-1 Env complexes has provided insight into viral residues critical for neutralization, while testing of viruses for antibody susceptibility has verified the impact of some of these residues. …”
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