Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…Our findings reveal several significant advantages of this approach: Firstly, the incorporation of C3 transferase mRNA into MP-LNPs does not compromise the structural integrity of the nanoparticles, ensuring efficient mRNA expression within the spinal cord. …”
Get full text

Cost-efficient assignment panel for ducks. Setup of a cost-efficient assignment panel for duck populations.  by Chapuis, Hervé, Brard-Fudulea, Sophie, Hazard, Azélie, Vignal, Alain, Demars, Julie, Rouger, Romuald, Teissier, Marc, Gilbert, Hélène

“…This new design impacted the population structure, creating more sire x dam combinations, offering possibilities for a better estimation of non-additive genetic effects, which could prove relevant in the foie gras sector. …”
Get full text

Psychometric properties of the Arabic emotional and behavioral reaction to intrusions questionnaire among sample of Arabic speaking adults by Emmanuelle Awad, Diana Malaeb, Amthal Alhuwailah, Mai Helmy, Muna Barakat, Rabih Hallit, Sami El Khatib, Mohamad Rahal, Syed Arman Rabbani, Reem Alzayer, Nada H. Farrag, Rita El Hajjar, Jinan Mallouh, Souheil Hallit, Feten Fekih-Romdhane, Sahar Obeid, Rita ElHagar

“…A Confirmatory Factor Analysis (CFA) was conducted to examine the factor structure of the EBRIQ. Results A total of 755 participants completed the survey, with a mean age of 21.89 ± 4.18 years and 77.5% females. …”
Get full text

Salinity Tolerance of Artificially Restored Vegetation Under Different Irrigation Strategies in Arid, Abandoned Mining Areas by Aishajiang Aili, Yuguang Zhang, Tao Lin, Hailiang Xu, Abdul Waheed, Wanyu Zhao, Jia Wang, Chuhan Wang

“…<i>C. mongolicum</i>, however, displayed optimal vertical growth under border irrigation, although drip irrigation promoted a denser, more compact crown structure. Salinity tolerance varied by species, with 8 g/L salinity being optimal for all, while higher salinity levels (12 g/L and 16 g/L) reduced growth across species, underscoring the importance of salinity management in restoration efforts. …”
Get full text

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

“…Conclusions Our high-throughput IFC-based platform simplifies the process of identifying VUS pathogenicity through six assays and allows for the recognition of useful pathophysiological markers that structure follow-up experiments, thereby representing a novel valuable tool for precise functional diagnostics in genomics.…”
Get full text

Video Review Can Measure Surgical Robotic Skill Development in a Resident Robotic Hernia Curriculum: A Retrospective Cohort Study by Sarah B. Hays, MD, Amr I. Al Abbas, MD, Kristine Kuchta, MS, Aram Rojas, MD, Melissa Ramirez Barriga, BS, Syed Abbas Mehdi, MBBS, MPH, Stephen Haggerty, MD, H. Mason Hedberg, MD, John Linn, MD, Mark Talamonti, MD, Melissa E. Hogg, MD, MS

“…The drills were recorded and graded according to the modified objective structured assessment of technical skills (OSATS) and time to completion. …”
Get full text

MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference by Peishan Li, Peishan Li, Peishan Li, Lutao Gao, Lutao Gao, Lutao Gao, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lin Peng, Lin Peng, Lin Peng, Chunhui Bai, Chunhui Bai, Chunhui Bai, Linnan Yang, Linnan Yang, Linnan Yang

“…It consisted of three main components: (1) LLAVA data enhancement, which introduced a multimodal macromodel to improve the understanding of node attributes; (2) agricultural product association relationship fusion, which constructed and improved the complex association network structure among products to ensure that the system can better understand the substitution relationship, complementary relationship, and implied consumption logic among products; (3) user modal preference feature extraction block, which deeply mined the interaction data between consumers and products, and advanced the effective user feature information from the correspondence between global user representations and local modal user representations.Results and DiscussionWe conduct experiments on a real dataset from Amazon's large-scale e-commerce platform to verify the effectiveness of MP-LLAVRec. …”
Get full text

Repetitive Mild but Not Single Moderate Brain Trauma Is Associated with TAR DNA-Binding Protein 43 Mislocalization and Glial Activation in the Mouse Spinal Cord by Tamara Janković, Jelena Rajič Bumber, Nika Gržeta Krpan, Petra Dolenec, Marc Jaeger, Jasna Kriz, Gordana Župan, Kristina Pilipović

“…Initial brain trauma triggers secondary pathophysiological processes that induce structural and functional impairment of the central nervous system, even in the regions distant to the lesion site. …”
Get full text

Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…The results showed that protocatechuic acid improved growth performance and jejunal structure in Salmonella-infected chickens (P < 0.05). …”
Get full text

Effects of plant functional group removal on caterpillars (Gynaephora alpherakii) performance and plant production in an alpine meadow by Rui Cao, Han Chen, Jingran Cai, Chen Hang, Ziyu Zhang, Yingchun Miao, Peng Xie

“…Our findings suggest that forb removal disrupts trophic interactions, with potential cascading effects on herbivore populations, plant community structure, and ecosystem productivity. These results underscore the importance of plant functional diversity in maintaining ecosystem stability, especially under changing environmental conditions.…”
Get full text

Unburned habitat essential for amphibian breeding persistence following wildfire by Larissa L. Bailey, Richard Henderson, Wendy A. Estes-Zumpf, Charles C. Rhoades, Ellie Miller, Dominique Lujan, Erin Muths

“…Soil burn severity reflects fire impacts on soil and surface organic layers, including vegetation loss and changes in soil structure and function. We found that wood frog (Lithobates sylvaticus) breeding persistence following fires was negatively influenced by the percentage of their terrestrial habitat (100 m buffer surrounding breeding ponds) that was burned. …”
Get full text

Managerial thinking in neonatal care: a qualitative study of place of care decision-making for preterm babies born at 27–31 weeks gestation in England by Neena Modi, Elizabeth S Draper, Miaoqing Yang, Sarah E Seaton, Kelvin Dawson, Vasiliki Bountziouka, Oliver Rivero-Arias, Thillagavathie Pillay, Natalie Armstrong, Alexis Paton, Elaine Boyle, Victor L Banda, Caroline Cupit, Bradley Manktelow, Abdul Qader T Ismail

“…As part of a national project seeking to optimise service delivery for this group of babies (OPTI-PREM), we undertook qualitative research to better understand how decisions about place of birth and care are made and operationalised.Design Qualitative analysis of ethnographic observation data in neonatal units and semi-structured interviews with neonatal staff.Setting Six neonatal units across two neonatal networks in England. …”
Get full text

The development of a nurse-led preoperative anaesthesia screening tool by Delphi consensus by M B Nejthardt, P Alexandris, S Bechan, M F A Bijli, S Chetty, J M Dippenaar, M Gibbs, M Johnson, H Kluyts, R Llewellyn, M Motiang, P Mogane, P Motshabi, B Mrara, F Roodt, U Singh, S Spijkerman, E Turton, J van der Westhuizen, B Biccard

“…The final screening tool consisted of 81 questions, of which 37 were deemed critical to identify patients who should be seen by a specialist prior to the day of surgery. Conclusion. A structured nurse-administered preoperative screening tool is proposed to identify high-risk patients who are likely to benefit from a timely preoperative specialist anaesthetist review to avoid cancellation on the day of surgery. …”
Get full text

Evaluation of nitrous oxide reduction in solid carbon source-driven counter-diffusional biofilm denitrification system by Yingrui Liu, Feng Chen, Yanying He, Yufen Wang, Tingting Zhu, Yindong Tong, Yingxin Zhao, Bing-Jie Ni, Yiwen Liu

“…Solid carbon-driven biofilm system can provide sufficient carbon source for denitrification, while its counter-diffusional structure could inevitably induce the delayed carbon-nitrogen contact and electron transport, further affecting carbon footprints mainly contributed by nitrous oxide (N2O) at wastewater treatment plants (WWTPs). …”
Get full text

Effect of a bimetal Mn/Zn catalyst supported on activated carbon for selective oxidation of ethyl lactate to ethyl pyruvate by G. Madhanagopal, K. Premalatha, P.N. Poovizhi, V. Sumithra, S. Mahalingam, L. Guganathan, S. Sivakumar, A. Subramani, P. Tamizhdurai

“…This success is attributed to the well-designed structure incorporating zinc into the AC-supported manganese. …”
Get full text

Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats by Ahmed W. Al-Humadi, Carel W. le Roux, Neil G. Docherty, Werd Al-Najim, Martin Tze Wah Kueh, Andreas C. Lazaris, Charis Liapi

“…<b>Conclusions</b>: Ch deprivation affected kidney function and structure in STZ-induced diabetic rats. Choline deficiency and diabetes seem to have a synergistic effect, as evidenced by kidney biochemistry, histopathology, and immunohistochemistry. …”
Get full text

Cardiac Abnormalities in Acromegaly Patients: A Cardiac Magnetic Resonance Study by Xiaopeng Guo, Jian Cao, Peijun Liu, Yihan Cao, Xiao Li, Lu Gao, Zihao Wang, Ligang Fang, Zhengyu Jin, Yining Wang, Bing Xing

“…Age, body mass index (BMI), disease duration, and hypertension were associated with cardiac abnormalities (all p<0.05). In conclusion, structural and functional cardiac abnormalities can be comprehensively evaluated by CMR in acromegaly patients. …”
Get full text

NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion by Xudi Pang, Xuejun He, Ying Yang, Ling Wang, Yuzhen Sun, Huiming Cao, Yong Liang

“…The ablation experiments indicated that NeuTox 2.0 can learn the deeper structural differences of molecules from various feature extractions and capture complex interactions and mapping relationships between various modalities, thereby improving performance for neurotoxicity prediction. …”
Get full text

Anti-NMDAR-Positive Small-Cell Lung Cancer Paraneoplastic Limbic Encephalitis: A Case Report and Literature Review by Raman Sohal, Steven H. Adams, Vishal Phogat, Abha Harish, Carlos Ynigo D. Lopez, Michael P. A. Williams, Kamal K. Khurana, Basel Abuzuaiter, Nia Jagroop, Bhavya Narapureddy

“…Given that PLE can precede the diagnosis of cancer, it is very important that once infectious, metabolic, nutritional, or structural disorders associated with short-term memory loss are ruled out that vigorous effort must be made to rule out underlying malignancy. …”
Get full text

Experimental analysis of micro-cavity influence on the effective solar absorptance of white sand curtain on porous obstructions of particle heating receivers by Rageh Saeed, Shaker Alaqel, Eldwin Djajadiwinata, Nader S. Saleh, Abdulelah Alswaiyd, Hany Al-Ansary, Syed Noman Danish, Abdelrahman El-Leathy, Zeyad Al-Suhaibani, Sheldon Jeter, Redhwan Almuzaiqer, Zeyad Almutairi

“…Particle curtain ESA was scrutinized across various parameters, particle flow rate, and PHR structural geometry, represented by porous obstruction packing, perforation size, and arrangements. …”
Get full text