Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis... by P. S. Demenkov, E. A. Antropova, A. V. Adamovskaya, E. I. Mishchenko, T. M. Khlebodarova, T. V. Ivanisenko, N. V. Ivanisenko, A. S. Venzel, I. N. Lavrik, V. A. Ivanisenko

“…The criteria are based on indicators of the structural and functional organization of reconstructed gene networks of hepatocarcinoma, the extrinsic apoptosis pathway, and regulatory pathways of virus-extrinsic apoptosis pathway interaction and aberrant gene methylation-extrinsic apoptosis pathway interaction using ANDSystem. …”
Get full text

Petals morphology formation and pseudocapacitive properties of LiGa5O8 ceramics by Aditya Sharma, Manas Nasit, Nitin Kumar Gautam, Shalendra Kumar, Ranjeet Brajpuriya, B.H. Lee, S.O. Won, Mayora Varshney, Nishima Chaddha, H.J. Shin

“…X-ray diffraction (XRD) results confirmed the spinel structure stability up to 1300 ⁰C. Scanning electron microscopy (SEM) results convey petals-like morphology formation in the LiGa5O8 compounds. …”
Get full text

Metal-free production of natural blue colorants through anthocyanin–protein interactions by Wenxin Wang, Peiqing Yang, Fuqing Gao, Yongtao Wang, Zhenzhen Xu, Xiaojun Liao

“…Methods: Using human serum albumin (HSA) as a model protein, we investigated the structural influences of ACNs on their blue color generation using visible absorption spectroscopy, fluorescence quenching, and molecular simulations. …”
Get full text

Effect of the Floor Level on the Probability of a Neurologically Favorable Discharge after Cardiac Arrest according to the Event Location by Han Joo Choi, Hyung Jun Moon, Won Jung Jeong, Gi Woon Kim, Jae Hyug Woo, Kyoung Mi Lee, Hyuk Joong Choi, Yong Jin Park, Choung Ah Lee

“…The results suggest that the prognosis of an OHCA patient is more likely to be affected by the building structure and use rather than the floor height.…”
Get full text

Effect of Cu content on microstructure and high-temperature oxidation behaviors of AlCuxCoCrFeNi2.1 high-entropy alloys manufactured by laser directed energy deposition by Zhaoyang Liu, Jiawei Liu, Xiaokang Fan, Tao Zou, Zhongwei Liang

“…The results showed that the increase of Cu content facilitates the microstructure transformation from fine FCC/BCC lamellar eutectic structure to well-developed FCC columnar dendrites and depleted BCC interdendrites. …”
Get full text

3D bioprinting lobule-like hepatorganoids with induced vascularization for orthotopic implantation by Jianing Yan, Zhichao Ye, Yiwei Lu, Yuyang Yuan, Xiaofeng Wang, Tingting Yan, Jun Yin, Yifan Wang

“…In this research, we developed a 3D bioprinting method using gelatin methacryloyl (GelMA) hydrogel to fabricate lobule-like hepatorganoids, which faithfully mimic the structure of hepatic lobules with lower level of hypoxia (lobule vs 60°, 90°, control; 0.4880 vs 1.009, 0.6778, 0.8704; p < 0.01), high secretion of albumin (lobule vs 60°, 90°, control; 13.47 vs 12.39, 12.65, 10.08 mg/L; p < 0.01) and urea (lobule vs 60°, 90°, control; 5.304 vs 5.233, 4.781, 4.358 mg/L; p < 0.01) in vitro; and promotion of angiogenesis and maintenance of activity following orthotopic implantation. …”
Get full text

Microstructural modifications in bitumens rejuvenated by oil from pyrolysis of waste tires by Michela Alfe, Valentina Gargiulo, Giovanna Ruoppolo, Francesco Cammarota, Pietro Calandra, Cesare Oliviero Rossi, Valeria Loise, Michele Porto, Roberto Di Capua, Paolino Caputo

“…The blends were also investigated using atomic force microscopy, and the asphaltenic fraction was assessed via optical microscopy.Results and discussionAll the data consistently indicate that oil addition not only reduces the viscosity of bitumen and restores it to values close to the original unaged bitumen but also changes the intermolecular structure to recover the self-assembly pattern typical of the unaged sample. …”
Get full text

Reinvestigation into the role of lipopolysaccharide Glycosyltransferases in Helicobacter pylori protein glycosylation by Hong Li, Xiaoqiong Tang, Tiandi Yang, Tingting Liao, Aleksandra W. Debowski, Tiankuo Yang, Yalin Shen, Hans-Olof Nilsson, Stuart M. Haslam, Barbara Mulloy, Anne Dell, Keith A. Stubbs, Wolfgang Fischer, Rainer Haas, Hong Tang, Barry J. Marshall, Mohammed Benghezal

“…However, these proteins have not been purified for sugar-specific staining or structural analysis to confirm the existence of carbohydrate motifs. …”
Get full text

Deep application of controlled-release urea increases the yield and saponin content of Panax notoginseng by regulating soil nitrate distribution by Yun-xia Su, Yun-xia Su, Yun-xia Su, Ping Zhao, Li-jie Jia, Li-jie Jia, Li-jie Jia, Yuan-feng Cao, Guan-ze Liu, Guan-ze Liu, Jun-wen Chen, Jun-wen Chen, Sheng-chao Yang, Sheng-chao Yang, Yan-li Zhou, Guang-qiang Long, Guang-qiang Long, Guang-qiang Long

“…The distribution depth of soil NO3⁻-N and plant roots increased with the depth of CRU application, with a high overlap in time and space, indicating P. notoginseng N uptake peaked when CRU was applied at a depth of 6 cm (R6). Structural equation modeling indicated that soil NO3⁻-N supply in specific microareas directly affected the N uptake and increased total saponin content by increasing root length and surface area, thus boosting yield.ConclusionThis study identifies that the deep application of CRU at a depth of 6 cm has the potential to enhance both yield and quality of P. notoginseng and highlights that the spatial-temporal matching of soil NO₃⁻-N and plant roots was the key to applying CRU to ensure high yield and quality.…”
Get full text

Risk perceptions and changes in tobacco use in relation to Coronavirus Disease 2019 pandemic: A qualitative study on adolescent tobacco users in Hong Kong by Tianqi Chen, Lijun Wang, Yee Tak Derek Cheung, Man Ping Wang, Tai Hing Lam, Sai Yin Ho

“…Methods We conducted semi-structured telephone interviews from January to April 2021 and in February 2022 on 40 adolescents (63% boys, Secondary school grades 2–6) who participated in our previous smoking surveys and were using cigarettes, ECs or HTPs before the first wave of the COVID-19 pandemic in January 2020. …”
Get full text

The Role of Technical Car Features in Managing and Promoting New Peer-to-Peer Car-Sharing Systems: Insights from Potential Users and Strategic Implications for Service Providers by Katarzyna Turoń, Andrzej Kubik, Piotr Folęga, Andrzej Wilk, Peter Bindzar, Truong M. N. Bui

“…The analysis reveals that key factors influencing users’ decisions include fuel/energy consumption, safety features, and technological advancement, with a particular emphasis on driver assistance systems, including autonomous driving capabilities. The network structure, characterized by a relatively low density (0.2536) and a short average path length (1.872), suggests that a few central vehicle features dominate user decisions, and improvements in these key areas can quickly propagate through the decision-making process, enhancing overall user satisfaction. …”
Get full text

Simulation of Image-Guided Microwave Ablation Therapy Using a Digital Twin Computational Model by Frankangel Servin, Jarrod A. Collins, Jon S. Heiselman, Katherine C. Frederick-Dyer, Virginia B. Planz, Sunil K. Geevarghese, Daniel B. Brown, William R. Jarnagin, Michael I. Miga

“…Healthcare digital twins (DTs) are anatomically one-to-one biophysical models constructed from structural, functional, and biomarker-based imaging data to simulate patient-specific therapies and guide clinical decision-making. …”
Get full text

Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve by Julia Schwarz, Franziska Zistler, Adriana Usheva, Anika Fix, Sebastian Zinn, Juliana Zimmermann, Franziska Knolle, Franziska Knolle, Gerhard Schneider, Rachel Nuttall

“…Cortical gray matter (GM) volume, cortical thickness and brain age, extracted from structural T1 images, served as our measures of life-course related brain changes (BC). …”
Get full text

Relationships between environmental variables and free-living nematode communities in seasonally flooded wetlands by T.T. Tran, Y.M.T. Nguyen, L.T. Pham, B.K. Veettil, S.N. Hoang, Q.X. Ngo

“…This study aims to provide a new database of the nematode’s structure in the seasonally flooded wetland and its relation with environmental variables as well as detection of the ecological quality, considering nematodes as bioindicators. …”
Get full text

Antioxidant effect of Lactobacillus fermentum HFY02-fermented soy milk on D-galactose-induced aging mouse model by Tiantian Hu, Rui Chen, Yu Qian, Ke Ye, Xingyao Long, Kun-Young Park, Xin Zhao

“…Further more, the mRNA expression of GSH and SOD in mouse liver were obviously up-regulated by soybean milk fermented by LF-HFY02. The skin tissue structure of mice in the LF-HFY02 fermented soybean milk group was more complete, the collagen fibers were increased and arranged orderly and liver inflammation has improved compared with the model group. …”
Get full text

Synthesis of Mg-, Al- and Mg/Al-date palm fronds modified biochars: characterization and investigations on phosphorus adsorption characteristics by Jellali, Salah, Hadroug, Samar, Al-Wardy, Malik, Hamdi, Helmi,  Al-Sabahi, Jamal, Bekri, Imene, Al-Raeesi, Ahmed, Hamdi, Wissem,  Jeguirim, Mejdi

“…In this study, three biochars were synthesized at 500 °C from pre-impregnated date palm fronds (DPFs) with 1 M solutions containing either MgCl2 (DPF-Mg-B), AlCl3 (DPF-Al-B) or a combination of MgCl2/AlCl3 (DPF-Mg/Al-B). Subsequently, the structural, textural, and surface chemistry properties of these biochars were assessed. …”
Get full text

Knowledge, attitudes and practices regarding pulmonary rehabilitation among patients with chronic respiratory diseases: a cross-sectional questionnaire-based study in a tertiary ho... by Xueli Bai, Yuan Chen, Xiansheng Liu, Lingling Wang, Xiaohong Zhang, Jie Ding, Lin Su, Ruiying Wang, Shuang Wei

“…The secondary outcome assessed the association between demographic factors (age, gender, income, education, smoking status) and KAP scores using structural equation modelling (SEM).Results The mean KAP scores were 1.26±2.85 for knowledge, 30.46±3.63 for attitudes and 34.58±5.55 for practices. …”
Get full text

Shifts in the rhizosphere microbiome and exudation profile of avocado (Persea americana Mill.) during infection by Phytophthora cinnamomi and in presence of a biocontrol bacterial... by Frédérique Reverchon, Mariel García-Meléndez, Edgar Guevara-Avendaño, Oscar Mora-Chávez, Itzel A. Solís-García, Wesley Dáttilo, José A. Guererro-Analco, Alfonso Méndez-Bravo, Juan L. Monribot-Villanueva, Violeta Patiño-Conde, Fernando Pineda-García, Eria A. Rebollar

“…The dysbiosis (disturbance of the microbiome structure of healthy plants) caused by these pathogens, combined with the recruitment of beneficial microorganisms by the diseased plant, may cause shifts in the rhizosphere microbiome during the infection process. …”
Get full text

Cobalt (II) phthalocyanine derived Co3O4@HCNFs as highly effective bifunctional electrocatalysts for iodide redox couple reduction (IRR) and oxygen reduction reaction (ORR) by Ziyu Guo, Wenyu Gong, Jianing Guo, Mingxing Wu

“…Moreover, the specific hollow structure with opens at both ends is beneficial for mass diffusion to ensure sufficient contact between the electrolyte and the electrocatalysts, which is also a possible reason for the high catalytic activity of Co3O4@HCNFs. …”
Get full text

Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation by Hiroto Nakano, Sadao Hikishima, Makoto Mori, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, David B. Teplow, Kenjiro Ono

“…This research aimed to uncover the structural and functional characteristics of globular-shaped Aβ oligomers (gAβO) under in vitro conditions. …”
Get full text