Acute Respiratory Failure due to Neuromyelitis Optica Treated Successfully with Plasmapheresis by Massa Zantah, Timothy B. Coyle, Debapriya Datta

“…Acute respiratory failure from cervical myelitis due to NMO is known to occur but is uncommon in monophasic disease and is treated with high dose steroids. We report a case of a patient with NMO who developed acute respiratory failure related to cervical spinal cord involvement, refractory to pulse dose steroid therapy, which resolved with plasmapheresis.…”
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Adult-onset Still's disease: A great masquerader triggered by hepatitis A infection by Jhasaketan Meher, Keshao B Nagpure, Md Sabah Siddiqui, A M Vishnu Dev

“…She was managed with corticosteroids with dramatic response and continued to be in remission even after steroid withdrawal.…”
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Orbital Pseudotumor as an Extrahepatic Complication of Chronic HCV Infection by Owen Huang, Tina Shah, Divya Sundarapandiyan, Matthew J. Akiyama

“…The patient was diagnosed with orbital pseudotumor as an extrahepatic complication of chronic HCV infection, and he was managed with prednisone which dramatically decreased his eye swelling and pain. Steroid treatment may serve as a bridge to suppress symptoms of extrahepatic manifestations, especially in ocular cases, while HCV-infected patients await treatment to eradicate their HCV infection.…”
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Hypogammaglobulinemia in a Family with Crohn’s Disease by Robert Enns, Guido van Rosendaal

“…A 55-year-old woman presented with steroid refractory Crohn’s disease. In anticipation of surgical therapy, a protein electrophoresis was done and demonstrated low serum immunoglobulins. …”
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Recent Advances in the Recognition and Management of Eosinophilic Esophagitis by Gregory Eustace, Xianyong Gui, Marietta Iacucci

“…Dietary therapy, topical steroid therapy, proton pump inhibitors and endoscopic dilation are the main approaches to therapy; however, novel targeted therapies are being developed. …”
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A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease by Nilesh Chande, Terry Ponich, James Gregor

“…BACKGROUND: Methotrexate (MTX) is effective in remission induction and maintenance in steroid-dependent Crohn's disease (CD), but is often considered to be a second-line immunosuppressive agent, to be used in cases of failure or intolerance to azathioprine (AZA) or 6-mercaptopurine (6-MP). …”
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Leukocytapheresis in patients with inflammatory bowel diseases by Małgorzata Woźniak, Ilona Kurnatowska, Ewa Małecka-Panas, Renata Talar-Wojnarowska

“…Given that it has a favourable safety profile and seems to have steroid sparing effects, its position in the treatment of UC is likely to expand. …”
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NSAIDs in the Treatment of Adult Asthma: Sodium Cromoglycate and Nedocromil Sodium by Michel-Y Rouleau

“…These medications have a similar efficacy profile in asthma although it has been suggested that nedocromil is more powerful than cromoglycate, particularly in its steroid sparing effects. Both drugs have been recommended as alternatives to steroids in the treatment of mild asthma. …”
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Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy by Antonio Faieta, Tavis Dancik

“…A 65-year-old male patient with metastatic CCRCC developed steroid-dependent, grade 3 AIN secondary to nivolumab weeks after its initiation that resulted in 3 hospitalizations with acute renal failure. …”
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Malpractice and Avascular Necrosis: Legal Outcomes by Rose M Carter

“…Avascular necrosis has been established as a possible serious complication of steroid treatment in inflammatory bowel disease. Two specific Canadian cases illustrating the sequence of medical history, time, expert testimony and legal outcomes are presented. …”
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Mechanism of <italic>Hindu Datura</italic> in the Treatment of Rheumatoid Arthritis from the Perspective of Network Pharmacology by Changlong FU, Yangyang MEI, Xihai LI, Zhiwei QIU, Changxing CHEN, Chunsong ZHENG

“…Objective:To construct the active component target of <italic>Hindu datura</italic> and the disease target of rheumatoid arthritis by using network pharmacology, to predict the specific molecular signal and pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis, and to analyze its potential therapeutic target and molecular mechanism.Methods:All the chemical components of <italic>hindu datura</italic> were summarized and screened through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)database, retrieval was performed with the preset oral bioavailability(OB)≥30%and drug like(DL)≥0.18.Uniprot database was used to screen the entire correlation basis of the effective chemical compound.After screening the disease target with"rheumatoid arthritis"as the retrieval word using GeneCards and OMIM database, the superimposed target area between the drug target of <italic>hindu datura</italic> and the disease target of rheumatoid arthritis was summarized and analyzed, and it could be used as the prediction target gene of <italic>hindu datura</italic> for treating rheumatoid arthritis.Network targets were constructed and analyzed for the exported data based on Cytoscape 3.7.1 software and STRING 7.8 database.Finally, GO functional enrichment analysis and KEGG signal pathway analysis were performed to further screen the main targets and signal pathways.Results:①Through screening and analysis, 27 effective compounds, 318 corresponding target genes and 125 predicted target genes were obtained for the treatment of rheumatoid arthritis.②The core genes in PPI network mainly included JUN, AKT1, RELA, MAPK1, etc.③GO functional enrichment analysis showed that the biological process(BP)for the treatment of rheumatoid arthritis by <italic>hindu datura</italic> mainly involves response to lipopolysaccharide, response to lipopolysaccharide, response to molecule of bacterial origin, response to metalion, response to oxidative stress, response to steroid hormone, cellular response to oxidative stress, reactive oxygen species metabolic process, response to oxygen levels, etc..The cell component(CC)consisted of membrane raft, membrane region, plasma membrane raft and presynaptic membrane; molecular functions(MF)mainly involved the nuclear receptor activity, transcription factor activity(direct ligand regulated sequence-specific DNA binding), steroid hormone receptor activity, cytokine receptors, cytokine activity, DNA-binding transcription activator activity, RNA polymeraseⅡtranscription factor binding, kinase regulator activity, receptor ligand activity, etc.The analysis of KEGG signaling pathway showed that the obvious pathway of <italic>hindu datura</italic> in the treatment of rheumatoid arthritis may involve IL-17 signaling pathway, TNF signal pathway, HIF-1signalpathway, Toll-like receptor signal pathway, etc.Conclusion:The potential mechanism of <italic>hindu datura</italic> for the treatment of rheumatoid arthritis is to exert anti-inflammatory, analgesic and antioxidant effects, which involve a number of interactive signal pathways.…”
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Comparison of Concomitant Mesalamine and Immunomodulator Therapy and Immunomodulator Monotherapy for Crohn’s Disease by Min Seob Kwak, Kyung-Jo Kim, Jae Hee Cheon, Wan Soo Kim, Jeong-Mi Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang

“…The cumulative probabilities of steroid use at 5 and 10 years were 24.9% and 75.8% in the 5-ASA + AZA/6-MP group and 31.2% and 87.8% in the AZA/6-MP group, respectively (P=0.187). …”
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Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction by Ewa L. Gregoraszczuk, Anna Ptak

“…Most of the representatives of POPs influence the activation of transcription factors, not only activation of aromatic hydrocarbon receptor (AhR), but also the steroid hormone receptors. This minireview will focus on a variety of PAH activities in oocyte, ovary, placenta, and mammary gland. …”
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Chemical Neurolysis of the Inferior Hypogastric Plexus for the Treatment of Cancer-Related Pelvic and Perineal Pain by Sahar Abd-Elbaky Mohamed, Doaa Gomaa Ahmed, Mohamad Farouk Mohamad

“…The inferior hypogastric plexus block (performed using a trans-sacral approach under fluoroscopy and using a local anesthetics/steroid combination) for the diagnosis and treatment of chronic pain conditions involving the lower pelvic viscera was first described in 2007. …”
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Otosyphilis with Clinical and Serologic Responses with Weekly Intramuscular Penicillin: A Case Report and Literature Review by Ali Etemady-Deylamy, Getahun Abate

“…She initially received oral steroids and trans-tympanic steroid injections with transient improvement of symptoms. …”
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Pediatric progressive multifocal leucoencephalopathy presenting with neuroregression in a child with newly diagnosed HIV by Payal Keswaani, Shreya Chauhan, Praveen Kumar

“…The entity has been observed in immunocompromised conditions such as human immunodeficiency virus (HIV) infection, haematological malignancies, post-transplant patients and prolonged steroid use. Although it is very well described in HIV-infected adults, paediatric cases have rarely been reported in the available literature. …”
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Acquired Hemophilia A with a Rare Presentation of Acute Subdural Hematoma by Yoshihide Sehara, Yuka Hayashi, Jun Mimuro

“…Once the diagnosis of acquired hemophilia A (AHA) was made, steroid therapy was performed, which leads him to complete remission of AHA. …”
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Transient Hiccups Associated with Oral Dexamethasone by Mark E. Peacock

“…Although the association may be anecdotal, many clinicians consider hiccups a potential side effect of steroid therapy, especially high doses of steroids. …”
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Organizing Pneumonia Associated with Pegylated Interferon α and Ribavirin Therapy by Amit Chopra, Creticus Marak, Narendrakumar Alappan, Chang Shim

“…Patient has near complete recovery with withdrawal of pegylated interferon α and steroid therapy. We report this case to raise the awareness of this rare but potentially life-threatening pulmonary complication of pegylated interferon α therapy.…”
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Vancomycin-Induced DRESS Syndrome: An Important Concern in Orthopedic Surgery by Emma Littlehales, Odhrán Murray, Robert Dunsmuir

“…The criteria for diagnosis of DRESS, including the RegiSCAR scoring system and commonly affected systems (renal, cardiac, and hepatic), are detailed, and we also discuss evidence for steroid treatment and considerations important in the use of this.…”
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