The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions by C. Brizuela, George T.-J. Huang, A. Diogenes, T. Botero, M. Khoury

“…It will also provide overall information on the emerging technologies in biological and synthetic matrices, biomaterials, and signaling molecules, recent advances in stem cell therapy, and updated experimental results. This review brings useful and timely clinical evidence for practitioners to understand the challenges faced for a successful cell-based RET and the importance of preserving or reestablishing tooth vitality. …”
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Induced Pluripotent Stem Cells and Outer Retinal Disease by Jin Yang, Bingcui Cai, Patrick Glencer, Zhiqing Li, Xiaomin Zhang, Xiaorong Li

“…Having two eyes makes perfect natural control possible after a single eye receives gene or stem cell therapy. For this reason, research about exploring retinal diseases’ underlying molecular mechanisms and potential therapeutic approach using stem cell technique has been developing rapidly. …”
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The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus by Ju-El Kim, Jong-Won Lee, Gi Doo Cha, Jeong-Kee Yoon

“…Consequently, MSC-derived exosomes have attracted attention as a novel treatment for DM as an alternative to stem cell therapy. In this review, we will introduce the potential of MSC-derived exosomes for the treatment of DM by discussing the studies that have used MSC-derived exosomes to treat DM, which have shown therapeutic effects in both type 1 and type 2 DM.…”
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Intestinal organoids: The path towards clinical application by Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani

“…In this review, we outline the current state of translational research involving adult stem cell and pluripotent stem cell derived intestinal organoids, highlighting the advances and limitations in disease modeling, drug-screening, personalized medicine, and stem cell therapy. Preclinical studies have demonstrated a remarkable functional recapitulation of infectious and genetic diseases, and there is mounting evidence for the reliability of intestinal organoids as a patient-specific avatar. …”
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Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss by Mingliang Tang, Xiaoqian Yan, Qilin Tang, Rongrong Guo, Peng Da, Dan Li

“…This review intends to illustrate the current problems in stem cell-based treatment against deafness and to introduce electric field stimulation as a physical factor to regulate stem cell behavior and facilitate stem cell therapy to treat hearing loss in the future.…”
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Neural Induction, Neural Fate Stabilization, and Neural Stem Cells by Sally A. Moody, Hyun-Soo Je

“…The promise of stem cell therapy is expected to greatly benefit the treatment of neurodegenerative diseases. …”
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miRNAs in Extracellular Vesicles from iPS-Derived Cardiac Progenitor Cells Effectively Reduce Fibrosis and Promote Angiogenesis in Infarcted Heart by Wanling Xuan, Lei Wang, Meifeng Xu, Neal L. Weintraub, Muhammad Ashraf

“…Cardiac stem cell therapy offers the potential to ameliorate postinfarction remodeling and development of heart failure but requires optimization of cell-based approaches. …”
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MRI-guided focused ultrasound for treating Parkinson’s disease with human mesenchymal stem cells by Sheng-Kai Wu, Chia-Lin Tsai, Aisha Mir, Kullervo Hynynen

“…In the quantification analysis of the TH stain, a significant reservation of dopamine neurons was seen in the MSCs + FUS group as compared with the MSCs group (ST: p = 0.03; SN: p = 0.0005). Mesenchymal stem cell therapy may be a viable treatment option for neurodegenerative diseases such as Parkinson’s. …”
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Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration by Adegbenro Omotuyi John Fakoya, David Adeiza Otohinoyi, Joshua Yusuf

“…Regenerative therapeutic techniques now appear to be a potential approach to solve this conundrum posed by these poorly self-regenerating tissues. Stem cell therapy alone appears not to be sufficient to provide the desired tissue regeneration and hence the drive for biomaterials that can support its transplantation and translation, providing not only physical support to seeded cells but also chemical and physiological cues to the cells to facilitate tissue regeneration. …”
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Parental perception of treatment options for mucopolysaccharidosis: a survey to bridge the gap for personalized medicine by Anna-Maria Wiesinger, Florian B. Lagler

“…Results Most likely parents would choose an approach to repurposed treatments for their child (neuronopathic: 82%, 14/17 and non-neuronopathic: 94%, 16/17), followed by enzyme replacement therapy (ERT, both 88%, 15/17), hematopoietic stem cell therapy (HSCT, 70%, 12/17 and 76%, 13/17), and finally gene therapy (GT, 58%, 10/17 and 53%, 9/17). …”
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Adipose-Derived Stem Cells Are an Efficient Treatment for Fistula-in-ano of Japanese Rabbit by Xiao Qin, Peng Wang, Yongming Huang, Yansen Li, Min Chao, Wei Wang

“…Taken together, our findings demonstrate that ADSCs rapidly promote fistula healing through differentiation, a promising stem cell therapy for FIA. The rabbit is an effective animal model for evaluating FIA therapeutic options.…”
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Therapeutic potential of SOX family transcription factors in osteoarthritis by Yue Huang, Zhuo Wang

“…Non-coding RNA may play a role in the onset and progression of osteoarthritis by modulating various SOX family members, including SOX2, SOX4, SOX5, SOX6, SOX8, SOX9 and SOX11.Conclusion SOX9 has the capability of mitigating the onset and progression of osteoarthritis through means such as medication therapy, stem cell therapy, recombinant adeno-associated virus (rAAV) vector therapy, physical therapy and other approaches.…”
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Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects by Long Chen, Lang Li, Fei Xing, Jing Peng, Kun Peng, Yuanzheng Wang, Zhou Xiang

“…Stem cell therapy is considered an optimistic approach to replace current treatments for cartilage defects. …”
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Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation by Nathalia Silva Dutra Alves, Gustavo Roncoli Reigado, Mayara Santos, Izabela Daniel Sardinha Caldeira, Henrique dos Santos Hernandes, Bruna Leticia Freitas-Marchi, Elina Zhivov, Felipe Santiago Chambergo, Viviane Abreu Nunes

“…This review examines core technologies including stem cell therapy, bioengineered skin substitutes, platelet-rich plasma (PRP), exosome-based therapies, and gene editing techniques like CRISPR. …”
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Engineering extracellular vesicles for ROS scavenging and tissue regeneration by Ahmed Abdal Dayem, Ellie Yan, Minjae Do, Yoojung Kim, Yeongseo Lee, Ssang-Goo Cho, Deok-Ho Kim

“…Abstract Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. …”
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Administration of Melatonin in Diabetic Retinopathy Is Effective and Improves the Efficacy of Mesenchymal Stem Cell Treatment by Samraa H. Abdel-Kawi, Khalid S. Hashem

“…Stem cell transplantation is a promising therapeutic technique for the treatment of a variety of diseases; nevertheless, stem cell therapy may not always work as well as it could. …”
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Stem Cell-Based Therapeutic Approaches to Restore Sensorineural Hearing Loss in Mammals by Muhammad Waqas, Iram Us-Salam, Zainab Bibi, Yunfeng Wang, He Li, Zhongshou Zhu, Shuangba He

“…Therefore, much attention has been paid on developing regenerative therapies to regenerate/replace the lost hair cells to treat the damaged cochlear sensory epithelium. The stem cell therapy is a promising approach to develop the functional hair cells and neuronal cells from endogenous and exogenous stem cell pool to recover hearing loss. …”
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The effect of Klotho protein complexed with nanomaterials on bone mesenchymal stem cell performance in the treatment of diabetic ischaemic ulcer by Rui Tang, Gang Zhao, Yuqiao Wang, Ruixue Zhang

“…The most important aspects of stem cell therapy are improving the microenvironment, cell homing and continuous factor stimulation. …”
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Injectable Tumoricidal Neural Stem Cell-Laden Hydrogel for Treatment of Glioblastoma Multiforme—An In Vivo Safety, Persistence, and Efficacy Study by Jasmine L. King, Alain Valdivia, Shawn D. Hingtgen, S. Rahima Benhabbour

“…Tumoricidal neural stem cells were encapsulated in the injectable CS hydrogel as stem cell therapy for treatment of post-surgical GBM. In this report, we investigated the safety of the injectable CS hydrogel in an immune-competent mouse model. …”
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Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions by Diana Marian, Giuseppe Toro, Giovanbattista D’Amico, Maria Consiglia Trotta, Michele D’Amico, Alexandru Petre, Ioana Lile, Anca Hermenean, Anca Fratila

“…It examines traditional techniques like guided bone regeneration and bone grafting, alongside newer methods such as stem cell therapy, gene therapy, and 3D bioprinting. Each approach is considered for its strengths in supporting bone growth and integration, especially in cases where complex bone defects make regeneration difficult. …”
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