Association of clinical knowledge with patient care ownership among resident physicians: a nationwide cross-sectional study in Japan by Hirohisa Fujikawa, Hidetaka Tamune, Yuji Nishizaki, Taro Shimizu, Yu Yamamoto, Kiyoshi Shikino, Miwa Sekine, Hiroyuki Kobayashi, Yasuharu Tokuda

“…Results We included 1836 participants in our statistical analysis. Multivariable linear regression analysis revealed that after adjustment for possible confounders, GM-ITE total scores showed a significantly negative association with PCO in the highest score quartile (adjusted mean difference − 0.20, 95% confidence interval (CI) -0.33 to -0.07, compared with the lowest score quartile). …”
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Mental health service satisfaction among adults with mental illness attending a psychiatric outpatient clinic: a cross-sectional study by Wondale Getinet Alemu, Wondale Getinet Alemu, Lillian Mwanri, Clemence Due, Telake Azale, Anna Ziersch

“…To examine the association of sociodemographic, clinical, social support, and substance use factors, bivariate and multivariate logistic regression analyses were applied. Statistical significance was declared at a p-value of <0.05 and 95% CI.ResultsThe rate of low mental health service satisfaction among people with mental illness in this study was 24.7%. …”
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Clinical Utility of an Alzheimer’s Disease Blood Test Among Cognitively Impaired Patients: Results from the Quality Improvement PrecivityAD2 (QUIP II) Clinician Survey Study by Mark Monane, Demetrius M. Maraganore, Robert M. Carlile, Kim G. Johnson, David A. Merrill, Darren R. Gitelman, Kenneth S. Sharlin, Lawren A. VandeVrede, Kristi K. George, Jimin Wang, Tim West, Leslie Jacobs, Philip B. Verghese, Joel B. Braunstein

“…Louis, MO) combines the plasma Aβ42/Aβ40 ratio and the p-tau217/np-tau217 ratio (%p-tau217) measurements in a statistical algorithm to yield an Amyloid Probability Score 2 (APS2) that informs on the likelihood of brain amyloid plaques. …”
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Improvement of soil quality through biochar in rice under wastewater irrigated soil: Effects on heavy metals reduction by Sayon Mukherjee, Satish Kumar Singh, Raimundo Jiménez Ballesta, Abhik Patra, Surendra Singh Jatav

“…Research Highlights • Biochar and its subsequent modification reduce the heavy metals content in different plant parts of rice • Application of H3PO4 modified biochar at 10 t ha-1 has declined the root concentration of Cr alone by 24.5% • FeCl3 modified biochar also reduced all heavy metals uptake in different plant parts • Performance of modified biochar at lower rates can produce statistically similar results with the higher dose of simple biochar • Reduction of translocation coefficient and translocation factor within plant emphasizes the beneficial effect of biochar application to crop …”
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Leveraging Autofluorescence for Tumor Detection, Diagnosis, and Accurate Excision with Surgical Margin Assessment in Tumor Excision by Antonis Perdiou, Ramona Dumitrescu, Daniela Jumanca, Octavia Balean, Ruxandra Sava-Rosianu, Serban Talpos, Dacian Virgil Lalescu, Atena Galuscan

“…Histopathological analysis was the gold standard for margin evaluation, with margins coded as tumor-free margins (0), close (1), or infiltrated (2). <b>Results:</b> Statistically significant differences were observed in tumor-free margins between the control (73.17%) and experimental (97%) groups (<i>p</i> = 0.003). …”
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A combined wavelet analysis-quantile mapping (WA-QM) method for bias correction: capturing the intra-annual temporal patterns in climate model precipitation simulations and project... by Xia Wu, Zhu Liu, Qingyun Duan

“…Compared to the standalone QM approach, WA-QM showed greater accuracy in monthly statistical metrics. In the CA region, WA-SDM reduced the monthly root mean square error of the mean by 25.2%, the standard deviation by 17.6%, and the 90th percentile by 26.7% compared to SDM. …”
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Effectiveness of flipped classrooms in Chinese students of clinical medicine major undergoing clinical practice: a meta-analysis by Xinrui Sun, Xin Yuan, Linyu Zhang, Yi Zhang, Xue Xiao, Hanmin Liu, Fang Ma

“…The Cochran Q test and the I2 statistic were used for heterogeneity analysis. The funnel plots were used to assess the publication bias. …”
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COVID-19 Pandemic Experiences in Pediatric Intensive Care Unit: An Iranian Referral Hospital-Based Study by Masoud Mohammadpour, Seyed Abbas Hassani, Meisam Sharifzadeh, Leila Tahernia, Setareh Mamishi, Bahareh Yaghmaie, Zeinab Najafi, Farzaneh Beirami, Mehrnoush Afsharipour, Maryam Minuyeefar, Mina Dolatzadeh, Neda Pak, Anahita Majmaa, Zahra Zamani, Shima Mahmoudi

“…In total, 99 patients were admitted to COVID PICU, 42.4% (42 patients) were males, and 66 patients had positive SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR). There was no statistically significant difference in the frequency of clinical signs and symptoms (except for fever) among patients with positive SARS-CoV-2 RT-PCR and negative ones. …”
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The Effect of Platelet and Mean Platelet Volume Levels on Standard-dose Methylprednisolone Treatment Response in Primary Immune Thrombocytopenia by Emrah KILICASLAN, Murat YILDIRIM, Selim SAYIN, Erdem CEVIK, Meltem AYLI, Muhammet Kursat KAPTAN

“…The mean platelet volume (MPV) levels of the NR group were statistically lower than that of the CR group (p=0.018). …”
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Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials by Sathish Muthu, Sathish Muthu, Sathish Muthu, Vibhu Krishnan Viswanathan, Vibhu Krishnan Viswanathan, Prakash Gangadaran, Prakash Gangadaran, Prakash Gangadaran

“…Diverse post-intervention pain scores [visual analog score (VAS)] and functional scores [Oswestry Disability Index (ODI), SF-36], as reported in the reviewed studies, were evaluated. Statistical analysis was performed using STATA 17 software. 5 RCTs including 310 patients (PRP/Steroids = 153/157) were included in the analysis. …”
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Distinct effects of fine and coarse aerosols on microphysical processes of shallow-precipitation systems in summer over southern China by F. Chen, F. Chen, Y. Yang, L. Yu, Y. Li, W. Liu, Y. Liu, Y. Liu, S. Lolli

“…Using 8 years of data from Dual-frequency Precipitation Radar measurements, aerosol reanalysis, and atmospheric reanalysis, this study investigates the potential influence of coarse and fine aerosol particles on the structure of the precipitation and the microphysical processes of shallow precipitation in southern China. Statistical results indicate that during coarse-aerosol-polluted conditions, shallow-precipitation clouds have a lower mean height of the storm top (STH; <span class="inline-formula">∼3.2</span> km) but a higher mean near-surface rain rate (RR; <span class="inline-formula">∼1.78</span> <span class="inline-formula">mm h⁻¹</span>) and are characterized by high concentrations of large raindrops, driven mainly by significant collision–coalescence processes (accounting for 74.1 %). …”
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Biochemical failure-free survival of 18F-rhPSMA-7 and 18F-flotufolastat PET-guided salvage radiotherapy for patients with recurrent prostate cancer by Marco M. E. Vogel, Isabel Rauscher, Jürgen E. Gschwend, Türkay Hekimsoy, Nicola Gabler, Charlotte Olufs, Calogero D’Alessandria, Jan C. Peeken, Stephanie E. Combs, Matthias Eiber

“…%bFS was greater for PSMA-PET-guided SRT than C-SRT at all evaluated timepoints. 18F-rhPSMA-7/18F-flotufolastat-guided SRT yielded favorable disease outcomes. Although statistical significance was not reached, likely due to the limited sample size in this preliminary analysis, our data illustrate potential for 18F-flotufolastat-PET-guided SRT.…”
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Key Decision‐Making in Post‐Failed Internal Fixation of Intertrochanteric Fractures Hip Arthroplasty: A Multicenter Retrospective Study on Fracture Healing's Impact on Femoral Comp... by Jiexin Huang, Jiagu Huang, Haiqi Ding, Jianhua Lyu, Changyu Huang, Yang Chen, Qijin Wang, Hongyan Li, Baijian Wu, Ying Huang, Minghui Yang, Xinyu Fang, Wenming Zhang

“…A subgroup analysis was conducted to further evaluate the influence of the proximal medial buttress and greater trochanteric healing on femoral stem selection. Statistical analysis included binary and ordinal logistic regression to identify factors influencing the choice of femoral stems. …”
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Prevalence of sudden unexpected death of infants and its subcategories in low- or middle-income countries: a systematic review protocol by Liesl Zühlke, David Coetzee, Mark Engel, Natasha R Rhoda, Eunice Turawa, Imen Ayouni, Shanaaz Mathews

“…Where possible, data on prevalence, incidence and subcategories will be pooled using a random effects meta-analysis to account for variability between estimates. The I2 statistic will establish the level of heterogeneity due to variation in estimates rather than chance. …”
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Comparison of prophylactic topical application of Cryptomphalus aspersa secretion versus betamethasone for telecobalt radiation-induced skin reactions in locally advanced head and... by Ramashish Kumar, Ashok Chauhan, Sovan Sarang Dhar, Nitish Kumar

“…The difference in the development of skin reactions observed was statistically significant at 6th week, at completion of treatment as well as at the 1st month of follow-up (grade-1) between the two groups (P<0.001). …”
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Insights into the contribution of multiple factors on Ixodes ricinus abundance across Europe spanning 20 years using different machine learning algorithms by Samantha Lansdell, Abin Zorto, Misaki Seto, Edessa Negera, Saeed Sharif, Sally Cutler

“…To assess which ML model was most suited to prediction of I. ricinus abundance, four performance metric values were calculated per model: Normalised Root Mean Square Error (NRMSE), Scatter Index (SI), Mean Absolute Percentage Error (MAPE) and R2, all of which describe the statistical relationship between predicted and actual I. ricinus abundance values. …”
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Aluminium adjuvants versus placebo or no intervention in vaccine randomised clinical trials: a systematic review with meta-analysis and Trial Sequential Analysis by Christian Gluud, Marija Barbateskovic, Sara Russo Krauss, Janus C Jakobsen, Sesilje Bondo Petersen, Sarah Louise Klingenberg, Snezana Djurisic, Mette Kenfelt, De Zhao Kong

“…Heterogeneity was quantified with I2 statistic. We GRADE assessed the certainty of the evidence.Results We included 102 randomised clinical trials (26 457 participants). …”
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Effects of Clinicopathological Characteristics on the Survival of Patients Treated with PD-1/PD-L1 Inhibitor Monotherapy or Combination Therapy for Advanced Cancer: A Systemic Revi... by Yuhan Wei, Yongfu Li, Qi Du, Xinyi Peng, Jiangtao Jin, Hong Guo, Yongyan Li, Qin Li

“…EGFR wild-type patients could benefit from immunotherapy monotherapy (HR, 0.77; P<0.001) while those of the mutant type had no survival benefit (HR, 1.11; P=0.54), and the difference was statistically significant (interaction, P=0.005). KRAS wild-type patients had no survival benefit from monotherapy (HR, 0.89; P=0.49). …”
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Feasibility pilot of a novel coaching intervention to optimize cannabis use for chronic pain management among Veterans by Kevin F. Boehnke, Gabrielle Bowyer, Jenna McAfee, Tristin Smith, Catherine Klida, Vivian Kurtz, Evangelos Litinas, Poonam Purohit, Anne Arewasikporn, Dana Horowitz, Laura Thomas, Jennifer Eckersley, Mia Railing, David A. Williams, Daniel J. Clauw, Kelley M. Kidwell, Amy S. B. Bohnert, Rachel S. Bergmans

“…Participants reported statistically significant decreased pain intensity (7.1/10 vs. 5.7/10) and pain interference (T-score 66.3 vs. 61.8), and increased social satisfaction (T-score 41.4 vs. 44.3). …”
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Effects of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis by Feng Sun, Sanbao Chai, Lishi Li, Kai Yu, Zhirong Yang, Shanshan Wu, Yuan Zhang, Linong Ji, Siyan Zhan

“…Reductions of weight treated with liraglutide—1.8 mg once daily (LIR1.8QD) reach statistical significance (−1.43 kg (95% CI: −2.73, −0.15)) versus LIR1.2QD and (−0.98 kg (95% CI: −1.94, −0.02)) versus placebo. …”
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