Pharmacological class effects of anticancer drugs: opportunities for decreasing healthcare spending by Gregory R Pond, Ian F Tannock, Daniel A Goldstein, Leonard B Saltz

“…In the field of general medicine, class effects, or therapeutic interchangeability, have been declared for several families of drugs including statins, calcium channel blockers and ACE inhibitors. …”
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Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis by Jie Wang, Kaijie Qiu, Songsheng Zhou, Yichao Gan, Keting Jiang, Donghuan Wang, Haibiao Wang

“…Certain drugs like aspirin, statins, GLP-1 RAs, and metformin may reduce HCC occurrence, but further research is needed to confirm these effects.…”
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Comprehensive review of myocardial injury after noncardiac surgery: prevention, intervention, and long-term management strategies by Moiud Mohyeldin, Sarah J. Norman, Ayzia Carney, Courtney Odza

“…We discuss the role of aspirin, statins, anticoagulation, and Dual Antiplatelet Therapy (DAPT) within the context of MINS, drawing on evidence from notable clinical trials as well as observational studies. …”
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Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination by Marta Rodrigues de Carvalho, Myrian Mathildes Sá de Deus Rocha, Vinícius Alves Bezerra, Maciel Eduardo de Pontes, Maria Cristina del Negro, Julio Salgado Antunes, Vinícius Viana Abreu Montanaro, Rubens Nelson Morato Fernandez

“…The diagnosis of probable post-vaccination IMNM was made due to the absence of other factors that may have led to the development of autoantibodies (medicines; e.g., statins, drugs) and the temporal relationship between exposure and event. …”
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Survey of medication history of patients with stroke after discharge from an acute hospital ward: a case series study by Yuko Fukuda, Risa Ito, Misaki Kakihana, Tsutomu Takahashi, Tetsuji Kanemoto, Toshiyuki Sahara, Masahiko Tsujikawa, Mitsuko Onda

“…Furthermore, discrepancies in medication discontinuation or reduction recommended by a stroke specialist, which may increase the risk of stroke recurrence, were identified in five patients (seven drugs: four antiplatelet drugs and three statins). Of 13 discrepancies, community pharmacists inquired about 3 cases with physicians, none were approved. …”
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Atorvastatin Improves Inflammatory Response in Atherosclerosis by Upregulating the Expression of GARP by Xiaoqi Zhao, Yuzhou Liu, Yucheng Zhong, Bo Liu, Kunwu Yu, Huairui Shi, Ruirui Zhu, Kai Meng, Wei Zhang, Bangwei Wu, Qiutang Zeng

“…The antiatherosclerosis effects of statins partly depend on their multiple immune modulatory potencies. …”
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Vasospasm in Cerebral Inflammation by Michael Eisenhut

“…Therapeutic trials in vasospasm related to inflammation in subarachnoid haemorrhage in humans showed a reduction of vasospasm through calcium antagonists, endothelin receptor antagonists, statins, and plasminogen activators. Combination of therapeutic modalities addressing calcium dependent and independent vasospasm, the underlying inflammation, and depletion of nitric oxide simultaneously merit further study in all conditions with cerebral inflammation in double blind randomised placebo controlled trials. …”
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The Chylomicron: Relationship to Atherosclerosis by Gerald H. Tomkin, Daphne Owens

“…The ratio of dietary to synthesised cholesterol is variable but tightly regulated: hence intervention with diet at best reduces serum cholesterol by <20% andusually <10%. Statins are the mainstay of cholesterol reduction therapy, but they increase cholesterol absorption, an example of the relationship between synthesis and absorption. …”
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Stroke Prevention: Managing Modifiable Risk Factors by Silvia Di Legge, Giacomo Koch, Marina Diomedi, Paolo Stanzione, Fabrizio Sallustio

“…The use of antiplatelets and statins has been shown to reduce the risk of recurrent stroke and other vascular events. …”
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Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy by Zhuangzhuang Zhang, Jianwen Deng, Weiping Sun, Zhaoxia Wang

“…Results Germline and somatic mutations mediate the onset and development of CCM through several molecular pathways. Medications such as statins, fasudil, rapamycin, and propranolol can alleviate CCM symptoms or hinder its progression by specifically modulating the corresponding targets. …”
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Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease by Helen C. Steel, Riana Cockeran, Ronald Anderson, Charles Feldman

“…This is focused on macrolides, corticosteroids, and statins with respect to their modes of anti-inflammatory action, current status, and limitations.…”
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The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination by Graham Skelhorne-Gross, Christopher J. B. Nicol

“…In spite of this, several groups reported exciting results with therapeutic regimens that combine PPARγ ligands with other compounds: chemotherapeutic agents, retinoid x receptor (RXR)α agonists, statins, or cell-to-cell signaling molecules in preclinical cancer models and human trials. …”
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Drugs Involved in Dyslipidemia and Obesity Treatment: Focus on Adipose Tissue by Sofia Dias, Sílvia Paredes, Laura Ribeiro

“…We revised the effects, and underlying mechanisms, of the current approved drugs for dyslipidemia and obesity (fibrates, statins, niacin, resins, ezetimibe, and orlistat; sibutramine; and diethylpropion, phentermine/topiramate, bupropion and naltrexone, and liraglutide) on adipose tissue. …”
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Telomere Biology: Key to unlocking the fountain of youth…A Systematic Review. by Anirban Poddar, Anup Kumar Rana, Ranjita Santra, Phalguni Chakrabarti

“…As the role of telomere biology is well established in ageing,current research therefore aims to develop means to reduce telomere attrition,thereby reducing ageing & age related diseases.This review will focus on summarising the role of telomere biology in ageing & age related diseases while highlighting the recent advances in research aiming towards enhanced longevity & healthy ageing.This review will further emphasize on telomere targetted therapeutics such as telomerase activators & tankyrase inhibitors while also highlighting the role of antioxidative & antiinflammatory agents alongwith indirectly related approaches such as statins.…”
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Anti-Hyperlipidemic Effect of Zinc complex of Betulinic acid in High Fat Diet- Induced Hyperlipidemia by Mehwish Tayyab, Adnan Jehangir, Farhana Ayub, Nimra Ijaz, Sameer Ahmed`, Attiya Munir

“…Drugs of first choice, Statins, despite being well tolerable, are accompanied by many adverse effects. …”
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Current Controversies in the Prediction, Diagnosis, and Management of Cerebral Vasospasm: Where Do We Stand? by Young Lee, Scott L. Zuckerman, J. Mocco

“…Finally, the recent literature regarding interventions for the prophylaxis and treatment of vasospasm, including hyperdynamic therapy, albumin, calcium channel agonists, statins, magnesium sulfate, and endothelin antagonists is summarized. …”
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Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future by S. Gitto, G. Vitale, E. Villa, P. Andreone

“…Other drugs have been studied such as metformin, ursodeoxycholic acid, statins, pentoxiphylline, and orlistat with only partially positive results. …”
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The Story of CD4+CD28− T Cells Revisited: Solved or Still Ongoing? by Kathrin Maly, Michael Schirmer

“…So far it has been shown that treatment with TNF-α blockers, abatacept, statins, and polyclonal antilymphocyte globulins (ATG) mediates reduction of the CD4+CD28− T cell level. …”
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Atorvastatin-Diltiazem Combination Induced Rhabdomyolysis Leading to Diagnosis of Hypothyroidism by N. D. B. Ehelepola, S. M. B. Y. Sathkumara, H. M. P. A. G. S. Bandara, K. L. R. Kalupahana

“…Statins and hypothyroidism, independently, can rarely cause rhabdomyolysis. …”
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Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function by Luis Miguel Román-Pintos, Geannyne Villegas-Rivera, Adolfo Daniel Rodríguez-Carrizalez, Alejandra Guillermina Miranda-Díaz, Ernesto Germán Cardona-Muñoz

“…Treatment should be directed to improve etiologic factors besides reducing symptoms; several approaches have been evaluated to reduce neuropathic impairments and improve nerve conduction, such as oral antidiabetics, statins, and antioxidants (alpha-lipoic acid, ubiquinone, and flavonoids).…”
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