Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy by Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen

“…Female subjects underwent fewer revascularization procedures (23.5% versus 42.3%; P=0.014), less coronary artery bypass graft surgery (2.9% versus 13.1%; P=0.025) and were less likely to be on statin treatment (72.0% versus 84.7%; P=0.022) by 9‐month follow‐up. …”
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Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis by Aldo Bonaventura, François Mach, Aline Roth, Sébastien Lenglet, Fabienne Burger, Karim J. Brandt, Aldo Pende, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Franco Dallegri, Michele Cea, Nicolas Vuilleumier, Fabrizio Montecucco, Federico Carbone

“…This risk of MACEs increased independently of age, male gender, serum CRP, and statin use. In conclusion, in patients with severe carotid artery stenosis, high CRP levels within upstream portions of carotid plaques directly and positively correlate with intraplaque inflammatory cells and predict MACEs at an 18-month follow-up period.…”
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Effectiveness of Electronic Quality Improvement Activities to Reduce Cardiovascular Disease Risk in People With Chronic Kidney Disease in General Practice: Cluster Randomized Trial... by Jo-Anne Manski-Nankervis, Barbara Hunter, Natalie Lumsden, Adrian Laughlin, Rita McMorrow, Douglas Boyle, Patty Chondros, Shilpanjali Jesudason, Jan Radford, Megan Prictor, Jon Emery, Paul Amores, An Tran-Duy, Craig Nelson

“…Of the 470 intervention patients and 425 control patients that received a recommendation for statins, 61 (13%) and 38 (9%) were prescribed statins at follow-up (Diff 4.3%, 95% CI 0 to 8.6%; odds ratio 1.55, 95% CI 1.02 to 2.35; P=.04). …”
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Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India by Thomas Alexander, Jagdish S. Hiremath, Jitendra P. S. Swahney, Subhash Chandra, Peeyush Jain, Praveen Chandra, Nakul Sinha, T. Sashikanth, Yugandhar Bachhu, Anil Balachandran, Pathiyil Balagopalan Jayagopal, T. Govindan Unni, Tiny Nair, Kumaresan Kannan, Dorairaj Prabhakar, M. Chenniappan, Ajay U. Mahajan, Rajiv D. Karnik, Chandrashekhar K. Ponde, Prashant Advani, Idris Ahmed Khan, Brij Mohan Goyal, P. R. Vaidyanathan, Hiren Prajapati, Willem J. Verberk

“…Key predictors for an increasing number of prescribed drugs included statin use/dyslipidemia, age, blood pressure level, and diabetes. …”
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Posttraumatic Stress Disorder Is Associated With Endothelial Dysfunction in Women With HIV by Nishant Vatsa, MD, Alireza Rahbar, MD, Tanveer Kauser, MPH, Ariel Kirksey, BS, Daniel A. Gold, MD, Vardhmaan Jain, MD, Matthew E. Gold, MD, Heqiong Wang, MD, MPH, Christina Mehta, PhD, MSPH, Caitlin A. Moran, MD, Alicia K. Smith, PhD, Kimbi Hagen, EdD, Med, Ighovwerha Ofotokun, MD, MSc, Cecile D. Lahiri, MD, MS, Laurence Sperling, MD, Viola Vaccarino, MD, PhD, Puja K. Mehta, MD, Arshed A. Quyyumi, MD, Gretchen N. Neigh, PhD, Vasiliki Michopoulos, PhD

“…The impact of PTSD, HIV, and their interaction on endothelial function was evaluated using linear regression models adjusted for demographics, CVD risk factors, depressive symptoms, and statin use. Results: Overall, 55 (63.2%) had HIV, 24 (27.5%) had PTSD, and 13 (14.9%) had both. …”
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Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: a randomized phase 2 controlled pilot trial by Verónica V. Olavarría, Paola R. Campodónico, Valeska Vollrath, Paula von Geldern, Carolina Velásquez, Patricia Pavez, Barbara Valente, Pamela Donoso, Alexandra Ginesta, Gabriel Cavada, Enrico Mazzon, Víctor Navia, Matías Guzmán, Pablo Brinck, Andrés Gallardo, Pablo Gonzalez, Pablo M. Lavados

“…The primary outcome was the mean difference in LDL-C between groups at 90 days, adjusted by statin use. Safety, feasibility and acceptability (assessed through a 14-item questionnaire administered to all patients who completed the follow-up) were also evaluated. …”
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Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study by Elisa Russo, Francesca Viazzi, Roberto Pontremoli, Fabio Angeli, Carlo Maria Barbagallo, Bruno Berardino, Michele Bombelli, Federica Cappelli, Edoardo Casiglia, Rosario Cianci, Michele Ciccarelli, Arrigo F. G. Cicero, Massimo Cirillo, Pietro Cirillo, Lanfranco D’Elia, Giovambattista Desideri, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Grassi, Guido Iaccarino, Egidio Imbalzano, Luciano Lippa, Francesca Mallamaci, Alessandro Maloberti, Stefano Masi, Maria Masulli, Alberto Mazza, Alessandro Mengozzi, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Fosca Quarti-Trevano, Marcello Rattazzi, Gianpaolo Reboldi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Agostino Virdis, Massimo Volpe, Claudio Borghi, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

“…Conclusions Both IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. The joint effect of the TG/HDL-C ratio and the elevated SUA/GFR ratio was greater than the presence of each single risk factor on CV mortality. …”
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Musculoskeletal Adverse Events Associated with PCSK9 Inhibitors: Disproportionality Analysis of the FDA Adverse Event Reporting System by Lingqing Ding, Congqin Chen, Yongkuan Yang, Jie Fang, Longxing Cao, Yige Liu

“…Concomitant use with statins leaded to an increased occurrence of MAEs (ROR 32.15 (25.55-40.46)), and the risk differed among different statins. …”
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Effect of Simvastatin and Atorvastatin on Serum Vitamin D and Bone Mineral Density in Hypercholesterolemic Patients: A Cross-Sectional Study by Abrar Thabit, Abdullah Alhifany, Razan Alsheikh, Sameh Namnqani, Ameen Al-Mohammadi, Soha Elmorsy, Mohammed Qari, Mohammed Ardawi

“…Besides lipid-lowering effect of statins, they have been shown to have nonlipid lowering effects, such as improving bone health. …”
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Proprotein Convertase Subtilisin/Kexin Type 9: From the Discovery to the Development of New Therapies for Cardiovascular Diseases by Nicola Ferri

“…The identification of the HMG-CoA reductase inhibitors, statins, has represented a dramatic innovation of the pharmacological modulation of hypercholesterolemia and associated cardiovascular diseases. …”
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Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients by Esmat Khaleqsefat, Khder Hussein Rasul, Ramiar Kamal Kheder, Sonia Baban, Jamil Baban

“…However, individual responses to statins can vary markedly, possibly due to genetic variations in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene. …”
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Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery by Gulnur Sevin, Yasemin Delen Akcay, Gonen Ozsarlak-Sozer, Mukadder Yasa

“…3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly known as statins, are the medical treatment of choice for hypercholesterolemia. …”
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Effect of Staggered vs. Simultaneous Co-Administration of Bempedoic Acid on Pharmacokinetics of Pravastatin: Randomized, Cross-Over Clinical Trial in Healthy Volunteers by Felicitas Stoll, Salvatore Amato, Max Sauter, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Antje Blank

“…Because it is an inhibitor of the hepatic transporters OATP1B1 and OATP1B3, two uptake transporters regulating the intrahepatic availability of statins, it increases the systemic exposure of co-administered statins. …”
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Analysis of the drug treatment in patients with stable coronary artery disease before and after surgical myocardial revascularization by О.J. Zharinov, О.А. Yepanchintseva, К.O. Mikhaliev, I.V. Shklianka

“…At the same time, we paid attention to the insufficient usage of statins. I.e., high-intensity treatment with statins during one week before surgery was prescribed only in 19 (12.2 %) patients. …”
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Renoprotective Effect of Pitavastatin against TAA-Induced Renal Injury: Involvement of the miR-93/PTEN/AKT/mTOR Pathway by Marawan A. Elbaset, Bassim M. S. A. Mohamed, Passant E. Moustafa, Tuba Esatbeyoglu, Sherif M. Afifi, Alyaa F. Hessin, Sahar S. Abdelrahman, Hany M. Fayed

“…By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost kidney antioxidant capacity and minimize oxidative damage. Statins have several benefits, including antioxidant and anti-inflammatory characteristics. …”
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Primary and Secondary Hypogonadism in Male Persons with Diabetes Mellitus by João Martin Martins, Mafalda de Pina Jorge, Catarina Martins Maia, João Roque, Carlos Lemos, Daniel Nunes, Dinis Reis, Catarina Mota

“…Low TT levels were related to older age, poor metabolic control, metformin and statins use, and microvascular disease.…”
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Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study by Rajish S. K. Shil, Adam Seed, Nkongho Egbe Franklyn, Brendan F. Sargent, Greta K. Wood, Yun Huang, Katherine C. Dodd, James B. Lilleker, Thomas A. Pollak, Sylviane Defres, Thomas M. Jenkins, Nicholas W. S. Davies, David A. Cousins, Michael S. Zandi, Thomas A. Jackson, Laura A. Benjamin, Ava Easton, Tom Solomon, John R. Bradley, Patrick F. Chinnery, Craig J. Smith, Timothy R. Nicholson, Alan Carson, Rhys H. Thomas, Mark Alexander Ellul, Nicholas W. Wood, Gerome Breen, Benedict Daniel Michael, the COVID-CNS Study Group

“…Female sex, age > 50 years, and hypertension were associated with worse outcomes, and statins or ACE inhibitors with better outcomes.…”
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Detection of the Hematopoietic Stem and Progenitor Cell Marker CD133 during Angiogenesis in Three-Dimensional Collagen Gel Culture by Masumi Akita, Kayoko Tanaka, Sachiko Matsumoto, Kumiko Komatsu, Keiko Fujita

“…The present study provides insight into the function of CD133 during angiogenesis as well as an explanation for the antiangiogenic effect of statins.…”
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Xanthoma of Bone: A Case Report by Hasnae Guerrouj, Ayat Mouaden, Nouzha BenRais

“…The patient was put under fenofibrate and statins. The evolution was marked by gradual regression of lesions in bone scans of control.…”
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Do doctors in dispensing practices with a financial conflict of interest prescribe more expensive drugs? A cross-sectional analysis of English primary care prescribing data by Ben Goldacre, Carl Reynolds, Anna Powell-Smith, Alex J Walker, Tom A Yates, Richard Croker, Liam Smeeth

“…Data were obtained prescribing of statins, proton pump inhibitors (PPIs), angiotensin receptor blockers (ARBs) and ACE inhibitors (ACEis). …”
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