Evolving View of Coronary Artery Calcium: A Personalized Shared Decision-Making Tool in Primary Prevention by Omar Dzaye, Cara Reiter-Brennan, Albert D. Osei, Olusola A. Orimoloye, S. M. Iftekhar Uddin, Mohammadhassan Mirbolouk, Michael J. Blaha

“…The 2018 guidelines, for the first time, clearly recognize the significance of a CAC score of zero, where intensive statin therapy is likely not beneficial and not routinely recommended in selected patients. …”
Get full text

Biomarkers of residual risk and all-cause mortality after acute coronary syndrome. by Anna Toso, Mario Leoncini, Mauro Maioli, Simona Villani, Francesco Bellandi

“…Conclusions: In this population on high-intensity statin therapy only hsCRP and eGFR were independently associated with medium-term mortality. …”
Get full text

Dyslipidaemia in patients with chronic kidney disease – a neglected cardiovascular risk factor by M R Essop, F Seedat, F J Raal

“…Of those on LLT, all were on statin therapy, of which simvastatin at a mean dose of 20 mg daily was the most commonly prescribed LLT. …”
Get full text

Neurofilament Light Chain Assessment in Type 2 Diabetic Patients with Distal Symmetrical Polyneuropathy by Israa Abdelmalik Salem, Sura Ahmed Abdulsattar, Haider Fadhil Alrubaye

“…In patients who were taking antilipidemic statin therapy, the serum levels of the Neurofilament Light Chain were substantially reduced compared to those not receiving it. …”
Get full text

Vascular Protective Effects of Morinda citrifolia Leaf Extract on Postmenopausal Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Microscopic Level by C. L. G. Chong, Faizah Othman, Farida Hussan

“…In addition, we do not recommend the use of statin in the absence of dyslipidemia as it causes PVAT deposition.…”
Get full text

Assessment of Clinical Features in HIV-Infected Patients with Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention in China by Ying Liu, Yongfu Chen, Yiwei Hao, Jing Xiao, Bei Li, Leidan Zhang, Junyan Han, Hongxin Zhao

“…In PLWH (mean age: 53.6 ± 10.6 years, 95.8% male, and 79.2% on ART), high-density lipoprotein cholesterol was lower than in HIV-negative controls; however, the statin use was more common, the incidence of hypertension was lower, and low-density lipoprotein cholesterol, and the body mass index were significantly lower than in controls. …”
Get full text

Prediction Model of New Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome by Na Wu, Junzheng Li, Xiang Xu, Zhiquan Yuan, Lili Yang, Yanxiu Chen, Tingting Xia, Qin Hu, Zheng Chen, Chengying Li, Ying Xiang, Zhihui Zhang, Li Zhong, Yafei Li

“…Age, admission heart rate, left atrial diameter, right atrial diameter, heart failure, brain natriuretic peptide (BNP) level, less statin use, and no percutaneous coronary intervention (PCI) were independent predictors of NOAF. …”
Get full text

Endovascular Treatment and Outcomes for Femoropopliteal In-Stent Restenosis: Insights from the XLPAD Registry by Michael H. Vu, Glaiza-Mae Sande-Docor, Yulun Liu, Shirling Tsai, Mitul Patel, Chris Metzger, Mehdi H. Shishehbor, Emmanouil S. Brilakis, Nicolas W. Shammas, Peter Monteleone, Subhash Banerjee

“…ISR patients were more frequently on antiplatelet (94.5% vs 89.4%, p=0.007) and statin (68.9% vs 60.3%, p=0.003) therapies. Lesion length was similar (ISR: 145 ± 99 mm vs. non-ISR: 142 ± 99 mm, p=0.55). …”
Get full text

Evaluation of Treatment Patterns and Maintenance Dose Titration Among Patients With Crohn’s Disease Initiating Biologics With 3 Years of Follow-Up by Ruizhi Zhao, Zhijie Ding, Parul Gupta, Laurence Gozalo, Robert Bruette, Victor M. Johnson, Keshia Maughn, Yihang Liu, Sumesh Kachroo

“…**Methods:** This retrospective observational study was conducted using the STATinMED RWD Insights all-payer medical and pharmacy data. …”
Get full text

The relationship between cholesterol levels and thyroid eye disease by Caroline Cardo, Roberto Bernardo Santos, Ana Beatriz Pinotti Pedro Miklos, Sabrina Barbosa Jaconis, João Hamilton Romaldini, Danilo Villagelin

“…Laboratory results and information on smoking habits, statin use and medications affecting lipid profiles during the euthyroid state were analyzed. …”
Get full text

Intercostal Nerve Cryoablation During Lobectomy for Postsurgical Pain: A Safe and Cost-Effective Intervention by Daniel L. Miller, Jacob Hutchins, Michael A. Ferguson, Yazid Barhoush, Emily Achter, John P. Kuckelman

Get full text

Treating chronic kidney disease in Danish primary care: results from the observational ATLAS study by Morten Lindhardt, Søren Tang Knudsen, Thomas Saxild, Morten Charles, Rikke Borg

“…ACEis/ARBs were prescribed to 65%, statins to 56%, SGTL2is to 14%, and MRAs to 8% of all individuals. …”
Get full text

“Inclisiran: Early LDL-C target achievement in a real-life population” by Francesco Briani, Mauro Bagli, Gabriele Venturi, Francesco Bacchion, Antonio Mugnolo

“…After exclusion of two patients due to statin therapy modification or discontinuation during follow-up, a final number of 31 patients were included. …”
Get full text

Exposure to major coronary heart disease events reduces lung cancer risk: a mendelian randomization study based on a European population by Dongming He, Hongting Lu, Xinhuai Ou, Tiaozhan Zheng, Zhiwen Zheng, Zhanyu Xu, Xiaohong Duan, Shikang Li

“…Relevant single nucleotide polymorphisms (SNPs) associated with MCHDE and lung cancer were carefully selected, with particular attention given to mitigating potential confounders, such as smoking behaviors and statin use. Results The MR analysis, utilizing FinnGen's MCHDE as the exposure factor, revealed a significant reduction in the incidence of non-small cell lung cancer (NSCLC) [odds ratio (OR) 0.893, 95% confidence interval (CI) 0.800–0.998] and small cell lung cancer (SCLC) [OR 0.684, 95% CI 0.500–0.936], highlighting the protective effect of MCHDE against these cancer subtypes. …”
Get full text

Serum Lipids Alterations in Patients Under Systemic JAK Inhibitors Treatments in Dermatology: Clinical Aspects and Management by Giovanni Paolino, Mario Valenti, Andrea Carugno, Matteo Bianco, Dario Didona, Matteo Riccardo Di Nicola, Pier Luigi Acutis, Carmen Cantisani, Vittoria Giulia Bianchi, Nicola Zerbinati, Alessandra Narcisi, Antonio Costanzo, Santo Raffaele Mercuri

“…Monitoring lipid levels, alongside lifestyle modifications and possible statin use, can manage these effects without the need to stopping treatment.…”
Get full text

Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus by Caroline Pereira Domingueti, Rodrigo Bastos Fóscolo, Janice Sepúlveda Reis, Fernanda Magalhães Freire Campos, Luci Maria S. Dusse, Maria das Graças Carvalho, Karina Braga Gomes, Ana Paula Fernandes

“…Cytokines and haemostatic biomarkers remained associated with nephropathy after adjustments (use of statin, acetylsalicylic acid, angiotensin converting enzyme inhibitor, and angiotensin antagonist). …”
Get full text

Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland by Michał Kania, Konrad Mazur, Michał Terlecki, Bartłomiej Matejko, Jerzy Hohendorff, Zlata Chaykivska, Mateusz Fiema, Marianna Kopka, Małgorzata Kostrzycka, Magdalena Wilk, Tomasz Klupa, Przemysław Witek, Barbara Katra, Marek Klocek, Marek Rajzer, Maciej T. Malecki

“…Factors contributing to lower mortality were in-hospital use of statin, thiazide diuretic, and calcium channel blocker. …”
Get full text

Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis by Flora Magno de Jesus Oliveira, Cassiano Felippe Gonçalves-de-Albuquerque, Isabel Matos Medeiros de Moraes, Patrícia Alves Reis, Vinicius Novaes Rocha, Patrícia Torres Bozza, Adriana Ribeiro Silva, Hugo Caire de Castro Faria Neto

“…In previous study from our group, statin pretreatment avoided cognitive damage and neuroinflammation in sepsis survivors. …”
Get full text

Infliximab Induces Increase in Triglyceride Levels in Psoriatic Arthritis Patients by Karla R. Castro, Nádia E. Aikawa, Carla Gonçalves Saad, Júlio C. B. Moraes, Ana C. Medeiros, Licia Maria H. Mota, Clovis A. A. Silva, Eloísa Bonfá, Jozélio F. Carvalho

“…None had dyslipoproteinemia or previous statin use. Total cholesterol (TC) and its fractions, inflammatory markers, and prednisone use were evaluated. …”
Get full text

Impact of Novel Guidelines on Multifactorial Control and Its Association with Mortality in Adult Patients with Hypertension and Newly Diagnosed Type 2 Diabetes: A 4-Year Prospectiv... by Ngoc-Thanh-Van Nguyen, Hoa Ngoc Chau, Nam Hoai Le, Hai Hoang Nguyen, Hoai-An Nguyen

“…Renin–angiotensin–aldosterone inhibitor, metformin, and statin were prescribed in 89.8%, 66.3%, and 67.1%. …”
Get full text