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101
Rosuvastatin-Induced Oral Ulcer: A Case Report and Review of Literature
Published 2022-01-01“…The benefits of prescribing statins are well published in the treatment of hypercholesterolemia. …”
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102
Lovastatin Decreases the Expression of CD133 and Influences the Differentiation Potential of Human Embryonic Stem Cells
Published 2016-01-01“…The lipophilic statin lovastatin decreases cholesterol synthesis and is a safe and effective treatment for the prevention of cardiovascular diseases. …”
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103
Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration
Published 2015-01-01“…Simvastatin is among the most commonly used prescription medications for cholesterol reduction and the most common statin-related adverse drug reaction is skeletal muscle toxicity. …”
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104
Diabetes and Stroke Prevention: A Review
Published 2012-01-01“…Lipids should be treated with a statin whatever the starting cholesterol. Antiplatelet treatment is also essential but there are no specific recommendations for the diabetic person. …”
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105
Nitric Oxide in Cerebral Vasospasm: Theories, Measurement, and Treatment
Published 2013-01-01“…Recent evidence indicates that targeting NOS dysfunction, for example, through erythropoietin or statin administration, also shows promise at preventing vasospasm and neurotoxicity. …”
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106
Creating National Weights for a Patient-level Longitudinal Database
Published 2016-03-01“…The annual number of statin users were predicted as 6 709 438 using weighted MEPS data. …”
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107
Anti-inflammatory and immunomodulatory effects of rosuvastatin in patients with low-to-moderate cardiovascular risk
Published 2022-06-01“…Statins have shown anti-inflammatory pleiotropic effects in subjects with/at risk of cardiovascular disease. …”
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108
The Role of Angiotensin Antagonism in Coronary Plaque Regression: Insights from the Glagovian Model
Published 2021-01-01“…Significant coronary atheromatous plaque regression has been previously demonstrated in various studies using statin agents. Similar results have been reported in different studies using angiotensin inhibitor agents, notably ARB agents. …”
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109
Minimally Invasive Periodontology: A Treatment Philosophy and Suggested Approach
Published 2021-01-01“…This may involve repeated rounds of nonsurgical periodontal therapy, and adjuncts such as locally delivered statin gels and subantimicrobial-dose doxycycline appear to be effective. …”
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110
Targeting epithelial-mesenchymal transition signaling pathways with Dietary Phytocompounds and repurposed drug combinations for overcoming drug resistance in various cancers
Published 2025-02-01“…This review summarises major EMT-associated pathways and their cross talks with their mechanistic insights and the role of different dietary phytochemicals (curcumin, ginger, fennel, black pepper, and clove) and their natural analogs and also repurposed drugs (metformin, statin, chloroquine, and vitamin D) which are commonly used in regulating EMT in various preclinical studies. …”
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111
Simvastatin Does Not Affect Vitamin D Status, but Low Vitamin D Levels Are Associated with Dyslipidemia: Results from a Randomised, Controlled Trial
Published 2010-01-01“…Objectives. Statin drugs act as inhibitors of the 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase enzyme early in the mevalonate pathway, thereby reducing the endogenous cholesterol synthesis. …”
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112
Wound repair in rabbits using autologous biomaterials combined with rosuvastatin
Published 2025-02-01“…Rosuvastatin (RSV), a lipidlowering statin, exhibits pleiotropic effects that may promote tissue repair, warranting investigation into its use alone or combined with biomaterials for wound healing. …”
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113
Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro
Published 2015-01-01“…It has been previously revealed that statins used at high concentrations display antileukemic potential towards chronic lymphocytic leukemia (CLL) cells. …”
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114
A Rare Cause of Secondary Amyloidosis: Common Variable Immunodeficiency Disease
Published 2012-01-01“…A treatment regimen (an ACE inhibitor and a statin) with monthly administration of intravenous immunoglobulin was started.…”
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115
High-Serum Angiopoietin-Like Protein 3 Levels Associated with Cardiovascular Outcome in Patients with Coronary Artery Disease
Published 2020-01-01“…Patients reporting MACEs had lower statin use (P=0.022) and higher serum C-reactive protein (P<0.001) and serum ANGPTL3 (P<0.001) levels than those without MACEs. …”
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116
Differences Between Lovastatin and Simvastatin Hydrolysis in Healthy Male and Female Volunteers: Gut Hydrolysis of Lovastatin is Twice that of Simvastatin
Published 2003-01-01“…This study was based on the plasma concentration-time curves and the pharmacokinetics of lovastatin and simvastatin with its respective active metabolite statin-β-hydroxy acid obtained from two different bioequivalence studies, each with 18 females and 18 males. …”
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117
A scoping review of randomized trials assessing the impact of n-of-1 trials on clinical outcomes.
Published 2022-01-01“…<h4>Findings</h4>Twelve randomized trials of the n-of-1 approach were identified in conditions spanning chronic pain, osteoarthritis, chronic irreversible airflow limitation, attention-deficit hyperactivity disorder, hyperlipidemia, atrial fibrillation, statin intolerance, and hypertension. One trial showed a statistically significant benefit in the primary outcome. …”
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118
High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes
Published 2016-01-01“…No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (P<0.001), logarithmically transformed creatinine (log-creatinine; P<0.001), female DM patients (P<0.001), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; P=0.013) were positively correlated, while albumin (P=0.004) and glomerular filtration rate (GFR; P=0.043) were negatively correlated with serum A-FABP levels in type 2 DM patients. …”
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119
Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA’s adverse event reporting system database
Published 2025-02-01“…In addition to cholesterol reduction, it is imperative to lower triglyceride levels. The combination of statin and fibrate for reducing lipid levels has commonly been applied in clinical therapy. …”
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120
Rosuvastatin effects on the HDL proteome in hyperlipidemic patients
Published 2023-09-01“…Findings from this study introduce novel insights into the HDL proteome and statin pleiotropism.…”
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