Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network me... by Yuhua Jiang, Yingying Wang, Sijia Ma, Linlin Qian, Yeteng Jing, Xi Chen, Jinsheng Yang

“…Regarding the efficacy of lipid reduction, four principal medications were evaluated: evolocumab and atorvastatin [mean standard deviation (MD) −3.41, 95% CI −4.81 to −2.00] and evolocumab with rosuvastatin (MD −3.44, 95% CI −5.10 to −1.78) vs. placebo; alirocumab combined with rosuvastatin (MD −2.91, 95% CI −3.95 to −1.88) and alirocumab with atorvastatin (MD −2.90, 95% CI −3.97 to −1.84) vs. placebo. …”
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Modified Endothelial Activation and Stress Index: A New Predictor for Survival Outcomes in Classical Hodgkin Lymphoma Treated with Doxorubicin-Bleomycin-Vinblastine-Dacarbazine-Bas... by Fazıl Çağrı Hunutlu, Hikmet Öztop, Vildan Gürsoy, Tuba Ersal, Ezel Elgün, Şeyma Yavuz, Selin İldemir Ekizoğlu, Azim Ali Ekizoğlu, Vildan Özkocaman, Fahir Özkalemkaş

“…The prognostic value of the mEASIX score was evaluated using the receiver operating characteristic (ROC) analysis, Cox regression analysis, and the Kaplan–Meier method, and then compared with standard risk assessment methods. <b>Results:</b> The median age at diagnosis was 33 years, and the rate of patients in the advanced stage was 67%. …”
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Performance of sewage sludge reuse in the manufacturing of fired bricks by K. Moulato, M. Ammari, L. Ben Allal

“…The sludge was classified as fine with a silty-clay character, with a plasticity index of 54.63 percent, and was therefore very plastic, and had trace element concentrations below the authorized standards. A sample containing 10 percent of sludge gives a strength of 25.9 megapascal which is close to that of the control brick. …”
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Prevalence, Pattern and Factors Associated with Developmental Delay amongst Under-5 Children in Nigeria: Evidence from Multiple Indicator Cluster Survey 2011–2017 by Olayide Olubunmi Olabumuyi, Obioma Chukwudi Uchendu, Pauline Aruoture Green

“…This underscores the need for surveillance and interventions focussed on improving child literacy, nutritional status and household standard of living across the zones.…”
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Effect of supplementing epinephrine in maturation media on the developmental competence of buffalo oocytes by Ali Husnain, Abdul Khaliq, Talha Ashraf, Abdul Rehman, Muhammad Yasir Zahoor, Muhammad Binyameen, Amjad Riaz

“…Results represented as least square means and respective standard error of means (LSM ± SEM). Adding epinephrine to the maturation media did not affect the nuclear maturation and cleavage. …”
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Factors influencing waist circumference among urban bank employees in Northeast Ethiopia: a cross-sectional study by Woynshet Yimer, Lakew Asmare, Fikre Bayu Gebeyehu, Tihtna Alemu, Anisa Mehamed, Fanos Yeshanew Ayele

“…Normality, homoscedasticity, significant outliers, and multicollinearity were assessed, and a p-value of less than 0.05, along with a 95% confidence interval, was considered statistically significant.ResultsA total of 345 participants were included in the final analysis, with a 95% response rate. The overall mean ± standard deviation (SD) of the waist circumference of the employees was 81.7 ± 6.8 cm, with 82.4 ± 6.5 cm for men and 80.7 ± 7.2 cm for women. …”
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Movement therapy in advanced heart failure assisted by a lightweight wearable robot: a feasibility pilot study by Isabell Anna Just, Denis Fries, Sina Loewe, Volkmar Falk, Nikola Cesarovic, Frank Edelmann, Anna Feuerstein, Florian L. Haufe, Michele Xiloyannis, Robert Riener, Felix Schoenrath

“…Methods and results Twenty patients in functional NYHA class III performed activities of daily life (ADL, n = 10) or participated in a single, standardized, 60 min rehabilitation exercise unit (REU, n = 10) with and without the Myosuit. …”
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Caffeinated chewing gum enhances maximal strength and muscular endurance during bench press and back squat exercises in resistance-trained men by Li Ding, Jue Liu, Yi Yao, Li Guo, Bin Chen, Yinhang Cao, Olivier Girard

“…The aim of this study was to determine the efficacy of caffeinated chewing gum on maximal strength and muscular endurance during bench press and back squat exercises.MethodsIn a randomized, double-blind design, 16 resistance-trained males (age: 21.6 ± 2.0 years, height: 176.8 ± 6.1 cm, mass: 79.6 ± 8.8 kg) chewed either caffeinated gum (3 mg/kg) or a placebo gum on two occasions, 1 week apart. After a standardized warm-up, participants chewed the gum for 5 min before performing maximal strength test (one-repetition maximum [1RM]) and muscular endurance test (60% 1RM repetitions to failure) for bench press and back squat exercises. 1RM, number of repetitions, ratings of perceived exertion and pain perception were assessed.ResultsCaffeinated chewing gum significantly improved 1RM in both bench press (105.3 ± 14.5 vs. 100.3 ± 13.4 kg, +5.0% [95% confidence interval (CI): 3.7–6.3%], p &lt; 0.01) and back squat (172.3 ± 20.2 vs. 161.9 ± 22.3 kg, +6.8% [95%CI: 4.1–9.5%], p &lt; 0.01) exercises with small effect size (Cohen’s d: 0.36 [95%CI: 0.09–0.63] and 0.49 [95%CI: 0.22–0.76], respectively), despite similar levels of pain perception and RPE (p &gt; 0.05). …”
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Safety profiles of IDH inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database by Ximu Sun, Han Zhou, Yanming Li, Yanhui Luo, Qixiang Guo, Yixin Sun, Chenguang Jia, Bin Wang, Maoquan Qin, Peng Guo

“…Only IDH inhibitors reported as the target drug and coded as the primary suspect (PS) were included in the analysis. AEs were standardized and classified according to the preferred term (PT) and system organ classification (SOC) in the Medical Dictionary for Regulatory Activities (MedDRA) version 26.0. …”
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Development of an artificial intelligence-based application for the diagnosis of sarcopenia: a retrospective cohort study using the health examination dataset by Chang-Won Jeong, Dong-Wook Lim, Si-Hyeong Noh, Sung Hyun Lee, Chul Park

“…Additionally, we developed an algorithm for the calculation of T-Score calculated as (measurement value-Young adult mean)/(Young adult SD) using the Aggregation Pipeline by MongoDB, with the mean and standard deviation for skeletal muscle area (SMA), SMA/height2, SMA/weight, and SMA/body mass index (BMI) for both sexes and different age groups. …”
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Role of Chest X-Ray in Coronavirus Disease and Correlation of Radiological Features with Clinical Outcomes in Indian Patients by Satyanand Sathi, Richa Tiwari, Savita Verma, Anil Kumar Garg, Virendra Singh Saini, Manoj Kumar Singh, Amit Mittal, Devinder Vohra

“…A severity index in the form of maximum radiological assessment of lung edema (RALE) score was calculated for each lung, and scores of both the lungs were summed to obtain a final score. The mean ± standard deviation (SD) and frequency (%) were determined, and an unpaired t test, Spearman’s rank correlation coefficient, and logistic regression analyses were performed for statistical analyses. …”
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Association between weight-adjusted-waist index and long-term prognostic outcomes in cardiovascular disease patients: results from the NHANES 1999–2018 study by Hanbin Li, Wen Zhong, Hongxin Cheng, Shiqi Wang, Ran Li, Lu Wang, Chengqi He, Quan Wei

“…Methods The diagnosis of CVD was based on standardized medical condition questionnaires that incorporated participants’ self-reported physician diagnoses. …”
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Real-World Life Analysis of a Continuous Glucose Monitoring and Smart Insulin Pen System in Type 1 Diabetes: A Cohort Study by Paola Pantanetti, Giovanni Cangelosi, Sara Morales Palomares, Gaetano Ferrara, Federico Biondini, Stefano Mancin, Gabriele Caggianelli, Mauro Parozzi, Marco Sguanci, Fabio Petrelli

“…Glycemic parameters were monitored using CGM data and analyzed with descriptive statistics, including mean, standard deviation (SD), and interquartile range (IQR). …”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3&beta; Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Shuyu Zheng,1,2 Zejuan Xie,1 Ziao Zhou,1 Shanshan Wang,1 Yanlin Xin,1 Jiamin Lin,1 Keyu Cheng,1 Tianming Lu,1 Ruogu Qi,1 Yuanyuan Guo1 1Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310009, People’s Republic of ChinaCorrespondence: Ruogu Qi; Yuanyuan Guo, Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China, Email rqi@njucm.edu.cn; guoyy@njucm.edu.cnPurpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. Prior studies showed Platycodin D (PD)-induced cell cycle arrest and apoptosis in NSCLC via RNA regulatory network, yet elucidating PD’s mechanisms in NSCLC progression is challenging in the real world.Methods: Biological effects of PD on NSCLC cell lines A549 and PC-9 were assessed through in vitro assays, encompassing apoptosis, proliferation, colony formation, migration and invasion. …”
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The Relationship Between Serum 25 hydroxy Vitamin D Deficiency and Dietary Pattern in Baxshin Hospital, Sulaimani City by Mohammed I M Gubari, Jeza Muhamad Abdul Aziz, Fadhil Ahmed Mohialdeen, Khalid Anwar Hama-Ghareeb, Bakhtyar Kamal Muhamed, Hemn Abdalla Omer

“…The age of the sample ranged from 18 to 65 years old with the mean of 34.34 years old with a standard deviation of 12.6. One hundred sixty-two (14.3%) of the 1131 participants were female, nine hundred sixty-nine (85.7%) of the participants were male. 65.5 % of them exposure to sun less than 30, 34.5% exposure to sun more than half hour. …”
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INTERNATIONAL AND NATIONAL LEGAL MECHANISMS OF JUDICIAL LIABILITY IN THE CONDITIONS OF ECONOMIC GLOBALISATION OF MODERN SOCIETY by Konul Akhundova

“…The mechanism for bringing judges to disciplinary responsibility has been established in accordance with international standards, including 1) a special procedure for bringing judges to disciplinary responsibility, which is defined by law; 2) the formation of an independent body that should consider such cases; 3) ensuring the right of a judge to participate in such procedure directly or through a representative, to exercise his right of defence and to express his opinion; 4) the right to appeal against the decision taken on the basis of the results of this procedure; 5) the exhaustiveness of the sanctions that can be applied and their proportionality. …”
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In Vitro Activities of Ceftobiprole and Doripenem Tested against Frequently Encountered Aerobic and Facultative Gram-Positive and Gram-Negative Bacterial Pathogens Isolated from Pa... by James A Karlowsky, Mel DeCorby, Daryl J Hoban, George G Zhanel

“…MEtHODS: Isolates were tested for their susceptibility to a panel of antimicrobial agents using the Clinical and Laboratory Standards Institute broth microdilution method. RESULTS: Ceftobiprole inhibited all isolates of methicillin-resistant Staphylococcus aureus (n=385), methicillin-resistant Staphylococcus epidermidis (n=20), methicillin-susceptible S aureus (n=1095) and methicillin-susceptible S epidermidis (n=108) at a minimum inhibitory concentration (MIC) of 2 μg/mL or less; all isolates of Streptococcus pyogenes (n=105) were inhibited by ceftobiprole at 0.06 μg/mL or less. …”
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Developing a comprehensive inventory to define harm reduction housing by Sofia Zaragoza, Joseph Silcox, Sabrina Rapisarda, Charlie Summers, Patricia Case, Clara To, Avik Chatterjee, Alexander Y. Walley, Miriam Komaromy, Traci C Green

“…Characterizing the critical components of HRH through this tool will aid in standardizing the concept and practice of HRH for PWUD and may assist other cities in planning and implementing HRH.…”
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High-performance CT features supporting accurate pre-operative tumor staging in colon cancer by Jianhua Yuan, Cangzheng Jin, Jianrong Si, Baobao Liu, Xiaohan Si, Jianzhi Chen

“…Multi-slice spiral computed tomography (CT) is currently the standard method for pre-operative clinical tumor staging, but accurately applying the CT findings in tumor staging remains a challenge due to the poor pathological understanding of the CT signs. …”
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Efficacy of non-invasive brain stimulation interventions on cognitive impairment: an umbrella review of meta-analyses of randomized controlled trials by Minmin Wu, Wenjing Song, Xue Wang, Lili Teng, Jinting Li, Jiongliang Zhang, Xinyue Li, Donghui Yu, Huanhuan Jia, Binhan Wang, Qiang Tang, Luwen Zhu

“…Repetitive transcranial magnetic stimulation (rTMS) significantly enhanced short-term global cognition (standardized mean difference [SMD], 0.44; 95% CI 0.02–0.86), language (SMD, 1.64; 95% CI 1.22–2.06), executive function (SMD, 1.64; 95% CI 0.18–0.83), and long-term global cognition (SMD, 0.29; 95% CI 0.07–0.50). …”
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