Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer by Olusola Olalekan Elekofehinti, Hannah Oluwaseun Popoola, Adedotun Olayemi Oluwatuyi, Opeyemi Iwaloye, Moses Orimoloye Akinjiyan, Oluwamodupe Cecilia, Frank Abimbola Ogundolie, Olalekan Isaac Olatunde, Oussama Abchir, Samir Chtita, Joao Batista Texeira Rocha

“…Method In this study, computational models such as flexible docking, induced fit docking, and binding free energy calculation were employed to identify small molecule inhibitors from known bioactive compounds of Spondias mombin in reference to 5-fluorouracil (Colorectal cancer standard drug) targeting apoptosis-signaling kinase 1. …”
Get full text

A dextrorotatory residues-incorporated bioactive dodecapeptide against enterohemorrhagic Escherichia coli by Ping Zeng, Xuemei Yang, Kwok-Yin Wong, Sheng Chen, Kin-Fai Chan, Sharon Shui Yee Leung, Lanhua Yi

“…Methods: Spatial conformation of synthetic peptide zp39 (GIIAGIIiKIKk-NH2, lowercase letters indicate dextrorotatory amino acids) was predicted by PEPstrMOD and its secondary structure was further determined by circular dichroism (CD) spectroscopy. Then, standard E. coli O157:H7 strain ATCC 43888 was used to evaluate the bioactivity of zp39. …”
Get full text

Parasitic infection prevalence in tuberculosis patients and their household contacts in the Littoral Region of Cameroon by Lucy Cho Nchang, Chefor Magha, Patience Agwa Fonong, Narcisse Victor Tchamatchoua Gandjui, Nancielle Mbiatong Tchatat, Desmond Akumtoh Nkimbeng, Frank Noel Nietcho, Juluis Visnel Foyet, Fanny Fri Fombad, Tatiana Djikeussi Katcho, Jerome Fru Cho, Achim Hoerauf, Manuel Ritter, Samuel Wanji

“…Blood, stool, urine and skin snip samples were collected following standard guidelines for investigation of parasitic infections. …”
Get full text

PD-1-expressing macrophages and CD8 T cells are independent predictors of clinical benefit from PD-1 inhibition in advanced mesothelioma by Solange Peters, Urania Dafni, Panagiota Zygoura, Sanjay Popat, Mary O'Brien, Rolf A Stahel, Alessandra Curioni-Fontecedro, Georges Coukos, Amy Roy, Riyaz Shah, Krisztian Homicsko, James Spicer, Stephen P Finn, David Gilligan, Maxim Norkin, Stephanie Tissot, Nicholas Shakarishvili, Anthony Pope, Patricia Fisher, Sylvie Rusakiewicz, Ekaterina Fortis, Nesa Marti, Roswitha Kammler

“…We aimed to identify novel markers in malignant pleural mesothelioma to select patients better.Methods We performed a multiplex-immune histochemistry analysis of tumor samples from the phase III PROMISE-meso study, which randomized 144 pretreated patients to receive either pembrolizumab or standard second-line chemotherapy. Our panel focused on CD8+T cell, CD68+macrophages, and the expression of PD-1 and PD-L1 on these and cancer cells. …”
Get full text

Seasonal Variations in Chemical Composition and Antibacterial and Antioxidant Activities of <i>Rosmarinus officinalis</i> L. Essential Oil from Southwestern Romania by Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Andrei Biţă, Felicia Tuţulescu, Antonia Radu, Maria Viorica Ciocîlteu, George Dan Mogoşanu

“…The analysis aimed to identify and quantify the various components by comparing their mass spectra with reference spectra from the National Institute of Standards and Technology (NIST) Library 2020. The minimum inhibitory concentration (MIC) values of <i>Staphylococcus aureus</i> minimum were determined using the microdilution method (96-well plates). …”
Get full text

In vitro modeling of feline gut fermentation: a comprehensive analysis of fecal microbiota and metabolic activity by Qianle Ren, Qianle Ren, Yuling Li, Mingmei Duan, Jinjun Li, Fangshu Shi, Yun Zhou, Wanjing Hu, Junfu Mao, Xiaoqiong Li

“…Despite advancements in standardized protocols for culturing human GM, research concerning animals—particularly companion animals—remains limited. …”
Get full text

Risk Factors of Anaemia among Children under Five Years in the Hohoe Municipality, Ghana: A Case Control Study by Phyllis Atta Parbey, Elvis Tarkang, Emmanuel Manu, Hubert Amu, Martin Amogre Ayanore, Fortress Yayra Aku, Sorengmen Amos Ziema, Samuel Adolf Bosoka, Martin Adjuik, Margaret Kweku

“…Continuous variables were presented as means and standard deviations and categorical variables as frequencies and proportions. …”
Get full text

Improper lung volume-dose parameters are risk factors for acute fatal radiation pneumonitis among esophageal cancer patients receiving chemoradiotherapy: a case-control study by Ruinuo Jia, Liuyan Li, Xiaoyi Liu, Junqian Zhang, Shuoguo Li, Ziqi Wang, Jingxia Li, Bingyi Xu, Manxi Sheng, Lei Ni, Danni Yang, Shegan Gao, Shegan Gao, Shegan Gao

“…BackgroundDefinitive concurrent chemoradiotherapy (DCRT) is the standard treatment for locally advanced unresectable esophageal cancer (EC). …”
Get full text

The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study by Bernhard Winder, Bernhard Winder, Bernhard Winder, Sophia J. Kiechl, Sophia J. Kiechl, Benoît Bernar, Benoît Bernar, Nina Gande, Anna Staudt, Anna K. Stock, Anna K. Stock, Christoph Hochmayr, Ralf Geiger, Andrea Griesmacher, Stefan Kiechl, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach, Michael Knoflach, the Early Vascular Ageing (EVA)-Tyrol Study Group, Carmen Reiter, Christina Schreiner Julia Klingenschmid, Julia Marxer, Martina Kothmayer, Maximilian Pircher, Manuela Bock-Bartl, Mandy Asare, Maximilian Bohl, Raimund Pechlaner

“…PA was rated by an in-person interview on the basis of average minutes of moderate- or vigorous sports per day and by the Baecke questionnaire expressed as Baecke score (BS).ResultsComplete data set was available for 1,001 adolescents with a mean age of 17.8 years (standard deviation ±0.9 years). 558 (55.7%) of participants were female. cIMT was positively associated with both measures of PA in univariate (minutes sports per day: p &lt; 0.001; BS: p &lt; 0.001) as well as multivariable analysis adjusting for established cardiovascular risk factors (minutes sports per day: p = 0.001; BS: p = 0.002). …”
Get full text

Limnospira (Cyanobacteria) chemical fingerprint reveals local molecular adaptation by Théotime Roussel, Cédric Hubas, Sébastien Halary, Mathias Chynel, Charlotte Duval, Jean-Paul Cadoret, Tarik Meziane, Léa Vernès, Claude Yéprémian, Cécile Bernard, Benjamin Marie

“…., 2023), we develop a specific analysis of the metabolomic diversity of 93 strains of Limnospira, grown under standardized lab culture conditions. Overall, this original work showed distinct chemical fingerprints that were correlated with the respective biogeographic origins of the strains. …”
Get full text

Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome by Valerie Lohner, Laura Perna, Ben Schöttker, Robert Perneczky, Hermann Brenner, Ute Mons

“…Results: Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 % confidence interval): all-cause mortality: 1.36 (1.10–1.68); cardiovascular mortality: 1.42 (1.05–1.93)). …”
Get full text

Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk... by Narayanaswamy Venketasubramanian, Deidre Anne De Silva, Christopher P L H Chen, Cyrus G Escabillas, John Harold Hiyadan, Johnny K Lokin, Romulo U Esagunde, Joel M Advincula, Christian Oliver C Co, Maria Epifania V Collantes, Annabelle Y Lao, Yeow-Hoay Koh, Carol Huilian Tham

“…Additionally, telephone assessment at week 4 includes the simplified mRS and PROMIS-10.Safety will be evaluated by standard assessments and occurrence of adverse events over the duration of the study.Discussion Interventions that enhance recovery beyond the acute period of stroke are needed. …”
Get full text

Fetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Prospective Multicenter Cohort Study in Portugal by Mariza Fevereiro-Martins, Laura Aguiar, Ângela Inácio, Carlos Cardoso, Ana Carolina Santos, Carlos Marques-Neves, Hercília Guimarães, Rui Pinto, Manuel Bicho

“…Clinical data were collected during hospitalization, and HbF fractions were measured from blood samples in the first four weeks of life using standardized methods. Infants were stratified by ROP presence and treatment requirement. …”
Get full text

Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh by Farhana Khanam, Natasha Y. Rickett, Faisal Ahmmed, Md Taufiqul Islam, Cecilia Kathure Mbae, Justin Im, Asma Binte Aziz, Beatrice Ongadi, Fahima Chowdhury, Ashraful Islam Khan, Afroza Akter, Md Golam Firoj, Sadia Isfat Ara Rahman, Kassa Haile, Se Eun Park, Martin Bundi Mwebia, Moses Mwangi, Benjamin Ngugi, Meseret Gebre Behute, Kelvin Kering, Suneth Agampodi, Suman Kanungo, Xinxue Liu, Andrew J. Pollard, K. Zaman, Deok Ryun Kim, Samuel Kariuki, Firdausi Qadri, John D. Clemens

“…Plasma IgG anti-Vi antibodies were measured using a standard enzyme-linked immunosorbent assay in random serosurveys of a population that had not previously received typhoid vaccination. …”
Get full text

Transcatheter Closure of Perimembranous and Intracristal Ventricular Septal Defects Using Amplatzer Duct Occluder II in Children by Shenrong Liu, Wenqian Zhang, Junjie Li, Shushui Wang, Mingyang Qian, Jijun Shi, Yumei Xie, Zhiwei Zhang

“…We retrospectively analyzed all children, who presented to our hospital consecutively between March 2014 and June 2020 for attempted transcatheter closure of pmVSD or icVSD with the ADO II device. Standard safety and last-follow-up outcomes were assessed and compared. …”
Get full text

A Regional Gravimetric and Hybrid Geoid Model in Northern Greece from Dedicated Gravity Campaigns by Georgios S. Vergos, Dimitrios A. Natsiopoulos, Elisavet G. Mamagiannou, Eleni A. Tzanou, Anastasia I. Triantafyllou, Ilias N. Tziavos, Dimitrios Ramnalis, Vassilios Polychronos

“…., after the stochastic treatment of the adjusted residuals, gave a std of the difference to the GNSS/leveling data of 1.1 cm, with 99.8% and 99.9% of the height difference being smaller than the 1 cm and 2 cm standard errors, thus achieving a 1 cm accuracy regional geoid.…”
Get full text

Clinical Characteristics of Virologically Confirmed Respiratory Syncytial Virus in English Primary Care: Protocol for an Observational Study of Acute Respiratory Infection by Uy Hoang, Utkarsh Agrawal, José Manuel Ordóñez-Mena, Zachary Marcum, Jennifer Radin, Andre Araujo, Catherine A Panozzo, Orsolya Balogh, Mihir Desai, Ahreej Eltayeb, Tianyi Lu, Catia Nicodemo, Xinchun Gu, Rosalind Goudie, Xuejuan Fan, Elizabeth Button, Jessica Smylie, Mark Joy, Gavin Jamie, William Elson, Rachel Byford, Joan Madia, Sneha Anand, Filipa Ferreira, Stavros Petrou, David Martin, Simon de Lusignan

“…According to data from the UK Health Security Agency, the peak RSV swab positivity was in International Standards Organization week 48, 2023. Data collection remains ongoing, and results from the subset of practices participating in this study are not yet available. …”
Get full text

Body Composition in Crohn’s Disease and Ulcerative Colitis: Correlation with Disease Severity and Duration by Dawesh P. Yadav, Saurabh Kedia, Kumble Seetharama Madhusudhan, Sawan Bopanna, Sandeep Goyal, Saransh Jain, Naval K. Vikram, Raju Sharma, Govind K. Makharia, Vineet Ahuja

“…Lean mass and fat-free mass index (FFMI) were calculated with standard formulae. Visceral fat area (VFA), subcutaneous fat area (SCA), and visceral to subcutaneous fat ratio (VF/SC) were evaluated in CD patients on abdominal CT. …”
Get full text

Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin by Hua Fang, Huajing Chang, Danjing Chen, Wenxin Qiu, Jiangwang Fang, Yunli Wu, Xian-E. Peng

“…The estimated glomerular filtration rate (eGFR) was calculated using standardized creatinine. Associations between perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA) with eGFR and the risk of decreased renal function (eGFR < 90 vs. eGFR ≥ 90) using linear and logistic regression, weighted quantile sum (WQS) regression, Bayesian kernel machine regression (BKMR), and restricted cubic spline (RCS) analyses. …”
Get full text

Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

“…This study aims to assess the effectiveness of RAS, KA or both to improve clinical outcomes, functional measures, radiographic precision and prosthetic survivorship when compared with current gold standards of surgical care.Methods and analysis A national registry-nested, multicentre, double-blinded, 2×2 factorial, randomised trial will be undertaken with 300 patients undergoing primary unilateral TKA performed by 15 surgeons. …”
Get full text