Nanobody-enhanced chimeric antigen receptor T-cell therapy: overcoming barriers in solid tumors with VHH and VNAR-based constructs by Shasha Guo, Xiaozhi Xi

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Single-Domain Antibodies That Specifically Recognize Intact Capsids of Multiple Foot-and-Mouth Disease Serotype O Strains by Michiel M. Harmsen, Nishi Gupta, Quillan Dijkstra, Sandra van de Water, Marga van Setten, Aldo Dekker

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Nanobody-as versatile tool emerging in autoimmune diseases by Ling Wang, Ran Luo, Weilang Zhang, Hanyu Jiang, Yongkang Yu, Wenhu Zhou, Fan Zhang, Jian Ma, Lin Mei

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Characterization of a Potential Therapeutic Anti-Canine PD-1 Single Domain Antibody Produced in Yeast by Kartikeya Vijayasimha, Andrew J. Annalora, Dan V. Mourich, Carl E. Ruby, Brian P. Dolan, Laura Crowell, Vu Ha Minh Le, Maureen K. Larson, Shay Bracha, Christopher K. Cebra

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Distinct types of VHHs in Alpaca by Xinhao Wang, Lu Zhang, Yao Zhang, Jiaguo Li, Wenfeng Xu, Weimin Zhu

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Editorial: Single-domain antibodies—biology, engineering and emerging applications, volume II by Kevin A. Henry, Kevin A. Henry, Greg Hussack, Jan Gettemans, Cory L. Brooks

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Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery by Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton

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Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies by Silke Pudewell, Julia Heuser, Inna Dorogobed, Britta Lipinski, Thi Hong Hue Tran, Pia Metzenmacher, Richard Kunze, Felix Geyer, Stefan Zielonka, Doreen M. Floss, Harald Kolmar, Jens M. Moll, Jürgen Scheller

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Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM by Xiaofeng Zhou, Zhifang Liu, Weixiong Zhang, Lin Dai, Tao Chen, Zexiong Lin, Hong Pan, Qi Qi, Henry Wei

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PepH3-modified nanocarriers for delivery of therapeutics across the blood-brain barrier by Anikó Szecskó, Mária Mészáros, Beatriz Simões, Marco Cavaco, Catarina Chaparro, Gergő Porkoláb, Miguel A.R.B. Castanho, Mária A. Deli, Vera Neves, Szilvia Veszelka

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Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22 by Scott McComb, Mehdi Arbabi-Ghahroudi, Kevin A. Hay, Brian A. Keller, Sharlene Faulkes, Michael Rutherford, Tina Nguyen, Alex Shepherd, Cunle Wu, Anne Marcil, Annie Aubry, Greg Hussack, Devanand M. Pinto, Shannon Ryan, Shalini Raphael, Henk van Faassen, Ahmed Zafer, Qin Zhu, Susanne Maclean, Anindita Chattopadhyay, Komal Gurnani, Rénald Gilbert, Christine Gadoury, Umar Iqbal, Dorothy Fatehi, Anna Jezierski, Jez Huang, Robert A. Pon, Mhairi Sigrist, Robert A. Holt, Brad H. Nelson, Harold Atkins, Natasha Kekre, Eric Yung, John Webb, Julie S. Nielsen, Risini D. Weeratna

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A Novel Method for Preparing Uniform Micro-Sized Dry Powder Formulations, Including Aggregation-Controlled VHH by Tatsuru Moritani, Hidekazu Masaki, Ryo Yonehara, Takeru Suzuki, Hidenao Arai, Masayuki Tsuchiya, Naoto Nemoto

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Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases by Tao Yin, Aubin Ramon, Matthew Greenig, Pietro Sormanni, Luciano D’Adamio

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Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design by Yuan Fang, Menghua Song, Tianning Pu, Xiaoqing Song, Kailu Xu, Pengcheng Shen, Ting Cao, Yiman Zhao, Simon Hsu, Dongmei Han, Qiang Huang

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It’s a match: use of the radionuclide theranostic pair 133La/225Ac for the radiopharmacological characterization of EGFR-targeted single-domain antibodies by Johanna Trommer, Martin Ullrich, Falco Reissig, Santiago Andres Brühlmann, Anne-Kathrin Nitt-Weber, Zbynek Novy, Katarina Hajduova, Daniela Kurfurstova, Romana Hendrychova, Jan Bouchal, Milos Petrik, Christin Neuber, Wiebke Sihver, Sven Stadlbauer, Jens Pietzsch, Martin Kreller, Klaus Kopka, Constantin Mamat, Kristof Zarschler

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An anti-idiotypic single domain antibody as Cry2Aa toxin mimotope and analysis of its binding region through molecular docking by Manman Lin, Guangjie Han, Chuanming Li, Lixin Huang, Qin Liu, Nan Zhang, Yang Xia, Yurong Lu, Xianjin Liu, Yuan Liu, Jian Xu, Johnson Lin

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A new treatment for canine B-cell lymphoma based on a recombinant single-domain antibody immunotoxin derived from Pseudomonas aeruginosa exotoxin A by Ana S. André, Ana S. André, Joana N. R. Dias, Joana N. R. Dias, Isa Moutinho, Isa Moutinho, Joana Loureiro, Joana Loureiro, Ana Leonardo, Ana Leonardo, Sara Nogueira, Sara Nogueira, Rafaela P. Marimon, Rafaela P. Marimon, Pedro Bule, Pedro Bule, Jorge Correia, Jorge Correia, Rui Malhó, Lurdes Gano, João D. G. Correia, Solange Gil, Solange Gil, João Gonçalves, Ira Pastan, Luís Tavares, Luís Tavares, Frederico Aires-da-Silva, Frederico Aires-da-Silva

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Immune modulation following α and β− radionuclide therapy targeting fibroblast activation protein-α in a preclinical tumor model by Hannelore Ceuppens, Kirsten De Ridder, Thomas Ertveldt, Katty Zeven, Wout De Mey, Ana Rita Pombo Antunes, Laurent Navarro, Nina Dumauthioz, Tony Lahoutte, Jens M. Debacker, Nick Devoogdt, Marleen Keyaerts, Matthias D’Huyvetter, Cleo Goyvaerts, Karine Breckpot

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GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery by Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank, Ahmad Reza Mehdipour, Bram Laukens, Wim Nerinckx, Francis Santens, Simon Devos, Iebe Rossey, Karel Thooft, Sandrine Vanmarcke, Annelies Van Hecke, Xavier Saelens, Nico Callewaert

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Everestmab, a novel long-acting GLP-1/anti GLP-1R nanobody fusion protein, exerts potent anti-diabetic effects by Hongchao Pan, Yunnan Su, Yini Xie, Weiyong Wang, Wanli Qiu, Wei Chen, Wenying Lu, Zhao Lu, Weiwei Wang, Anquan Shang

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