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  1. 81

    T cell receptor signaling pathway subgroups and construction of a novel prognostic model in osteosarcoma by Huan Xu, Huimin Tao

    Published 2025-01-01
    “…Background: T cell receptor (TCR) signaling pathway is closely related to tumor progress and immunotherapy. …”
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    cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values by Danyang Zhang, Bingxue Zhang

    Published 2025-01-01
    “…Gynecological cancers, including cervical, ovarian, and endometrial malignancies, remain a significant global health burden, exacerbated by disparities in access to preventive measures such as HPV vaccination and routine screening. The cGAS/STING signaling pathway, a pivotal mechanism in innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons and inflammatory cytokines. …”
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    Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia by Jae Hee Jun, Hwayeon Cha, Je Yeong Ko, Ho-Shik Kim, Kyung Hyun Yoo, Jong Hoon Park

    Published 2025-01-01
    “…Abstract Primary cilia are sensory organelles that regulate various signaling pathways. When microtubules are compared to a highway, motor proteins carry and transport cargo proteins, which are tuned by post-translational modifications, such as acetylation. …”
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    Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer by Haq Dad, Asger Hansen

    Published 2025-01-01
    “…While the androgen receptor (AR) signaling pathway is widely recognized as central to CRPC pathogenesis, emerging research highlights the critical involvement of the non-AR signaling pathway in the disease. …”
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