Structure simulation-based comparison of active site variations in fungal ornithine decarboxylases by Min Jeong Kim, Jeong Ho Chang

“…Polyamines play crucial roles in various biological processes, including cell proliferation and differentiation, immune response modulation, and signal transduction. Ornithine decarboxylase (ODC) initiates polyamine biosynthesis by catalyzing the conversion of ornithine to putrescine in a pyridoxal phosphate (PLP)-dependent manner. …”
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Continuous Delivery of D-Luciferin by Implanted Micro-osmotic Pumps Enables True Real-Time Bioluminescence Imaging of Luciferase Activity in Vivo by Shimon Gross, Ute Abraham, Julie L. Prior, Erik D. Herzog, David Piwnica-Worms

“…Bioluminescence imaging (BLI) of luciferase reporters in small animal models offers an attractive approach to monitor regulation of gene expression, signal transduction, and protein-protein interactions, as well as following tumor progression, cell engraftment, infectious pathogens, and target-specific drug action. …”
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Differential Gene Expression Profile of Human Neutrophils Cultured with Plasmodium falciparum-Parasitized Erythrocytes by Mohamad Alaa Terkawi, Ryo Takano, Kentaro Kato

“…The transcriptional response was characterized by the upregulation of numerous genes encoding multiple surface receptors, proteins involved in signal transduction pathways, and defense response proteins. …”
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Fresh-cut watermelon: postharvest physiology, technology, and opportunities for quality improvement by Ebenezer Quandoh, Karin Albornoz

“…Fresh-cut processing induces a series of physiological and biochemical events that lead to alterations in sensory, nutritional and microbiological quality. A signal transduction cascade involving increases in respiration and ethylene production rates and elevated activities of cell wall and membrane-degrading enzymes compromise cellular and tissue integrity. …”
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Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology by Kenneth Maiese, Jinling Hou, Zhao Zhong Chong, Yan Chen Shang

“…Furthermore, both EPO and FoxOs function not only as therapeutic targets, but also as biomarkers of disease onset and progression, since their cellular pathways are closely linked and overlap with several unique signal transduction pathways. Yet, EPO and FoxOs may sometimes have unexpected and undesirable effects that can raise caution for these agents and warrant further investigations. …”
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Polyamines Interaction with Gaseous Signaling Molecules for Resilience Against Drought and Heat Stress in Plants by Nidhi, Noushina Iqbal, Nafees A. Khan

“…The functions of PAs and GSM in stress perception, signal transduction, and stress-responsive pathways have been explored. …”
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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

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Metabolomics profiling reveals p-aminobenzoic acid enhances resistance to Fusarium head blight in wheat by Yiluo Tan, Kangjun Wang, Mingming Guo, Guangxu Zhang, Xiaofeng Li, Yijun Shi, Maosheng He, Dayong Xu, Feng Chen, Jiwei Fan

“…The most enriched KEGG pathways were plant hormone signal transduction and phenylpropanoid biosynthesis, which may constitute the major defence responses to FHB challenge. …”
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In-situ profiling of glycosylation on single cells with surface plasmon resonance imaging by Xiaoyin Liu, Jinbiao Ma, Yunrui Zhang, Yi Xu, Yunxiao Wang, Dehong Yang, Di Wang, Qingjun Liu, Fenni Zhang

“…Abstract Cellular glycosylation is crucial for cell recognition, signal transduction, and the development of various diseases, especially in tumor initiation, progression, and metastasis. …”
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Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

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Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease by Liguo Zhu, Ying Li, Longyuan Zhou, Guang Yang, Ying Wang, Jing Han, Li Li, Shenghong Zhang

“…RING-type E3 ubiquitin ligases catalyse the posttranslational proteolytic and nonproteolytic functions in various physiological and pathological processes, such as inflammation-associated signal transduction. Resulting from the diversity of substrates and functional mechanisms, RING-type ligases regulate microbe recognition and inflammation by being involved in multiple inflammatory signalling pathways. …”
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Sialidase NEU3 dynamically associates to different membrane domains specifically modifying their ganglioside pattern and triggering Akt phosphorylation. by Dario Bonardi, Nadia Papini, Mario Pasini, Loredana Dileo, Flavia Orizio, Eugenio Monti, Luigi Caimi, Bruno Venerando, Roberto Bresciani

“…Among sphingolipids, gangliosides play important roles in different biological events, including signal transduction and tumorigenesis. Sialidase NEU3 shows high enzymatic specificity toward gangliosides. …”
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The Impact of Autophagy on Cell Death Modalities by Stefan W. Ryter, Kenji Mizumura, Augustine M. K. Choi

“…Autophagy and apoptosis have been shown to be coincident or antagonistic, depending on experimental context, and share cross-talk between signal transduction elements. Autophagy may modulate the outcome of other regulated forms of cell death such as necroptosis. …”
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A Non-Redundant Benchmark for Symmetric Protein Docking by Yumeng Yan, Sheng-You Huang

“…Symmetric proteins play important roles in many biological processes, such as signal transduction and molecular transportation. Therefore, determining the symmetric oligomeric structure of subunits is crucial to investigate the molecular mechanism of the related processes. …”
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Chemo-selective modification of cysteine residue: synthesis and application in the discovery of potential drug candidates by Yanyan Liao, Xuefeng Jiang

“…Cysteine (Cys), one of the less abundant AAs in many biological proteins, plays a vital role in the catalysis, signal transduction, and redox regulation of gene expression. …”
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Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma by Sonja Kabatnik, Xiang Zheng, Georgios Pappas, Sophia Steigerwald, Matthew P. Padula, Matthias Mann

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Methylation Marks of Blood Leukocytes of Native Hucul Mares Differentiated in Age by T. Ząbek, E. Semik-Gurgul, T. Szmatoła, A. Gurgul, A. Fornal, M. Bugno-Poniewierska

“…Genes colocated with age-related differentially methylated regions (age DMRs) are the members of pathways involved in cellular signal transduction, immune response, neurogenesis, differentiation, development, and cancer progression. …”
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Neurobiological Mechanism of Acupuncture for Relieving Visceral Pain of Gastrointestinal Origin by Fang Zhang, Luyi Wu, Jimeng Zhao, Tingting Lv, Zhihai Hu, Zhijun Weng, Shuoshuo Wang, Huangan Wu, Huirong Liu

“…The generation of pain involves a series of processes, including energy transduction of stimulatory signals in the sensory nerve endings (signal transduction), subsequent conduction in primary afferent nerve fibers of dorsal root ganglia, and transmission to spinal dorsal horn neurons, the ascending transmission of sensory signals in the central nervous system, and the processing of sensory signals in the cerebral cortex. …”
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Hormonal Contraceptive Use and Affective Disorders: An Updated Review by Mengelkoch S, Afshar K, Slavich GM

“…In this review, we summarize what is currently known about the impact of hormonal contraceptive use on mood symptoms, depression, and premenstrual disorders, and propose using the Social Signal Transduction Theory of Depression as a framework to generate predictions about the mechanistic pathways through which contraceptive use is associated with depression risk. …”
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Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation by Shiwen Fan, Kaixin Wang, Tianhao Zhang, Daling Deng, Jiwei Shen, Bowen Zhao, Daan Fu, Xiangdong Chen

“…Specifically, the focus includes GPX4’s physiological roles, antioxidant defense mechanisms, regulation of ferroptosis, involvement in signal transduction pathways, and metabolic regulation. …”
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