Dynamic physiology and transcriptomics revealed the alleviation effect of melatonin on Reaumuria trigyna under continuous alkaline salt stress by Xuebo Li, Lei Wang, Heyi Wang, Rui Hao, Lunkai Gao, Hongbo Cui, Hai Wu, Xiaodong Wu, Tong Qiao, Weijie Bai, Liming Zhang

“…The key mechanism identified involves melatonin’s ability to increase antioxidant enzyme activity, reduce reactive oxygen species and hydrogen peroxide levels, and alter gene expression patterns.DiscussionTranscriptomic analysis revealed significant changes in gene expression, particularly in photosynthetic signal transduction, phytohormone signaling, MAPK signaling, and the peroxisome pathway, which are crucial for the plant’s response to alkaline salt stress. …”
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Integration of ATAC-seq and RNA-seq reveals signal regulation during post-molt and inter-molt stages in muscle of Eriocheir sinensis by Bin Wang, Bin Wang, Jingjing Li, Mingzhi Zhang, Mingzhi Zhang, Anqi Li, Zhentao Song, Zhentao Song, Zhen He, Zhen He, Ruiqi Zhang, Ruiqi Zhang, Tong Hao, Tong Hao, Jinsheng Sun, Jinsheng Sun

“…In all the enriched signaling pathways, GPCR signaling pathway includes the most differentially expressed genes (8 genes), which underlines its importance in the signal transduction from the post-molt stage to the inter-molt stage. …”
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Genome-Wide Expression Profiles of Hemp (Cannabis sativa L.) in Response to Drought Stress by Chunsheng Gao, Chaohua Cheng, Lining Zhao, Yongting Yu, Qing Tang, Pengfei Xin, Touming Liu, Zhun Yan, Yuan Guo, Gonggu Zang

“…Eleven KEGG pathways were significantly influenced, the most influenced being the plant hormone signal transduction pathway with 15 differentially expressed genes. …”
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Analysis of CYP701A1 genes in gossypium species and functional characterization through gene silencing by Zhao Liang, Di Jiachun, Guo Qi, Xu Zhenzhen, Zhao Jun, Xu Peng, Xu Jianwen, Liu Jianguang, Shen Xinlian, Chen Xusheng

“…Enrichment analysis through KEGG pathway highlighted ‘Plant hormone signal transduction’ as a prominent pathway with 234 differentially expressed genes. …”
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An Optimized Liquid Chromatography–Mass Spectrometry Method for Ganglioside Analysis in Cell Lines by Akeem Sanni, Andrew I. Bennett, Yifan Huang, Isabella Gidi, Moyinoluwa Adeniyi, Judith Nwaiwu, Min H. Kang, Michelle E. Keyel, ChongFeng Gao, C. Patrick Reynolds, Brian Haab, Yehia Mechref

“…These anionic lipids form lipid rafts and play crucial roles in regulating various proteins involved in signal transduction, adhesion, and cell–cell recognition. …”
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Comparative transcriptomic analysis and identification of candidate genes related to Verticillium wilt resistance in Gossypium barbadense and Gossypium hirsutum by Jieyin Zhao, Xingui Hu, Yuxiang Wang, Jiaxin Lu, Wenju Gao, Xuening Su, Quanjia Chen, Yanying Qu

“…Further analysis of the expression of hormone biosynthesis- and signal transduction-related genes revealed that most of the genes in the salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) biosynthesis pathways were highly expressed in Hai7124; the expression of SA and JA biosynthesis genes began to be significantly upregulated in the early stage of Verticillium wilt stress, while the expression of ET biosynthesis genes was upregulated mainly in the later stage. …”
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Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux by Mélanie R. Tardif, Julie Andrea Chapeton-Montes, Alma Posvandzic, Nathalie Pagé, Caroline Gilbert, Philippe A. Tessier

“…Altogether, these findings suggest that S100A12 and S100A8/A9 are secreted independently either via distinct mechanisms of secretion or following the activation of different signal transduction pathways.…”
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Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants by Aktham Mestareehi, Xiangmin Zhang, Berhane Seyoum, Zaher Msallaty, Abdullah Mallisho, Kyle Jon Burghardt, Anjaneyulu Kowluru, Zhengping Yi

“…Protein phosphatase 2A (PP2A), a major serine/threonine protein phosphatase, plays a pivotal role in cellular processes, such as signal transduction, cell proliferation, and apoptosis, and acts through dephosphorylating key signaling molecules such as AKT and AMPK. …”
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Progesterone induces meiosis through two obligate co-receptors with PLA2 activity by Nancy Nader, Lama Assaf, Lubna Zarif, Anna Halama, Sharan Yadav, Maya Dib, Nabeel Attarwala, Qiuying Chen, Karsten Suhre, Steven Gross, Khaled Machaca

“…Despite the established physiological importance of P4 nongenomic signaling, the details of its signal transduction cascade remain elusive. Here, using Xenopus oocyte maturation as a well-established physiological readout of nongenomic P4 signaling, we identify the lipid hydrolase ABHD2 (α/β hydrolase domain-containing protein 2) as an essential mPRβ co-receptor to trigger meiosis. …”
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Evolution of human genes encoding cell surface receptors involved in the regulation of appetite: an analysis based on the phylostratigraphic age and divergence indexes by E. V. Ignatieva, S. A. Lashin, Z. S. Mustafin, N. A. Kolchanov

“…This interaction activates signal transduction pathways in the cell. A large number of exogenous ligands of various origins, including drugs, are known for cell surface receptors, which accounts for interest in them from biomedical researchers. …”
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Genome-Wide Comprehensive Identification and In Silico Characterization of Lectin Receptor-Like Kinase Gene Family in Barley (Hordeum vulgare L.) by Fee Faysal Ahmed, Farah Sumaiya Dola, Md Shohel Ul Islam, Fatema Tuz Zohra, Nasrin Akter, Shaikh Mizanur Rahman, Md. Abdur Rauf Sarkar

“…They play crucial roles in plant growth, development, immune responses, signal transduction, and stress tolerance. However, the genome-wide identification and characterization of LecRLK genes and their regulatory elements have not been explored in a major cereal crop, barley (Hordeum vulgare L.). …”
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Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts by Qiankun Liu, Pengtao Li, Muhammad Jawad Umer, Mubashir Abbas, Yongqing Zhao, Yu Chen, Yanfang Li, Aiming Zhang, Yuling Liu, Yangyang Wei, Quanwei Lu, Mengying Yang, Yiman Liu, Xiaoyan Cai, Zhongli Zhou, Shuxun Yu, Fang Liu, Renhai Peng

“…Differentially expressed genes (DEGs) were significantly enriched in the plant hormone signal transduction and MAPK signaling pathways. Transcriptome based weighted gene coexpression network analysis (WGCNA) clustered 885 commonly differentially expressed genes into four distinct modules. …”
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Protective Effect of Amphipterygium adstringens Extract on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice by Mario Rodriguez-Canales, Ruben Jimenez-Rivas, Maria Margarita Canales-Martinez, Ana Judith Garcia-Lopez, Nelly Rivera-Yañez, Oscar Nieto-Yañez, Yadira Ledesma-Soto, Luvia Enid Sanchez-Torres, Miriam Rodriguez-Sosa, Luis Ignacio Terrazas, Marco Aurelio Rodriguez-Monroy

“…The results suggested the protective potential of AaEE in DSS-induced colitis and this might be attributed to its phytochemicals compounds that have been found to induce a wide spectrum of activities such as reduction in oxidative stress, suppression of inflammation, modulating numerous signal transduction pathways, and induction of apoptosis. …”
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The role of lactylation in tumor growth and cancer progression by Khulood Al-Malsi, Khulood Al-Malsi, Khulood Al-Malsi, Sinan Xie, Sinan Xie, Sinan Xie, Yunshi Cai, Yunshi Cai, Yunshi Cai, Nader Mohammed, Kunlin Xie, Kunlin Xie, Kunlin Xie, Tian Lan, Tian Lan, Tian Lan, Hong Wu, Hong Wu, Hong Wu

“…BackgroundLactate’s perception of lactate has changed over the last 30 years from a straightforward metabolic byproduct to a complex chemical with important biological activities, such as signal transduction, gluconeogenesis, and mitochondrial respiration. …”
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Changes in DNA methylation profile in liver tissue during progression of HCV-induced fibrosis to hepatocellular carcinoma by I. A. Goncharova, A. A. Zarubin, N. P. Babushkina, I. A. Koroleva, M. S. Nazarenko

“…Genes hypomethylated in liver tumor tissue in the setting of liver cirrhosis are related to olfactory signal transduction, neuroactive ligand-receptor interaction, keratinization, immune response, inhibition of serine proteases, and zinc metabolism. …”
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Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.) by Zhu Yang, Zhu Yang, Wenjie Kan, Wenjie Kan, Ziqi Wang, Caiguo Tang, Yuan Cheng, Yuan Cheng, Dacheng Wang, Dacheng Wang, Yameng Gao, Lifang Wu, Lifang Wu

“…Phytochromes are essential photoreceptors in plants that sense red and far-red light, playing a vital role in regulating plant growth and development through light signal transduction. Despite extensive research on phytochromes in model plants like Arabidopsis and rice, they have received relatively little attention in wheat. …”
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Identification of Host–Protein Interaction Network of Canine Parvovirus Capsid Protein VP2 in F81 Cells by Hongzhuan Zhou, Huanhuan Zhang, Xia Su, Fuzhou Xu, Bing Xiao, Jin Zhang, Qi Qi, Lulu Lin, Kaidi Cui, Qinqin Li, Songping Li, Bing Yang

“…The results showed that CPV VP2 protein participated mainly in cell metabolism, cell biosynthesis, protein folding and various signal transduction processes. According to the results of proteomics analysis, we randomly selected seven proteins for co-immunoprecipitation verification, and the experimental results were consistent with the LC-MS/MS data. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…TCZ exerts a protective effect on the kidneys by specifically binding to the IL-6 receptor and blocking the signal transduction of IL-6. Additionally, the levels of IL-6 were detected by employing ELISA kits. …”
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Integrated metabolome and transcriptome analysis reveals potential mechanism during the bud dormancy transition of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsi... by Huan Guan, Huan Guan, Yuhuan Zhao, Yuhuan Zhao, Qing Chen, Qianqian Zhang, Qianqian Zhang, Pengpeng Yang, Pengpeng Yang, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

“…The transcription factors MYB, ERF, bHLH, zinc finger, and MADS-box may regulate the genes involved in hormone signal transduction and starch and sucrose metabolism, which are critical for regulating the transition from endo- to ecodormancy in AMM buds. …”
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Effects of Carbonate Alkalinity on Antioxidants, Immunity and Intestinal Flora of <i>Penaeus vannamei</i> by Chuang Gao, Zhonghong Li, Bo Ma, Rantao Zuo, Xudong Shen, Mingkang Chen, Chuanqi Ren, Wenjun Zheng, Zhonglu Cai, Jiaxing Li, Shuang Li

“…The functional abundance of signal transduction histidine kinase was lower than that of the control group. …”
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